Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Polette A et al. | N-3 fatty acid-induced lipid peroxidation in human platelets is prevented by catechins. | 1996 | Thromb. Haemost. | pmid:8822591 |
Arm JP et al. | Effect of dietary supplementation with fish oil lipids on mild asthma. | 1988 | Thorax | pmid:3353893 |
Picado C et al. | Effects of a fish oil enriched diet on aspirin intolerant asthmatic patients: a pilot study. | 1988 | Thorax | pmid:3353894 |
Maldjian A et al. | Changes in sperm quality and lipid composition during cryopreservation of boar semen. | 2005 | Theriogenology | pmid:15626408 |
Mitre R et al. | Oral intake of shark liver oil modifies lipid composition and improves motility and velocity of boar sperm. | 2004 | Theriogenology | pmid:15451263 |
Cerolini S et al. | Effect of docosahexaenoic acid and alpha-tocopherol enrichment in chicken sperm on semen quality, sperm lipid composition and susceptibility to peroxidation. | 2006 | Theriogenology | pmid:16530814 |
Brinsko SP et al. | Effect of feeding a DHA-enriched nutriceutical on the quality of fresh, cooled and frozen stallion semen. | 2005 | Theriogenology | pmid:15725455 |
Gholami H et al. | Effect of feeding a docosahexaenoic acid-enriched nutriceutical on the quality of fresh and frozen-thawed semen in Holstein bulls. | 2010 | Theriogenology | pmid:20708237 |
Gliozzi TM et al. | Quality and lipid composition of spermatozoa in rabbits fed DHA and vitamin E rich diets. | 2009 | Theriogenology | pmid:19121864 |
Am-in N et al. | Lipid profiles of sperm and seminal plasma from boars having normal or low sperm motility. | 2011 | Theriogenology | pmid:21167582 |
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Hsu K | Long-chain polyunsaturated fatty acids as anti-HIV supplementation during breastfeeding. | 2009 | Taiwan J Obstet Gynecol | pmid:19346195 |
Young C et al. | Docosahexaenoic acid inhibits synaptic transmission and epileptiform activity in the rat hippocampus. | 2000 | Synapse | pmid:10881029 |
Nakamura M et al. | Optimal dose of preoperative enteral immunonutrition for patients with esophageal cancer. | 2009 | Surg. Today | pmid:19784723 |
Liu X et al. | Amide-type adduct of dopamine - plausible cause of Parkinson diseases. | 2014 | Subcell. Biochem. | pmid:24374917 |
Green D et al. | A double-blind, placebo-controlled trial of fish oil concentrate (MaxEpa) in stroke patients. | 1985 Jul-Aug | Stroke | pmid:3895595 |
Sekikawa A et al. | Differential association of docosahexaenoic and eicosapentaenoic acids with carotid intima-media thickness. | 2011 | Stroke | pmid:21757663 |
Belayev L et al. | Docosahexaenoic acid complexed to albumin elicits high-grade ischemic neuroprotection. | 2005 | Stroke | pmid:15569878 |
Belayev L et al. | Robust docosahexaenoic acid-mediated neuroprotection in a rat model of transient, focal cerebral ischemia. | 2009 | Stroke | pmid:19542051 |
Lalancette-Hébert M et al. | Accumulation of dietary docosahexaenoic acid in the brain attenuates acute immune response and development of postischemic neuronal damage. | 2011 | Stroke | pmid:21852616 |
Imre SG et al. | Increased proportion of docosahexanoic acid and high lipid peroxidation capacity in erythrocytes of stroke patients. | 1994 | Stroke | pmid:7974583 |
Nury T et al. | Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). | 2015 | Steroids | pmid:25683890 |
Ramaprasad TR et al. | Spray-dried milk supplemented with alpha-linolenic acid or eicosapentaenoic acid and docosahexaenoic acid decreases HMG Co A reductase activity and increases biliary secretion of lipids in rats. | 2006 | Steroids | pmid:16499938 |
Tian H et al. | 14S,21R-dihydroxy-docosahexaenoic acid treatment enhances mesenchymal stem cell amelioration of renal ischemia/reperfusion injury. | 2012 | Stem Cells Dev. | pmid:21846180 |
Gajewski BJ et al. | Predicting accrual in clinical trials with Bayesian posterior predictive distributions. | 2008 | Stat Med | pmid:17979152 |
Mohajeri S and Newman SA | Review of evidence for dietary influences on atopic dermatitis. | 2014 Jul-Aug | Skin Therapy Lett. | pmid:25188523 |
Wang Y et al. | Maresin 1 Inhibits Epithelial-to-Mesenchymal Transition in Vitro and Attenuates Bleomycin Induced Lung Fibrosis in Vivo. | 2015 | Shock | pmid:26196843 |
Feng Y et al. | [Progress in metabolic mechanism of docosahexenoic acid production by fermentation]. | 2010 | Sheng Wu Gong Cheng Xue Bao | pmid:21141112 |
Qian J et al. | [Technology investigation of extracting fish oil by enzymolysising ocean wild fish]. | 2008 | Sheng Wu Gong Cheng Xue Bao | pmid:18807986 |
Li HX and Yang GS | [Effects of docosahexaenoic acid on rat adipocytes proliferation and differentiation]. | 2005 | Sheng Wu Gong Cheng Xue Bao | pmid:16285532 |
Liu YJ | [Biological activity and mechanism of action of eicosapentaenic acid and docosahexaenoic acid from fish oil]. | 1987 | Sheng Li Ke Xue Jin Zhan | pmid:2823380 |
Goodnight SH | Effects of dietary fish oil and omega-3 fatty acids on platelets and blood vessels. | 1988 | Semin. Thromb. Hemost. | pmid:2845585 |
McEwen BJ et al. | Effects of omega-3 polyunsaturated fatty acids on platelet function in healthy subjects and subjects with cardiovascular disease. | 2013 | Semin. Thromb. Hemost. | pmid:23329646 |
Tam VC | Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections. | 2013 | Semin. Immunol. | pmid:24084369 |
Carlson SE | Docosahexaenoic acid and arachidonic acid in infant development. | 2001 | Semin Neonatol | pmid:11988033 |
Lee HN et al. | Resolution of inflammation as a novel chemopreventive strategy. | 2013 | Semin Immunopathol | pmid:23370700 |
Ozawa H | [Omega-3 polyunsaturated fatty acids and mental disorders]. | 2009 | Seishin Shinkeigaku Zasshi | pmid:20344875 |
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Nakagome K et al. | [Clinical application of omega 3 polyunsaturated fatty acids in psychiatry]. | 2009 | Seishin Shinkeigaku Zasshi | pmid:20344878 |
Hamazaki T et al. | [Emotion and omega 3 polyunsaturated fatty acids]. | 2009 | Seishin Shinkeigaku Zasshi | pmid:20344879 |
Matsuoka Y and Nishi D | [Possible use of omega 3 polyunsaturated fatty acids for prevention of PTSD]. | 2009 | Seishin Shinkeigaku Zasshi | pmid:20344880 |
Yoshikawa T | [Schizophrenia and omega 3 polyunsaturated fatty acids]. | 2009 | Seishin Shinkeigaku Zasshi | pmid:20344881 |
Yui K et al. | [Effects of arachidonic acids on social behavior in patients with autism spectrum disorders]. | 2009 | Seishin Shinkeigaku Zasshi | pmid:20217968 |
Arita M and Isobe Y | [Structure and function of anti-inflammatory lipid mediators derived from omega-3 polyunsaturated fatty acids]. | 2008 | Seikagaku | pmid:19086412 |
Masuzawa Y | [The mysteries of docosahexaenoic acid--possible functions of C22 polyenoic fatty acids]. | 1988 | Seikagaku | pmid:2976795 |
Zhang Q and Ma Y | [Determination of EPA and DHA in marine microalgaes by GC]. | 2004 | Se Pu | pmid:15807130 |
Lu J et al. | [Analysis of fatty acids in tissues of Penaeus vannamei cultured in sea- and fresh-waters by ultrasonic extraction-capillary gas chromatography]. | 2005 | Se Pu | pmid:16013568 |
Seki H et al. | Resolvins as regulators of the immune system. | 2010 | ScientificWorldJournal | pmid:20454764 |
Börgeson E and Godson C | Molecular circuits of resolution in renal disease. | 2010 | ScientificWorldJournal | pmid:20623097 |
Carlo T and Levy BD | Molecular circuits of resolution in airway inflammation. | 2010 | ScientificWorldJournal | pmid:20623098 |