Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Davidson MH et al. | Effects of docosahexaenoic acid on serum lipoproteins in patients with combined hyperlipidemia: a randomized, double-blind, placebo-controlled trial. | 1997 | J Am Coll Nutr | pmid:9176830 |
Connor WE et al. | Biochemical markers for puberty in the monkey testis: desmosterol and docosahexaenoic acid. | 1997 | J. Clin. Endocrinol. Metab. | pmid:9177405 |
Shimura T et al. | Docosahexanoic acid (DHA) improved glucose and lipid metabolism in KK-Ay mice with genetic non-insulin-dependent diabetes mellitus (NIDDM). | 1997 | Biol. Pharm. Bull. | pmid:9178930 |
Jones CR et al. | Evidence for the involvement of docosahexaenoic acid in cholinergic stimulated signal transduction at the synapse. | 1997 | Neurochem. Res. | pmid:9178948 |
Ikemoto A et al. | Membrane fatty acid modifications of PC12 cells by arachidonate or docosahexaenoate affect neurite outgrowth but not norepinephrine release. | 1997 | Neurochem. Res. | pmid:9178949 |
Ding ST and Lilburn MS | Changes in fatty acid profiles in different lipid classes during late development of turkey embryos from two genetic lines. | 1997 | Poult. Sci. | pmid:9181615 |
Terano T et al. | Eicosapentaenoic acid and docosahexaenoic acid inhibit DNA synthesis through inhibiting cdk2 kinase in vascular smooth muscle cells. | 1997 | Ann. N. Y. Acad. Sci. | pmid:9186612 |
Innis SM and Dyer R | Dietary triacylglycerols with palmitic acid (16:0) in the 2-position increase 16:0 in the 2-position of plasma and chylomicron triacylglycerols, but reduce phospholipid arachidonic and docosahexaenoic acids, and alter cholesteryl ester metabolism in formula-Fed piglets. | 1997 | J. Nutr. | pmid:9202085 |
Petrukhina GN et al. | [The effect of the chronic internal administration of the new Russian n-3 polyunsaturated fatty acid concentrate--epaden--on blood coagulation system indices in rabbits]. | 1997 Mar-Apr | Eksp Klin Farmakol | pmid:9206567 |
Murakami T et al. | Suppressive action of docosahexaenoic acid enriched-Euglena on reduction of endothelium-dependent relaxation in stroke-prone spontaneously hypertensive rats (SHRSP). | 1997 | J. Nutr. Sci. Vitaminol. | pmid:9219094 |
Reynaud D and Pace-Asciak CR | Docosahexaenoic acid causes accumulation of free arachidonic acid in rat pineal gland and hippocampus to form hepoxilins from both substrates. | 1997 | Biochim. Biophys. Acta | pmid:9219915 |
Hempenius RA et al. | Preliminary safety assessment of an arachidonic acid-enriched oil derived from Mortierella alpina: summary of toxicological data. | 1997 | Food Chem. Toxicol. | pmid:9225015 |
Peng HW et al. | Urine lipids in patients with a history of filariasis. | 1997 | Urol. Res. | pmid:9228676 |
Panchenko VM et al. | [Effects of eifitol on lipid metabolism in patients with clinically different ischemic heart diseases]. | 1997 | Klin Med (Mosk) | pmid:9229613 |
Huang ZH et al. | N-6 and n-3 polyunsaturated fatty acids stimulate translocation of protein kinase Calpha, -betaI, -betaII and -epsilon and enhance agonist-induced NADPH oxidase in macrophages. | 1997 | Biochem. J. | pmid:9230140 |
Takahashi M et al. | Suppression of azoxymethane-induced rat colon carcinoma development by a fish oil component, docosahexaenoic acid (DHA). | 1997 | Carcinogenesis | pmid:9230276 |
Rotstein NP et al. | Apoptosis of retinal photoreceptors during development in vitro: protective effect of docosahexaenoic acid. | 1997 | J. Neurochem. | pmid:9231708 |
Schønberg SA and Skorpen F | Paracetamol counteracts docosahexaenoic acid-induced growth inhibition of A-427 lung carcinoma cells and enhances tumor cell proliferation in vitro. | 1997 Jul-Aug | Anticancer Res. | pmid:9252660 |
Oliveira FL et al. | Triglyceride hydrolysis of soy oil vs fish oil emulsions. | 1997 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:9252949 |
Vidgren HM et al. | Incorporation of n-3 fatty acids into plasma lipid fractions, and erythrocyte membranes and platelets during dietary supplementation with fish, fish oil, and docosahexaenoic acid-rich oil among healthy young men. | 1997 | Lipids | pmid:9252957 |