Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Xiong A et al. | Distinct roles of different forms of vitamin E in DHA-induced apoptosis in triple-negative breast cancer cells. | 2012 | Mol Nutr Food Res | pmid:22707267 |
Barbadoro P et al. | Fish oil supplementation reduces cortisol basal levels and perceived stress: a randomized, placebo-controlled trial in abstinent alcoholics. | 2013 | Mol Nutr Food Res | pmid:23390041 |
Cho JY et al. | Oral administration of docosahexaenoic acid attenuates colitis induced by dextran sulfate sodium in mice. | 2011 | Mol Nutr Food Res | pmid:20824662 |
Wielinga PY et al. | Arachidonic acid/docosahexaenoic acid-supplemented diet in early life reduces body weight gain, plasma lipids, and adiposity in later life in ApoE*3Leiden mice. | 2012 | Mol Nutr Food Res | pmid:22611002 |
Huang CB and Ebersole JL | A novel bioactivity of omega-3 polyunsaturated fatty acids and their ester derivatives. | 2010 | Mol Oral Microbiol | pmid:20331795 |
Sun C et al. | DHA regulates lipogenesis and lipolysis genes in mice adipose and liver. | 2011 | Mol. Biol. Rep. | pmid:20383747 |
Gelsomino G et al. | Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition. | 2013 | Mol. Cancer | pmid:24225025 |
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Swamy MV et al. | Modulation of cyclooxygenase-2 activities by the combined action of celecoxib and decosahexaenoic acid: novel strategies for colon cancer prevention and treatment. | 2004 | Mol. Cancer Ther. | pmid:14985462 |
Ding WQ and Lind SE | Phospholipid hydroperoxide glutathione peroxidase plays a role in protecting cancer cells from docosahexaenoic acid-induced cytotoxicity. | 2007 | Mol. Cancer Ther. | pmid:17431126 |
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Lengqvist J et al. | Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain. | 2004 | Mol. Cell Proteomics | pmid:15073272 |
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Wang TM et al. | Docosahexaenoic acid and eicosapentaenoic acid reduce C-reactive protein expression and STAT3 activation in IL-6-treated HepG2 cells. | 2013 | Mol. Cell. Biochem. | pmid:23361365 |
Crabtree JT et al. | Differential distribution and metabolism of arachidonic acid and docosahexaenoic acid by human placental choriocarcinoma (BeWo) cells. | 1998 | Mol. Cell. Biochem. | pmid:9746226 |
Rousseau D et al. | Dietary n-3 polyunsaturated fatty acids affect the development of renovascular hypertension in rats. | 2001 | Mol. Cell. Biochem. | pmid:11716352 |
Hashimoto M et al. | Docosahexaenoic acid but not eicosapentaenoic acid withstands dietary cholesterol-induced decreases in platelet membrane fluidity. | 2006 | Mol. Cell. Biochem. | pmid:16933035 |
Grynberg A et al. | Eicosapentaenoic and docosahexaenoic acids in cultured rat ventricular myocytes and hypoxia-induced alterations of phospholipase-A activity. | 1992 | Mol. Cell. Biochem. | pmid:1480156 |
Ishigamori H et al. | Docosahexaenoic acid-containing phosphatidylethanolamine enhances HL-60 cell differentiation by regulation of c-jun and c-myc expression. | 2005 | Mol. Cell. Biochem. | pmid:16335792 |
Palacios A et al. | Antioxidant effect of conjugated linoleic acid and vitamin A during non enzymatic lipid peroxidation of rat liver microsomes and mitochondria. | 2003 | Mol. Cell. Biochem. | pmid:12962148 |
Hossain Z et al. | Docosahexaenoic acid and eicosapentaenoic acid-enriched phosphatidylcholine liposomes enhance the permeability, transportation and uptake of phospholipids in Caco-2 cells. | 2006 | Mol. Cell. Biochem. | pmid:16477371 |
Zand H et al. | Docosahexaenoic acid sensitizes Ramos cells to Gamma-irradiation-induced apoptosis through involvement of PPAR-gamma activation and NF-kappaB suppression. | 2008 | Mol. Cell. Biochem. | pmid:18566752 |
Sugasini D and Lokesh BR | Enhanced incorporation of docosahexaenoic acid in serum, heart, and brain of rats given microemulsions of fish oil. | 2013 | Mol. Cell. Biochem. | pmid:23812902 |
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Infante JP | Docosahexaenoate-containing phospholipids in sarcoplasmic reticulum and retinal photoreceptors. A proposal for a role in Ca2+-ATPase calcium transport. | 1987 | Mol. Cell. Biochem. | pmid:2955214 |
Murphy MG et al. | Diets enriched in menhaden fish oil, seal oil, or shark liver oil have distinct effects on the lipid and fatty-acid composition of guinea pig heart. | 1997 | Mol. Cell. Biochem. | pmid:9450671 |
Jahangiri A et al. | Termination of asynchronous contractile activity in rat atrial myocytes by n-3 polyunsaturated fatty acids. | 2000 | Mol. Cell. Biochem. | pmid:10839192 |
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Denys A et al. | Eicosapentaenoic acid and docosahexaenoic acid modulate MAP kinase enzyme activity in human T-cells. | 2002 | Mol. Cell. Biochem. | pmid:12030372 |
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Infante JP and Huszagh VA | Zellweger syndrome knockout mouse models challenge putative peroxisomal beta-oxidation involvement in docosahexaenoic acid (22:6n-3) biosynthesis. | 2001 | Mol. Genet. Metab. | pmid:11161822 |
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Lukiw WJ and Bazan NG | Inflammatory, apoptotic, and survival gene signaling in Alzheimer's disease. A review on the bioactivity of neuroprotectin D1 and apoptosis. | 2010 | Mol. Neurobiol. | pmid:20414817 |
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Bazan NG et al. | Endogenous signaling by omega-3 docosahexaenoic acid-derived mediators sustains homeostatic synaptic and circuitry integrity. | 2011 | Mol. Neurobiol. | pmid:21918832 |
Stark DT and Bazan NG | Neuroprotectin D1 induces neuronal survival and downregulation of amyloidogenic processing in Alzheimer's disease cellular models. | 2011 | Mol. Neurobiol. | pmid:21431475 |
Bazan NG | Neuroinflammation and proteostasis are modulated by endogenously biosynthesized neuroprotectin D1. | 2012 | Mol. Neurobiol. | pmid:22956271 |
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Rao JS et al. | Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex. | 2007 | Mol. Psychiatry | pmid:16983392 |
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Anderson RE et al. | Low docosahexaenoic acid levels in rod outer segments of rats with P23H and S334ter rhodopsin mutations. | 2002 | Mol. Vis. | pmid:12355064 |
Li F et al. | DHA does not protect ELOVL4 transgenic mice from retinal degeneration. | 2009 | Mol. Vis. | pmid:19536303 |
Gross EA et al. | G239T mutation in Repeat 1 of human IRBP: possible implications for more than one binding site in a single repeat. | 2000 | Mol. Vis. | pmid:10756181 |
Sheets KG et al. | Microglial ramification and redistribution concomitant with the attenuation of choroidal neovascularization by neuroprotectin D1. | 2013 | Mol. Vis. | pmid:23922492 |
Sheets KG et al. | Neuroprotectin D1 attenuates laser-induced choroidal neovascularization in mouse. | 2010 | Mol. Vis. | pmid:20216940 |
Li F et al. | High levels of retinal docosahexaenoic acid do not protect photoreceptor degeneration in VPP transgenic mice. | 2010 | Mol. Vis. | pmid:20806040 |
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Lau BY et al. | Investigating the role of polyunsaturated fatty acids in bone development using animal models. | 2013 | Molecules | pmid:24248147 |
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Abdulnour RE et al. | Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation. | 2016 | Mucosal Immunol | pmid:26647716 |
Arnardottir H et al. | Human milk proresolving mediators stimulate resolution of acute inflammation. | 2016 | Mucosal Immunol | pmid:26462421 |
Eickmeier O et al. | Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury. | 2013 | Mucosal Immunol | pmid:22785226 |
Li D et al. | Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion. | 2013 | Mucosal Immunol | pmid:23462912 |