Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Mizwicki MT et al. | 1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer's disease patients. | 2013 | J. Alzheimers Dis. | pmid:23186989 |
Carlson SJ et al. | The role of the ω-3 fatty acid DHA in the human life cycle. | 2013 | JPEN J Parenter Enteral Nutr | pmid:23192455 |
Kimura R et al. | DHA attenuates postprandial hyperlipidemia via activating PPARα in intestinal epithelial cells. | 2013 | J. Lipid Res. | pmid:24133194 |
Le HD et al. | The effect of varying ratios of docosahexaenoic acid and arachidonic acid in the prevention and reversal of biochemical essential fatty acid deficiency in a murine model. | 2013 | Metab. Clin. Exp. | pmid:23151438 |
Lecchi C et al. | Effects of EPA and DHA on lipid droplet accumulation and mRNA abundance of PAT proteins in caprine monocytes. | 2013 | Res. Vet. Sci. | pmid:23102647 |
Casey JM et al. | Effect of stearidonic acid-enriched soybean oil on fatty acid profile and metabolic parameters in lean and obese Zucker rats. | 2013 | Lipids Health Dis | pmid:24139088 |
Chang CY et al. | Docosahexaenoic acid reduces cellular inflammatory response following permanent focal cerebral ischemia in rats. | 2013 | J. Nutr. Biochem. | pmid:24139673 |
Fernández-Iglesias A et al. | DHA sensitizes FaO cells to tert-BHP-induced oxidative effects. Protective role of EGCG. | 2013 | Food Chem. Toxicol. | pmid:24140970 |
Song YJ et al. | Regulatory functions of docosahexaenoic acid on ion channels in rat ventricular myocytes. | 2013 | Eur Rev Med Pharmacol Sci | pmid:24142611 |
Lee LK et al. | The role of long chain omega-3 polyunsaturated fatty acids in reducing lipid peroxidation among elderly patients with mild cognitive impairment: a case-control study. | 2013 | J. Nutr. Biochem. | pmid:22898566 |
Marze S et al. | In vitro digestion of fish oils rich in n-3 polyunsaturated fatty acids studied in emulsion and at the oil-water interface. | 2013 | Food Funct | pmid:23086175 |
Betancor MB et al. | Oxidative stress in sea bass Dicentrarchus labrax larvae: interaction of high dietary DHA contents and several antioxidant nutrients. | 2013 | Commun. Agric. Appl. Biol. Sci. | pmid:25141617 |
Hagemann A et al. | Content of essential fatty acids in cultivated Acartia tonsa nauplii fed a DHA-deficient Tetraselmis sp. concentrate. | 2013 | Commun. Agric. Appl. Biol. Sci. | pmid:25141657 |
Carlson SE et al. | DHA supplementation and pregnancy outcomes. | 2013 | Am. J. Clin. Nutr. | pmid:23426033 |
Cartiff SE et al. | Eicosapentaenoic and docosahexaenoic acids increase insulin sensitivity in growing steers. | 2013 | J. Anim. Sci. | pmid:23463554 |
Kataoka Y et al. | Epanova(®) and hypertriglyceridemia: pharmacological mechanisms and clinical efficacy. | 2013 | Future Cardiol | pmid:23463969 |
Mocking RJ et al. | Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression. | 2013 | Psychoneuroendocrinology | pmid:23465556 |
Gao M et al. | Isolation and characterization of Aurantiochytrium species: high docosahexaenoic acid (DHA) production by the newly isolated microalga, Aurantiochytrium sp. SD116. | 2013 | J Oleo Sci | pmid:23470441 |
Dobson EP et al. | Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase. | 2013 | J. Lipid Res. | pmid:23471029 |
Rai AK et al. | Bioefficacy of EPA-DHA from lipids recovered from fish processing wastes through biotechnological approaches. | 2013 | Food Chem | pmid:23017395 |
van den Elsen LW et al. | n-3 Long-chain PUFA reduce allergy-related mediator release by human mast cells in vitro via inhibition of reactive oxygen species. | 2013 | Br. J. Nutr. | pmid:23021516 |
Bazan NG | The docosanoid neuroprotectin D1 induces homeostatic regulation of neuroinflammation and cell survival. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23022417 |
Mayer-Davis EJ et al. | Nutritional factors and preservation of C-peptide in youth with recently diagnosed type 1 diabetes: SEARCH Nutrition Ancillary Study. | 2013 | Diabetes Care | pmid:23801797 |
Arem H et al. | Omega-3 and omega-6 fatty acid intakes and endometrial cancer risk in a population-based case-control study. | 2013 | Eur J Nutr | pmid:22915050 |
Mickleborough TD | Omega-3 polyunsaturated fatty acids in physical performance optimization. | 2013 | Int J Sport Nutr Exerc Metab | pmid:23400626 |
Kim HY and Spector AA | Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22959887 |
Minihane AM | Fish oil omega-3 fatty acids and cardio-metabolic health, alone or with statins. | 2013 | Eur J Clin Nutr | pmid:23403872 |
Miyahara T et al. | D-series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury. | 2013 | FASEB J. | pmid:23407709 |
Huang LL et al. | Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23474173 |
Morita M et al. | The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. | 2013 | Cell | pmid:23477864 |
Lee LK et al. | Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial. | 2013 | Psychopharmacology (Berl.) | pmid:22932777 |
Dangour AD and Allen E | Do omega-3 fats boost brain function in adults? Are we any closer to an answer? | 2013 | Am. J. Clin. Nutr. | pmid:23535110 |
Kitamura F et al. | Oxidized trilinoleate and tridocosahexaenoate induce pica behavior and change locomotor activity. | 2013 | J Oleo Sci | pmid:23535307 |
Mischoulon D and Freeman MP | Omega-3 fatty acids in psychiatry. | 2013 | Psychiatr. Clin. North Am. | pmid:23538073 |
Koltsida O et al. | Toll-like receptor 7 stimulates production of specialized pro-resolving lipid mediators and promotes resolution of airway inflammation. | 2013 | EMBO Mol Med | pmid:23584892 |
Miller E et al. | A short-term n-3 DPA supplementation study in humans. | 2013 | Eur J Nutr | pmid:22729967 |
Li J et al. | Comparative metabolomics analysis of docosahexaenoic acid fermentation processes by Schizochytrium sp. under different oxygen availability conditions. | 2013 | OMICS | pmid:23586678 |
Barros KV et al. | Fatty acids in plasma, white and red blood cells, and tissues after oral or intravenous administration of fish oil in rats. | 2013 | Clin Nutr | pmid:23541913 |
Mozaffarian D et al. | Plasma phospholipid long-chain ω-3 fatty acids and total and cause-specific mortality in older adults: a cohort study. | 2013 | Ann. Intern. Med. | pmid:23546563 |
Zhang G et al. | Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23553837 |
Watson AM et al. | Taurine supplementation of plant derived protein and n-3 fatty acids are critical for optimal growth and development of cobia, Rachycentron canadum. | 2013 | Lipids | pmid:23884630 |
Mocellin MC et al. | Fish oil decreases C-reactive protein/albumin ratio improving nutritional prognosis and plasma fatty acid profile in colorectal cancer patients. | 2013 | Lipids | pmid:23888317 |
Zhang J et al. | Different intakes of n-3 fatty acids among pregnant women in 3 regions of China with contrasting dietary patterns are reflected in maternal but not in umbilical erythrocyte phosphatidylcholine fatty acid composition. | 2013 | Nutr Res | pmid:23890350 |
Santos-Soto IJ et al. | Voluntary running in young adult mice reduces anxiety-like behavior and increases the accumulation of bioactive lipids in the cerebral cortex. | 2013 | PLoS ONE | pmid:24349072 |
Yao C et al. | Neuroprotectin D1 attenuates brain damage induced by transient middle cerebral artery occlusion in rats through TRPC6/CREB pathways. | 2013 | Mol Med Rep | pmid:23799606 |
Al-Farsi YM et al. | Impact of nutrition on serum levels of docosahexaenoic acid among Omani children with autism. | 2013 | Nutrition | pmid:23800562 |
Nakamoto K et al. | Hypothalamic GPR40 signaling activated by free long chain fatty acids suppresses CFA-induced inflammatory chronic pain. | 2013 | PLoS ONE | pmid:24349089 |
Samieri C et al. | Relationship between diet and plasma long-chain n-3 PUFAs in older people: impact of apolipoprotein E genotype. | 2013 | J. Lipid Res. | pmid:23801662 |
Végran F et al. | Socs3 induction by PPARγ restrains cancer-promoting inflammation. | 2013 | Cell Cycle | pmid:23803735 |
Sun YB et al. | Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney. | 2013 | PLoS ONE | pmid:24391884 |
Fietkau R et al. | A disease-specific enteral nutrition formula improves nutritional status and functional performance in patients with head and neck and esophageal cancer undergoing chemoradiotherapy: results of a randomized, controlled, multicenter trial. | 2013 | Cancer | pmid:23765693 |
Jiang LH et al. | Oral administration of docosahexaenoic acid activates the GDNF-MAPK-CERB pathway in hippocampus of natural aged rat. | 2013 | Pharm Biol | pmid:23767459 |
Weiss GA et al. | High levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactation. | 2013 | Lipids Health Dis | pmid:23767972 |
Codabaccus MB et al. | Restoration of EPA and DHA in rainbow trout (Oncorhynchus mykiss) using a finishing fish oil diet at two different water temperatures. | 2013 | Food Chem | pmid:23768353 |
Correia Bacarin C et al. | Fish oil provides robust and sustained memory recovery after cerebral ischemia: influence of treatment regimen. | 2013 | Physiol. Behav. | pmid:23770426 |
Leino O et al. | Effects of docosahexaenoic acid and methylmercury on child's brain development due to consumption of fish by Finnish mother during pregnancy: a probabilistic modeling approach. | 2013 | Food Chem. Toxicol. | pmid:21723361 |
Jones ML et al. | Maternal dietary omega-3 fatty acid intake increases resolvin and protectin levels in the rat placenta. | 2013 | J. Lipid Res. | pmid:23723388 |
Alhazzaa R et al. | Bioconversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation. | 2013 | PLoS ONE | pmid:24040040 |
Shida T et al. | Colonic delivery of docosahexaenoic acid improves impaired glucose tolerance via GLP-1 secretion and suppresses pancreatic islet hyperplasia in diabetic KK-A(y) mice. | 2013 | Int J Pharm | pmid:23618969 |
Berger H et al. | SOCS3 transactivation by PPARγ prevents IL-17-driven cancer growth. | 2013 | Cancer Res. | pmid:23619236 |
Barber E et al. | Comparative actions of omega-3 fatty acids on in-vitro lipid droplet formation. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24012207 |
Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. | 2013 | JAMA | pmid:23644932 | |
Veszelka S et al. | Docosahexaenoic acid reduces amyloid-β induced toxicity in cells of the neurovascular unit. | 2013 | J. Alzheimers Dis. | pmid:23645098 |
Stephenson JA et al. | Unsaturated fatty acids differ between hepatic colorectal metastases and liver tissue without tumour in humans: results from a randomised controlled trial of intravenous eicosapentaenoic and docosahexaenoic acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23647811 |
Nishinaka T et al. | [Elucidation of mechanisms underlying docosahexaenoic acid-induced antinociception]. | 2013 | Yakugaku Zasshi | pmid:23649389 |
Ravacci GR et al. | Lipid raft disruption by docosahexaenoic acid induces apoptosis in transformed human mammary luminal epithelial cells harboring HER-2 overexpression. | 2013 | J. Nutr. Biochem. | pmid:22749134 |
Jing K et al. | Omega-3 polyunsaturated fatty acids and cancer. | 2013 | Anticancer Agents Med Chem | pmid:23919748 |
Pagán A et al. | Materno-fetal transfer of docosahexaenoic acid is impaired by gestational diabetes mellitus. | 2013 | Am. J. Physiol. Endocrinol. Metab. | pmid:23921142 |
Sheets KG et al. | Microglial ramification and redistribution concomitant with the attenuation of choroidal neovascularization by neuroprotectin D1. | 2013 | Mol. Vis. | pmid:23922492 |
Rapoport SI | Translational studies on regulation of brain docosahexaenoic acid (DHA) metabolism in vivo. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22766388 |
Baselga-Escudero L et al. | Chronic administration of proanthocyanidins or docosahexaenoic acid reverses the increase of miR-33a and miR-122 in dyslipidemic obese rats. | 2013 | PLoS ONE | pmid:23922812 |
Bjorgvinsdottir L et al. | Inflammatory response following heart surgery and association with n-3 and n-6 long-chain polyunsaturated fatty acids in plasma and red blood cell membrane lipids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23999253 |
Iwasaka H et al. | Utilization of waste syrup for production of polyunsaturated fatty acids and xanthophylls by Aurantiochytrium. | 2013 | J Oleo Sci | pmid:24005017 |
O'Sullivan BP et al. | Evolution of pancreatic function during the first year in infants with cystic fibrosis. | 2013 | J. Pediatr. | pmid:23245194 |
Rincón Cervera Mà et al. | Acyl migration evaluation in monoacylglycerols from Echium plantagineum seed oil and Marinol. | 2013 | J. Biosci. Bioeng. | pmid:23287502 |
Chen HW et al. | Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells. | 2013 | Arch. Toxicol. | pmid:23288142 |
Matsuoka Y et al. | Tachikawa project for prevention of posttraumatic stress disorder with polyunsaturated fatty acid (TPOP): study protocol for a randomized controlled trial. | 2013 | BMC Psychiatry | pmid:23289548 |
Ritter JC et al. | Quality analysis of commercial fish oil preparations. | 2013 | J. Sci. Food Agric. | pmid:23255124 |
Fogagnolo Mauricio A et al. | Effects of fish oil containing eicosapentaenoic acid and docosahexaenoic acid on dystrophic mdx mice. | 2013 | Clin Nutr | pmid:23218947 |
Harris WS et al. | Omega-3 fatty acids and cardiovascular disease: new developments and applications. | 2013 | Postgrad Med | pmid:24200766 |
Ding N et al. | Short-term effects of different fish oil formulations on tissue absorption of docosahexaenoic acid in mice fed high- and low-fat diets. | 2013 | J Oleo Sci | pmid:24200935 |
Steffen BT et al. | n-3 and n-6 Fatty acids are independently associated with lipoprotein-associated phospholipase A2 in the Multi-Ethnic Study of Atherosclerosis. | 2013 | Br. J. Nutr. | pmid:23551952 |
Derogis PB et al. | The development of a specific and sensitive LC-MS-based method for the detection and quantification of hydroperoxy- and hydroxydocosahexaenoic acids as a tool for lipidomic analysis. | 2013 | PLoS ONE | pmid:24204871 |
Wang D et al. | Organochlorine pesticides in fish from Taihu Lake, China, and associated human health risk assessment. | 2013 | Ecotoxicol. Environ. Saf. | pmid:24125867 |
Sato K et al. | Selective and potent inhibitory effect of docosahexaenoic acid (DHA) on U46619-induced contraction in rat aorta. | 2013 | J Smooth Muscle Res | pmid:24304639 |
Otsuka R et al. | Higher serum EPA or DHA, and lower ARA compositions with age independent fatty acid intake in Japanese aged 40 to 79. | 2013 | Lipids | pmid:23389403 |
Barbadoro P et al. | Fish oil supplementation reduces cortisol basal levels and perceived stress: a randomized, placebo-controlled trial in abstinent alcoholics. | 2013 | Mol Nutr Food Res | pmid:23390041 |
Phang M et al. | Eicosapentaenoic and docosahexaenoic acid supplementations reduce platelet aggregation and hemostatic markers differentially in men and women. | 2013 | J. Nutr. | pmid:23390192 |
Nikolakopoulou Z et al. | The induction of apoptosis in pre-malignant keratinocytes by omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) is inhibited by albumin. | 2013 | Toxicol. Lett. | pmid:23391486 |
Souied EH et al. | Oral docosahexaenoic acid in the prevention of exudative age-related macular degeneration: the Nutritional AMD Treatment 2 study. | 2013 | Ophthalmology | pmid:23395546 |
Andrade-Vieira R et al. | Omega-3 polyunsaturated fatty acid promotes the inhibition of glycolytic enzymes and mTOR signaling by regulating the tumor suppressor LKB1. | 2013 | Cancer Biol. Ther. | pmid:24025358 |
Li D et al. | Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion. | 2013 | Mucosal Immunol | pmid:23462912 |
Song X et al. | Different impacts of short-chain fatty acids on saturated and polyunsaturated fatty acid biosynthesis in Aurantiochytrium sp. SD116. | 2013 | J. Agric. Food Chem. | pmid:24053543 |
Kenchegowda S et al. | Involvement of pigment epithelium-derived factor, docosahexaenoic acid and neuroprotectin D1 in corneal inflammation and nerve integrity after refractive surgery. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22579364 |
Nobili V et al. | The I148M variant of PNPLA3 reduces the response to docosahexaenoic acid in children with non-alcoholic fatty liver disease. | 2013 | J Med Food | pmid:24074360 |
Gadaria-Rathod N et al. | Red blood cell fatty acid analysis for determining compliance with omega3 supplements in dry eye disease trials. | 2013 | J Ocul Pharmacol Ther | pmid:23971620 |
Weintraub H | Update on marine omega-3 fatty acids: management of dyslipidemia and current omega-3 treatment options. | 2013 | Atherosclerosis | pmid:24075771 |
Stulnig G et al. | Docosahexaenoic acid (DHA)-induced heme oxygenase-1 attenuates cytotoxic effects of DHA in vascular smooth muscle cells. | 2013 | Atherosclerosis | pmid:24075775 |
Nagachinta S and Akoh CC | Spray-dried structured lipid containing long-chain polyunsaturated fatty acids for use in infant formulas. | 2013 | J. Food Sci. | pmid:24024870 |
Kennedy DO | Reply to MP Pase and C Stough. | 2013 | Am. J. Clin. Nutr. | pmid:24027792 |