DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hydroa Vacciniforme D006837 1 associated lipids
Communication Disorders D003147 1 associated lipids
Trophoblastic Tumor, Placental Site D018245 1 associated lipids
Geographic Atrophy D057092 1 associated lipids
Phenylketonuria, Maternal D017042 1 associated lipids
Lordosis D008141 1 associated lipids
Refsum Disease, Infantile D052919 1 associated lipids
Pulmonary Valve Stenosis D011666 1 associated lipids
Cerebrovascular Trauma D020214 1 associated lipids
Histiocytoma, Malignant Fibrous D051677 1 associated lipids
Dysbiosis D064806 2 associated lipids
Paracoccidioidomycosis D010229 2 associated lipids
Intracranial Hemorrhages D020300 2 associated lipids
Leukemia, Prolymphocytic D015463 2 associated lipids
Decapitation D049248 2 associated lipids
Dementia D003704 2 associated lipids
Albinism D000417 3 associated lipids
Short Bowel Syndrome D012778 3 associated lipids
Depression, Postpartum D019052 3 associated lipids
Dyskinesias D020820 3 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with DHA

Download all related citations
Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Calder PC Dietary modification of inflammation with lipids. 2002 Proc Nutr Soc pmid:12296294
Blank C et al. Optimizing DHA levels in piglets by lowering the linoleic acid to alpha-linolenic acid ratio. 2002 J. Lipid Res. pmid:12235186
Innis SM and Dyer RA Brain astrocyte synthesis of docosahexaenoic acid from n-3 fatty acids is limited at the elongation of docosapentaenoic acid. 2002 J. Lipid Res. pmid:12235185
Goel DP et al. Effects of omega-3 polyunsaturated fatty acids on cardiac sarcolemmal Na(+)/H(+) exchange. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:12234824
Yang P et al. Quantitative high-performance liquid chromatography/electrospray ionization tandem mass spectrometric analysis of 2- and 3-series prostaglandins in cultured tumor cells. 2002 Anal. Biochem. pmid:12234478
Arsenov DV et al. [Effects of complexes of alpha-fetoprotein and amphiphilic docosaenoic acid derivatives on the humoral immune response in C57BL/6 mice]. 2002 May-Jun Eksp Klin Farmakol pmid:12227097
Fernandes MX et al. Brownian dynamics simulation of the unsaturated lipidic molecules oleic and docosahexaenoic acid confined in a cellular membrane. 2002 Biochim. Biophys. Acta pmid:12225849
Minda H et al. Effect of different types of feeding on fatty acid composition of erythrocyte membrane lipids in full-term infants. 2002 Acta Paediatr. pmid:12222708
Weiler HA and Fitzpatrick-Wong SC Modulation of essential (n-6):(n-3) fatty acid ratios alters fatty acid status but not bone mass in piglets. 2002 J. Nutr. pmid:12221227
Wallis JG et al. Polyunsaturated fatty acid synthesis: what will they think of next? 2002 Trends Biochem. Sci. pmid:12217522
Doolan GK et al. Fatty acid augmentation of the cardiac slowly activating delayed rectifier current (IKs) is conferred by hminK. 2002 FASEB J. pmid:12206993
Kimura S et al. Docosahexaenoic acid attenuated hypertension and vascular dementia in stroke-prone spontaneously hypertensive rats. 2002 Sep-Oct Neurotoxicol Teratol pmid:12200199
Cheruku SR et al. Higher maternal plasma docosahexaenoic acid during pregnancy is associated with more mature neonatal sleep-state patterning. 2002 Am. J. Clin. Nutr. pmid:12198007
pmid:12195273
Pilitsis JG et al. Free fatty acids in human cerebrospinal fluid following subarachnoid hemorrhage and their potential role in vasospasm: a preliminary observation. 2002 J. Neurosurg. pmid:12186453
Sugimoto Y et al. Effect of docosahexaenoic acid-fortified Chlorella vulgaris strain CK22 on the radial maze performance in aged mice. 2002 Biol. Pharm. Bull. pmid:12186415
Berger A et al. Unraveling lipid metabolism with microarrays: effects of arachidonate and docosahexaenoate acid on murine hepatic and hippocampal gene expression. 2002 Genome Biol. pmid:12184799
Turner ND et al. Oncogenic ras alters sensitivity of mouse colonocytes to butyrate and fatty acid mediated growth arrest and apoptosis. 2002 Cancer Lett. pmid:12183072
RVitelli M et al. Effects of docosahexaenoic acid on [Ca(2+)](i) increase induced by doxorubicin in ventricular rat cardiomyocytes. 2002 Life Sci. pmid:12175705
Jensen CL and Heird WC Lipids with an emphasis on long-chain polyunsaturated fatty acids. 2002 Clin Perinatol pmid:12168241
Ghebremeskel K et al. Liver triacylglycerols and free fatty acids in streptozotocin-induced diabetic rats have atypical n-6 and n-3 pattern. 2002 Comp. Biochem. Physiol. C Toxicol. Pharmacol. pmid:12161168
Akbar M and Kim HY Protective effects of docosahexaenoic acid in staurosporine-induced apoptosis: involvement of phosphatidylinositol-3 kinase pathway. 2002 J. Neurochem. pmid:12153489
Armstrong D et al. Preparation of microspheres and incorporation of lipid hydroperoxide for sustained release studies. 2002 Methods Mol. Biol. pmid:12152211
Jeffrey BG et al. n-3 fatty acid deficiency alters recovery of the rod photoresponse in rhesus monkeys. 2002 Invest. Ophthalmol. Vis. Sci. pmid:12147619
Nestel P et al. The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans. 2002 Am. J. Clin. Nutr. pmid:12145002
Hansen RA et al. Effects of dietary flaxseed oil supplementation on equine plasma fatty acid concentrations and whole blood platelet aggregation. 2002 Jul-Aug J. Vet. Intern. Med. pmid:12141309
Diaz O et al. The mechanism of docosahexaenoic acid-induced phospholipase D activation in human lymphocytes involves exclusion of the enzyme from lipid rafts. 2002 J. Biol. Chem. pmid:12140281
Benito Fernández J et al. [The influence of human milk and various artificial formulae commercially available in Spain on the fatty acid status of infants in the first two months of life]. 2002 An. Esp. Pediatr. pmid:12139873
Fam SS et al. Formation of highly reactive A-ring and J-ring isoprostane-like compounds (A4/J4-neuroprostanes) in vivo from docosahexaenoic acid. 2002 J. Biol. Chem. pmid:12133837
Murayama K et al. Fish oil (polyunsaturated fatty acid) prevents ischemic-induced injury in the mammalian retina. 2002 Exp. Eye Res. pmid:12126941
Shmeeda H et al. Heat acclimation in rats: modulation via lipid polyunsaturation. 2002 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:12121852
Haubner LY et al. Maternal dietary docosahexanoic acid content affects the rat pup auditory system. 2002 Brain Res. Bull. pmid:12121805
Minda H et al. Systematic review of fatty acid composition of plasma phospholipids of venous cord blood in full-term infants. 2002 Eur J Nutr pmid:12111050
Hibbeln JR Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: a cross-national, ecological analysis. 2002 J Affect Disord pmid:12103448
Barros MF et al. Cord blood essential fatty acid and alpha-tocopherol in full-term newborns in a Northeast Brazil area. 2002 Int J Vitam Nutr Res pmid:12098883
Teague WE et al. Polyunsaturated lipids in membrane fusion events. 2002 Cell. Mol. Biol. Lett. pmid:12097942
Stark KD et al. Fatty acid compositions of serum phospholipids of postmenopausal women: a comparison between Greenland Inuit and Canadians before and after supplementation with fish oil. 2002 Jul-Aug Nutrition pmid:12093443
Rapoport SI and Bosetti F Do lithium and anticonvulsants target the brain arachidonic acid cascade in bipolar disorder? 2002 Arch. Gen. Psychiatry pmid:12090811
Rinaldi B et al. Effects of docosahexaenoic acid on calcium pathway in adult rat cardiomyocytes. 2002 Life Sci. pmid:12088759
MacDonald IM What are your patients reading? 2002 Can. J. Ophthalmol. pmid:12083472
Saugstad LF Human nature is unique in the mismatch between the usual diet and the need for "food for the brain" (marine fat, DHA). Adding marine fat is beneficial in schizophrenia and manic-depressive psychosis. This underlines brain dysfunction in these neurological disorders is associated with deficient intake of marine fat(DHA). 2002 Nutr Health pmid:12083411
Dewailly E et al. Cardiovascular disease risk factors and n-3 fatty acid status in the adult population of James Bay Cree. 2002 Am. J. Clin. Nutr. pmid:12081820
Larque E et al. Perinatal supply and metabolism of long-chain polyunsaturated fatty acids: importance for the early development of the nervous system. 2002 Ann. N. Y. Acad. Sci. pmid:12079857
Leaden P et al. The protection of long chain polyunsaturated fatty acids by melatonin during nonenzymatic lipid peroxidation of rat liver microsomes. 2002 J. Pineal Res. pmid:12074095
Hashimoto M et al. Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats. 2002 J. Neurochem. pmid:12065621
Makrides M and Gibson RA The role of fats in the lifecycle stages: pregnancy and the first year of life. 2002 Med. J. Aust. pmid:12064969
Gibson RA et al. Essential role of fats throughout the lifecycle: summary and recommendations. 2002 Med. J. Aust. pmid:12064967
Bernard-Gallon DJ et al. Differential effects of n-3 and n-6 polyunsaturated fatty acids on BRCA1 and BRCA2 gene expression in breast cell lines. 2002 Br. J. Nutr. pmid:12064337
Haggarty P et al. The effect of maternal smoking and ethanol on fatty acid transport by the human placenta. 2002 Br. J. Nutr. pmid:12064333
Kraffe E et al. Evidence of a tetradocosahexaenoic cardiolipin in some marine bivalves. 2002 Lipids pmid:12056594
Chambrier C et al. Eicosapentaenoic acid induces mRNA expression of peroxisome proliferator-activated receptor gamma. 2002 Obes. Res. pmid:12055328
Hirafuji M et al. Docosahexaenoic acid potentiates interleukin-1beta induction of nitric oxide synthase through mechanism involving p44/42 MAPK activation in rat vascular smooth muscle cells. 2002 Br. J. Pharmacol. pmid:12055140
Suzuki R et al. Effects of n-3 polyunsaturated fatty acids on dermatitis in NC/Nga mice. 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12054914
Hammond BG et al. Safety assessment of DHA-rich microalgae from Schizochytrium sp. 2002 Regul. Toxicol. Pharmacol. pmid:12052009
Dunbar BL and Bauer JE Metabolism of dietary essential fatty acids and their conversion to long-chain polyunsaturated metabolites. 2002 J. Am. Vet. Med. Assoc. pmid:12051499
Contreras MA and Rapoport SI Recent studies on interactions between n-3 and n-6 polyunsaturated fatty acids in brain and other tissues. 2002 Curr. Opin. Lipidol. pmid:12045396
Irvine AJ et al. Dietary supplementation with (n-3) polyunsaturated fatty acids does not affect insulin sensitivity in healthy Labrador retriever dogs. 2002 J. Nutr. pmid:12042502
Yavin E et al. Docosahexaenoic acid abundance in the brain: a biodevice to combat oxidative stress. 2002 Nutr Neurosci pmid:12041873
Makrides M et al. Nutritional effect of including egg yolk in the weaning diet of breast-fed and formula-fed infants: a randomized controlled trial. 2002 Am. J. Clin. Nutr. pmid:12036817
Yoshii H et al. Autoxidation kinetic analysis of docosahexaenoic acid ethyl ester and docosahexaenoic triglyceride with oxygen sensor. 2002 Biosci. Biotechnol. Biochem. pmid:12036046
Hu PC and Chen BH Effects of riboflavin and fatty acid methyl esters on cholesterol oxidation during illumination. 2002 J. Agric. Food Chem. pmid:12033831
Innis SM et al. Docosahexaenoic acid and arachidonic acid enhance growth with no adverse effects in preterm infants fed formula. 2002 J. Pediatr. pmid:12032520
Ferrier GR et al. Differential effects of docosahexaenoic acid on contractions and L-type Ca2+ current in adult cardiac myocytes. 2002 Cardiovasc. Res. pmid:12031706
Denys A et al. Eicosapentaenoic acid and docosahexaenoic acid modulate MAP kinase enzyme activity in human T-cells. 2002 Mol. Cell. Biochem. pmid:12030372
Banno F et al. Lymphatic absorption of docosahexaenoic acid given as monoglyceride, diglyceride, triglyceride, and ethyl ester in rats. 2002 J. Nutr. Sci. Vitaminol. pmid:12026185
Guajardo MH et al. Retinal fatty acid binding protein reduce lipid peroxidation stimulated by long-chain fatty acid hydroperoxides on rod outer segments. 2002 Biochim. Biophys. Acta pmid:12020634
Mattos R et al. Uterine, ovarian, and production responses of lactating dairy cows to increasing dietary concentrations of menhaden fish meal. 2002 J. Dairy Sci. pmid:12018420
Wu GS and Rao NA Detection of docosahexaenoic acid hydroperoxides in retina by gas chromatography/mass spectrometry. 2002 Methods Mol. Biol. pmid:12013778
Leigh-Firbank EC et al. Eicosapentaenoic acid and docosahexaenoic acid from fish oils: differential associations with lipid responses. 2002 Br. J. Nutr. pmid:12010583
Yavin E et al. Docosahexaenoic acid sources for the developing brain during intrauterine life. 2001 Nutr Health pmid:12003088
Wainwright PE Dietary essential fatty acids and brain function: a developmental perspective on mechanisms. 2002 Proc Nutr Soc pmid:12002796
Moseley K et al. Lipid status and long-chain polyunsaturated fatty acid concentrations in adults and adolescents with phenylketonuria on phenylalanine-restricted diet. 2002 J. Inherit. Metab. Dis. pmid:11999981
Cha MC and Meckling-Gill KA Modifications of deoxycytidine kinase and deaminase activities by docosahexaenoic acid in normal and transformed rat fibroblasts. 2002 Biochem. Pharmacol. pmid:11992640
Carlson SE Docosahexaenoic acid and arachidonic acid in infant development. 2001 Semin Neonatol pmid:11988033
Zerouga M et al. Synthesis of a novel phosphatidylcholine conjugated to docosahexaenoic acid and methotrexate that inhibits cell proliferation. 2002 Anticancer Drugs pmid:11984074
Egea PF et al. Molecular recognition of agonist ligands by RXRs. 2002 Mol. Endocrinol. pmid:11981034
Voigt RG et al. Relationship between omega3 long-chain polyunsaturated fatty acid status during early infancy and neurodevelopmental status at 1 year of age. 2002 J Hum Nutr Diet pmid:11972740
Duplus E et al. Evidence for selective induction of phosphoenolpyruvate carboxykinase gene expression by unsaturated and nonmetabolized fatty acids in adipocytes. 2002 J. Cell. Biochem. pmid:11968005
Freedman SD et al. Characterization of LPS-induced lung inflammation in cftr-/- mice and the effect of docosahexaenoic acid. 2002 J. Appl. Physiol. pmid:11960971
Ahmad A et al. Decrease in neuron size in docosahexaenoic acid-deficient brain. 2002 Pediatr. Neurol. pmid:11955929
Little JM et al. Glucuronidation of the dietary fatty acids, phytanic acid and docosahexaenoic acid, by human UDP-glucuronosyltransferases. 2002 Drug Metab. Dispos. pmid:11950783
Lim SY and Suzuki H Dose-response effect of docosahexaenoic acid ethyl ester on maze behavior and brain fatty acid composition in adult mice. 2002 Int J Vitam Nutr Res pmid:11944198
Gutiérrez AM et al. Fatty acid profiles and lipid peroxidation of microsomes and mitochondria from liver, heart and brain of Cairina moschata. 2002 Int. J. Biochem. Cell Biol. pmid:11943591
Radominska-Pandya A and Chen G Photoaffinity labeling of human retinoid X receptor beta (RXRbeta) with 9-cis-retinoic acid: identification of phytanic acid, docosahexaenoic acid, and lithocholic acid as ligands for RXRbeta. 2002 Biochemistry pmid:11939783
Petryk L and Weiler HA Sows' milk attenuates dexamethasone-induced reductions in liver docosahexaenoic acid. 2002 Biol. Neonate pmid:11937725
Nestel P Fish oil fatty acids beneficially modulate vascular function. 2001 World Rev Nutr Diet pmid:11935976
Suzuki H et al. Effect of DHA oil supplementation on intelligence and visual acuity in the elderly. 2001 World Rev Nutr Diet pmid:11935973
Crawford MA et al. Docosahexaenoic acid and cerebral evolution. 2001 World Rev Nutr Diet pmid:11935972
Hamazaki T et al. Effect of docosahexaenoic acid on hostility. 2001 World Rev Nutr Diet pmid:11935969
Sato M et al. Cloning of rat delta 6-desaturase and its regulation by dietary eicosapentaenoic or docosahexaenoic acid. 2001 World Rev Nutr Diet pmid:11935956
Lagarde M et al. Lysophosphatidylcholine as a carrier of docosahexaenoic acid to target tissues. 2001 World Rev Nutr Diet pmid:11935951
Hamazaki T et al. The effect of docosahexaenoic acid on aggression in elderly Thai subjects--a placebo-controlled double-blind study. 2002 Nutr Neurosci pmid:11929196
Revajová V et al. Influencing the immune parameters in germ-free piglets by administration of seal oil with increased content of omega-3 PUFA. 2001 Arch Tierernahr pmid:11921854
Hawkes JS et al. A randomized trial of supplementation with docosahexaenoic acid-rich tuna oil and its effects on the human milk cytokines interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha. 2002 Am. J. Clin. Nutr. pmid:11916764
Igbavboa U et al. A new role for apolipoprotein E: modulating transport of polyunsaturated phospholipid molecular species in synaptic plasma membranes. 2002 J. Neurochem. pmid:11902115
Pan J and Chung FL Formation of cyclic deoxyguanosine adducts from omega-3 and omega-6 polyunsaturated fatty acids under oxidative conditions. 2002 Chem. Res. Toxicol. pmid:11896684
Lyzogub VG et al. [Role of the skin in destabilization of coronary circulation]. 2001 Sep-Dec Lik. Sprava pmid:11881380
Kitajka K et al. The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acids. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:11880617
Urquhart P et al. The effect of conjugated linoleic acid on arachidonic acid metabolism and eicosanoid production in human saphenous vein endothelial cells. 2002 Biochim. Biophys. Acta pmid:11880240
Kuchbaev AE and Bastarbekova GM [Phospholipid and fatty acid content of the blood of sheep infected with the nematode Dictyocaulus filaria]. 2001 Sep-Oct Parazitologia pmid:11871259