DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fleming JA and Kris-Etherton PM | The evidence for α-linolenic acid and cardiovascular disease benefits: Comparisons with eicosapentaenoic acid and docosahexaenoic acid. | 2014 | Adv Nutr | pmid:25398754 |
| Lagarde M et al. | Structure-function relationships of non-cyclic dioxygenase products from polyunsaturated fatty acids: poxytrins as a class of bioactive derivatives. | 2014 | Biochimie | pmid:25223888 |
| Gilbert K et al. | Resolvin D1, a metabolite of omega-3 polyunsaturated fatty acid, decreases post-myocardial infarct depression. | 2014 | Mar Drugs | pmid:25402828 |
| Metcalf RG et al. | U-shaped relationship between tissue docosahexaenoic acid and atrial fibrillation following cardiac surgery. | 2014 | Eur J Clin Nutr | pmid:24169465 |
| Bremer AA et al. | Fish oil supplementation ameliorates fructose-induced hypertriglyceridemia and insulin resistance in adult male rhesus macaques. | 2014 | J. Nutr. | pmid:24108131 |
| Papanikolaou Y et al. | U.S. adults are not meeting recommended levels for fish and omega-3 fatty acid intake: results of an analysis using observational data from NHANES 2003-2008. | 2014 | Nutr J | pmid:24694001 |
| Gong J et al. | Maresin 1 mitigates LPS-induced acute lung injury in mice. | 2014 | Br. J. Pharmacol. | pmid:24697684 |
| Ottosson NE et al. | Drug-induced ion channel opening tuned by the voltage sensor charge profile. | 2014 | J. Gen. Physiol. | pmid:24420769 |
| Li S et al. | The targeting mechanism of DHA ligand and its conjugate with Gemcitabine for the enhanced tumor therapy. | 2014 | Oncotarget | pmid:25004114 |
| Hong SH et al. | Docosahexaenoic acid confers enduring neuroprotection in experimental stroke. | 2014 | J. Neurol. Sci. | pmid:24433927 |
| Mulder KA et al. | Omega-3 fatty acid deficiency in infants before birth identified using a randomized trial of maternal DHA supplementation in pregnancy. | 2014 | PLoS ONE | pmid:24427279 |
| Marklund M et al. | A dietary biomarker approach captures compliance and cardiometabolic effects of a healthy Nordic diet in individuals with metabolic syndrome. | 2014 | J. Nutr. | pmid:25080537 |
| Domenichiello AF et al. | Whole body synthesis rates of DHA from α-linolenic acid are greater than brain DHA accretion and uptake rates in adult rats. | 2014 | J. Lipid Res. | pmid:24212299 |
| Arafiles KH et al. | Value-added lipid production from brown seaweed biomass by two-stage fermentation using acetic acid bacterium and thraustochytrid. | 2014 | Appl. Microbiol. Biotechnol. | pmid:25086614 |
| Koutsos A et al. | Greater impact of dietary fat manipulation than apolipoprotein E genotype on ex vivo cytokine production - insights from the SATgenε study. | 2014 | Cytokine | pmid:24485322 |
| Di Gregorio E et al. | ELOVL5 mutations cause spinocerebellar ataxia 38. | 2014 | Am. J. Hum. Genet. | pmid:25065913 |
| Sokolov EI et al. | [Value of Fatty acids in formation of thrombotic status in patients with ischemic heart disease]. | 2014 | Kardiologiia | pmid:25177882 |
| Aslan M et al. | A pilot study investigating early postoperative changes of plasma polyunsaturated fatty acids after laparoscopic sleeve gastrectomy. | 2014 | Lipids Health Dis | pmid:24694037 |
| Gregory MK and James MJ | Functional characterization of the duck and turkey fatty acyl elongase enzymes ELOVL5 and ELOVL2. | 2014 | J. Nutr. | pmid:24919687 |
| Norris JM et al. | Erythrocyte membrane docosapentaenoic acid levels are associated with islet autoimmunity: the Diabetes Autoimmunity Study in the Young. | 2014 | Diabetologia | pmid:24240437 |
| Dai XW et al. | Erythrocyte membrane n-3 fatty acid levels and carotid atherosclerosis in Chinese men and women. | 2014 | Atherosclerosis | pmid:24401220 |
| Yamanushi TT et al. | Oral administration of eicosapentaenoic acid or docosahexaenoic acid modifies cardiac function and ameliorates congestive heart failure in male rats. | 2014 | J. Nutr. | pmid:24523492 |
| Aursnes M et al. | Total synthesis of the lipid mediator PD1n-3 DPA: configurational assignments and anti-inflammatory and pro-resolving actions. | 2014 | J. Nat. Prod. | pmid:24576195 |
| Meagher KA et al. | Regarding macular xanthophylls and ω-3 long-chain polyunsaturated fatty acids in age-related macular degeneration. | 2014 | JAMA Ophthalmol | pmid:24525935 |
| Arnold C et al. | Regarding macular xanthophylls and ω-3 long-chain polyunsaturated fatty acids in age-related macular degeneration--reply. | 2014 | JAMA Ophthalmol | pmid:24525936 |
| Brasky TM et al. | Associations of long-chain ω-3 fatty acids and fish intake with endometrial cancer risk in the VITamins And Lifestyle cohort. | 2014 | Am. J. Clin. Nutr. | pmid:24500149 |
| Sánchez-Reyes OB et al. | Free fatty acids and protein kinase C activation induce GPR120 (free fatty acid receptor 4) phosphorylation. | 2014 | Eur. J. Pharmacol. | pmid:24239485 |
| Nobili V et al. | Role of docosahexaenoic acid treatment in improving liver histology in pediatric nonalcoholic fatty liver disease. | 2014 | PLoS ONE | pmid:24505350 |
| Li X et al. | Production of structured phosphatidylcholine with high content of DHA/EPA by immobilized phospholipase Aâ‚-catalyzed transesterification. | 2014 | Int J Mol Sci | pmid:25170810 |
| Paterniti I et al. | Docosahexaenoic acid attenuates the early inflammatory response following spinal cord injury in mice: in-vivo and in-vitro studies. | 2014 | J Neuroinflammation | pmid:24405628 |
| Chen J et al. | Aspirin-triggered resolvin D1 down-regulates inflammatory responses and protects against endotoxin-induced acute kidney injury. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24709673 |
| Recchiuti A et al. | Immunoresolving actions of oral resolvin D1 include selective regulation of the transcription machinery in resolution-phase mouse macrophages. | 2014 | FASEB J. | pmid:24692596 |
| Colas RA et al. | Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:24696140 |
| Liu Y et al. | The fish oil ingredient, docosahexaenoic acid, activates cytosolic phospholipase Aâ‚‚ via GPR120 receptor to produce prostaglandin Eâ‚‚ and plays an anti-inflammatory role in macrophages. | 2014 | Immunology | pmid:24673159 |
| Røsjø E et al. | Increasing serum levels of vitamin A, D and E are associated with alterations of different inflammation markers in patients with multiple sclerosis. | 2014 | J. Neuroimmunol. | pmid:24713402 |
| Létondor A et al. | Erythrocyte DHA level as a biomarker of DHA status in specific brain regions of n-3 long-chain PUFA-supplemented aged rats. | 2014 | Br. J. Nutr. | pmid:25331622 |
| Kim W et al. | Dietary fish oil and DHA down-regulate antigen-activated CD4+ T-cells while promoting the formation of liquid-ordered mesodomains. | 2014 | Br. J. Nutr. | pmid:23962659 |
| Kermack AJ et al. | A randomised controlled trial of a preconceptional dietary intervention in women undergoing IVF treatment (PREPARE trial). | 2014 | BMC Womens Health | pmid:25407227 |
| Wang JL et al. | Preparation and characterization of novel lipid carriers containing microalgae oil for food applications. | 2014 | J. Food Sci. | pmid:24446860 |
| Giovannelli J et al. | Validation of a short, qualitative food frequency questionnaire in French adults participating in the MONA LISA-NUT study 2005-2007. | 2014 | J Acad Nutr Diet | pmid:24083967 |
| Zhang B et al. | Polyunsaturated fatty acids for the prevention of atrial fibrillation after cardiac surgery: an updated meta-analysis of randomized controlled trials. | 2014 | J Cardiol | pmid:23911138 |
| Rius B et al. | Resolvin D1 primes the resolution process initiated by calorie restriction in obesity-induced steatohepatitis. | 2014 | FASEB J. | pmid:24249635 |
| Choi EY et al. | DHA suppresses Prevotella intermedia lipopolysaccharide-induced production of proinflammatory mediators in murine macrophages. | 2014 | Br. J. Nutr. | pmid:24252501 |
| Liu M et al. | Protectin DX, a double lipoxygenase product of DHA, inhibits both ROS production in human neutrophils and cyclooxygenase activities. | 2014 | Lipids | pmid:24254970 |
| Hutchins-Wiese HL et al. | High-dose eicosapentaenoic acid and docosahexaenoic acid supplementation reduces bone resorption in postmenopausal breast cancer survivors on aromatase inhibitors: a pilot study. | 2014 | Nutr Cancer | pmid:24274259 |
| Ponnampalam EN et al. | Sources of variation of health claimable long chain omega-3 fatty acids in meat from Australian lamb slaughtered at similar weights. | 2014 | Meat Sci. | pmid:23265412 |
| Amiri-Jami M et al. | Engineering of EPA/DHA omega-3 fatty acid production by Lactococcus lactis subsp. cremoris MG1363. | 2014 | Appl. Microbiol. Biotechnol. | pmid:24389665 |
| James MJ et al. | Pitfalls in the use of randomised controlled trials for fish oil studies with cardiac patients. | 2014 | Br. J. Nutr. | pmid:24933212 |
| Chang D et al. | Serum free fatty acids level in senile cataract. | 2014 | J Am Coll Nutr | pmid:25079310 |
| Purcell R et al. | High-fat meals rich in EPA plus DHA compared with DHA only have differential effects on postprandial lipemia and plasma 8-isoprostane F2α concentrations relative to a control high-oleic acid meal: a randomized controlled trial. | 2014 | Am. J. Clin. Nutr. | pmid:25099540 |