DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Abortion, Habitual D000026 5 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Adenocarcinoma D000230 166 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Albinism D000417 3 associated lipids
Alzheimer Disease D000544 76 associated lipids
Anaphylaxis D000707 35 associated lipids
Anemia D000740 21 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Angina Pectoris D000787 27 associated lipids
Angina, Unstable D000789 14 associated lipids
Hypoxia D000860 23 associated lipids
Aortic Diseases D001018 11 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arthus Reaction D001183 8 associated lipids
Asthma D001249 52 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Atrial Fibrillation D001281 16 associated lipids
Autoimmune Diseases D001327 27 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Kawabata T et al. Age-related changes of dietary intake and blood eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid levels in Japanese men and women. 2011 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:21420843
Kilari A et al. Associations of long-chain polyunsaturated fatty acid concentrations with birth outcome in term Indian mothers and their neonates. 2011 May-Jun Am. J. Hum. Biol. pmid:21484911
Jones JL et al. A Mediterranean-style low-glycemic-load diet improves variables of metabolic syndrome in women, and addition of a phytochemical-rich medical food enhances benefits on lipoprotein metabolism. 2011 May-Jun J Clin Lipidol pmid:21600524
Gladyshev MI et al. Effect of water temperature on the content of essential polyunsaturated fatty acids in freshwater zooplankton. 2011 Mar-Apr Dokl. Biochem. Biophys. pmid:21590375
Larson MK et al. Omega-3 fatty acids modulate collagen signaling in human platelets. 2011 Mar-Apr Prostaglandins Leukot. Essent. Fatty Acids pmid:21177087
McDaniel JC et al. Fish oil supplementation alters levels of lipid mediators of inflammation in microenvironment of acute human wounds. 2011 Mar-Apr Wound Repair Regen pmid:21362086
Lam YY et al. Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: the effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids. 2011 Jul-Aug Biochim. Biophys. Acta pmid:21570480
Mason CM et al. Prescription omega-3s: an overview for nurse practitioners. 2011 Jul-Aug J Cardiovasc Nurs pmid:21666421
Gao F et al. Liver conversion of docosahexaenoic and arachidonic acids from their 18-carbon precursors in rats on a DHA-free but α-LNA-containing n-3 PUFA adequate diet. 2011 Jul-Aug Biochim. Biophys. Acta pmid:21651989
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Lamaziere A et al. Differential distribution of DHA-phospholipids in rat brain after feeding: A lipidomic approach. 2011 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:21109411
Vilaseca MA et al. Long-chain polyunsaturated fatty acid concentration in patients with inborn errors of metabolism. 2011 Jan-Feb Nutr Hosp pmid:21519739
Sato SB et al. Differential roles of internal and terminal double bonds in docosahexaenoic acid: Comparative study of cytotoxicity of polyunsaturated fatty acids to HT-29 human colorectal tumor cell line. 2011 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:20952172
Kulkarni AV et al. Reduced placental docosahexaenoic acid levels associated with increased levels of sFlt-1 in preeclampsia. 2011 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:20956072
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Yang R et al. Metabolomics-lipidomics of eicosanoids and docosanoids generated by phagocytes. 2011 Curr Protoc Immunol pmid:22048801
Corsetto PA et al. Effects of n-3 PUFAs on breast cancer cells through their incorporation in plasma membrane. 2011 Lipids Health Dis pmid:21569413
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Bonnet N and Ferrari SL Effects of long-term supplementation with omega-3 fatty acids on longitudinal changes in bone mass and microstructure in mice. 2011 J. Nutr. Biochem. pmid:21036590
Yates CM et al. Docosahexaenoic acid inhibits the adhesion of flowing neutrophils to cytokine stimulated human umbilical vein endothelial cells. 2011 J. Nutr. pmid:21613456
Freeman MP et al. Omega-3 fatty acids for major depressive disorder associated with the menopausal transition: a preliminary open trial. 2011 Menopause pmid:21037490
Mills JD et al. Dietary supplementation with the omega-3 fatty acid docosahexaenoic acid in traumatic brain injury. 2011 Neurosurgery pmid:21135750
Bilal S et al. Fat-1 transgenic mice with elevated omega-3 fatty acids are protected from allergic airway responses. 2011 Biochim. Biophys. Acta pmid:21616147
Hamazaki-Fujita N et al. Polyunsaturated fatty acids and blood circulation in the forebrain during a mental arithmetic task. 2011 Brain Res. pmid:21616479
Uddin MS et al. Isolation and characterization of lecithin from squid (Todarodes pacificus) viscera deoiled by supercritical carbon dioxide extraction. 2011 J. Food Sci. pmid:21535756
Ajami M et al. Expression of Bcl-2 and Bax after hippocampal ischemia in DHA + EPA treated rats. 2011 Neurol. Sci. pmid:21617951
Yepuri G et al. Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA. 2011 Br. J. Nutr. pmid:21281526
Wei MY and Jacobson TA Effects of eicosapentaenoic acid versus docosahexaenoic acid on serum lipids: a systematic review and meta-analysis. 2011 Curr Atheroscler Rep pmid:21975919
Golub N et al. Greasing the wheels of managing overweight and obesity with omega-3 fatty acids. 2011 Med. Hypotheses pmid:21981905
Sanden M et al. Atlantic salmon (Salmo salar L.) as a net producer of long-chain marine ω-3 fatty acids. 2011 J. Agric. Food Chem. pmid:22017199
Ruusunen A et al. Serum polyunsaturated fatty acids are not associated with the risk of severe depression in middle-aged Finnish men: Kuopio Ischaemic Heart Disease Risk Factor (KIHD) study. 2011 Eur J Nutr pmid:20574779
Yui K et al. [Therapeutic effects of larger doses of arachidonic acid added to DHA on social impairment and its relation to alterations of polyunsaturated fatty acids in individuals with autism spectrum disorders]. 2011 Nihon Shinkei Seishin Yakurigaku Zasshi pmid:21800702
Curatolo N et al. Oral administration of docosahexaenoic acid/eicosapentaeinoic acids is not anticonvulsant in rats: implications for translational research. 2011 Pediatr. Res. pmid:21857379
Lu FS et al. Oxidative stability of marine phospholipids in the liposomal form and their applications. 2011 Lipids pmid:21088919
Mozaffarian D et al. Circulating long-chain ω-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study. 2011 Ann. Intern. Med. pmid:21810709
Rioux FM et al. Relationship between maternal DHA and iron status and infants' cognitive performance. 2011 Can J Diet Pract Res pmid:21645426
Torshin IIu et al. [Systematic analysis of molecular mechanisms of action of omega-3 polyunsaturated fatty acids on arrhythmia]. 2011 Kardiologiia pmid:21649594
Palmer CD et al. 17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli. 2011 J. Leukoc. Biol. pmid:21653234
Jiang T et al. Omega-3 fatty acids affected human perception of ground beef negatively. 2011 Meat Sci. pmid:21621335
Lai LH et al. [Effects of docosahexaenoic acid on sodium channel current and transient outward potassium channel current in rat ventricular myocytes]. 2011 Zhonghua Xin Xue Guan Bing Za Zhi pmid:21781602
Brignardello J et al. Increase of plasma fatty acids without changes in n-6/n-3-PUFA ratio in asymptomatic obese subjects. 2011 Arch Latinoam Nutr pmid:22308941
Serhan CN and Petasis NA Resolvins and protectins in inflammation resolution. 2011 Chem. Rev. pmid:21766791
Pan JP et al. Some subtypes of endocannabinoid/endovanilloid receptors mediate docosahexaenoic acid-induced enhanced spatial memory in rats. 2011 Brain Res. pmid:21803345
Imhoff-Kunsch B et al. Prenatal docosahexaenoic acid supplementation and infant morbidity: randomized controlled trial. 2011 Pediatrics pmid:21807696
Kim HY et al. A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development. 2011 Prostaglandins Other Lipid Mediat. pmid:21810478
Jing K et al. Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53. 2011 Autophagy pmid:21811093
Zargar A and Ito MK Long chain omega-3 dietary supplements: a review of the National Library of Medicine Herbal Supplement Database. 2011 Metab Syndr Relat Disord pmid:21787228
Martin CR et al. Decreased postnatal docosahexaenoic and arachidonic acid blood levels in premature infants are associated with neonatal morbidities. 2011 J. Pediatr. pmid:21658712
Vargas ML et al. Metabolic and endocrine effects of long-chain versus essential omega-3 polyunsaturated fatty acids in polycystic ovary syndrome. 2011 Metab. Clin. Exp. pmid:21640360
German JB Dietary lipids from an evolutionary perspective: sources, structures and functions. 2011 Matern Child Nutr pmid:21366863
Glaser C et al. Genetic variation in polyunsaturated fatty acid metabolism and its potential relevance for human development and health. 2011 Matern Child Nutr pmid:21366865
Maqbool A et al. The skinny on tuna fat: health implications. 2011 Public Health Nutr pmid:21324226
Ramakrishnan U Fatty acid status and maternal mental health. 2011 Matern Child Nutr pmid:21366870
Mayurasakorn K et al. Docosahexaenoic acid: brain accretion and roles in neuroprotection after brain hypoxia and ischemia. 2011 Curr Opin Clin Nutr Metab Care pmid:21178607
Tyburczy C et al. Heart arachidonic acid is uniquely sensitive to dietary arachidonic acid and docosahexaenoic acid content in domestic piglets. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21885269
Fedorova-Dahms I et al. Safety evaluation of DHA-rich Algal Oil from Schizochytrium sp. 2011 Food Chem. Toxicol. pmid:21914458
Lebbadi M et al. Endogenous conversion of omega-6 into omega-3 fatty acids improves neuropathology in an animal model of Alzheimer's disease. 2011 J. Alzheimers Dis. pmid:21914946
Kuan CY et al. Long-chain polyunsaturated fatty acids promote paclitaxel cytotoxicity via inhibition of the MDR1 gene in the human colon cancer Caco-2 cell line. 2011 J Am Coll Nutr pmid:21917707
Makhoul Z et al. Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. 2011 Eur J Clin Nutr pmid:21427737
Abelsohn A et al. Healthy fish consumption and reduced mercury exposure: counseling women in their reproductive years. 2011 Can Fam Physician pmid:21322285
da Costa KA et al. Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine N-methyltransferase activity in humans. 2011 Am. J. Clin. Nutr. pmid:21411618
Freeman MP and Rapaport MH Omega-3 fatty acids and depression: from cellular mechanisms to clinical care. 2011 J Clin Psychiatry pmid:21382308
Wagner K et al. Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception. 2011 Prostaglandins Other Lipid Mediat. pmid:21854866
Arsenault D et al. DHA improves cognition and prevents dysfunction of entorhinal cortex neurons in 3xTg-AD mice. 2011 PLoS ONE pmid:21383850
Song KS et al. Omega-3-polyunsaturated fatty acids suppress pancreatic cancer cell growth in vitro and in vivo via downregulation of Wnt/Beta-catenin signaling. 2011 Pancreatology pmid:22213040
Nochera CL et al. Consumption of DHA + EPA by low-income women during pregnancy and lactation. 2011 Nutr Clin Pract pmid:21724916
Bento AF et al. Omega-3 fatty acid-derived mediators 17(R)-hydroxy docosahexaenoic acid, aspirin-triggered resolvin D1 and resolvin D2 prevent experimental colitis in mice. 2011 J. Immunol. pmid:21724996
D'Alessandro A et al. Docosohaexanoic acid-supplemented PACA44 cell lines and over-activation of Krebs cycle: an integrated proteomic, metabolomic and interactomic overview. 2011 J Proteomics pmid:21723426
Maki KC et al. Effects of prescription omega-3-acid ethyl esters on fasting lipid profile in subjects with primary hypercholesterolemia. 2011 J. Cardiovasc. Pharmacol. pmid:21297494
Bradbury J Docosahexaenoic acid (DHA): an ancient nutrient for the modern human brain. 2011 Nutrients pmid:22254110
Ferreira M et al. Effect of the nutritional status of semi-continuous microalgal cultures on the productivity and biochemical composition of Brachionus plicatilis. 2011 Mar. Biotechnol. pmid:21487686
Smithers LG et al. Maternal supplementation with docosahexaenoic acid during pregnancy does not affect early visual development in the infant: a randomized controlled trial. 2011 Am. J. Clin. Nutr. pmid:21490140
Yalçın S et al. Effect of maternal corticosterone on utilisation of residual yolk sac fatty acids by developing broiler embryo. 2011 Br. Poult. Sci. pmid:21491250
Morris MC and Tangney CC A potential design flaw of randomized trials of vitamin supplements. 2011 JAMA pmid:21467288
Shoji H et al. Effects of parenteral soybean oil lipid emulsion on the long-chain polyunsaturated fatty acid profile in very-low-birth-weight infants. 2011 Acta Paediatr. pmid:21366690
Madsen T et al. Marine n-3 polyunsaturated fatty acids in patients with end-stage renal failure and in subjects without kidney disease: a comparative study. 2011 J Ren Nutr pmid:20833075
Chen P et al. Poxytrins, a class of oxygenated products from polyunsaturated fatty acids, potently inhibit blood platelet aggregation. 2011 FASEB J. pmid:20833872
Egert S and Stehle P Impact of n-3 fatty acids on endothelial function: results from human interventions studies. 2011 Curr Opin Clin Nutr Metab Care pmid:21252652
Arshad A et al. Potential applications of fish oils rich in n-3 fatty acids in the palliative treatment of advanced pancreatic cancer. 2011 Br. J. Nutr. pmid:21745426
Recchiuti A et al. MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits. 2011 FASEB J. pmid:20956612
Basselin M et al. Imaging upregulated brain arachidonic acid metabolism in HIV-1 transgenic rats. 2011 J. Cereb. Blood Flow Metab. pmid:20664612
Poudyal H et al. Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action. 2011 Prog. Lipid Res. pmid:21762726
Weise C et al. Dietary docosahexaenoic acid in combination with arachidonic acid ameliorates allergen-induced dermatitis in mice. 2011 Pediatr Allergy Immunol pmid:21294775
Meijerink J et al. The ethanolamide metabolite of DHA, docosahexaenoylethanolamine, shows immunomodulating effects in mouse peritoneal and RAW264.7 macrophages: evidence for a new link between fish oil and inflammation. 2011 Br. J. Nutr. pmid:21294934
Drover JR et al. Cognitive function in 18-month-old term infants of the DIAMOND study: a randomized, controlled clinical trial with multiple dietary levels of docosahexaenoic acid. 2011 Early Hum. Dev. pmid:21295417
Gibson RA et al. Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life. 2011 Matern Child Nutr pmid:21366864
Barden A et al. The effects of oxidation products of arachidonic acid and n3 fatty acids on vascular and platelet function. 2011 Free Radic. Res. pmid:21235285
Stephensen CB et al. ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation. 2011 J. Lipid Res. pmid:21296957
Kitayama A et al. Correlations of fish intake and plasma docosahexaenoic acid levels with each congener of PCDDs/PCDFs/dioxin-like PCBs in blood from the Japanese population. 2011 Int Arch Occup Environ Health pmid:21298441
Blasbalg TL et al. Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. 2011 Am. J. Clin. Nutr. pmid:21367944
Wang F et al. Docosahexaenoic acid (DHA) sensitizes brain tumor cells to etoposide-induced apoptosis. 2011 Curr. Mol. Med. pmid:21663587
Lima-Garcia JF et al. The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats. 2011 Br. J. Pharmacol. pmid:21418187
Xu ZZ and Ji RR Resolvins are potent analgesics for arthritic pain. 2011 Br. J. Pharmacol. pmid:21418190
McNamara RK Omega-3 fatty acid deficiency: a preventable risk factor for schizophrenia? 2011 Schizophr. Res. pmid:21276713
Taoka Y et al. Effect of Tween 80 on the growth, lipid accumulation and fatty acid composition of Thraustochytrium aureum ATCC 34304. 2011 J. Biosci. Bioeng. pmid:21216665
Majkova Z et al. Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls. 2011 Toxicol. Appl. Pharmacol. pmid:21130106
Patterson RE et al. Marine fatty acid intake is associated with breast cancer prognosis. 2011 J. Nutr. pmid:21178081
Stein AD et al. Growth to age 18 months following prenatal supplementation with docosahexaenoic acid differs by maternal gravidity in Mexico. 2011 J. Nutr. pmid:21178082
Rogers LK et al. Maternal docosahexaenoic acid supplementation decreases lung inflammation in hyperoxia-exposed newborn mice. 2011 J. Nutr. pmid:21178083
Scott SD et al. Use of raw glycerol to produce oil rich in polyunsaturated fatty acids by a thraustochytrid. 2011 Enzyme Microb. Technol. pmid:22112910