Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Van Biervliet S et al. | Docosahexaenoic acid trials in cystic fibrosis: a review of the rationale behind the clinical trials. | 2005 | J. Cyst. Fibros. | pmid:15752678 |
Goirand F et al. | Effect of dietary docosahexaenoic acid on the endothelium-dependent vasorelaxation in diabetic rats. | 2005 | Clin. Exp. Pharmacol. Physiol. | pmid:15743401 |
Itomura M et al. | The effect of fish oil on physical aggression in schoolchildren--a randomized, double-blind, placebo-controlled trial. | 2005 | J. Nutr. Biochem. | pmid:15741051 |
Aro TL et al. | Fatty acids and fat-soluble vitamins in salted herring (Clupea harengus) products. | 2005 | J. Agric. Food Chem. | pmid:15740028 |
Valenzuela A et al. | Effect of supplementation with docosahexaenoic acid ethyl ester and sn-2 docosahexaenyl monoacylglyceride on plasma and erythrocyte fatty acids in rats. | 2005 Jan-Feb | Ann. Nutr. Metab. | pmid:15735367 |
Hashimoto M et al. | Chronic administration of docosahexaenoic acid ameliorates the impairment of spatial cognition learning ability in amyloid beta-infused rats. | 2005 | J. Nutr. | pmid:15735092 |
Mollard RC et al. | Low levels of dietary arachidonic and docosahexaenoic acids improve bone mass in neonatal piglets, but higher levels provide no benefit. | 2005 | J. Nutr. | pmid:15735085 |
Serhan CN et al. | Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers. | 2004 | Lipids | pmid:15726828 |
Anderson RE and Penn JS | Environmental light and heredity are associated with adaptive changes in retinal DHA levels that affect retinal function. | 2004 | Lipids | pmid:15726827 |
Brinsko SP et al. | Effect of feeding a DHA-enriched nutriceutical on the quality of fresh, cooled and frozen stallion semen. | 2005 | Theriogenology | pmid:15725455 |
Kojima M et al. | Serum levels of polyunsaturated fatty acids and risk of colorectal cancer: a prospective study. | 2005 | Am. J. Epidemiol. | pmid:15718482 |
GarcÃa-Calatayud S et al. | Brain docosahexaenoic acid status and learning in young rats submitted to dietary long-chain polyunsaturated fatty acid deficiency and supplementation limited to lactation. | 2005 | Pediatr. Res. | pmid:15718358 |
Groh-Wargo S et al. | Body composition in preterm infants who are fed long-chain polyunsaturated fatty acids: a prospective, randomized, controlled trial. | 2005 | Pediatr. Res. | pmid:15718356 |
Serhan CN | Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectins. | 2005 | Curr Opin Clin Nutr Metab Care | pmid:15716788 |
Gronert K et al. | A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense. | 2005 | J. Biol. Chem. | pmid:15708862 |
Narayanan NK et al. | A combination of docosahexaenoic acid and celecoxib prevents prostate cancer cell growth in vitro and is associated with modulation of nuclear factor-kappaB, and steroid hormone receptors. | 2005 | Int. J. Oncol. | pmid:15703837 |
Geelen A et al. | Effects of n-3 fatty acids from fish on premature ventricular complexes and heart rate in humans. | 2005 | Am. J. Clin. Nutr. | pmid:15699229 |
Li H et al. | EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: evidence for a PPAR-gamma-dependent mechanism. | 2005 | Kidney Int. | pmid:15698426 |
Okuda N et al. | Relation of long chain n-3 polyunsaturated fatty acid intake to serum high density lipoprotein cholesterol among Japanese men in Japan and Japanese-American men in Hawaii: the INTERLIPID study. | 2005 | Atherosclerosis | pmid:15694947 |
Økland HM et al. | Proximate composition, fatty acid and lipid class composition of the muscle from deep-sea teleosts and elasmobranchs. | 2005 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:15694592 |
Beblo S et al. | Effects of alcohol intake during pregnancy on docosahexaenoic acid and arachidonic acid in umbilical cord vessels of black women. | 2005 | Pediatrics | pmid:15687427 |
Rajamoorthi K et al. | Packing and viscoelasticity of polyunsaturated omega-3 and omega-6 lipid bilayers as seen by (2)H NMR and X-ray diffraction. | 2005 | J. Am. Chem. Soc. | pmid:15686391 |
Carrillo-DomÃnguez S et al. | Cholesterol and n-3 and n-6 fatty acid content in eggs from laying hens fed with red crab meal (Pleuroncodes planipes). | 2005 | Poult. Sci. | pmid:15685957 |
Szabó A et al. | Differential utilization of hepatic and myocardial fatty acids during forced molt of laying hens. | 2005 | Poult. Sci. | pmid:15685949 |
Turner AJ et al. | Targeting amyloid-degrading enzymes as therapeutic strategies in neurodegeneration. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15681797 |
Gleize B et al. | Docosahexaenoic acid-enriched egg phospholipids supplementation induces accretion of arachidonic acid in rat blood lipids. | 2004 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:15672471 |
Gerbi A et al. | Dose dependent accretion of docosahexaenoic acid (DHA) in cardiac membranes of rats fed egg yolk powder enriched in DHA. | 2004 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:15672470 |
Mutch DM et al. | An integrative metabolism approach identifies stearoyl-CoA desaturase as a target for an arachidonate-enriched diet. | 2005 | FASEB J. | pmid:15670975 |
Verlengia R et al. | Effects of EPA and DHA on proliferation, cytokine production, and gene expression in Raji cells. | 2004 | Lipids | pmid:15669761 |
Du ZY et al. | Alteration of 20:5n-3 and 22:6n-3 fat contents and liver peroxisomal activities in fenofibrate-treated rainbow trout. | 2004 | Lipids | pmid:15669760 |
Sul D et al. | Benzene increases the ratio of arachidonic acids to docosahexaenoic acids and inhibits the de novo synthesis of ceramide in the rat liver. | 2005 Jan-Feb | J Appl Toxicol | pmid:15669040 |
Yamamoto K et al. | Identification of putative metabolites of docosahexaenoic acid as potent PPARgamma agonists and antidiabetic agents. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15664804 |
Chiu LC et al. | Docosahexaenoic acid from a cultured microalga inhibits cell growth and induces apoptosis by upregulating Bax/Bcl-2 ratio in human breast carcinoma MCF-7 cells. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15659818 |
Katsumata T and Katayama Y | [Icosapentanoic acid (EPA), docosahexanoic acid (DHA)]. | 2004 | Nippon Rinsho | pmid:15658280 |
Marszalek JR et al. | Long-chain acyl-CoA synthetase 6 preferentially promotes DHA metabolism. | 2005 | J. Biol. Chem. | pmid:15655248 |
Storey A et al. | Eicosapentaenoic acid and docosahexaenoic acid reduce UVB- and TNF-alpha-induced IL-8 secretion in keratinocytes and UVB-induced IL-8 in fibroblasts. | 2005 | J. Invest. Dermatol. | pmid:15654981 |
Stark KD et al. | Alcohol consumption in pregnant, black women is associated with decreased plasma and erythrocyte docosahexaenoic acid. | 2005 | Alcohol. Clin. Exp. Res. | pmid:15654301 |
Milne GL et al. | The cyclopentenone (A2/J2) isoprostanes--unique, highly reactive products of arachidonate peroxidation. | 2005 Jan-Feb | Antioxid. Redox Signal. | pmid:15650409 |
Zemski Berry KA and Murphy RC | Free radical oxidation of plasmalogen glycerophosphocholine containing esterified docosahexaenoic acid: structure determination by mass spectrometry. | 2005 Jan-Feb | Antioxid. Redox Signal. | pmid:15650405 |
Hossain Z et al. | Effect of polyunsaturated fatty acid-enriched phosphatidylcholine and phosphatidylserine on butyrate-induced growth inhibition, differentiation and apoptosis in Caco-2 cells. | 2006 Mar-Apr | Cell Biochem. Funct. | pmid:15648055 |
Nguyen LQ et al. | Feeding of spinach or sweet-potato leaves and growth performance of growing pigs kept on smallholder farms in Central Vietnam. | 2004 | Trop Anim Health Prod | pmid:15643817 |
Hofmanová J et al. | Polyunsaturated fatty acids sensitize human colon adenocarcinoma HT-29 cells to death receptor-mediated apoptosis. | 2005 | Cancer Lett. | pmid:15639338 |
Kaul U et al. | Fish oil supplements for prevention of restenosis after coronary angioplasty. | 1992 | Int. J. Cardiol. | pmid:1563884 |
Hamam F and Shahidi F | Production and stability of structured lipids from algal oils and capric acid. | 2004 | Biofactors | pmid:15630303 |
Nagata J et al. | Effects of structured lipids containing eicosapentaenoic or docosahexaenoic acid and caprylic acid on serum and liver lipid profiles in rats. | 2004 | Biofactors | pmid:15630273 |
McCabe AJ et al. | Docosahexaenoic acid reduces in vitro invasion of renal cell carcinoma by elevated levels of tissue inhibitor of metalloproteinase-1. | 2005 | J. Nutr. Biochem. | pmid:15629236 |
Denys A et al. | n-3 PUFAs modulate T-cell activation via protein kinase C-alpha and -epsilon and the NF-kappaB signaling pathway. | 2005 | J. Lipid Res. | pmid:15627650 |
Maldjian A et al. | Changes in sperm quality and lipid composition during cryopreservation of boar semen. | 2005 | Theriogenology | pmid:15626408 |
Engler MM et al. | Docosahexaenoic acid restores endothelial function in children with hyperlipidemia: results from the EARLY study. | 2004 | Int J Clin Pharmacol Ther | pmid:15624283 |
Hirasawa A et al. | Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. | 2005 | Nat. Med. | pmid:15619630 |
Sun L et al. | Inhibition of osteoporosis due to restricted food intake by the fish oils DHA and EPA and perilla oil in the rat. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15618634 |
Verlengia R et al. | Comparative effects of eicosapentaenoic acid and docosahexaenoic acid on proliferation, cytokine production, and pleiotropic gene expression in Jurkat cells. | 2004 | J. Nutr. Biochem. | pmid:15590269 |
Puskás LG et al. | Cholesterol and cholesterol plus DHA diet-induced gene expression and fatty acid changes in mouse eye and brain. | 2004 | Biochimie | pmid:15589691 |
Dijck-Brouwer DA et al. | Lower fetal status of docosahexaenoic acid, arachidonic acid and essential fatty acids is associated with less favorable neonatal neurological condition. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15589396 |
Huang BX et al. | Probing conformational changes of human serum albumin due to unsaturated fatty acid binding by chemical cross-linking and mass spectrometry. | 2005 | Biochem. J. | pmid:15588254 |
Whalley LJ et al. | Cognitive aging, childhood intelligence, and the use of food supplements: possible involvement of n-3 fatty acids. | 2004 | Am. J. Clin. Nutr. | pmid:15585782 |
Cao DH et al. | Protective effect of chronic ethyl docosahexaenoate administration on brain injury in ischemic gerbils. | 2004 | Pharmacol. Biochem. Behav. | pmid:15582673 |
Rupp H et al. | Risk stratification by the "EPA+DHA level" and the "EPA/AA ratio" focus on anti-inflammatory and antiarrhythmogenic effects of long-chain omega-3 fatty acids. | 2004 | Herz | pmid:15580322 |
Hussein N et al. | Long-chain conversion of [13C]linoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men. | 2005 | J. Lipid Res. | pmid:15576848 |
Hibbeln JR et al. | Omega-3 status and cerebrospinal fluid corticotrophin releasing hormone in perpetrators of domestic violence. | 2004 | Biol. Psychiatry | pmid:15576068 |
Danbara N et al. | Conjugated docosahexaenoic acid is a potent inducer of cell cycle arrest and apoptosis and inhibits growth of colo 201 human colon cancer cells. | 2004 | Nutr Cancer | pmid:15572300 |
Jia Q et al. | Docosahexaenoic acid attenuates mycotoxin-induced immunoglobulin a nephropathy, interleukin-6 transcription, and mitogen-activated protein kinase phosphorylation in mice. | 2004 | J. Nutr. | pmid:15570035 |
Belayev L et al. | Docosahexaenoic acid complexed to albumin elicits high-grade ischemic neuroprotection. | 2005 | Stroke | pmid:15569878 |
DeMar JC et al. | Half-lives of docosahexaenoic acid in rat brain phospholipids are prolonged by 15 weeks of nutritional deprivation of n-3 polyunsaturated fatty acids. | 2004 | J. Neurochem. | pmid:15569256 |
Das UN | Can perinatal supplementation of long-chain polyunsaturated fatty acids prevents schizophrenia in adult life? | 2004 | Med. Sci. Monit. | pmid:15567990 |
Katsura K et al. | Effects of hyperglycemia and hypercapnia on lipid metabolism during complete brain ischemia. | 2004 | Brain Res. | pmid:15567345 |
Miura Y et al. | Docosahexaenoic acid induces apoptosis via the Bax-independent pathway in HL-60 cells. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15564688 |
Manav M et al. | Omega-3 fatty acids and selenium as coronary heart disease risk modifying factors in Asian Indian and Chinese males. | 2004 Nov-Dec | Nutrition | pmid:15561485 |
Tanabe Y et al. | Improvement of spatial cognition with dietary docosahexaenoic acid is associated with an increase in Fos expression in rat CA1 hippocampus. | 2004 | Clin. Exp. Pharmacol. Physiol. | pmid:15554911 |
Ko YH et al. | Cloning and expression of Tsaiya duck liver fatty acid binding protein. | 2004 | Poult. Sci. | pmid:15554058 |
Eschen O et al. | Soluble adhesion molecules in healthy subjects: a dose-response study using n-3 fatty acids. | 2004 | Nutr Metab Cardiovasc Dis | pmid:15553594 |
Hastings N et al. | Molecular cloning and functional characterization of fatty acyl desaturase and elongase cDNAs involved in the production of eicosapentaenoic and docosahexaenoic acids from alpha-linolenic acid in Atlantic salmon (Salmo salar). | 2004 Sep-Oct | Mar. Biotechnol. | pmid:15549653 |
Adiv OE et al. | Influence of co-administration of oral insulin and docosahexaenoic acid in mice. | 2004 | J. Nutr. Biochem. | pmid:15542356 |
Virtanen JK et al. | Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:15539625 |
Aslan A and Triadafilopoulos G | Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study. | 1992 | Am. J. Gastroenterol. | pmid:1553930 |
Lefkowitz W et al. | Where does the developing brain obtain its docosahexaenoic acid? Relative contributions of dietary alpha-linolenic acid, docosahexaenoic acid, and body stores in the developing rat. | 2005 | Pediatr. Res. | pmid:15531740 |
Giltay EJ et al. | Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects. | 2004 | Am. J. Clin. Nutr. | pmid:15531662 |
Wassall SR et al. | Order from disorder, corralling cholesterol with chaotic lipids. The role of polyunsaturated lipids in membrane raft formation. | 2004 | Chem. Phys. Lipids | pmid:15530450 |
Jellema A et al. | Weight reduction, but not a moderate intake of fish oil, lowers concentrations of inflammatory markers and PAI-1 antigen in obese men during the fasting and postprandial state. | 2004 | Eur. J. Clin. Invest. | pmid:15530150 |
Fan YY et al. | Dietary docosahexaenoic acid suppresses T cell protein kinase C theta lipid raft recruitment and IL-2 production. | 2004 | J. Immunol. | pmid:15528352 |
Speake BK et al. | Evidence for placental transfer of lipids during gestation in the viviparous lizard, Pseudemoia entrecasteauxii. | 2004 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:15528170 |
Martin DA et al. | Prenatal dietary docosahexaenoic acid supplementation in combination with protein restriction does not affect blood pressure in adult Wistar rats. | 2004 | Nutr Neurosci | pmid:15526988 |
Furimsky A et al. | Percoll gradient-centrifuged capacitated mouse sperm have increased fertilizing ability and higher contents of sulfogalactosylglycerolipid and docosahexaenoic acid-containing phosphatidylcholine compared to washed capacitated mouse sperm. | 2005 | Biol. Reprod. | pmid:15525814 |
Wynter MP et al. | Effect of n-3 fatty acids on the antitumour effects of cytotoxic drugs. | 2004 Sep-Oct | In Vivo | pmid:15523890 |
Zhou D et al. | Vitamin A deficiency reduces liver and colon docosahexaenoic acid levels in rats fed high linoleic and low alpha-linolenic acid diet. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15519497 |
Love R | Good fats prevent dendritic damage in mouse model of AD. | 2004 | Lancet Neurol | pmid:15515234 |
Foley JM et al. | Fatty acids and exercise affect glucose transport but not tumour growth in F-344 rats. | 2004 | Can J Appl Physiol | pmid:15507696 |
Gueck T et al. | Alterations of mast cell mediator production and release by gamma-linolenic and docosahexaenoic acid. | 2004 | Vet. Dermatol. | pmid:15500483 |
Harries M et al. | Phase I/II study of DHA-paclitaxel in combination with carboplatin in patients with advanced malignant solid tumours. | 2004 | Br. J. Cancer | pmid:15494716 |
Danbara N et al. | Dietary effects of conjugated docosahexaenoic acid on N-methyl-N-nitrosourea-induced mammary carcinogenesis in female Sprague-Dawley rats. | 2004 | Oncol. Rep. | pmid:15492796 |
Buckley R et al. | Circulating triacylglycerol and apoE levels in response to EPA and docosahexaenoic acid supplementation in adult human subjects. | 2004 | Br. J. Nutr. | pmid:15469651 |
Subbaiah PV et al. | Evidence for altered positional specificity of LCAT in vivo: studies with docosahexaenoic acid feeding in humans. | 2004 | J. Lipid Res. | pmid:15466370 |
Strokin M et al. | Role of Ca2+-independent phospholipase A2 and n-3 polyunsaturated fatty acid docosahexaenoic acid in prostanoid production in brain: perspectives for protection in neuroinflammation. | 2004 | Int. J. Dev. Neurosci. | pmid:15465285 |
Alexopoulos E et al. | Treatment of severe IgA nephropathy with omega-3 fatty acids: the effect of a "very low dose" regimen. | 2004 | Ren Fail | pmid:15462115 |
Valentine RC and Valentine DL | Omega-3 fatty acids in cellular membranes: a unified concept. | 2004 | Prog. Lipid Res. | pmid:15458813 |
Mitre R et al. | Oral intake of shark liver oil modifies lipid composition and improves motility and velocity of boar sperm. | 2004 | Theriogenology | pmid:15451263 |
Ethier I et al. | Docosahexaenoic acid reduces haloperidol-induced dyskinesias in mice: involvement of Nur77 and retinoid receptors. | 2004 | Biol. Psychiatry | pmid:15450789 |
Huan M et al. | Suicide attempt and n-3 fatty acid levels in red blood cells: a case control study in China. | 2004 | Biol. Psychiatry | pmid:15450784 |
Gordge MP et al. | Anti-platelet therapy in diabetic and non-diabetic progressive renal failure. | 1992 | Clin. Nephrol. | pmid:1541067 |
Pacetti D et al. | High-performance liquid chromatography/electrospray ionization ion-trap tandem mass spectrometric analysis and quantification of phosphatidylcholine molecular species in the serum of cystic fibrosis subjects supplemented with docosahexaenoic acid. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15386630 |