Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ojima A et al. | Selective transacylation of 1-O-alkylglycerophosphoethanolamine by docosahexaenoate and arachidonate in rat brain microsomes. | 1987 | J. Neurochem. | pmid:2951496 |
Anderson RE et al. | Abnormal plasma levels of polyunsaturated fatty acid in autosomal dominant retinitis pigmentosa. | 1987 | Exp. Eye Res. | pmid:2951269 |
Scott BL et al. | Docosahexaenoate metabolism and fatty-acid composition in developing retinas of normal and rd mutant mice. | 1987 | Exp. Eye Res. | pmid:2951268 |
Hadjiagapiou C and Spector AA | Docosahexaenoic acid metabolism and effect on prostacyclin production in endothelial cells. | 1987 | Arch. Biochem. Biophys. | pmid:2949698 |
Bazan NG et al. | Decreased content of docosahexaenoate and arachidonate in plasma phospholipids in Usher's syndrome. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2948509 |
Hong CY et al. | Effect of phosphatidylcholine, lysophosphatidylcholine, arachidonic acid and docosahexaenoic acid on the motility of human sperm. | 1986 | Int. J. Androl. | pmid:2947864 |
Scorolli L et al. | [Changes induced by zinc and docosahexenoic acid in acute NaIO3 poisoning]. | 1986 | Bull Mem Soc Fr Ophtalmol | pmid:2947655 |
Meduri R et al. | [Effects of zinc and docosahexenoic acid on the corneal and cerebral lesions of rabbits infected with herpesvirus]. | 1986 | Bull Mem Soc Fr Ophtalmol | pmid:2947654 |
Carlson SE et al. | Docosahexaenoic acid status of preterm infants at birth and following feeding with human milk or formula. | 1986 | Am. J. Clin. Nutr. | pmid:2947455 |
German JB and Kinsella JE | Hydroperoxide metabolism in trout gill tissue: effect of glutathione on lipoxygenase products generated from arachidonic acid and docosahexaenoic acid. | 1986 | Biochim. Biophys. Acta | pmid:2946321 |
pmid:29462158 | ||||
Weiner MA | Cholesterol in foods rich in omega-3 fatty acids. | 1986 | N. Engl. J. Med. | pmid:2943996 |
Applegate KR and Glomset JA | Computer-based modeling of the conformation and packing properties of docosahexaenoic acid. | 1986 | J. Lipid Res. | pmid:2943846 |
Guisto NM et al. | Active labeling of phosphatidylcholines by [1-14C]docosahexaenoate in isolated photoreceptor membranes. | 1986 | Biochim. Biophys. Acta | pmid:2942188 |
Yergey JA et al. | High-performance liquid chromatography/thermospray mass spectrometry of eicosanoids and novel oxygenated metabolites of docosahexaenoic acid. | 1986 | Anal. Chem. | pmid:2942056 |
Tou JS | Acylation of docosahexaenoic acid into phospholipids by intact human neutrophils. | 1986 | Lipids | pmid:2941637 |
Maddaiah VT and Clejan S | Growth hormone and liver mitochondria: time course of effects on respiration and fatty acid composition in hypophysectomized rats. | 1986 | Endocrinology | pmid:2941269 |
pmid:29407798 | ||||
pmid:29394279 | ||||
pmid:29392935 | ||||
Organisciak DT et al. | Rod outer segment lipids in vitamin A-adequate and -deficient rats. | 1986 | Exp. Eye Res. | pmid:2937648 |
Huterer S and Wherrett JR | Incorporation of polyunsaturated fatty acids into bis(monoacylglycero)phosphate and other lipids of macrophages and of fibroblasts from control and Niemann-Pick patients. | 1986 | Biochim. Biophys. Acta | pmid:2937457 |
Masuzawa Y et al. | Selective acylation of alkyllysophospholipids by docosahexaenoic acid in Ehrlich ascites cells. | 1986 | Biochim. Biophys. Acta | pmid:2936397 |
Hagve TA and Christophersen BO | Evidence for peroxisomal retroconversion of adrenic acid (22:4(n-6)) and docosahexaenoic acids (22:6(n-3)) in isolated liver cells. | 1986 | Biochim. Biophys. Acta | pmid:2935195 |
Sugiura T et al. | Transacylation of 1-O-alkyl-SN-glycero-3-phosphocholine (lyso platelet-activating factor) and 1-O-alkenyl-SN-glycero-3-phosphoethanolamine with docosahexaenoic acid (22:6 omega 3). | 1985 | Biochem. Biophys. Res. Commun. | pmid:2935146 |
Dietary fish oil increases omega-3 long-chain polyunsaturated fatty acids in human milk. | 1985 | Nutr. Rev. | pmid:2934649 | |
pmid:29345914 | ||||
Mabe H et al. | [Effect of calcium entry blocker, nimodipine, on the cerebral function and metabolic recovery following experimental cerebral ischemia]. | 1985 | No To Shinkei | pmid:2934079 |
pmid:29331380 | ||||
Reynolds JW | Enteral and parenteral nutrition of low birth weight infants. | 1985 | Bol Asoc Med P R | pmid:2933046 |
Cunnane SC et al. | Magnesium deficiency in the rat increases tissue levels of docosahexaenoic acid. | 1985 | J. Nutr. | pmid:2932544 |
Reddy TS et al. | Change in content, incorporation and lipoxygenation of docosahexaenoic acid in retina and retinal pigment epithelium in canine ceroid lipofuscinosis. | 1985 | Neurosci. Lett. | pmid:2931631 |
pmid:29307174 | ||||
pmid:29305860 | ||||
pmid:29302056 | ||||
pmid:29293497 | ||||
pmid:29291262 | ||||
pmid:29261735 | ||||
pmid:29254330 | ||||
pmid:29236708 | ||||
pmid:29232116 | ||||
pmid:29185935 | ||||
Aukema HM and Holub BJ | Effect of dietary supplementation with a fish oil concentrate on the alkenylacyl class of ethanolamine phospholipid in human platelets. | 1989 | J. Lipid Res. | pmid:2918250 |
pmid:29173199 | ||||
pmid:29166957 | ||||
pmid:29158057 | ||||
pmid:29129771 | ||||
pmid:29126901 | ||||
Sugasini D and Subbaiah PV | Rate of acyl migration in lysophosphatidylcholine (LPC) is dependent upon the nature of the acyl group. Greater stability of sn-2 docosahexaenoyl LPC compared to the more saturated LPC species. | 2017 | PLoS ONE | pmid:29117232 |
pmid:29109234 | ||||
pmid:29105065 | ||||
pmid:29097166 | ||||
pmid:29095817 | ||||
pmid:29095488 | ||||
pmid:29092879 | ||||
Tsuchiya T et al. | Involvement of Resveratrol and ω-3 Polyunsaturated Fatty Acids on Sirtuin 1 Gene Expression in THP1 Cells. | 2017 | Am. J. Med. Sci. | pmid:29078847 |
pmid:29073223 | ||||
pmid:29053802 | ||||
pmid:29049383 | ||||
pmid:29040972 | ||||
Garg ML et al. | Dietary cholesterol and/or n-3 fatty acid modulate delta 9-desaturase activity in rat liver microsomes. | 1988 | Biochim. Biophys. Acta | pmid:2901857 |
pmid:28976605 | ||||
pmid:28972155 | ||||
Tobin A | Fish oil supplementation. | 1988 | Lancet | pmid:2896884 |
Villalpando DM et al. | Dietary docosahexaenoic acid supplementation prevents the formation of cholesterol oxidation products in arteries from orchidectomized rats. | 2017 | PLoS ONE | pmid:28968462 |
pmid:28966307 | ||||
Bittiner SB et al. | A double-blind, randomised, placebo-controlled trial of fish oil in psoriasis. | 1988 | Lancet | pmid:2893189 |
pmid:28931587 | ||||
pmid:28924085 | ||||
pmid:28919754 | ||||
pmid:28918747 | ||||
pmid:28912100 | ||||
pmid:28900017 | ||||
Lippestad M et al. | Resolvin D1 Increases Mucin Secretion in Cultured Rat Conjunctival Goblet Cells via Multiple Signaling Pathways. | 2017 | Invest. Ophthalmol. Vis. Sci. | pmid:28892824 |
Di Nunzio M et al. | Is cytotoxicity a determinant of the different in vitro and in vivo effects of bioactives? | 2017 | BMC Complement Altern Med | pmid:28882181 |
Jones RG and Henderson MJ | Fish oils as medicines. | 1987 | Lancet | pmid:2887931 |
Licensed fish-oil concentrate versus cod-liver oil. | 1987 | Lancet | pmid:2887752 | |
pmid:28873537 | ||||
pmid:28855224 | ||||
pmid:28849990 | ||||
Stylos E et al. | Tailoring naringenin conjugates with amplified and triple antiplatelet activity profile: Rational design, synthesis, human plasma stability and in vitro evaluation. | 2017 | Biochim Biophys Acta Gen Subj | pmid:28844979 |
pmid:28833063 | ||||
pmid:28831958 | ||||
pmid:28831954 | ||||
pmid:28827082 | ||||
pmid:28817068 | ||||
pmid:28807874 | ||||
pmid:28803993 | ||||
Lee Y et al. | Analysis of endogenous lipids during intestinal wound healing. | 2017 | PLoS ONE | pmid:28800645 |
pmid:28797567 | ||||
pmid:28787084 | ||||
pmid:28779028 | ||||
pmid:28768838 | ||||
Chouinard-Watkins R et al. | Phospholipid class-specific brain enrichment in response to lysophosphatidylcholine docosahexaenoic acid infusion. | 2017 | Biochim. Biophys. Acta | pmid:28760485 |
pmid:28751936 | ||||
pmid:28744874 | ||||
pmid:28740349 | ||||
pmid:28733268 | ||||
Nakamoto K et al. | Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice. | 2017 | PLoS ONE | pmid:28723961 |
pmid:28717347 |