DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Communication Disorders D003147 1 associated lipids
Hydroa Vacciniforme D006837 1 associated lipids
Geographic Atrophy D057092 1 associated lipids
Trophoblastic Tumor, Placental Site D018245 1 associated lipids
Lordosis D008141 1 associated lipids
Phenylketonuria, Maternal D017042 1 associated lipids
Refsum Disease, Infantile D052919 1 associated lipids
Pulmonary Valve Stenosis D011666 1 associated lipids
Cerebrovascular Trauma D020214 1 associated lipids
Histiocytoma, Malignant Fibrous D051677 1 associated lipids
Decapitation D049248 2 associated lipids
Leukemia, Prolymphocytic D015463 2 associated lipids
Dementia D003704 2 associated lipids
Dysbiosis D064806 2 associated lipids
Intracranial Hemorrhages D020300 2 associated lipids
Paracoccidioidomycosis D010229 2 associated lipids
Myoglobinuria D009212 3 associated lipids
Dyslexia D004410 3 associated lipids
Albinism D000417 3 associated lipids
Short Bowel Syndrome D012778 3 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with DHA

Download all related citations
Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Lee HN et al. Resolution of inflammation as a novel chemopreventive strategy. 2013 Semin Immunopathol pmid:23370700
Carlson SE Docosahexaenoic acid and arachidonic acid in infant development. 2001 Semin Neonatol pmid:11988033
Tam VC Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections. 2013 Semin. Immunol. pmid:24084369
Goodnight SH Effects of dietary fish oil and omega-3 fatty acids on platelets and blood vessels. 1988 Semin. Thromb. Hemost. pmid:2845585
McEwen BJ et al. Effects of omega-3 polyunsaturated fatty acids on platelet function in healthy subjects and subjects with cardiovascular disease. 2013 Semin. Thromb. Hemost. pmid:23329646
Liu YJ [Biological activity and mechanism of action of eicosapentaenic acid and docosahexaenoic acid from fish oil]. 1987 Sheng Li Ke Xue Jin Zhan pmid:2823380
Feng Y et al. [Progress in metabolic mechanism of docosahexenoic acid production by fermentation]. 2010 Sheng Wu Gong Cheng Xue Bao pmid:21141112
Qian J et al. [Technology investigation of extracting fish oil by enzymolysising ocean wild fish]. 2008 Sheng Wu Gong Cheng Xue Bao pmid:18807986
Li HX and Yang GS [Effects of docosahexaenoic acid on rat adipocytes proliferation and differentiation]. 2005 Sheng Wu Gong Cheng Xue Bao pmid:16285532
Wang Y et al. Maresin 1 Inhibits Epithelial-to-Mesenchymal Transition in Vitro and Attenuates Bleomycin Induced Lung Fibrosis in Vivo. 2015 Shock pmid:26196843
Mohajeri S and Newman SA Review of evidence for dietary influences on atopic dermatitis. 2014 Jul-Aug Skin Therapy Lett. pmid:25188523
Gajewski BJ et al. Predicting accrual in clinical trials with Bayesian posterior predictive distributions. 2008 Stat Med pmid:17979152
Tian H et al. 14S,21R-dihydroxy-docosahexaenoic acid treatment enhances mesenchymal stem cell amelioration of renal ischemia/reperfusion injury. 2012 Stem Cells Dev. pmid:21846180
Nury T et al. Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). 2015 Steroids pmid:25683890
Ramaprasad TR et al. Spray-dried milk supplemented with alpha-linolenic acid or eicosapentaenoic acid and docosahexaenoic acid decreases HMG Co A reductase activity and increases biliary secretion of lipids in rats. 2006 Steroids pmid:16499938
Green D et al. A double-blind, placebo-controlled trial of fish oil concentrate (MaxEpa) in stroke patients. 1985 Jul-Aug Stroke pmid:3895595
Sekikawa A et al. Differential association of docosahexaenoic and eicosapentaenoic acids with carotid intima-media thickness. 2011 Stroke pmid:21757663
Belayev L et al. Docosahexaenoic acid complexed to albumin elicits high-grade ischemic neuroprotection. 2005 Stroke pmid:15569878
Belayev L et al. Robust docosahexaenoic acid-mediated neuroprotection in a rat model of transient, focal cerebral ischemia. 2009 Stroke pmid:19542051
Lalancette-Hébert M et al. Accumulation of dietary docosahexaenoic acid in the brain attenuates acute immune response and development of postischemic neuronal damage. 2011 Stroke pmid:21852616
Imre SG et al. Increased proportion of docosahexanoic acid and high lipid peroxidation capacity in erythrocytes of stroke patients. 1994 Stroke pmid:7974583
Liu X et al. Amide-type adduct of dopamine - plausible cause of Parkinson diseases. 2014 Subcell. Biochem. pmid:24374917
Nakamura M et al. Optimal dose of preoperative enteral immunonutrition for patients with esophageal cancer. 2009 Surg. Today pmid:19784723
Young C et al. Docosahexaenoic acid inhibits synaptic transmission and epileptiform activity in the rat hippocampus. 2000 Synapse pmid:10881029
Hsu K Long-chain polyunsaturated fatty acids as anti-HIV supplementation during breastfeeding. 2009 Taiwan J Obstet Gynecol pmid:19346195
Arita M and Serhan CN [Novel chemical mediators in the resolution of inflammation]. 2007 Tanpakushitsu Kakusan Koso pmid:17419455
Maldjian A et al. Changes in sperm quality and lipid composition during cryopreservation of boar semen. 2005 Theriogenology pmid:15626408
Mitre R et al. Oral intake of shark liver oil modifies lipid composition and improves motility and velocity of boar sperm. 2004 Theriogenology pmid:15451263
Cerolini S et al. Effect of docosahexaenoic acid and alpha-tocopherol enrichment in chicken sperm on semen quality, sperm lipid composition and susceptibility to peroxidation. 2006 Theriogenology pmid:16530814
Brinsko SP et al. Effect of feeding a DHA-enriched nutriceutical on the quality of fresh, cooled and frozen stallion semen. 2005 Theriogenology pmid:15725455
Gholami H et al. Effect of feeding a docosahexaenoic acid-enriched nutriceutical on the quality of fresh and frozen-thawed semen in Holstein bulls. 2010 Theriogenology pmid:20708237
Gliozzi TM et al. Quality and lipid composition of spermatozoa in rabbits fed DHA and vitamin E rich diets. 2009 Theriogenology pmid:19121864
Am-in N et al. Lipid profiles of sperm and seminal plasma from boars having normal or low sperm motility. 2011 Theriogenology pmid:21167582
Arm JP et al. Effect of dietary supplementation with fish oil lipids on mild asthma. 1988 Thorax pmid:3353893
Picado C et al. Effects of a fish oil enriched diet on aspirin intolerant asthmatic patients: a pilot study. 1988 Thorax pmid:3353894
Croset M and Lagarde M In vitro incorporation and metabolism of icosapentaenoic and docosahexaenoic acids in human platelets--effect on aggregation. 1986 Thromb. Haemost. pmid:3022414
Polette A et al. N-3 fatty acid-induced lipid peroxidation in human platelets is prevented by catechins. 1996 Thromb. Haemost. pmid:8822591
Larson MK et al. Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects. 2008 Thromb. Haemost. pmid:18841286
Véricel E et al. Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients. 2015 Thromb. Haemost. pmid:25832443
Del Turco S et al. Parallel decrease of tissue factor surface exposure and increase of tissue factor microparticle release by the n-3 fatty acid docosahexaenoate in endothelial cells. 2007 Thromb. Haemost. pmid:17598015
Croft KD et al. The effect of dietary fish oil on platelet metabolism of 14C arachidonic acid. 1986 Thromb. Res. pmid:3705024
Vreeken J et al. Transient aggregation resistance of human blood platelets in fresh plasma. II. Physiological relevance: influence of fish oil. 1989 Thromb. Res. pmid:2551059
Lee KW et al. Effects of omega-3 polyunsaturated fatty acids on plasma indices of thrombogenesis and inflammation in patients post-myocardial infarction. 2006 Thromb. Res. pmid:16154181
Prisco D et al. Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. 1998 Thromb. Res. pmid:9733153
Mezzano D et al. Cardiovascular risk factors in vegetarians. Normalization of hyperhomocysteinemia with vitamin B(12) and reduction of platelet aggregation with n-3 fatty acids. 2000 Thromb. Res. pmid:11108902
Andriamampandry MD et al. Antithrombotic effects of (n-3) polyunsaturated fatty acids in rat models of arterial and venous thrombosis. 1999 Thromb. Res. pmid:10065894
Barcelli U et al. Enhancing effect of dietary supplementation with omega-3 fatty acids on plasma fibrinolysis in normal subjects. 1985 Thromb. Res. pmid:2996169
Hansen J et al. Dietary supplementation with highly purified eicosapentaenoic acid and docosahexaenoic acid does not influence PAI-1 activity. 2000 Thromb. Res. pmid:10713313
Mundal HH et al. The effect of N-3 fatty acids and nifedipine on platelet function in hypertensive males. 1993 Thromb. Res. pmid:8303664
Conquer JA et al. Effect of supplementation with dietary seal oil on selected cardiovascular risk factors and hemostatic variables in healthy male subjects. 1999 Thromb. Res. pmid:10588467