| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cerebrovascular Trauma | D020214 | 1 associated lipids |
| Histiocytoma, Malignant Fibrous | D051677 | 1 associated lipids |
| Communication Disorders | D003147 | 1 associated lipids |
| Hydroa Vacciniforme | D006837 | 1 associated lipids |
| Trophoblastic Tumor, Placental Site | D018245 | 1 associated lipids |
| Geographic Atrophy | D057092 | 1 associated lipids |
| Phenylketonuria, Maternal | D017042 | 1 associated lipids |
| Lordosis | D008141 | 1 associated lipids |
| Refsum Disease, Infantile | D052919 | 1 associated lipids |
| Pulmonary Valve Stenosis | D011666 | 1 associated lipids |
| Intracranial Hemorrhages | D020300 | 2 associated lipids |
| Paracoccidioidomycosis | D010229 | 2 associated lipids |
| Dementia | D003704 | 2 associated lipids |
| Decapitation | D049248 | 2 associated lipids |
| Leukemia, Prolymphocytic | D015463 | 2 associated lipids |
| Dysbiosis | D064806 | 2 associated lipids |
| Myoglobinuria | D009212 | 3 associated lipids |
| Dyslexia | D004410 | 3 associated lipids |
| Albinism | D000417 | 3 associated lipids |
| Short Bowel Syndrome | D012778 | 3 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| van de Lagemaat M et al. | Post term dietary-induced changes in DHA and AA status relate to gains in weight, length, and head circumference in preterm infants. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21995887 |
| Fritsche KL and Cassity NA | Metabolism of [3H]arachidonic acid by n-3 polyunsaturated fatty acid-enriched piglet alveolar macrophages. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981628 |
| Glew RH et al. | The fatty acid composition of the serum phospholipids of children with sickle cell disease in Nigeria. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12401435 |
| Fokkema MR et al. | Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090255 |
| Dalton A et al. | A randomised control trial in schoolchildren showed improvement in cognitive function after consuming a bread spread, containing fish flour from a marine source. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19201180 |
| Dijck-Brouwer DA et al. | Lower fetal status of docosahexaenoic acid, arachidonic acid and essential fatty acids is associated with less favorable neonatal neurological condition. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15589396 |
| Kris-Etherton PM et al. | Dietary reference intakes for DHA and EPA. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19525100 |
| Lapillonne A and Jensen CL | Reevaluation of the DHA requirement for the premature infant. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19577914 |
| Graf BA et al. | Age dependent incorporation of 14C-DHA into rat brain and body tissues after dosing various 14C-DHA-esters. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20580213 |
| Rapoport SI and Igarashi M | Can the rat liver maintain normal brain DHA metabolism in the absence of dietary DHA? | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19540098 |
| Freeman MP | Omega-3 fatty acids and perinatal depression: a review of the literature and recommendations for future research. | 2006 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16930971 |
| McNamara RK | Deciphering the role of docosahexaenoic acid in brain maturation and pathology with magnetic resonance imaging. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22521863 |
| Gustafson KM et al. | Docosahexaenoic acid and cognitive function: Is the link mediated by the autonomic nervous system? | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18930644 |
| Hanssens L et al. | The clinical benefits of long-term supplementation with omega-3 fatty acids in cystic fibrosis patients - A pilot study. | 2016 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:27154364 |
| Lagarde M et al. | Dose-effect and metabolism of docosahexaenoic acid: pathophysiological relevance in blood platelets. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22520055 |
| Gustafson KM et al. | Effects of docosahexaenoic acid supplementation during pregnancy on fetal heart rate and variability: a randomized clinical trial. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23433688 |
| Rapoport SI et al. | Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20226642 |
| Peltier S et al. | Preferential enrichment of liver phospholipids in docosahexaenoate relative to eicosapentaenoate in omega-3-depleted rats injected with a medium-chain triglyceride: fish oil emulsion. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18083359 |
| Brenna JT and Diau GY | The influence of dietary docosahexaenoic acid and arachidonic acid on central nervous system polyunsaturated fatty acid composition. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18023566 |
| Bonham MP et al. | Habitual fish consumption does not prevent a decrease in LCPUFA status in pregnant women (the Seychelles Child Development Nutrition Study). | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18585023 |
| Gramer G et al. | Long-chain polyunsaturated fatty acid status in children, adolescents and adults with phenylketonuria. | 2016 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:27269713 |
| Harris JI et al. | Statin treatment alters serum n-3 and n-6 fatty acids in hypercholesterolemic patients. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15310527 |
| Rapoport SI | Brain arachidonic and docosahexaenoic acid cascades are selectively altered by drugs, diet and disease. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18973997 |
| Michael-Titus AT | Omega-3 fatty acids and neurological injury. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18036801 |
| Ye S et al. | Polyunsaturated docosahexaenoic acid suppresses oxidative stress induced endothelial cell calcium influx by altering lipid composition in membrane caveolar rafts. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20206488 |
| Plourde M et al. | Unresolved issues in the link between docosahexaenoic acid and Alzheimer's disease. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18036804 |
| Calon F and Cole G | Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18037281 |
| Tu WC et al. | Correlations between blood and tissue omega-3 LCPUFA status following dietary ALA intervention in rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22521090 |
| Pifferi F et al. | n-3 Fatty acids modulate brain glucose transport in endothelial cells of the blood-brain barrier. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18042368 |
| Childs CE et al. | Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters. | 2010 Oct-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20817424 |
| Kikuchi S et al. | Modulation of eosinophil chemotactic activities to leukotriene B4 by n-3 polyunsaturated fatty acids. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610849 |
| Ren H et al. | Primary open-angle glaucoma patients have reduced levels of blood docosahexaenoic and eicosapentaenoic acids. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16410047 |
| Wittwer J and Hersberger M | The two faces of the 15-lipoxygenase in atherosclerosis. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17869078 |
| Watanabe S et al. | Dietary docosahexaenoic acid but not eicosapentaenoic acid suppresses lipopolysaccharide-induced interleukin-1 beta mRNA induction in mouse spleen leukocytes. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10841036 |
| Schuchardt JP and Hahn A | Bioavailability of long-chain omega-3 fatty acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23676322 |
| Gow RV et al. | Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23664595 |
| Sato SB et al. | Differential roles of internal and terminal double bonds in docosahexaenoic acid: Comparative study of cytotoxicity of polyunsaturated fatty acids to HT-29 human colorectal tumor cell line. | 2011 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20952172 |
| Kulkarni AV et al. | Reduced placental docosahexaenoic acid levels associated with increased levels of sFlt-1 in preeclampsia. | 2011 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20956072 |
| Magnusardottir AR et al. | Docosahexaenoic acid in red blood cells of women of reproductive age is positively associated with oral contraceptive use and physical activity. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19071003 |
| Gibson RA et al. | Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22515943 |
| Alnajjar A et al. | Effect of n-3 and n-6 polyunsaturated fatty acids on lymphocyte proliferation, interleukin production and phospholipid fatty acids composition in type 2 diabetic and healthy subjects in Jordan people. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16650969 |
| Storck Lindholm E et al. | Different fatty acid pattern in breast milk of obese compared to normal-weight mothers. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23273824 |
| Taha AY et al. | Threshold changes in rat brain docosahexaenoic acid incorporation and concentration following graded reductions in dietary alpha-linolenic acid. | 2016 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:26869088 |
| Makrides M | DHA supplementation during the perinatal period and neurodevelopment: Do some babies benefit more than others? | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22698951 |
| Van Biervliet S et al. | Oral DHA supplementation in DeltaF508 homozygous cystic fibrosis patients. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18276127 |
| Innis SM et al. | Long chain omega-3 fatty acids: micronutrients in disguise. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22709913 |
| Karanian JW et al. | Lipoxygenase stimulating effects of hydroxylated docosahexaenoates produced by human platelets. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8066103 |
| Horrobin DF | Schizophrenia as a membrane lipid disorder which is expressed throughout the body. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888116 |
| Louw L and Dannhauser A | Keloids in rural black South Africans. Part 2: dietary fatty acid intake and total phospholipid fatty acid profile in the blood of keloid patients. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090250 |
| Bryhn M et al. | The bioavailability and pharmacodynamics of different concentrations of omega-3 acid ethyl esters. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16806871 |