DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Cerebrovascular Trauma D020214 1 associated lipids
Histiocytoma, Malignant Fibrous D051677 1 associated lipids
Hydroa Vacciniforme D006837 1 associated lipids
Communication Disorders D003147 1 associated lipids
Trophoblastic Tumor, Placental Site D018245 1 associated lipids
Geographic Atrophy D057092 1 associated lipids
Phenylketonuria, Maternal D017042 1 associated lipids
Lordosis D008141 1 associated lipids
Refsum Disease, Infantile D052919 1 associated lipids
Pulmonary Valve Stenosis D011666 1 associated lipids
Paracoccidioidomycosis D010229 2 associated lipids
Intracranial Hemorrhages D020300 2 associated lipids
Leukemia, Prolymphocytic D015463 2 associated lipids
Decapitation D049248 2 associated lipids
Dysbiosis D064806 2 associated lipids
Dementia D003704 2 associated lipids
Myoglobinuria D009212 3 associated lipids
Dyslexia D004410 3 associated lipids
Albinism D000417 3 associated lipids
Short Bowel Syndrome D012778 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Marcheselli VL et al. Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. 2003 J. Biol. Chem. pmid:12923200
Gu X et al. Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration. 2003 J. Biol. Chem. pmid:12923198
Dallongeville J et al. Fish consumption is associated with lower heart rates. 2003 Circulation pmid:12912821
Meyer A et al. Biosynthesis of docosahexaenoic acid in Euglena gracilis: biochemical and molecular evidence for the involvement of a Delta4-fatty acyl group desaturase. 2003 Biochemistry pmid:12911321
Trebble T et al. Inhibition of tumour necrosis factor-alpha and interleukin 6 production by mononuclear cells following dietary fish-oil supplementation in healthy men and response to antioxidant co-supplementation. 2003 Br. J. Nutr. pmid:12908901
Sekine S et al. Dietary docosahexaenoic acid-induced production of tissue lipid peroxides is not suppressed by higher intake of ascorbic acid in genetically scorbutic Osteogenic Disorder Shionogi/Shi-od/od rats. 2003 Br. J. Nutr. pmid:12908899
Burdge GC et al. Effect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [13C]alpha-linolenic acid to longer-chain fatty acids and partitioning towards beta-oxidation in older men. 2003 Br. J. Nutr. pmid:12908891
Tiangson CL et al. Docosahexaenoic acid level of the breast milk of some Filipino women. 2003 Int J Food Sci Nutr pmid:12907409
Otto SJ et al. Increased risk of postpartum depressive symptoms is associated with slower normalization after pregnancy of the functional docosahexaenoic acid status. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12907133
Mashek DG and Grummer RR Effects of long chain fatty acids on lipid and glucose metabolism in monolayer cultures of bovine hepatocytes. 2003 J. Dairy Sci. pmid:12906057
Agostoni C and Verduci E DHA in pregnancy benefits child development. 2003 Pediatr. Res. pmid:12904586
Mickleborough TD et al. Fish oil supplementation reduces severity of exercise-induced bronchoconstriction in elite athletes. 2003 Am. J. Respir. Crit. Care Med. pmid:12904324
Ruiz-Meana M and García-Dorado D Direct myocardial effects of fish oil on ischemia-reperfusion injury. Beyond lipid membrane composition? 2003 Cardiovasc. Res. pmid:12903630
Miyazawa D et al. Dietary alpha-linolenic acid suppresses the formation of lysophosphatidic acid, a lipid mediator, in rat platelets compared with linoleic acid. 2003 Life Sci. pmid:12899931
Ferdinandusse S et al. Studies on the metabolic fate of n-3 polyunsaturated fatty acids. 2003 J. Lipid Res. pmid:12897190
Hu SX and Yang JN [Biological effects of docosahexaenoic acid on the retina]. 2003 Zhonghua Yan Ke Za Zhi pmid:12894762
Ajuyah AO et al. Maternal diet with diverse omega-6/omega-3 ratio affects the brain docosahexaenoic acid content of growing chickens. 2003 Biol. Neonate pmid:12890936
Bellamy CM et al. Can supplementation of diet with omega-3 polyunsaturated fatty acids reduce coronary angioplasty restenosis rate? 1992 Eur. Heart J. pmid:1289091
Malcolm CA et al. Scotopic electroretinogram in term infants born of mothers supplemented with docosahexaenoic acid during pregnancy. 2003 Invest. Ophthalmol. Vis. Sci. pmid:12882824
Yuri T et al. Dietary docosahexaenoic acid suppresses N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats more effectively than eicosapentaenoic acid. 2003 Nutr Cancer pmid:12881016
Heard CM et al. The in vitro delivery of NSAIDs across skin was in proportion to the delivery of essential fatty acids in the vehicle--evidence that solutes permeate skin associated with their solvation cages? 2003 Int J Pharm pmid:12878406
Ponder DL et al. Docosahexaenoic acid status of term infants fed breast milk or infant formula containing soy oil or corn oil. 1992 Pediatr. Res. pmid:1287559
Rodemer C et al. Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice. 2003 Hum. Mol. Genet. pmid:12874108
Morris MC et al. Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. 2003 Arch. Neurol. pmid:12873849
Moriguchi K et al. Dietary docosahexaenoic acid protects against N-methyl-N-nitrosourea-induced retinal degeneration in rats. 2003 Exp. Eye Res. pmid:12873446
Véricel E et al. Pro- and antioxidant activities of docosahexaenoic acid on human blood platelets. 2003 J. Thromb. Haemost. pmid:12871467
Lee JY et al. Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids. 2003 J. Biol. Chem. pmid:12865424
Lagarde M et al. Pathophysiologic role of redox status in blood platelet activation. Influence of docosahexaenoic acid. 2003 Lipids pmid:12848295
Gawrisch K et al. The structure of DHA in phospholipid membranes. 2003 Lipids pmid:12848292
Mitchell DC et al. Enhancement of G protein-coupled signaling by DHA phospholipids. 2003 Lipids pmid:12848291
Cleland LG et al. A biomarker of n-3 compliance in patients taking fish oil for rheumatoid arthritis. 2003 Lipids pmid:12848288
Visioli F et al. Dietary intake of fish vs. formulations leads to higher plasma concentrations of n-3 fatty acids. 2003 Lipids pmid:12848287
Smuts CM et al. High-DHA eggs: feasibility as a means to enhance circulating DHA in mother and infant. 2003 Lipids pmid:12848286
Dewailly E et al. Fish consumption and blood lipids in three ethnic groups of Québec (Canada). 2003 Lipids pmid:12848280
Crawford MA et al. The potential role for arachidonic and docosahexaenoic acids in protection against some central nervous system injuries in preterm infants. 2003 Lipids pmid:12848275
Fan YY et al. Chemopreventive n-3 fatty acids activate RXRalpha in colonocytes. 2003 Carcinogenesis pmid:12844485
Montgomery C et al. Maternal docosahexaenoic acid supplementation and fetal accretion. 2003 Br. J. Nutr. pmid:12844385
Strokin M et al. Docosahexaenoic acid and arachidonic acid release in rat brain astrocytes is mediated by two separate isoforms of phospholipase A2 and is differently regulated by cyclic AMP and Ca2+. 2003 Br. J. Pharmacol. pmid:12839876
Hoffman DR et al. Visual function in breast-fed term infants weaned to formula with or without long-chain polyunsaturates at 4 to 6 months: a randomized clinical trial. 2003 J. Pediatr. pmid:12838196
Högyes E et al. Neuroprotective effect of developmental docosahexaenoic acid supplement against excitotoxic brain damage in infant rats. 2003 Neuroscience pmid:12831859
Speake BK et al. Distribution of lipids from the yolk to the tissues during development of the water python (Liasis fuscus). 2003 J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. pmid:12827419
Qian SY et al. Identification of spin trapped carbon-centered radicals in soybean lipoxygenase-dependent peroxidations of omega-3 polyunsaturated fatty acids by LC/ESR, LC/MS, and tandem MS. 2003 Free Radic. Biol. Med. pmid:12826254
Rojas CV et al. Gene expression analysis in human fetal retinal explants treated with docosahexaenoic acid. 2003 Invest. Ophthalmol. Vis. Sci. pmid:12824268
Chen H et al. EPA and DHA attenuate ox-LDL-induced expression of adhesion molecules in human coronary artery endothelial cells via protein kinase B pathway. 2003 J. Mol. Cell. Cardiol. pmid:12818567
Erkkilä AT et al. n-3 Fatty acids and 5-y risks of death and cardiovascular disease events in patients with coronary artery disease. 2003 Am. J. Clin. Nutr. pmid:12816772
Judé S et al. Peroxidation of docosahexaenoic acid is responsible for its effects on I TO and I SS in rat ventricular myocytes. 2003 Br. J. Pharmacol. pmid:12813005
Wang Z Role of redox state in modulation of ion channel function by fatty acids and phospholipids. 2003 Br. J. Pharmacol. pmid:12812990
Ng R Fish oil therapy in recurrent IgA nephropathy. 2003 Ann. Intern. Med. pmid:12809474
Hulbert AJ Life, death and membrane bilayers. 2003 J. Exp. Biol. pmid:12796449
Clements KM et al. Spontaneously hypertensive and Wistar Kyoto rats differ in delayed matching-to-place performance and response to dietary long-chain polyunsaturated fatty acids. 2003 Dev Psychobiol pmid:12794779
pmid:12794672
Rodriguez A et al. Preterm infant formula supplementation with alpha linolenic acid and docosahexaenoic acid. 2003 Eur J Clin Nutr pmid:12792656
Del Castillo IC et al. Docosahexaenoic acid selectively augments muscarinic stimulation of epithelial Cl- secretion. 2003 J. Surg. Res. pmid:12788663
Youssef JA et al. Age-independent, gray matter-localized, brain-enhanced oxidative stress in male fischer 344 rats: brain levels of F(2)-isoprostanes and F(4)-neuroprostanes. 2003 Free Radic. Biol. Med. pmid:12788483
Eldho NV et al. Polyunsaturated docosahexaenoic vs docosapentaenoic acid-differences in lipid matrix properties from the loss of one double bond. 2003 J. Am. Chem. Soc. pmid:12785780
Torres CF et al. Lipase-catalyzed ethanolysis of fish oils: multi-response kinetics. 2003 Biotechnol. Bioeng. pmid:12783483
Beck S et al. Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation. 2003 J. Biol. Chem. pmid:12782627
Barceló-Coblijn G et al. Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n-6 to n-3 fatty acid ratio. 2003 Biochim. Biophys. Acta pmid:12782153
Harel M and Place AR Tissue essential fatty acid composition and competitive response to dietary manipulations in white bass (Morone chrysops), striped bass (M. saxatilis) and hybrid striped bass (M. chrysopsxM. saxatilis). 2003 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:12781976
de Swaaf ME et al. Analysis of docosahexaenoic acid biosynthesis in Crypthecodinium cohnii by 13C labelling and desaturase inhibitor experiments. 2003 J. Biotechnol. pmid:12770501
Yusufi AN et al. Differential effects of low-dose docosahexaenoic acid and eicosapentaenoic acid on the regulation of mitogenic signaling pathways in mesangial cells. 2003 J. Lab. Clin. Med. pmid:12761475
Sano Y et al. A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord. 2003 J. Biol. Chem. pmid:12754259
Llorente AM et al. Effect of maternal docosahexaenoic acid supplementation on postpartum depression and information processing. 2003 Am. J. Obstet. Gynecol. pmid:12748510
Armstrong VT et al. Rapid flip-flop in polyunsaturated (docosahexaenoate) phospholipid membranes. 2003 Arch. Biochem. Biophys. pmid:12745257
Almansa E et al. Temperature-activity relationship for the intestinal Na+-K+-ATPase of Sparus aurata. A role for the phospholipid microenvironment? 2003 J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. pmid:12743726
Mashek DG and Grummer RR Short communication: Net uptake of nonesterified long chain fatty acids by the perfused caudate lobe of the caprine liver. 2003 J. Dairy Sci. pmid:12741546
Merritt RJ et al. Safety evaluation of sources of docosahexaenoic acid and arachidonic acid for use in infant formulas in newborn piglets. 2003 Food Chem. Toxicol. pmid:12738195
Gu X et al. Oxidatively truncated docosahexaenoate phospholipids: total synthesis, generation, and Peptide adduction chemistry. 2003 J. Org. Chem. pmid:12737551
Sarkadi-Nagy E et al. The influence of prematurity and long chain polyunsaturate supplementation in 4-week adjusted age baboon neonate brain and related tissues. 2003 Pediatr. Res. pmid:12736388
Cha MC et al. Dietary docosahexaenoic acid levels influence the outcome of arabinosylcytosine chemotherapy in L1210 leukemic mice. 2002 Nutr Cancer pmid:12734065
Sumino H et al. Effects of hormone replacement therapy on circulating docosahexaenoic acid and eicosapentaenoic acid levels in postmenopausal women. 2003 Endocr. J. pmid:12733709
Thorpe M Infant formula supplemented with DHA: are there benefits? 2003 J Am Diet Assoc pmid:12733531
Berry CB and McBean GJ An investigation into the role of calcium in the modulation of rat synaptosomal D-[3H]aspartate transport by docosahexaenoic acid. 2003 Brain Res. pmid:12729959
Inagaki K et al. Evidence of isozymes for delta6 fatty acid desaturase in rat hepatocytes. 2003 Biosci. Biotechnol. Biochem. pmid:12729021
Marangell LB et al. A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression. 2003 Am J Psychiatry pmid:12727707
Li H et al. [Effect of fish oil supplementation on fatty acid composition and neurotransmitters of growing rats]. 2000 Wei Sheng Yan Jiu pmid:12725043
Mattos R et al. Polyunsaturated fatty acids and bovine interferon-tau modify phorbol ester-induced secretion of prostaglandin F2 alpha and expression of prostaglandin endoperoxide synthase-2 and phospholipase-A2 in bovine endometrial cells. 2003 Biol. Reprod. pmid:12724278
Wallace FA et al. Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects. 2003 Br. J. Nutr. pmid:12720588
Kew S et al. Lack of effect of foods enriched with plant- or marine-derived n-3 fatty acids on human immune function. 2003 Am. J. Clin. Nutr. pmid:12716684
James MJ et al. Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids. 2003 Am. J. Clin. Nutr. pmid:12716664
Rotstein NP et al. Protective effect of docosahexaenoic acid on oxidative stress-induced apoptosis of retina photoreceptors. 2003 Invest. Ophthalmol. Vis. Sci. pmid:12714668
Insua MF et al. Cell cycle regulation in retinal progenitors by glia-derived neurotrophic factor and docosahexaenoic acid. 2003 Invest. Ophthalmol. Vis. Sci. pmid:12714666
Pass the fish (oil capsules), please. Following the latest recommendations from the American Heart Association may mean reaching for fish oil supplements. 2003 Harv Heart Lett pmid:12711572
Horrobin D et al. The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12711245
Mansour MP et al. The effect of growth phase on the lipid class, fatty acid and sterol composition in the marine dinoflagellate, Gymnodinium sp. in batch culture. 2003 Phytochemistry pmid:12711135
Wright TC et al. Effect of combinations of fish meal and feather meal on milk fatty acid content and nitrogen utilization in dairy cows. 2003 J. Dairy Sci. pmid:12703623
[Additional omega-3-fatty acids. Infarct mortality gets reduced]. 2003 MMW Fortschr Med pmid:12688033
Komatsu W et al. Docosahexaenoic acid suppresses nitric oxide production and inducible nitric oxide synthase expression in interferon-gamma plus lipopolysaccharide-stimulated murine macrophages by inhibiting the oxidative stress. 2003 Free Radic. Biol. Med. pmid:12684085
Wu FC et al. Dietary docosahexaenoic acid is more optimal than eicosapentaenoic acid affecting the level of cellular defence responses of the juvenile grouper Epinephelus malabaricus. 2003 Fish Shellfish Immunol. pmid:12681278
Koo WW Efficacy and safety of docosahexaenoic acid and arachidonic acid addition to infant formulas: can one buy better vision and intelligence? 2003 J Am Coll Nutr pmid:12672705
Meireles LA et al. Lipid class composition of the microalga Pavlova lutheri: eicosapentaenoic and docosahexaenoic acids. 2003 J. Agric. Food Chem. pmid:12670163
Youssef J et al. Pantothenic acid: an organ-specific pro-oxidant vitamin. Brain and liver neuroprostane levels in rats fed a pantothenic acid-deficient diet. 2002 Adv. Exp. Med. Biol. pmid:12664639
Reich EE et al. Formation of novel D-ring and E-ring isoprostane-like compounds (D4/E4-neuroprostanes) in vivo from docosahexaenoic acid. 2002 Adv. Exp. Med. Biol. pmid:12664634
Djoussé L et al. Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. 2003 Am. J. Clin. Nutr. pmid:12663278
Finnegan YE et al. Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. 2003 Am. J. Clin. Nutr. pmid:12663273
Abril R et al. Safety assessment of DHA-rich microalgae from Schizochytrium sp. Part V: target animal safety/toxicity study in growing swine. 2003 Regul. Toxicol. Pharmacol. pmid:12662911
Nesbitt GH et al. Effect of n-3 fatty acid ratio and dose on clinical manifestations, plasma fatty acids and inflammatory mediators in dogs with pruritus. 2003 Vet. Dermatol. pmid:12662263
de Swaaf ME et al. Fed-batch cultivation of the docosahexaenoic-acid-producing marine alga Crypthecodinium cohnii on ethanol. 2003 Appl. Microbiol. Biotechnol. pmid:12658513
Okada M et al. How does prolonged caloric restriction ameliorate age-related impairment of long-term potentiation in the hippocampus? 2003 Brain Res. Mol. Brain Res. pmid:12654517
Tully AM et al. Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case-control study. 2003 Br. J. Nutr. pmid:12654166