DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Igarashi M et al. | Dietary n-6 polyunsaturated fatty acid deprivation increases docosahexaenoic acid metabolism in rat brain. | 2012 | J. Neurochem. | pmid:22117540 |
| Lim SJ et al. | Docosahexaenoic acid sensitizes colon cancer cells to sulindac sulfide-induced apoptosis. | 2012 | Oncol. Rep. | pmid:22395735 |
| Sørensen IM et al. | Serum long chain n-3 fatty acids (EPA and DHA) in the pregnant mother are independent of risk of type 1 diabetes in the offspring. | 2012 | Diabetes Metab. Res. Rev. | pmid:22396195 |
| Hutchins-Wiese HL et al. | Hind limb suspension and long-chain omega-3 PUFA increase mRNA endocannabinoid system levels in skeletal muscle. | 2012 | J. Nutr. Biochem. | pmid:22051448 |
| Jayashankar S et al. | Cerebral gene expression and neurobehavioural responses in mice pups exposed to methylmercury and docosahexaenoic acid through the maternal diet. | 2012 | Environ. Toxicol. Pharmacol. | pmid:22056564 |
| Lee SM et al. | Characterization of lecithin isolated from anchovy (Engraulis japonica) residues deoiled by supercritical carbon dioxide and organic solvent extraction. | 2012 | J. Food Sci. | pmid:22757698 |
| Keim SA et al. | Breastfeeding and long-chain polyunsaturated fatty acid intake in the first 4 post-natal months and infant cognitive development: an observational study. | 2012 | Matern Child Nutr | pmid:21615865 |
| Petrie JR et al. | Metabolic engineering plant seeds with fish oil-like levels of DHA. | 2012 | PLoS ONE | pmid:23145108 |
| Noreen EE and Brandauer J | The effects of supplemental fish oil on blood pressure and morning cortisol in normotensive adults: a pilot study. | 2012 | J Complement Integr Med | pmid:23104856 |
| Towhidi A and Parks JE | Effect of n-3 fatty acids and α-tocopherol on post-thaw parameters and fatty acid composition of bovine sperm. | 2012 | J. Assist. Reprod. Genet. | pmid:22869241 |
| Tillman EM et al. | Eicosapentaenoic acid and docosahexaenoic acid synergistically attenuate bile acid-induced hepatocellular apoptosis. | 2012 | JPEN J Parenter Enteral Nutr | pmid:22038211 |
| Fasano E et al. | DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. | 2012 | Biochim. Biophys. Acta | pmid:22898250 |
| Jackson PA et al. | DHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: a near IR spectroscopy pilot study. | 2012 | Br. J. Nutr. | pmid:22018509 |
| Tyburczy C et al. | Growth, clinical chemistry and immune function in domestic piglets fed varying ratios of arachidonic acid and DHA. | 2012 | Br. J. Nutr. | pmid:22040360 |
| Schmitt D et al. | Toxicologic evaluation of DHA-rich algal oil: Genotoxicity, acute and subchronic toxicity in rats. | 2012 | Food Chem. Toxicol. | pmid:22898615 |
| Serini S et al. | DHA induces apoptosis and differentiation in human melanoma cells in vitro: involvement of HuR-mediated COX-2 mRNA stabilization and β-catenin nuclear translocation. | 2012 | Carcinogenesis | pmid:22045024 |
| Jackson PA et al. | Docosahexaenoic acid-rich fish oil modulates the cerebral hemodynamic response to cognitive tasks in healthy young adults. | 2012 | Biol Psychol | pmid:22020134 |
| An WS et al. | Omega-3 fatty acid supplementation increases 1,25-dihydroxyvitamin D and fetuin-A levels in dialysis patients. | 2012 | Nutr Res | pmid:22901557 |
| Li N et al. | Arginyl-glutamine dipeptide or docosahexaenoic acid attenuates hyperoxia-induced small intestinal injury in neonatal mice. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22020559 |
| Morris MC | Nutritional determinants of cognitive aging and dementia. | 2012 | Proc Nutr Soc | pmid:22067138 |
| Samaee SM and Estévez A | Embryo and larva development in Dentex dentex, a marine pelagophil teleost: an endeavor to find a series of new fatty acid interrelations. | 2012 | J Exp Zool A Ecol Genet Physiol | pmid:22021057 |
| Betancor MB et al. | Vitamin C enhances vitamin E status and reduces oxidative stress indicators in sea bass larvae fed high DHA microdiets. | 2012 | Lipids | pmid:23086553 |
| Hou L et al. | Reduction of n-3 PUFAs, specifically DHA and EPA, and enhancement of peroxisomal beta-oxidation in type 2 diabetic rat heart. | 2012 | Cardiovasc Diabetol | pmid:23057715 |
| Pineda-Peña EA et al. | Docosahexaenoic acid, an omega-3 polyunsaturated acid protects against indomethacin-induced gastric injury. | 2012 | Eur. J. Pharmacol. | pmid:23063544 |
| Giudetti AM and Cagnazzo R | Beneficial effects of n-3 PUFA on chronic airway inflammatory diseases. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:23064030 |
| Molloy C et al. | Docosahexaenoic acid and visual functioning in preterm infants: a review. | 2012 | Neuropsychol Rev | pmid:23065239 |
| Beezhold BL and Johnston CS | Restriction of meat, fish, and poultry in omnivores improves mood: a pilot randomized controlled trial. | 2012 | Nutr J | pmid:22333737 |
| Rondanelli M et al. | Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment. | 2012 | Nutr Neurosci | pmid:22334085 |
| Rockett BD et al. | Fish oil increases raft size and membrane order of B cells accompanied by differential effects on function. | 2012 | J. Lipid Res. | pmid:22315394 |
| Hjorth E and Freund-Levi Y | Immunomodulation of microglia by docosahexaenoic acid and eicosapentaenoic acid. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:22316559 |
| Liu RZ et al. | A fatty acid-binding protein 7/RXRβ pathway enhances survival and proliferation in triple-negative breast cancer. | 2012 | J. Pathol. | pmid:22322885 |
| Deckelbaum RJ et al. | Conclusions and recommendations from the symposium, Heart Healthy Omega-3s for Food: Stearidonic Acid (SDA) as a Sustainable Choice. | 2012 | J. Nutr. | pmid:22323767 |
| Harden CJ et al. | Effect of different long-chain fatty acids on cholecystokinin release in vitro and energy intake in free-living healthy males. | 2012 | Br. J. Nutr. | pmid:22313587 |
| Tan Z et al. | Enzymatic synthesis of phytosteryl docosahexaneates and evaluation of their anti-atherogenic effects in apo-E deficient mice. | 2012 | Food Chem | pmid:23442661 |
| Bragt MC and Mensink RP | Comparison of the effects of n-3 long chain polyunsaturated fatty acids and fenofibrate on markers of inflammation and vascular function, and on the serum lipoprotein profile in overweight and obese subjects. | 2012 | Nutr Metab Cardiovasc Dis | pmid:21429719 |
| D'Eliseo D et al. | Docosahexaenoic acid inhibits invasion of human RT112 urinary bladder and PT45 pancreatic carcinoma cells via down-modulation of granzyme B expression. | 2012 | J. Nutr. Biochem. | pmid:21684140 |
| Skender B et al. | Docosahexaenoic fatty acid (DHA) in the regulation of colon cell growth and cell death: a review. | 2012 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:23069883 |
| Felbinger TW et al. | Supplementation in acute lung injury. | 2012 | JAMA | pmid:22235078 |
| Xue B et al. | Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway. | 2012 | PLoS ONE | pmid:23071533 |
| Bistrian BR | Supplementation in acute lung injury. | 2012 | JAMA | pmid:22235079 |
| Kisos H et al. | Increased neuronal α-synuclein pathology associates with its accumulation in oligodendrocytes in mice modeling α-synucleinopathies. | 2012 | PLoS ONE | pmid:23077527 |
| König K et al. | Supplementation in acute lung injury. | 2012 | JAMA | pmid:22235080 |
| Schmitt D et al. | Toxicologic evaluations of DHA-rich algal oil in rats: developmental toxicity study and 3-month dietary toxicity study with an in utero exposure phase. | 2012 | Food Chem. Toxicol. | pmid:22960629 |
| Waldron MK et al. | Plasma phospholipid fatty acid and ex vivo neutrophil responses are differentially altered in dogs fed fish- and linseed-oil containing diets at the same n-6:n-3 fatty acid ratio. | 2012 | Lipids | pmid:22252853 |
| Huang TY et al. | A fermentation strategy for producing docosahexaenoic acid in Aurantiochytrium limacinum SR21 and increasing C22:6 proportions in total fatty acid. | 2012 | Bioresour. Technol. | pmid:22929740 |
| Browning LM et al. | Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish. | 2012 | Am. J. Clin. Nutr. | pmid:22932281 |
| Pan XX et al. | Efficient display of active Geotrichum sp. lipase on Pichia pastoris cell wall and its application as a whole-cell biocatalyst to enrich EPA and DHA in fish oil. | 2012 | J. Agric. Food Chem. | pmid:22934819 |
| Zhao M et al. | Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women. | 2012 | J. Nutr. | pmid:22955512 |
| Bazan NG | Neuroinflammation and proteostasis are modulated by endogenously biosynthesized neuroprotectin D1. | 2012 | Mol. Neurobiol. | pmid:22956271 |
| Zicker SC et al. | Evaluation of cognitive learning, memory, psychomotor, immunologic, and retinal functions in healthy puppies fed foods fortified with docosahexaenoic acid-rich fish oil from 8 to 52 weeks of age. | 2012 | J. Am. Vet. Med. Assoc. | pmid:22916855 |
| Moreno-Indias I et al. | The effect of diet and DHA addition on the sensory quality of goat kid meat. | 2012 | Meat Sci. | pmid:21907501 |
| Cortie CH and Else PL | Dietary docosahexaenoic Acid (22:6) incorporates into cardiolipin at the expense of linoleic Acid (18:2): analysis and potential implications. | 2012 | Int J Mol Sci | pmid:23203135 |
| Alvarez-Nölting R et al. | Protection by DHA of early hippocampal changes in diabetes: possible role of CREB and NF-κB. | 2012 | Neurochem. Res. | pmid:21909958 |
| Pifferi F et al. | Fatty acid composition of the brain, retina, liver and adipose tissue of the grey mouse lemur (Microcebus murinus, primate). | 2012 | Lipids | pmid:22684890 |
| Cortina MS et al. | Recovery of corneal sensitivity, calcitonin gene-related peptide-positive nerves, and increased wound healing induced by pigment epithelial-derived factor plus docosahexaenoic acid after experimental surgery. | 2012 | Arch. Ophthalmol. | pmid:21911652 |
| Heinze VM and Actis AB | Dietary conjugated linoleic acid and long-chain n-3 fatty acids in mammary and prostate cancer protection: a review. | 2012 | Int J Food Sci Nutr | pmid:21762028 |
| Munro IA and Garg ML | Dietary supplementation with n-3 PUFA does not promote weight loss when combined with a very-low-energy diet. | 2012 | Br. J. Nutr. | pmid:22214842 |
| Georgiadi A et al. | Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. | 2012 | Physiol. Genomics | pmid:22274564 |
| Basselin M et al. | Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans. | 2012 | Brain Res. Bull. | pmid:22178644 |
| van der Meij BS et al. | Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT. | 2012 | Eur J Clin Nutr | pmid:22234041 |
| Odusanwo O et al. | Resolvin D1 prevents TNF-α-mediated disruption of salivary epithelial formation. | 2012 | Am. J. Physiol., Cell Physiol. | pmid:22237406 |
| Deike E et al. | The effects of fish oil supplementation on markers of inflammation in chronic kidney disease patients. | 2012 | J Ren Nutr | pmid:22285316 |
| Trépanier MO et al. | Increases in seizure latencies induced by subcutaneous docosahexaenoic acid are lost at higher doses. | 2012 | Epilepsy Res. | pmid:22285511 |
| Wu MH et al. | Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10. | 2012 | J. Nutr. Biochem. | pmid:22285823 |
| Han CY et al. | NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes. | 2012 | J. Biol. Chem. | pmid:22287546 |
| Huang T et al. | Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism. | 2012 | Nutr J | pmid:22260268 |
| Mraz J et al. | Culture of common carp (Cyprinus carpio) with defined flesh quality for prevention of cardiovascular diseases using finishing feeding strategy. | 2012 | Neuro Endocrinol. Lett. | pmid:23183512 |
| Johnson M et al. | Fatty acids in ADHD: plasma profiles in a placebo-controlled study of Omega 3/6 fatty acids in children and adolescents. | 2012 | Atten Defic Hyperact Disord | pmid:22753087 |
| Quinn EA and Kuzawa CW | A dose-response relationship between fish consumption and human milk DHA content among Filipino women in Cebu City, Philippines. | 2012 | Acta Paediatr. | pmid:22759234 |
| Turk HF et al. | Alteration of EGFR spatiotemporal dynamics suppresses signal transduction. | 2012 | PLoS ONE | pmid:22761867 |
| Hacioglu G et al. | Docosahexaenoic acid provides protective mechanism in bilaterally MPTP-lesioned rat model of Parkinson's disease. | 2012 | Folia Histochem. Cytobiol. | pmid:22763967 |
| Scheltens P et al. | Efficacy of Souvenaid in mild Alzheimer's disease: results from a randomized, controlled trial. | 2012 | J. Alzheimers Dis. | pmid:22766770 |
| Moreno-Indias I et al. | Docosahexaenoic acid in the goat kid diet: effects on immune system and meat quality. | 2012 | J. Anim. Sci. | pmid:22665635 |
| Holly LT et al. | Dietary therapy to promote neuroprotection in chronic spinal cord injury. | 2012 | J Neurosurg Spine | pmid:22735048 |
| Moallem U and Zachut M | Short communication: the effects of supplementation of various n-3 fatty acids to late-pregnant dairy cows on plasma fatty acid composition of the newborn calves. | 2012 | J. Dairy Sci. | pmid:22720961 |
| Garneau V et al. | Omega-3 fatty acids status in human subjects estimated using a food frequency questionnaire and plasma phospholipids levels. | 2012 | Nutr J | pmid:22775977 |
| Maqbool A et al. | Relation between dietary fat intake type and serum fatty acid status in children with cystic fibrosis. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22699835 |
| Arsenault D et al. | Chronic dietary intake of α-linolenic acid does not replicate the effects of DHA on passive properties of entorhinal cortex neurons. | 2012 | Br. J. Nutr. | pmid:21851757 |
| Oblozinský M et al. | New pharmaceutical insights related to the pathways of PUFAs. | 2012 | Ceska Slov Farm | pmid:23251954 |
| Turchini GM et al. | Jumping on the omega-3 bandwagon: distinguishing the role of long-chain and short-chain omega-3 fatty acids. | 2012 | Crit Rev Food Sci Nutr | pmid:22698270 |
| Trikalinos TA et al. | Concordance of randomized and nonrandomized studies was unrelated to translational patterns of two nutrient-disease associations. | 2012 | J Clin Epidemiol | pmid:22047889 |
| Passos PP et al. | Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. | 2012 | J. Chem. Neuroanat. | pmid:22687395 |
| Bianchini F et al. | 22Â :Â 6n-3 DHA inhibits differentiation of prostate fibroblasts into myofibroblasts and tumorigenesis. | 2012 | Br. J. Nutr. | pmid:22390897 |
| Lorenzetti A et al. | Improving sperm quality and spermatogenesis through a bioactive marine compound: an experimental study. | 2012 | Acta Biomed | pmid:23393918 |
| Corsetto PA et al. | Chemical-physical changes in cell membrane microdomains of breast cancer cells after omega-3 PUFA incorporation. | 2012 | Cell Biochem. Biophys. | pmid:22622660 |
| Bell S et al. | The effect of omega-3 fatty acids on the atherogenic lipoprotein phenotype in patients with nephrotic range proteinuria. | 2012 | Clin. Nephrol. | pmid:22595386 |
| Hajjaji N et al. | Tumor and non-tumor tissues differential oxidative stress response to supplemental DHA and chemotherapy in rats. | 2012 | Cancer Chemother. Pharmacol. | pmid:22610354 |
| Njoroge SW et al. | DHA and EPA reverse cystic fibrosis-related FA abnormalities by suppressing FA desaturase expression and activity. | 2012 | J. Lipid Res. | pmid:22095831 |
| Angulo J et al. | Dietary fatty acid intervention of lactating cows simultaneously affects lipid profiles of meat and milk. | 2012 | J. Sci. Food Agric. | pmid:22549272 |
| Zhou SJ et al. | Fish-oil supplementation in pregnancy does not reduce the risk of gestational diabetes or preeclampsia. | 2012 | Am. J. Clin. Nutr. | pmid:22552037 |
| Correia M et al. | Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization. | 2012 | PLoS ONE | pmid:22529974 |
| Calder PC | Long-chain fatty acids and inflammation. | 2012 | Proc Nutr Soc | pmid:22369781 |
| Drzymała-Czyż S et al. | Discrepancy between clinical and histological effects of DHA supplementation in a rat model of pouchitis. | 2012 | Folia Histochem. Cytobiol. | pmid:22532147 |
| Kelley DS and Adkins Y | Similarities and differences between the effects of EPA and DHA on markers of atherosclerosis in human subjects. | 2012 | Proc Nutr Soc | pmid:22369859 |
| Bernstein AM et al. | A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease. | 2012 | J. Nutr. | pmid:22113870 |
| Daud ZA et al. | Effects of protein and omega-3 supplementation, provided during regular dialysis sessions, on nutritional and inflammatory indices in hemodialysis patients. | 2012 | Vasc Health Risk Manag | pmid:22536073 |
| Yui K et al. | Effects of large doses of arachidonic acid added to docosahexaenoic acid on social impairment in individuals with autism spectrum disorders: a double-blind, placebo-controlled, randomized trial. | 2012 | J Clin Psychopharmacol | pmid:22370992 |
| Finocchiaro C et al. | Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study. | 2012 | Br. J. Nutr. | pmid:22114792 |
| Crnkovic S et al. | Docosahexaenoic acid-induced unfolded protein response, cell cycle arrest, and apoptosis in vascular smooth muscle cells are triggered by Ca²âº-dependent induction of oxidative stress. | 2012 | Free Radic. Biol. Med. | pmid:22391221 |
| Aisen PS et al. | Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease. | 2012 | Cold Spring Harb Perspect Med | pmid:22393531 |