DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gazzah N et al. | Decrease of brain phospholipid synthesis in free-moving n-3 fatty acid deficient rats. | 1995 | J. Neurochem. | pmid:7830085 |
| Bazan NG and Rodriguez de Turco EB | Review: pharmacological manipulation of docosahexaenoic-phospholipid biosynthesis in photoreceptor cells: implications in retinal degeneration. | 1994 | J Ocul Pharmacol | pmid:7836869 |
| Kurlandsky LE et al. | The absorption and effect of dietary supplementation with omega-3 fatty acids on serum leukotriene B4 in patients with cystic fibrosis. | 1994 | Pediatr. Pulmonol. | pmid:7838619 |
| Popp-Snijders C and Blonk MC | Omega-3 fatty acids in adipose tissue of obese patients with non-insulin-dependent diabetes mellitus reflect long-term dietary intake of eicosapentaenoic and docosahexaenoic acid. | 1995 | Am. J. Clin. Nutr. | pmid:7840075 |
| Terasawa F et al. | Effects of dietary casein and soy-protein on metabolic conversion of eicosapentaenoic acid to docosahexaenoic acid in the liver of rat. | 1994 | J. Nutr. Sci. Vitaminol. | pmid:7844642 |
| Yamashiro Y et al. | Docosahexaenoic acid status of patients with extrahepatic biliary atresia. | 1994 | J. Pediatr. Surg. | pmid:7844720 |
| Vaidyanathan VV et al. | Regulation of diacylglycerol kinase in rat brain membranes by docosahexaenoic acid. | 1994 | Neurosci. Lett. | pmid:7845615 |
| Lokesh BR and Kinsella JE | Effects of n-3 polyunsaturated fatty acids on the reacylation of arachidonic acid in peritoneal macrophages. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846090 |
| Alexander-North LS et al. | Polyunsaturated fatty acids increase lipid radical formation induced by oxidant stress in endothelial cells. | 1994 | J. Lipid Res. | pmid:7852854 |
| Al MD et al. | The relationship between the essential fatty acid status of mother and child and the occurrence of pregnancy-induced hypertension. Intermediate results of a prospective longitudinal study. | 1994 | World Rev Nutr Diet | pmid:7856218 |
| Tessier C et al. | Docosahexaenoic acid is a potent inhibitor of rat uterine stromal cell proliferation. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7864887 |
| Poling JS et al. | Time- and voltage-dependent block of delayed rectifier potassium channels by docosahexaenoic acid. | 1995 | Mol. Pharmacol. | pmid:7870048 |
| Chen LY et al. | Reduction in human neutrophil superoxide anion generation by n-3 polyunsaturated fatty acids: role of cyclooxygenase products and endothelium-derived relaxing factor. | 1994 | Thromb. Res. | pmid:7871491 |
| Bazan NG et al. | Docosahexaenoic acid supply to the retina and its conservation in photoreceptor cells by active retinal pigment epithelium-mediated recycling. | 1994 | World Rev Nutr Diet | pmid:7871812 |
| Anderson RE et al. | The accretion of docosahexaenoic acid in the retina. | 1994 | World Rev Nutr Diet | pmid:7871813 |
| von Houwelingen AC and Hornstra G | Trans fatty acids in early human development. | 1994 | World Rev Nutr Diet | pmid:7871822 |
| Martinez M | Polyunsaturated fatty acids in the developing human brain, red cells and plasma: influence of nutrition and peroxisomal disease. | 1994 | World Rev Nutr Diet | pmid:7871835 |
| Santos MJ et al. | Influence of dietary supplementation with fish on plasma fatty acid composition in coronary heart disease patients. | 1995 | Ann. Nutr. Metab. | pmid:7872656 |
| Purasiri P et al. | Modulation of cytokine production in vivo by dietary essential fatty acids in patients with colorectal cancer. | 1994 | Clin. Sci. | pmid:7874864 |
| Gibney MJ and Daly E | The incorporation of n-3 polyunsaturated fatty acids into plasma lipid and lipoprotein fractions in the postprandial phase in healthy volunteers. | 1994 | Eur J Clin Nutr | pmid:7889895 |
| Karikó K et al. | Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor-1 mRNA in cultured human endothelial cells. | 1995 | FEBS Lett. | pmid:7890029 |
| Ghebremeskel K et al. | Fatty acid composition of plasma and red cell phospholipids of preterm babies fed on breast milk and formulae. | 1995 | Eur. J. Pediatr. | pmid:7895755 |
| Green P and Yavin E | Elongation, desaturation, and esterification of essential fatty acids by fetal rat brain in vivo. | 1993 | J. Lipid Res. | pmid:7905509 |
| Anderson GJ and Connor WE | Accretion of n-3 fatty acids in the brain and retina of chicks fed a low-linolenic acid diet supplemented with docosahexaenoic acid. | 1994 | Am. J. Clin. Nutr. | pmid:7911000 |
| Makrides M et al. | Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. | 1994 | Am. J. Clin. Nutr. | pmid:7913291 |
| Winters BL et al. | Linolenic acid provides a source of docosahexaenoic acid for artificially reared rat pups. | 1994 | J. Nutr. | pmid:7916377 |
| Tremoli E et al. | n-3 fatty acid ethyl ester administration to healthy subjects and to hypertriglyceridemic patients reduces tissue factor activity in adherent monocytes. | 1994 | Arterioscler. Thromb. | pmid:7918310 |
| del Carmen Boyano-Adánez M et al. | Protein kinase C-mediated phospholipase D activity is increased by linolenic acid supplementation in NG 108-15 cells. | 1994 | Biochim. Biophys. Acta | pmid:7918608 |
| Arm JP et al. | Leukotrienes, fish-oil, and asthma. | 1994 May-Jun | Allergy Proc | pmid:7926711 |
| Ikeda I et al. | alpha-Linolenic, eicosapentaenoic and docosahexaenoic acids affect lipid metabolism differently in rats. | 1994 | J. Nutr. | pmid:7931698 |
| Karanian JW et al. | Inhibitory effects of n-6 and n-3 hydroxy fatty acids on thromboxane (U46619)-induced smooth muscle contraction. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7932158 |
| Kang JX and Leaf A | Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7937911 |
| Eritsland J et al. | Long-term effects of n-3 fatty acids on serum lipids and glycaemic control. | 1994 | Scand. J. Clin. Lab. Invest. | pmid:7939369 |
| Anti M et al. | Effects of different doses of fish oil on rectal cell proliferation in patients with sporadic colonic adenomas. | 1994 | Gastroenterology | pmid:7958682 |
| Saito M and Nakatsugawa K | Increased susceptibility of liver to lipid peroxidation after ingestion of a high fish oil diet. | 1994 | Int J Vitam Nutr Res | pmid:7960494 |
| Carlson SE | Lessons learned from randomizing infants to marine oil-supplemented formulas in nutrition trials. | 1994 | J. Pediatr. | pmid:7965451 |
| Gibson RA et al. | Ratios of linoleic acid to alpha-linolenic acid in formulas for term infants. | 1994 | J. Pediatr. | pmid:7965453 |
| Hardy SC and Kleinman RE | Fat and cholesterol in the diet of infants and young children: implications for growth, development, and long-term health. | 1994 | J. Pediatr. | pmid:7965456 |
| Yano Y et al. | Production of docosahexaenoic acid by marine bacteria isolated from deep sea fish. | 1994 | Lipids | pmid:7968276 |
| Imre SG et al. | Increased proportion of docosahexanoic acid and high lipid peroxidation capacity in erythrocytes of stroke patients. | 1994 | Stroke | pmid:7974583 |
| Thies F et al. | Preferential incorporation of sn-2 lysoPC DHA over unesterified DHA in the young rat brain. | 1994 | Am. J. Physiol. | pmid:7977854 |
| Brossard N et al. | Stable isotope tracer and gas-chromatography combustion isotope ratio mass spectrometry to study the in vivo compartmental metabolism of docosahexaenoic acid. | 1994 | Anal. Biochem. | pmid:7978245 |
| Bright JM et al. | The effects of n-3 fatty acid supplementation on bleeding time, plasma fatty acid composition, and in vitro platelet aggregation in cats. | 1994 Jul-Aug | J. Vet. Intern. Med. | pmid:7983618 |
| Belluzzi A et al. | Effects of new fish oil derivative on fatty acid phospholipid-membrane pattern in a group of Crohn's disease patients. | 1994 | Dig. Dis. Sci. | pmid:7995183 |
| Carlson SE et al. | Long-chain fatty acids and early visual and cognitive development of preterm infants. | 1994 | Eur J Clin Nutr | pmid:7995262 |
| Shahar E et al. | Dietary n-3 polyunsaturated fatty acids and smoking-related chronic obstructive pulmonary disease. Atherosclerosis Risk in Communities Study Investigators. | 1994 | N. Engl. J. Med. | pmid:8015569 |
| Sacks FM et al. | Short report: the effect of fish oil on blood pressure and high-density lipoprotein-cholesterol levels in phase I of the Trials of Hypertension Prevention. | 1994 | J. Hypertens. | pmid:8021472 |
| Haglund O et al. | Effects of fish oil on some parameters of fibrinolysis and lipoprotein(a) in healthy subjects. | 1994 | Am. J. Cardiol. | pmid:8023790 |
| Wang H et al. | The effects of n-3 fatty acids on the secretion of carboxyl-terminally truncated forms of human apoprotein B. | 1994 | J. Biol. Chem. | pmid:8034600 |
| Felouati BE et al. | Oestradiol-induced changes in the composition of phospholipid classes of quail oviduct: specific replacement of arachidonic acid by docosahexaenoic acid in alkenylacyl-glycerophosphoethanolamine. | 1994 | Biochem. J. | pmid:8042978 |