DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Chung BH et al. | Effects of docosahexaenoic acid and eicosapentaenoic acid on androgen-mediated cell growth and gene expression in LNCaP prostate cancer cells. | 2001 | Carcinogenesis | pmid:11470750 |
| Green P et al. | Enhanced free radical scavenging and decreased lipid peroxidation in the rat fetal brain after treatment with ethyl docosahexaenoate. | 2001 | Biochim. Biophys. Acta | pmid:11470241 |
| Miyauchi O et al. | Protective effect of docosahexaenoic acid against retinal ischemic injury: an electroretinographic study. | 2001 Jul-Aug | Ophthalmic Res. | pmid:11464070 |
| Whitehouse AS and Tisdale MJ | Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11453634 |
| Tanaka S et al. | Medium-chain fatty acids stimulate interleukin-8 production in Caco-2 cells with different mechanisms from long-chain fatty acids. | 2001 | J. Gastroenterol. Hepatol. | pmid:11446882 |
| López-Ferrer S et al. | n-3 enrichment of chicken meat. 1. Use of very long-chain fatty acids in chicken diets and their influence on meat quality: fish oil. | 2001 | Poult. Sci. | pmid:11441841 |
| Hashimoto M et al. | Effects of docosahexaenoic acid on annular lipid fluidity of the rat bile canalicular plasma membrane. | 2001 | J. Lipid Res. | pmid:11441145 |
| Kinoshita H and Ota Y | Concentration of docosahexaenoic acid from fish oils using Geotrichum sp. FO347-2. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11440112 |
| Thies F et al. | Dietary supplementation with gamma-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans. | 2001 | J. Nutr. | pmid:11435508 |
| Burke PA et al. | Sites of conditional essential fatty acid deficiency in end stage liver disease. | 2001 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:11434649 |
| Anderson RE et al. | Low docosahexaenoic acid levels in rod outer segment membranes of mice with rds/peripherin and P216L peripherin mutations. | 2001 | Invest. Ophthalmol. Vis. Sci. | pmid:11431433 |
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| Otto SJ et al. | Comparison of the peripartum and postpartum phospholipid polyunsaturated fatty acid profiles of lactating and nonlactating women. | 2001 | Am. J. Clin. Nutr. | pmid:11382662 |
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| Rump P et al. | Leptin and phospholipid-esterified docosahexaenoic acid concentrations in plasma of women: observations during pregnancy and lactation. | 2001 | Eur J Clin Nutr | pmid:11360128 |
| Peet M et al. | Two double-blind placebo-controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia. | 2001 | Schizophr. Res. | pmid:11356585 |
| Berger A et al. | Anandamide and diet: inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11353819 |
| Rapoport SI et al. | Delivery and turnover of plasma-derived essential PUFAs in mammalian brain. | 2001 | J. Lipid Res. | pmid:11352974 |
| Wang H et al. | Regulation of apolipoprotein secretion by long-chain polyunsaturated fatty acids in newborn swine enterocytes. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11352806 |
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| Hammond BG et al. | Safety assessment of DHA-rich microalgae from Schizochytrium sp. | 2001 | Regul. Toxicol. Pharmacol. | pmid:11350203 |
| Hammond BG et al. | Safety assessment of DHA-rich microalgae from Schizochytrium sp. | 2001 | Regul. Toxicol. Pharmacol. | pmid:11350202 |
| Jørgensen MH et al. | Is there a relation between docosahexaenoic acid concentration in mothers' milk and visual development in term infants? | 2001 | J. Pediatr. Gastroenterol. Nutr. | pmid:11345178 |
| Siddiqui RA et al. | Docosahexaenoic acid induces apoptosis in Jurkat cells by a protein phosphatase-mediated process. | 2001 | Biochim. Biophys. Acta | pmid:11341974 |
| Engler MB and Engler MM | Docosahexaenoic acid--induced vasorelaxation in hypertensive rats: mechanisms of action. | 2000 | Biol Res Nurs | pmid:11337819 |
| Colquhoun A et al. | Eicosapentaenoic acid and docosahexaenoic acid effects on tumour mitochondrial metabolism, acyl CoA metabolism and cell proliferation. | 2001 | Cell Biochem. Funct. | pmid:11335934 |
| Umegaki K et al. | Docosahexaenoic acid supplementation-increased oxidative damage in bone marrow DNA in aged rats and its relation to antioxidant vitamins. | 2001 | Free Radic. Res. | pmid:11328678 |
| Modeste AB et al. | [Hydroa vacciniforme: dietary fish oil]. | 2001 | Ann Dermatol Venereol | pmid:11319390 |
| Seung Kim HF et al. | Inhibitory effects of omega-3 fatty acids on protein kinase C activity in vitro. | 2001 | Mol. Psychiatry | pmid:11317232 |
| Durrington PN et al. | An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia. | 2001 | Heart | pmid:11303007 |
| Rudra PK and Krokan HE | Cell-specific enhancement of doxorubicin toxicity in human tumour cells by docosahexaenoic acid. | 2001 Jan-Feb | Anticancer Res. | pmid:11299749 |
| Delton-Vandenbroucke I et al. | Dual regulation of glutathione peroxidase by docosahexaenoic acid in endothelial cells depending on concentration and vascular bed origin. | 2001 | Free Radic. Biol. Med. | pmid:11295532 |
| Schneider SM et al. | Activity of the leukocyte NADPH oxidase in whole neutrophils and cell-free neutrophil preparations stimulated with long-chain polyunsaturated fatty acids. | 2001 | Inflammation | pmid:11293662 |
| Su HM et al. | Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. | 2001 | J. Lipid Res. | pmid:11290830 |
| Collett ED et al. | n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11287318 |
| Ikeda I et al. | Reduced hepatic triglyceride secretion in rats fed docosahexaenoic acid-rich fish oil suppresses postprandial hypertriglyceridemia. | 2001 | J. Nutr. | pmid:11285319 |
| Arrington JL et al. | Docosahexaenoic acid suppresses function of the CD28 costimulatory membrane receptor in primary murine and Jurkat T cells. | 2001 | J. Nutr. | pmid:11285317 |
| Lee JY et al. | Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. | 2001 | J. Biol. Chem. | pmid:11278967 |
| Green P et al. | Ethyl docosahexaenoate-associated decrease in fetal brain lipid peroxide production is mediated by activation of prostanoid and nitric oxide pathways. | 2001 | Biochim. Biophys. Acta | pmid:11278180 |
| Donadio JV et al. | A randomized trial of high-dose compared with low-dose omega-3 fatty acids in severe IgA nephropathy. | 2001 | J. Am. Soc. Nephrol. | pmid:11274240 |
| Elias SL and Innis SM | Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length. | 2001 | Am. J. Clin. Nutr. | pmid:11273857 |
| Rump P et al. | Essential fatty acid composition of plasma phospholipids and birth weight: a study in term neonates. | 2001 | Am. J. Clin. Nutr. | pmid:11273856 |
| Hayashi M et al. | Uptake and accumulation of exogenous docosahexaenoic acid by Chlorella. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11272831 |
| Fujita S et al. | Docosahexaenoic acid improves long-term potentiation attenuated by phospholipase A(2) inhibitor in rat hippocampal slices. | 2001 | Br. J. Pharmacol. | pmid:11264234 |
| Assies J et al. | Significantly reduced docosahexaenoic and docosapentaenoic acid concentrations in erythrocyte membranes from schizophrenic patients compared with a carefully matched control group. | 2001 | Biol. Psychiatry | pmid:11257236 |
| Moriguchi T et al. | Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum. | 2001 | J. Lipid Res. | pmid:11254754 |
| Higdon JV et al. | Supplementation of postmenopausal women with fish oil does not increase overall oxidation of LDL ex vivo compared to dietary oils rich in oleate and linoleate. | 2001 | J. Lipid Res. | pmid:11254753 |
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| Gamoh S et al. | Chronic administration of docosahexaenoic acid improves the performance of radial arm maze task in aged rats. | 2001 | Clin. Exp. Pharmacol. Physiol. | pmid:11251638 |
| Al MD et al. | Relation between birth order and the maternal and neonatal docosahexaenoic acid status. | 1997 | Eur J Clin Nutr | pmid:11248881 |
| Xiao YF et al. | Single point mutations affect fatty acid block of human myocardial sodium channel alpha subunit Na+ channels. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11248125 |
| Infante JP and Huszagh VA | Impaired arachidonic (20:4n-6) and docosahexaenoic (22:6n-3) acid synthesis by phenylalanine metabolites as etiological factors in the neuropathology of phenylketonuria. | 2001 | Mol. Genet. Metab. | pmid:11243724 |
| van den Ham EC et al. | Evaluation of the relation between n-3 and n-6 fatty acid status and parity in nonpregnant women from the Netherlands. | 2001 | Am. J. Clin. Nutr. | pmid:11237941 |
| Thies F et al. | Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y. | 2001 | Am. J. Clin. Nutr. | pmid:11237929 |
| Agostoni C et al. | Biochemical effects of supplemented long-chain polyunsaturated fatty acids in hyperphenylalaninemia. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11237478 |
| Hamazaki T et al. | Anti-stress effects of DHA. | 2000 | Biofactors | pmid:11237197 |
| Saito M | Dietary docosahexaenoic acid does not promote tissue lipid peroxide formation to the extent expected from the peroxidizability index of the lipids. | 2000 | Biofactors | pmid:11237175 |
| Christophe A and Robberecht E | Directed modification instead of normalization of fatty acid patterns in cystic fibrosis: an emerging concept. | 2001 | Curr Opin Clin Nutr Metab Care | pmid:11224654 |
| Song JH and Miyazawa T | Enhanced level of n-3 fatty acid in membrane phospholipids induces lipid peroxidation in rats fed dietary docosahexaenoic acid oil. | 2001 | Atherosclerosis | pmid:11223421 |
| Hung P et al. | Dietary effects of eicosapentaenoic and docosahexaenoic acid esters on lipid metabolism and immune parameters in Sprague-Dawley rats. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11210121 |
| Frenoux JM et al. | A polyunsaturated fatty acid diet lowers blood pressure and improves antioxidant status in spontaneously hypertensive rats. | 2001 | J. Nutr. | pmid:11208936 |
| Lance VA et al. | Hyperlipidemia and reproductive failure in captive-reared alligators: vitamin E, vitamin A, plasma lipids, fatty acids, and steroid hormones. | 2001 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:11207442 |
| al-Awadhi AM and Dunn CD | Effects of fish-oil constituents and plasma lipids on fibrinolysis in vitro. | 2000 | Br. J. Biomed. Sci. | pmid:11204855 |
| Ashford A et al. | Electron microscopy may reveal structure of docosahexaenoic acid-rich oil within Schizochytrium sp. | 2000 | Lipids | pmid:11202000 |
| Conquer JA et al. | Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment. | 2000 | Lipids | pmid:11201991 |
| Du M et al. | Effects of dietary conjugated linoleic acid and linoleic:linolenic acid ratio on polyunsaturated fatty acid status in laying hens. | 2000 | Poult. Sci. | pmid:11194037 |
| Morita N et al. | Biosynthesis of fatty acids in the docosahexaenoic acid-producing bacterium Moritella marina strain MP-1. | 2000 | Biochem. Soc. Trans. | pmid:11171265 |
| Ito Y et al. | Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population. | 2001 | Cancer Lett. | pmid:11165751 |
| Wiesenfeld PW et al. | Effect of long-chain fatty acids in the culture medium on fatty acid composition of WEHI-3 and J774A.1 cells. | 2001 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:11163311 |
| Infante JP and Huszagh VA | Zellweger syndrome knockout mouse models challenge putative peroxisomal beta-oxidation involvement in docosahexaenoic acid (22:6n-3) biosynthesis. | 2001 | Mol. Genet. Metab. | pmid:11161822 |
| Chen ZY and Istfan NW | Docosahexaenoic acid, a major constituent of fish oil diets, prevents activation of cyclin-dependent kinases and S-phase entry by serum stimulation in HT-29 cells. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11161587 |
| Tocher DR and Dick JR | Effects of essential fatty acid deficiency and supplementation with docosahexaenoic acid (DHA; 22:6n-3) on cellular fatty acid compositions and fatty acyl desaturation in a cell culture model. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11161581 |
| Lim S and Suzuki H | Changes in maze behavior of mice occur after sufficient accumulation of docosahexaenoic acid in brain. | 2001 | J. Nutr. | pmid:11160553 |
| Helge JW et al. | Training affects muscle phospholipid fatty acid composition in humans. | 2001 | J. Appl. Physiol. | pmid:11160068 |
| Brand A et al. | Lipid constituents in oligodendroglial cells alter susceptibility to H2O2-induced apoptotic cell death via ERK activation. | 2001 | J. Neurochem. | pmid:11158263 |
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| Otto SJ et al. | Changes in the maternal essential fatty acid profile during early pregnancy and the relation of the profile to diet. | 2001 | Am. J. Clin. Nutr. | pmid:11157328 |
| Cho E et al. | Prospective study of dietary fat and the risk of age-related macular degeneration. | 2001 | Am. J. Clin. Nutr. | pmid:11157315 |
| Nagakura T et al. | Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma. | 2000 | Eur. Respir. J. | pmid:11153584 |
| Yokoyama A et al. | Effect of aerosolized docosahexaenoic acid in a mouse model of atopic asthma. | 2000 | Int. Arch. Allergy Immunol. | pmid:11146390 |
| Hoffman DR et al. | Impact of early dietary intake and blood lipid composition of long-chain polyunsaturated fatty acids on later visual development. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:11144440 |
| Reich EE et al. | Brain regional quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease. | 2001 | Am. J. Pathol. | pmid:11141503 |
| Lauritzen L et al. | The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. | 2001 Jan-Mar | Prog. Lipid Res. | pmid:11137568 |
| Mizota A et al. | Protective effects of dietary docosahexaenoic acid against kainate-induced retinal degeneration in rats. | 2001 | Invest. Ophthalmol. Vis. Sci. | pmid:11133871 |
| Sorbera LA et al. | Effects of polyunsaturated fatty acids and prostaglandins on oocyte maturation in a marine teleost, the European sea bass (Dicentrarchus labrax). | 2001 | Biol. Reprod. | pmid:11133697 |
| MarÃn MC et al. | Dietary long-chain fatty acids and visual response in malnourished nursing infants. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11133176 |
| Harel M et al. | Modulation of arachidonate and docosahexaenoate in Morone chrysops larval tissues and the effect on growth and survival. | 2000 | Lipids | pmid:11132186 |
| Haban P et al. | Supplementation with long-chain n-3 fatty acids in non-insulin-dependent diabetes mellitus (NIDDM) patients leads to the lowering of oleic acid content in serum phospholipids. | 2000 | Eur J Nutr | pmid:11131366 |