DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Lordosis D008141 1 associated lipids
Phenylketonuria, Maternal D017042 1 associated lipids
Refsum Disease, Infantile D052919 1 associated lipids
Pulmonary Valve Stenosis D011666 1 associated lipids
Cerebrovascular Trauma D020214 1 associated lipids
Histiocytoma, Malignant Fibrous D051677 1 associated lipids
Hydroa Vacciniforme D006837 1 associated lipids
Communication Disorders D003147 1 associated lipids
Geographic Atrophy D057092 1 associated lipids
Trophoblastic Tumor, Placental Site D018245 1 associated lipids
Dysbiosis D064806 2 associated lipids
Paracoccidioidomycosis D010229 2 associated lipids
Intracranial Hemorrhages D020300 2 associated lipids
Leukemia, Prolymphocytic D015463 2 associated lipids
Decapitation D049248 2 associated lipids
Dementia D003704 2 associated lipids
Dyskinesias D020820 3 associated lipids
Myocarditis D009205 3 associated lipids
Glaucoma, Open-Angle D005902 3 associated lipids
Neuroaxonal Dystrophies D019150 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Tanaka T et al. Mechanisms of accumulation of arachidonate in phosphatidylinositol in yellowtail. A comparative study of acylation systems of phospholipids in rat and the fish species Seriola quinqueradiata. 2003 Eur. J. Biochem. pmid:12654002
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Houston KD et al. Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma. 2003 Cancer Res. pmid:12649180
Smuts CM et al. A randomized trial of docosahexaenoic acid supplementation during the third trimester of pregnancy. 2003 Obstet Gynecol pmid:12636950
Itoh Y et al. Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. 2003 Nature pmid:12629551
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Chen WJ and Yeh SL Effects of fish oil in parenteral nutrition. 2003 Nutrition pmid:12620534
Suresh Y and Das UN Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus. Effect of omega-3 fatty acids. 2003 Nutrition pmid:12620523
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Narayanan BA et al. Modulation of inducible nitric oxide synthase and related proinflammatory genes by the omega-3 fatty acid docosahexaenoic acid in human colon cancer cells. 2003 Cancer Res. pmid:12615711
Mayer K et al. Parenteral nutrition with fish oil modulates cytokine response in patients with sepsis. 2003 Am. J. Respir. Crit. Care Med. pmid:12615625
Hibbeln JR et al. Smoking, gender, and dietary influences on erythrocyte essential fatty acid composition among patients with schizophrenia or schizoaffective disorder. 2003 Biol. Psychiatry pmid:12614996
Sturlan S et al. Docosahexaenoic acid enhances arsenic trioxide-mediated apoptosis in arsenic trioxide-resistant HL-60 cells. 2003 Blood pmid:12609832
Akimoto M et al. Lipase-catalyzed interesterification of soybean oil with an omega-3 polyunsaturated fatty acid concentrate prepared from sardine oil. 2003 Appl. Biochem. Biotechnol. pmid:12603099
Terry PD et al. Intakes of fish and marine fatty acids and the risks of cancers of the breast and prostate and of other hormone-related cancers: a review of the epidemiologic evidence. 2003 Am. J. Clin. Nutr. pmid:12600840
McFadyen M et al. Maternal and umbilical cord erythrocyte omega-3 and omega-6 fatty acids and haemorheology in singleton and twin pregnancies. 2003 Arch. Dis. Child. Fetal Neonatal Ed. pmid:12598503
Aoki H et al. Incorporation and accumulation of docosahexaenoic acid from the medium by Pichia methanolica HA-32. 2002 Biosci. Biotechnol. Biochem. pmid:12596859
Araseki M et al. Oxidative stability of polyunsaturated fatty acid in phosphatidylcholine liposomes. 2002 Biosci. Biotechnol. Biochem. pmid:12596850
Usami M et al. Effect of gamma-linolenic acid or docosahexaenoic acid on tight junction permeability in intestinal monolayer cells and their mechanism by protein kinase C activation and/or eicosanoid formation. 2003 Nutrition pmid:12591548
Kurowska EM et al. Bioavailability of omega-3 essential fatty acids from perilla seed oil. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12591004
Hong S et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. 2003 J. Biol. Chem. pmid:12590139
Berstad P et al. Supplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified fatty acids and soluble vascular cell adhesion molecule-1. 2003 Clin. Sci. pmid:12589702
Takeuchi T et al. Possible regulatory mechanism of DHA-induced anti-stress reaction in rats. 2003 Brain Res. pmid:12573522
Ait-Said F et al. Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway. 2003 Biochim. Biophys. Acta pmid:12573452
Saito M and Kubo K Relationship between tissue lipid peroxidation and peroxidizability index after alpha-linolenic, eicosapentaenoic, or docosahexaenoic acid intake in rats. 2003 Br. J. Nutr. pmid:12568661
Montine TJ et al. Antioxidants significantly affect the formation of different classes of isoprostanes and neuroprostanes in rat cerebral synaptosomes. 2003 Biochem. Pharmacol. pmid:12566089
Chiu CC et al. Omega-3 fatty acids for depression in pregnancy. 2003 Am J Psychiatry pmid:12562593
Kubo K et al. Docosahexaenoic acid-containing phosphatidylethanolamine in the external layer of liposomes protects docosahexaenoic acid from 2,2'-azobis(2-aminopropane)dihydrochloride-mediated lipid peroxidation. 2003 Arch. Biochem. Biophys. pmid:12559986
Howe PR et al. Tuna fishmeal as a source of DHA for n-3 PUFA enrichment of pork, chicken, and eggs. 2002 Lipids pmid:12558057
Huang H and Bao S [Studies on production of docosahexaenoic acid by Thraustochytrium aureum]. 2002 Wei Sheng Wu Xue Bao pmid:12557559
De Vizia B et al. Effect of an 8-month treatment with omega-3 fatty acids (eicosapentaenoic and docosahexaenoic) in patients with cystic fibrosis. 2003 Jan-Feb JPEN J Parenter Enteral Nutr pmid:12549599
Bakker EC et al. Long-chain polyunsaturated fatty acids at birth and cognitive function at 7 y of age. 2003 Eur J Clin Nutr pmid:12548302
Innis SM and Elias SL Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women. 2003 Am. J. Clin. Nutr. pmid:12540410
Lemaitre RN et al. n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study. 2003 Am. J. Clin. Nutr. pmid:12540389
Kielar ML et al. Docosahexaenoic acid ameliorates murine ischemic acute renal failure and prevents increases in mRNA abundance for both TNF-alpha and inducible nitric oxide synthase. 2003 J. Am. Soc. Nephrol. pmid:12538739
Sparreboom A et al. Disposition of docosahexaenoic acid-paclitaxel, a novel taxane, in blood: in vitro and clinical pharmacokinetic studies. 2003 Clin. Cancer Res. pmid:12538463
Qiu X Biosynthesis of docosahexaenoic acid (DHA, 22:6-4, 7,10,13,16,19): two distinct pathways. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12538082
Brenner RR Hormonal modulation of delta6 and delta5 desaturases: case of diabetes. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12538079
Park Y and Harris W EPA, but not DHA, decreases mean platelet volume in normal subjects. 2002 Lipids pmid:12530552
De Swaaf ME et al. High-cell-density fed-batch cultivation of the docosahexaenoic acid producing marine alga Crypthecodinium cohnii. 2003 Biotechnol. Bioeng. pmid:12529880
Wang Y et al. Docosahexaenoic acid inhibits cytokine-induced expression of P-selectin and neutrophil adhesion to endothelial cells. 2003 Eur. J. Pharmacol. pmid:12524156
Rousseau D et al. Dietary n-3 PUFAs affect the blood pressure rise and cardiac impairments in a hyperinsulinemia rat model in vivo. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12521943
Scorolli L et al. [Photodynamic therapy for age related macular degeneration with and without antioxidants]. 2002 Can. J. Ophthalmol. pmid:12518724
Kramer JA et al. Transcription profiling in rat liver in response to dietary docosahexaenoic acid implicates stearoyl-coenzyme a desaturase as a nutritional target for lipid lowering. 2003 J. Nutr. pmid:12514267
Woodman RJ et al. Docosahexaenoic acid but not eicosapentaenoic acid increases LDL particle size in treated hypertensive type 2 diabetic patients. 2003 Diabetes Care pmid:12502701
Francois CA et al. Supplementing lactating women with flaxseed oil does not increase docosahexaenoic acid in their milk. 2003 Am. J. Clin. Nutr. pmid:12499346
Favrelière S et al. DHA-enriched phospholipid diets modulate age-related alterations in rat hippocampus. 2003 Mar-Apr Neurobiol. Aging pmid:12498957
Cerbone AM et al. [EPA and DHA ethyl esters: potential mechanisms of antischemic action]. 1999 Cardiologia pmid:12497815
Briscoe CP et al. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. 2003 J. Biol. Chem. pmid:12496284
Yep YL et al. Bread enriched with microencapsulated tuna oil increases plasma docosahexaenoic acid and total omega-3 fatty acids in humans. 2002 Asia Pac J Clin Nutr pmid:12495260
Siddiqui RA et al. Cell-cycle arrest in Jurkat leukaemic cells: a possible role for docosahexaenoic acid. 2003 Biochem. J. pmid:12492401
Catalan J et al. Cognitive deficits in docosahexaenoic acid-deficient rats. 2002 Behav. Neurosci. pmid:12492301
Hashimoto M et al. [Mechanism of improvement of spatial cognition with dietary docosahexaenoic acid]. 2002 Nippon Yakurigaku Zasshi pmid:12491779
Baker SD et al. Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001. 2002 J. Natl. Cancer Inst. pmid:12488482
Amiano P et al. Very-long-chain omega-3 fatty acids as markers for habitual fish intake in Spain. 2002 IARC Sci. Publ. pmid:12484164
Woodman RJ et al. Effects of purified eicosapentaenoic acid and docosahexaenoic acid on platelet, fibrinolytic and vascular function in hypertensive type 2 diabetic patients. 2003 Atherosclerosis pmid:12482554
Igarashi T et al. Determination of docosahexaenoic acid and n-3 fatty acids in refined fish oils by 1H-NMR spectroscopy: IUPAC interlaboratory study. 2002 Nov-Dec J AOAC Int pmid:12477198
Seebungkert B and Lynch JW Effects of polyunsaturated fatty acids on voltage-gated K+ and Na+ channels in rat olfactory receptor neurons. 2002 Eur. J. Neurosci. pmid:12473076
Diep QN et al. PPARalpha activator effects on Ang II-induced vascular oxidative stress and inflammation. 2002 Hypertension pmid:12468571
Furuya H et al. Effect of ethanol and docosahexaenoic acid on nerve growth factor-induced neurite formation and neuron specific growth-associated protein gene expression in PC12 cells. 2002 Nihon Arukoru Yakubutsu Igakkai Zasshi pmid:12462067
Bourre JM and Dumont O The administration of pig brain phospholipids versus soybean phospholipids in the diet during the period of brain development in the rat results in greater increments of brain docosahexaenoic acid. 2002 Neurosci. Lett. pmid:12459515
Guallar E et al. Mercury, fish oils, and the risk of myocardial infarction. 2002 N. Engl. J. Med. pmid:12456850
Wang YW et al. Maternal dietary N-3 fatty acids alter the spleen fatty acid composition and bovine serum albumin-induced wing web swelling in broilers. 2002 Poult. Sci. pmid:12455601
Pratt VC et al. Plasma and neutrophil fatty acid composition in advanced cancer patients and response to fish oil supplementation. 2002 Br. J. Cancer pmid:12454764
Passi S et al. Fatty acid composition and antioxidant levels in muscle tissue of different Mediterranean marine species of fish and shellfish. 2002 J. Agric. Food Chem. pmid:12452651
Andersson A et al. Fatty acid composition of skeletal muscle reflects dietary fat composition in humans. 2002 Am. J. Clin. Nutr. pmid:12450886
Kearns SD and Haag M The effect of omega-3 fatty acids on Ca-ATPase in rat cerebral cortex. 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12445489
Wang L and Muttucumaru S Separation of biosynthetic polyunsaturated fatty acid (PUFA) with supercritical fluid. 2002 Biotechnol Annu Rev pmid:12436919
Meireles LA et al. Increase of the yields of eicosapentaenoic and docosahexaenoic acids by the microalga Pavlova lutheri following random mutagenesis. 2003 Biotechnol. Bioeng. pmid:12432580
Sanderson P et al. UK Food Standards Agency alpha-linolenic acid workshop report. 2002 Br. J. Nutr. pmid:12425738
Montine TJ et al. Neuronal oxidative damage from activated innate immunity is EP2 receptor-dependent. 2002 J. Neurochem. pmid:12423256
Abhyankar B Further reduction in mortality following myocardial infarction. 2002 Hosp Med pmid:12422496
Bowen RA and Clandinin MT Dietary low linolenic acid compared with docosahexaenoic acid alter synaptic plasma membrane phospholipid fatty acid composition and sodium-potassium ATPase kinetics in developing rats. 2002 J. Neurochem. pmid:12421348
Lee JY and Hwang DH Docosahexaenoic acid suppresses the activity of peroxisome proliferator-activated receptors in a colon tumor cell line. 2002 Biochem. Biophys. Res. Commun. pmid:12419306
Cherian G et al. Dietary conjugated linoleic acid with fish oil alters yolk n-3 and trans fatty acid content and volatile compounds in raw, cooked, and irradiated eggs. 2002 Poult. Sci. pmid:12412926
van Wezel-Meijler G et al. Dietary supplementation of long-chain polyunsaturated fatty acids in preterm infants: effects on cerebral maturation. 2002 Acta Paediatr. pmid:12412870
Nordøy A Statins and omega-3 fatty acids in the treatment of dyslipidemia and coronary heart disease. 2002 Minerva Med. pmid:12410168
Cetin I et al. Intrauterine growth restriction is associated with changes in polyunsaturated fatty acid fetal-maternal relationships. 2002 Pediatr. Res. pmid:12409524
Glew RH et al. The fatty acid composition of the serum phospholipids of children with sickle cell disease in Nigeria. 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12401435
Decsi T et al. Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children. 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12401433
Woodman RJ et al. Effects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension. 2002 Am. J. Clin. Nutr. pmid:12399272
Rodriguez de Turco EB et al. Systemic fatty acid responses to transient focal cerebral ischemia: influence of neuroprotectant therapy with human albumin. 2002 J. Neurochem. pmid:12390513
Ye D et al. Cytochrome p-450 epoxygenase metabolites of docosahexaenoate potently dilate coronary arterioles by activating large-conductance calcium-activated potassium channels. 2002 J. Pharmacol. Exp. Ther. pmid:12388664
Quan LG and Cha JK Preparation of isoprostanes and neuroprostanes. 2002 J. Am. Chem. Soc. pmid:12381179
Saito M and Kubo K An assessment of docosahexaenoic acid intake from the viewpoint of safety and physiological efficacy in matured rats. 2002 Ann. Nutr. Metab. pmid:12378040
Wu T et al. Enrichment of LDL with EPA and DHA decreased oxidized LDL-induced apoptosis in U937 cells. 2002 Lipids pmid:12371750
Brzustowicz MR et al. Controlling membrane cholesterol content. A role for polyunsaturated (docosahexaenoate) phospholipids. 2002 Biochemistry pmid:12369842
Acar N et al. Long-term intake of trans (n-3) polyunsaturated fatty acids reduces the b-wave amplitude of electroretinograms in rats. 2002 J. Nutr. pmid:12368410
Mathews SA et al. Comparison of triglycerides and phospholipids as supplemental sources of dietary long-chain polyunsaturated fatty acids in piglets. 2002 J. Nutr. pmid:12368399
Hulbert AJ et al. Acyl composition of muscle membranes varies with body size in birds. 2002 J. Exp. Biol. pmid:12364409
Mashek DG et al. Metabolic fate of long-chain unsaturated fatty acids and their effects on palmitic acid metabolism and gluconeogenesis in bovine hepatocytes. 2002 J. Dairy Sci. pmid:12362461
AbuGhazaleh AA et al. Fatty acid profiles of milk and rumen digesta from cows fed fish oil, extruded soybeans or their blend. 2002 J. Dairy Sci. pmid:12362459
Sergeeva M et al. Arachidonic acid and docosahexaenoic acid suppress thrombin-evoked Ca2+ response in rat astrocytes by endogenous arachidonic acid liberation. 2002 J. Neurochem. pmid:12358772
Anderson RE et al. Low docosahexaenoic acid levels in rod outer segments of rats with P23H and S334ter rhodopsin mutations. 2002 Mol. Vis. pmid:12355064
Krasevec JM et al. Maternal and infant essential fatty acid status in Havana, Cuba. 2002 Am. J. Clin. Nutr. pmid:12324298
Martin RE et al. Docosahexaenoic, arachidonic, palmitic, and oleic acids are differentially esterified into phospholipids of frog retina. 2002 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:12324228
Williard DE et al. Comparison of 20-, 22-, and 24-carbon n-3 and n-6 polyunsaturated fatty acid utilization in differentiated rat brain astrocytes. 2002 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:12324227
Ghys A et al. Red blood cell and plasma phospholipid arachidonic and docosahexaenoic acid levels at birth and cognitive development at 4 years of age. 2002 Early Hum. Dev. pmid:12324186
Burdge GC et al. Effect of reduced dietary protein intake on hepatic and plasma essential fatty acid concentrations in the adult female rat: effect of pregnancy and consequences for accumulation of arachidonic and docosahexaenoic acids in fetal liver and brain. 2002 Br. J. Nutr. pmid:12323087
Chapkin RS et al. Dietary n-3 PUFA affect TcR-mediated activation of purified murine T cells and accessory cell function in co-cultures. 2002 Clin. Exp. Immunol. pmid:12296847