DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ovide-Bordeaux S and Grynberg A | Docosahexaenoic acid affects insulin deficiency- and insulin resistance-induced alterations in cardiac mitochondria. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:14604840 |
| Ethier I et al. | The transcription factor NGFI-B (Nur77) and retinoids play a critical role in acute neuroleptic-induced extrapyramidal effect and striatal neuropeptide gene expression. | 2004 | Neuropsychopharmacology | pmid:14603264 |
| Burns PD et al. | Effect of fish meal supplementation on plasma and endometrial fatty acid composition in nonlactating beef cows. | 2003 | J. Anim. Sci. | pmid:14601888 |
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| Neuringer M and Jeffrey BG | Visual development: Neural basis and new assessment methods. | 2003 | J. Pediatr. | pmid:14597918 |
| Rapoport SI | In vivo approaches to quantifying and imaging brain arachidonic and docosahexaenoic acid metabolism. | 2003 | J. Pediatr. | pmid:14597911 |
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| Innis SM | Perinatal biochemistry and physiology of long-chain polyunsaturated fatty acids. | 2003 | J. Pediatr. | pmid:14597908 |
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| Werman MJ et al. | Effects of the marine unicellular alga Nannochloropsis sp. to reduce the plasma and liver cholesterol levels in male rats fed on diets with cholesterol. | 2003 | Biosci. Biotechnol. Biochem. | pmid:14586118 |
| Madani S et al. | Diacylglycerols containing Omega 3 and Omega 6 fatty acids bind to RasGRP and modulate MAP kinase activation. | 2004 | J. Biol. Chem. | pmid:14583629 |
| Mori TA et al. | Effect of eicosapentaenoic acid and docosahexaenoic acid on oxidative stress and inflammatory markers in treated-hypertensive type 2 diabetic subjects. | 2003 | Free Radic. Biol. Med. | pmid:14583341 |
| Watkins BA et al. | Conjugated linoleic acids alter the fatty acid composition and physical properties of egg yolk and albumen. | 2003 | J. Agric. Food Chem. | pmid:14582988 |
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| Cherian G and Sim J | Preferential accumulation of n-3 fatty acids in the brain of chicks from eggs enriched with n-3 fatty acids. | 1992 | Poult. Sci. | pmid:1454683 |
| Speake BK et al. | Differential incorporation of docosahexaenoic and arachidonic acids by the yolk sac membrane of the avian embryo. | 2003 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:14529761 |
| Wang Y et al. | Fish consumption, blood docosahexaenoic acid and chronic diseases in Chinese rural populations. | 2003 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:14527635 |
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| Alessandri JM et al. | Incorporation of docosahexaenoic acid into nerve membrane phospholipids: bridging the gap between animals and cultured cells. | 2003 | Am. J. Clin. Nutr. | pmid:14522727 |
| Ng KF and Innis SM | Behavioral responses are altered in piglets with decreased frontal cortex docosahexaenoic acid. | 2003 | J. Nutr. | pmid:14519814 |
| Coste TC et al. | Neuroprotective effect of docosahexaenoic acid-enriched phospholipids in experimental diabetic neuropathy. | 2003 | Diabetes | pmid:14514643 |
| Rørvik KA et al. | Synergistic effects of dietary iron and omega-3 fatty acid levels on survival of farmed Atlantic salmon, Salmo salar L., during natural outbreaks of furunculosis and cold water vibriosis. | 2003 | J. Fish Dis. | pmid:14513972 |
| Moriguchi T and Salem N | Recovery of brain docosahexaenoate leads to recovery of spatial task performance. | 2003 | J. Neurochem. | pmid:14511107 |
| Tanaka Y et al. | Effects of exercise on platelet and aortic functions in aged rats. | 2003 | Acta Physiol. Scand. | pmid:14510779 |
| Diau GY et al. | Docosahexaenoic and arachidonic acid influence on preterm baboon retinal composition and function. | 2003 | Invest. Ophthalmol. Vis. Sci. | pmid:14507905 |
| Brockman HL et al. | Packing and electrostatic behavior of sn-2-docosahexaenoyl and -arachidonoyl phosphoglycerides. | 2003 | Biophys. J. | pmid:14507702 |
| Wolff AC et al. | Phase I study of docosahexaenoic acid-paclitaxel: a taxane-fatty acid conjugate with a unique pharmacology and toxicity profile. | 2003 | Clin. Cancer Res. | pmid:14506145 |
| Zhang CW and Richmond A | Sustainable, high-yielding outdoor mass cultures of Chaetoceros muelleri var. subsalsum and Isochrysis galbana in vertical plate reactors. | 2003 May-Jun | Mar. Biotechnol. | pmid:14502402 |
| Qi AD et al. | [Effects of arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid on tension of rabbit aortic strips]. | 1992 | Yao Xue Xue Bao | pmid:1442036 |
| Uauy-Dagach R and Valenzuela A | Marine oils as a source of omega-3 fatty acids in the diet: how to optimize the health benefits. | 1992 | Prog Food Nutr Sci | pmid:1438808 |
| Martinez M | Treatment with docosahexaenoic acid favorably modifies the fatty acid composition of erythrocytes in peroxisomal patients. | 1992 | Prog. Clin. Biol. Res. | pmid:1438383 |
| pmid:14342243 | ||||
| NOBLE RC and MOORE JH | FURTHER STUDIES ON THE LIPID METABOLISM OF THE NORMAL AND VITAMIN B-12 DEFICIENT CHICK EMBRYO. | 1965 | Biochem. J. | pmid:14333549 |
| Sorci-Thomas M et al. | HepG2 cell LDL receptor activity and the accumulation of apolipoprotein B and E in response to docosahexaenoic acid and cholesterol. | 1992 | J. Lipid Res. | pmid:1431595 |
| pmid:14259461 | ||||
| Engler MB | Effect of omega-3 fatty acids, docosahexaenoic and eicosapentaenoic, on norepinephrine-induced contractions. | 1992 | Can. J. Physiol. Pharmacol. | pmid:1423009 |
| Chapkin RS et al. | Phospholipid molecular species composition of mouse liver nuclei. Influence of dietary n-3 fatty acid ethyl esters. | 1992 | Biochem. J. | pmid:1417777 |
| Du Plooy WJ et al. | The cumulative dose response effect of eicosapentaenoic and docosahexaenoic acid on blood pressure, plasma lipid profile and diet pattern in mild to moderate essential hypertensive black patients. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1409770 |
| Chen H et al. | Docosahexaenoic acid increases in frog retinal pigment epithelium following rod photoreceptor shedding. | 1992 | Exp. Eye Res. | pmid:1397136 |
| Sanders TA and Hinds A | The influence of a fish oil high in docosahexaenoic acid on plasma lipoprotein and vitamin E concentrations and haemostatic function in healthy male volunteers. | 1992 | Br. J. Nutr. | pmid:1390601 |
| Chen H et al. | Decreased docosahexaenoic acid levels in retina and pigment epithelium of frogs fed crickets. | 1992 | Exp. Eye Res. | pmid:1387848 |
| Sergienko AA et al. | [Effects of docosahexaenoic and eicosapentaenoic acids on the state of metabolites of the prostacyclin I2--thromboxane A2 system in streptozotocin diabetes mellitus]. | 1992 Mar-Apr | Vopr Pitan | pmid:1387492 |
| Parks JS et al. | Inhibition of lecithin:cholesterol acyltransferase activity by synthetic phosphatidylcholine species containing eicosapentaenoic acid or docosahexaenoic acid in the sn-2 position. | 1992 | J. Lipid Res. | pmid:1387413 |
| Chen ZY et al. | Gestational hyperlipidemia in the rat is characterized by accumulation of n - 6 and n - 3 fatty acids, especially docosahexaenoic acid. | 1992 | Biochim. Biophys. Acta | pmid:1387324 |
| Marsen TA et al. | Pharmacokinetics of omega-3-fatty acids during ingestion of fish oil preparations. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1387231 |
| Anti M et al. | Effect of omega-3 fatty acids on rectal mucosal cell proliferation in subjects at risk for colon cancer. | 1992 | Gastroenterology | pmid:1386825 |
| Wargovich MJ | Fish oil and colon cancer. | 1992 | Gastroenterology | pmid:1386824 |
| Cabré E et al. | Plasma polyunsaturated fatty acids in liver cirrhosis with or without chronic hepatic encephalopathy: a preliminary study. | 1992 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:1386392 |
| Gong J et al. | Plasma docosahexaenoic acid levels in various genetic forms of retinitis pigmentosa. | 1992 | Invest. Ophthalmol. Vis. Sci. | pmid:1386350 |
| Bazan NG et al. | Docosahexaenoic acid uptake and metabolism in photoreceptors: retinal conservation by an efficient retinal pigment epithelial cell-mediated recycling process. | 1992 | Adv. Exp. Med. Biol. | pmid:1386177 |
| Anderson RE et al. | Conservation of docosahexaenoic acid in the retina. | 1992 | Adv. Exp. Med. Biol. | pmid:1386176 |
| Birch DG et al. | Retinal development in very-low-birth-weight infants fed diets differing in omega-3 fatty acids. | 1992 | Invest. Ophthalmol. Vis. Sci. | pmid:1386065 |
| Aukema HM et al. | Abnormal lipid and fatty acid compositions of kidneys from mice with polycystic kidney disease. | 1992 | Lipids | pmid:1385849 |
| Naval J et al. | Expression of mRNAs for alpha-fetoprotein (AFP) and albumin and incorporation of AFP and docosahexaenoic acid in baboon fetuses. | 1992 | J. Biochem. | pmid:1379224 |
| Barceló-Coblijn G et al. | Modification by docosahexaenoic acid of age-induced alterations in gene expression and molecular composition of rat brain phospholipids. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:13679584 |
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| Farquharson J et al. | Infant cerebral cortex phospholipid fatty-acid composition and diet. | 1992 | Lancet | pmid:1357244 |
| Arbuckle LD et al. | Formula alpha-linolenic (18:3(n - 3)) and linoleic (18:2(n - 6)) acid influence neonatal piglet liver and brain saturated fatty acids, as well as docosahexaenoic acid (22:6(n - 3)). | 1992 | Biochim. Biophys. Acta | pmid:1350737 |
| Ramsay B et al. | Erythrocyte membrane docosahexaenoic acid in haemodialysis patients on epoetin. | 1992 | Lancet | pmid:1349964 |
| Bourre JM et al. | Dietary alpha-linolenic acid deficiency in adult rats for 7 months does not alter brain docosahexaenoic acid content, in contrast to liver, heart and testes. | 1992 | Biochim. Biophys. Acta | pmid:1347458 |
| pmid:13471511 | ||||
| Rice RD | Breastfeeding and intelligence. | 1992 | Lancet | pmid:1347109 |
| Mori TA et al. | Plasma lipid levels and platelet and neutrophil function in patients with vascular disease following fish oil and olive oil supplementation. | 1992 | Metab. Clin. Exp. | pmid:1328817 |
| Hrelia S et al. | Fatty acid composition of phosphoinositides in cultured cardiomyocytes: effects of docosahexaenoic acid and alpha 1-adrenoceptor stimulation. | 1992 | Cardioscience | pmid:1322735 |
| Langelier B et al. | Docosahexaenoic acid membrane content and mRNA expression of acyl-CoA oxidase and of peroxisome proliferator-activated receptor-delta are modulated in Y79 retinoblastoma cells differently by low and high doses of alpha-linolenic acid. | 2003 | J. Neurosci. Res. | pmid:13130515 |
| Takemoto Y et al. | Gas chromatography/mass spectrometry analysis of very long chain fatty acids, docosahexaenoic acid, phytanic acid and plasmalogen for the screening of peroxisomal disorders. | 2003 | Brain Dev. | pmid:13129591 |
| Hsu JM and Ding ST | Effect of polyunsaturated fatty acids on the expression of transcription factor adipocyte determination and differentiation-dependent factor 1 and of lipogenic and fatty acid oxidation enzymes in porcine differentiating adipocytes. | 2003 | Br. J. Nutr. | pmid:13129455 |
| Hrelia S et al. | Protein kinase C activity in neonatal cultured rat cardiomyocytes supplemented with docosahexaenoic acid. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1312843 |
| Stenson WF et al. | Dietary supplementation with fish oil in ulcerative colitis. | 1992 | Ann. Intern. Med. | pmid:1312317 |
| Davis PJ | n-3 and n-6 polyunsaturated fatty acids have different effects on acyl-CoA:cholesterol acyltransferase in J774 macrophages. | 1992 | Biochem. Cell Biol. | pmid:1299268 |
| Salem N and Pawlosky RJ | Docosahexaenoic acid is an essential nutrient in the nervous system. | 1992 | J. Nutr. Sci. Vitaminol. | pmid:1297729 |
| Wheaton DH et al. | Biological safety assessment of docosahexaenoic acid supplementation in a randomized clinical trial for X-linked retinitis pigmentosa. | 2003 | Arch. Ophthalmol. | pmid:12963609 |
| Kroes R et al. | A review of the safety of DHA45-oil. | 2003 | Food Chem. Toxicol. | pmid:12962995 |
| Palacios A et al. | Antioxidant effect of conjugated linoleic acid and vitamin A during non enzymatic lipid peroxidation of rat liver microsomes and mitochondria. | 2003 | Mol. Cell. Biochem. | pmid:12962148 |
| Xi ZP and Wang JY | Effect of dietary n-3 fatty acids on the composition of long- and very-long-chain polyenoic fatty acid in rat retina. | 2003 | J. Nutr. Sci. Vitaminol. | pmid:12953800 |
| Nishizawa C et al. | Effect of dietary DHA on DHA levels in retinal rod outer segments in young versus mature rats. | 2003 | Int J Vitam Nutr Res | pmid:12951898 |
| Bell JG et al. | Altered fatty acid compositions in atlantic salmon (Salmo salar) fed diets containing linseed and rapeseed oils can be partially restored by a subsequent fish oil finishing diet. | 2003 | J. Nutr. | pmid:12949367 |
| Auestad N et al. | Visual, cognitive, and language assessments at 39 months: a follow-up study of children fed formulas containing long-chain polyunsaturated fatty acids to 1 year of age. | 2003 | Pediatrics | pmid:12949309 |
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| Pilitsis JG et al. | Free fatty acids in cerebrospinal fluids from patients with traumatic brain injury. | 2003 | Neurosci. Lett. | pmid:12946571 |
| Hirafuji M et al. | Cardiovascular protective effects of n-3 polyunsaturated fatty acids with special emphasis on docosahexaenoic acid. | 2003 | J. Pharmacol. Sci. | pmid:12939515 |
| Malcolm CA et al. | Maternal docosahexaenoic acid supplementation during pregnancy and visual evoked potential development in term infants: a double blind, prospective, randomised trial. | 2003 | Arch. Dis. Child. Fetal Neonatal Ed. | pmid:12937042 |
| Trebble TM et al. | Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementation. | 2003 | Am. J. Clin. Nutr. | pmid:12936918 |
| Oikawa D et al. | Dietary CLA and DHA modify skin properties in mice. | 2003 | Lipids | pmid:12934670 |
| Bordoni A et al. | [The correlation between the acidic composition of diacylglycerol and protein kinase C activation in cultures of rat cardiomyocytes]. | 1992 | Cardiologia | pmid:1292868 |
| Oarada M et al. | Dietary supplementation with docosahexaenoic acid, but not with eicosapentaenoic acid, reduces host resistance to fungal infection in mice. | 2003 | Biochim. Biophys. Acta | pmid:12928111 |
| Engler MB | Vascular relaxation to omega-3 fatty acids: comparison to sodium nitroprusside, nitroglycerin, papaverine, and D600. | 1992 | Cardiovasc Drugs Ther | pmid:1292580 |
| Heath RB et al. | Selective partitioning of dietary fatty acids into the VLDL TG pool in the early postprandial period. | 2003 | J. Lipid Res. | pmid:12923230 |