DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with DHA

Download all related citations
Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Alexander JW Influence of EPA and DHA intravenous fat emulsions on nitrogen retention and protein kinetics in burned rats. 1999 Nutrition pmid:9990585
Sasaki T et al. Effects of dietary docosahexaenoic acid on surface molecules involved in T cell proliferation. 1999 Biochim. Biophys. Acta pmid:9989281
Krugman S and Law P Breastfeeding and IQ. 1999 Pediatrics pmid:9988628
Matorras R et al. Biochemical markers of n-3 long chain polyunsaturated fatty acid intake during pregnancy. 1998 Clin Exp Obstet Gynecol pmid:9987571
Cellini M et al. Fatty acid use in glaucomatous optic neuropathy treatment. 1998 Acta Ophthalmol Scand Suppl pmid:9972342
Azavache V et al. [The liver as a source of essential long chain polyunsaturated fatty acids for postnatal brain development in the rat]. 1998 Arch Latinoam Nutr pmid:9951533
Araya Araya J et al. [Differences in percent composition of long chain polyunsaturated fatty acids in maternal-fetal erythrocytes in term and preterm infants]. 1998 Arch Latinoam Nutr pmid:9951532
Weisinger HS et al. Effects of dietary n-3 fatty acid deficiency and repletion in the guinea pig retina. 1999 Invest. Ophthalmol. Vis. Sci. pmid:9950590
Nourooz-Zadeh J et al. F4-isoprostanes as specific marker of docosahexaenoic acid peroxidation in Alzheimer's disease. 1999 J. Neurochem. pmid:9930747
Hirafuji M et al. Effect of docosahexaenoic acid on intracellular calcium dynamics in vascular smooth muscle cells from normotensive and genetically hypertensive rats. 1998 Res. Commun. Mol. Pathol. Pharmacol. pmid:9920344
Terano T et al. Eicosapentaenoic acid and docosahexaenoic acid inhibit vascular smooth muscle cell proliferation by inhibiting phosphorylation of Cdk2-cyclinE complex. 1999 Biochem. Biophys. Res. Commun. pmid:9918868
Hashimoto M et al. The hypotensive effect of docosahexaenoic acid is associated with the enhanced release of ATP from the caudal artery of aged rats. 1999 J. Nutr. pmid:9915878
Baur LA et al. Relationships between maternal risk of insulin resistance and the child's muscle membrane fatty acid composition. 1999 Diabetes pmid:9892230
Lin Q et al. Ligand selectivity of the peroxisome proliferator-activated receptor alpha. 1999 Biochemistry pmid:9890897
Su HM et al. Bioequivalence of dietary alpha-linolenic and docosahexaenoic acids as sources of docosahexaenoate accretion in brain and associated organs of neonatal baboons. 1999 Pediatr. Res. pmid:9890614
Perin N et al. Dietary lipid composition modifies intestinal morphology and nutrient transport in young rats. 1999 J. Pediatr. Gastroenterol. Nutr. pmid:9890468
Kollman KA et al. Dietary lipids influence intestinal adaptation after massive bowel resection. 1999 J. Pediatr. Gastroenterol. Nutr. pmid:9890467
Marzo I et al. Loss of delta6-desaturase activity leads to impaired docosahexaenoic acid synthesis in Y-79 retinoblastoma cells. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9888202
Mani I et al. Evidence of nuclear PKC/MAP-kinase cascade in guinea pig model of epidermal hyperproliferation. 1999 J. Invest. Dermatol. pmid:9886262
Bernoud N et al. Preferential transfer of 2-docosahexaenoyl-1-lysophosphatidylcholine through an in vitro blood-brain barrier over unesterified docosahexaenoic acid. 1999 J. Neurochem. pmid:9886086
Akedo I et al. Three cases with familial adenomatous polyposis diagnosed as having malignant lesions in the course of a long-term trial using docosahexanoic acid (DHA)-concentrated fish oil capsules. 1998 Jpn. J. Clin. Oncol. pmid:9879296
Vaagenes H et al. Low doses of eicosapentaenoic acid, docosahexaenoic acid, and hypolipidemic eicosapentaenoic acid derivatives have no effect on lipid peroxidation in plasma. 1998 Lipids pmid:9870909
Hansen JB et al. Lipid peroxidation of isolated chylomicrons and oxidative status in plasma after intake of highly purified eicosapentaenoic or docosahexaenoic acids. 1998 Lipids pmid:9870908
Ishihara K et al. Effect of tetracosahexaenoic acid on the content and release of histamine, and eicosanoid production in MC/9 mouse mast cell. 1998 Lipids pmid:9870906
Ward GR et al. Long-chain polyunsaturated fatty acid levels in formulae influence deposition of docosahexaenoic acid and arachidonic acid in brain and red blood cells of artificially reared neonatal rats. 1998 J. Nutr. pmid:9868196
Cho HP et al. Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase. 1999 J. Biol. Chem. pmid:9867867
Khalfoun B et al. Docosahexaenoic and eicosapentaenoic acids inhibit the CD28-lymphocyte activation pathway in vitro. 1998 Transplant. Proc. pmid:9865267
Huster D et al. Influence of docosahexaenoic acid and cholesterol on lateral lipid organization in phospholipid mixtures. 1998 Biochemistry pmid:9860844
Martin RE Docosahexaenoic acid decreases phospholipase A2 activity in the neurites/nerve growth cones of PC12 cells. 1998 J. Neurosci. Res. pmid:9856864
Rotstein NP et al. Docosahexaenoic acid promotes differentiation of developing photoreceptors in culture. 1998 Invest. Ophthalmol. Vis. Sci. pmid:9856786
Yuan C et al. The unique lipid composition of gecko (Gekko Gekko) photoreceptor outer segment membranes. 1998 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:9854823
Saha SK et al. Thermogenesis and fatty acid composition of brown adipose tissue in rats rendered hyperthyroid and hypothyroid-with special reference to docosahexaenoic acid. 1998 Jpn. J. Physiol. pmid:9852344
Helland IB et al. Fatty acid composition in maternal milk and plasma during supplementation with cod liver oil. 1998 Eur J Clin Nutr pmid:9846598
Allen PC and Danforth HD Effects of dietary supplementation with n-3 fatty acid ethyl esters on coccidiosis in chickens. 1998 Poult. Sci. pmid:9835336
Martínez M and Mougan I Fatty acid composition of human brain phospholipids during normal development. 1998 J. Neurochem. pmid:9832152
Gibson RA and Makrides M The role of long chain polyunsaturated fatty acids (LCPUFA) in neonatal nutrition. 1998 Acta Paediatr. pmid:9825965
Price SA and Tisdale MJ Mechanism of inhibition of a tumor lipid-mobilizing factor by eicosapentaenoic acid. 1998 Cancer Res. pmid:9809986
Schofield M et al. Cholesterol versus cholesterol sulfate: effects on properties of phospholipid bilayers containing docosahexaenoic acid. 1998 Chem. Phys. Lipids pmid:9807808
Kubo K et al. Dietary docosahexaenoic acid dose not promote lipid peroxidation in rat tissue to the extent expected from peroxidizability index of the lipids. 1998 Biosci. Biotechnol. Biochem. pmid:9805370
Menard CR et al. Recycling of carbon into lipids synthesized de novo is a quantitatively important pathway of alpha-[U-13C]linolenate utilization in the developing rat brain. 1998 J. Neurochem. pmid:9798942
Scott DT et al. Formula supplementation with long-chain polyunsaturated fatty acids: are there developmental benefits? 1998 Pediatrics pmid:9794989
Rodriguez A et al. Fatty acid desaturase activities and polyunsaturated fatty acid composition in human liver between the seventeenth and thirty-sixth gestational weeks. 1998 Am. J. Obstet. Gynecol. pmid:9790399
Morley R Nutrition and cognitive development. 1998 Nutrition pmid:9785354
Maurage C et al. Effect of two types of fish oil supplementation on plasma and erythrocyte phospholipids in formula-fed term infants. 1998 Biol. Neonate pmid:9784633
Ikeda I et al. Effects of long-term feeding of marine oils with different positional distribution of eicosapentaenoic and docosahexaenoic acids on lipid metabolism, eicosanoid production, and platelet aggregation in hypercholesterolemic rats. 1998 Lipids pmid:9778137
Jenski LJ et al. The triggering signal dictates the effect of docosahexaenoic acid on lymphocyte function in vitro. 1998 Lipids pmid:9778134
Macleod JC et al. The electrical and mechanical response of adult guinea pig and rat ventricular myocytes to omega3 polyunsaturated fatty acids. 1998 Eur. J. Pharmacol. pmid:9774258
Lii CK et al. Effect of dietary lipid on gamma-glutamyl transferase-positive foci during hepatocarcinogenesis in rats. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9774170
Andriamampandry M et al. Diets enriched in (n-3) fatty acids affect rat coagulation factors dependent on vitamin K. 1998 C. R. Acad. Sci. III, Sci. Vie pmid:9766191
Mitchell DC et al. Why is docosahexaenoic acid essential for nervous system function? 1998 Biochem. Soc. Trans. pmid:9765880
Suzuki A et al. Enhanced colonic and rectal absorption of insulin using a multiple emulsion containing eicosapentaenoic acid and docosahexaenoic acid. 1998 J Pharm Sci pmid:9758676
Crabtree JT et al. Differential distribution and metabolism of arachidonic acid and docosahexaenoic acid by human placental choriocarcinoma (BeWo) cells. 1998 Mol. Cell. Biochem. pmid:9746226
Decsi T et al. Effects of dietary long-chain polyunsaturated fatty acids on plasma amino acids and indices of protein metabolism in infants: results from a randomized clinical trial. 1998 Ann. Nutr. Metab. pmid:9745105
Prisco D et al. Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. 1998 Thromb. Res. pmid:9733153
Waldron MK et al. Role of long-chain polyunsaturated n-3 fatty acids in the development of the nervous system of dogs and cats. 1998 J. Am. Vet. Med. Assoc. pmid:9731252
Kimura S et al. Docosahexaenoic acid inhibits blood viscosity in stroke-prone spontaneously hypertensive rats. 1998 Res. Commun. Mol. Pathol. Pharmacol. pmid:9730013
Birbes H et al. Protein kinase C inhibitors stimulate arachidonic and docosahexaenoic acids release from uterine stromal cells through a Ca2+-independent pathway. 1998 FEBS Lett. pmid:9720928
Watkins SM et al. Docosahexaenoic acid accumulates in cardiolipin and enhances HT-29 cell oxidant production. 1998 J. Lipid Res. pmid:9717717
Hibbeln JR et al. A replication study of violent and nonviolent subjects: cerebrospinal fluid metabolites of serotonin and dopamine are predicted by plasma essential fatty acids. 1998 Biol. Psychiatry pmid:9715355
Hibbeln JR et al. Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early- and late-onset alcoholics. 1998 Biol. Psychiatry pmid:9715354
Hawkins RA et al. Apoptotic death of pancreatic cancer cells induced by polyunsaturated fatty acids varies with double bond number and involves an oxidative mechanism. 1998 J. Pathol. pmid:9713361
Petroni A et al. The beta-oxidation of arachidonic acid and the synthesis of docosahexaenoic acid are selectively and consistently altered in skin fibroblasts from three Zellweger patients versus X-adrenoleukodystrophy, Alzheimer and control subjects. 1998 Neurosci. Lett. pmid:9708853
Oudot F et al. Polyunsaturated fatty acids influence prostanoid synthesis in vascular endothelial cells under hypoxia and reoxygenation. 1998 Int J Vitam Nutr Res pmid:9706502
Shikano M et al. 1a-docosahexaenoyl mitomycin C: a novel inhibitor of protein tyrosine kinase. 1998 Biochem. Biophys. Res. Commun. pmid:9704018
Birch EE et al. Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants. 1998 Pediatr. Res. pmid:9702915
Campbell FM et al. Placental membrane fatty acid-binding protein preferentially binds arachidonic and docosahexaenoic acids. 1998 Life Sci. pmid:9698032
Bell JG et al. Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9690713
Ohinata H et al. Effect of dietary docosahexaenoic acid on in vitro thermogenesis and fatty acid compositions of brown adipose tissue. 1998 Jpn. J. Physiol. pmid:9689148
Jarocka-Cyrta E et al. Early dietary experience influences ontogeny of intestine in response to dietary lipid changes in later life. 1998 Am. J. Physiol. pmid:9688652
Hamazaki T et al. Docosahexaenoic acid does not affect aggression of normal volunteers under nonstressful conditions. A randomized, placebo-controlled, double-blind study. 1998 Lipids pmid:9688168
de la Presa-Owens S et al. Addition of triglycerides with arachidonic acid or docosahexaenoic acid to infant formula has tissue- and lipid class-specific effects on fatty acids and hepatic desaturase activities in formula-fed piglets. 1998 J. Nutr. pmid:9687559
Clandinin MT et al. Docosahexaenoic acid increases thyroid-stimulating hormone concentration in male and adrenal corticotrophic hormone concentration in female weanling rats. 1998 J. Nutr. pmid:9687541
Infante JP and Huszagh VA Analysis of the putative role of 24-carbon polyunsaturated fatty acids in the biosynthesis of docosapentaenoic (22:5n-6) and docosahexaenoic (22:6n-3) acids. 1998 FEBS Lett. pmid:9684854
Connor WE et al. Uneven distribution of desmosterol and docosahexaenoic acid in the heads and tails of monkey sperm. 1998 J. Lipid Res. pmid:9684743
Nasa Y et al. Long-term supplementation with eicosapentaenoic acid salvages cardiomyocytes from hypoxia/reoxygenation-induced injury in rats fed with fish-oil-deprived diet. 1998 Jpn. J. Pharmacol. pmid:9681570
Guarini P et al. Effects of dietary fish oil and soy phosphatidylcholine on neutrophil fatty acid composition, superoxide release, and adhesion. 1998 Inflammation pmid:9675609
Martinez M and Vazquez E MRI evidence that docosahexaenoic acid ethyl ester improves myelination in generalized peroxisomal disorders. 1998 Neurology pmid:9674774
Hagve TA et al. Membrane fluidity and fatty acid metabolism in kidney cells from rats fed purified eicosapentaenoic acid or purified docosahexaenoic acid. 1998 Scand. J. Clin. Lab. Invest. pmid:9670342
Grimsgaard S et al. Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans. 1998 Am. J. Clin. Nutr. pmid:9665096
Hansen RA et al. Duration of effects of dietary fish oil supplementation on serum eicosapentaenoic acid and docosahexaenoic acid concentrations in dogs. 1998 Am. J. Vet. Res. pmid:9659553
Young C et al. Cancellation of low-frequency stimulation-induced long-term depression by docosahexaenoic acid in the rat hippocampus. 1998 Neurosci. Lett. pmid:9655627
Kelley DS et al. Dietary docosahexaenoic acid and immunocompetence in young healthy men. 1998 Lipids pmid:9655370
Jolly CA et al. Effect of dietary n-3 fatty acids on interleukin-2 and interleukin-2 receptor alpha expression in activated murine lymphocytes. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9654402
Monia ZA et al. Docosahexaenoic acid reduces both cyclic nucleotide and melatonin synthesis in rat pinealocytes. 1998 Prostaglandins Other Lipid Mediat. pmid:9653768
Edwards R et al. Depletion of docosahexaenoic acid in red blood cell membranes of depressive patients. 1998 Biochem. Soc. Trans. pmid:9649817
Burdge GC The role of docosahexaenoic acid in brain development and fetal alcohol syndrome. 1998 Biochem. Soc. Trans. pmid:9649756
Wright T et al. Docosahexaenoic acid-enriched milk. 1998 World Rev Nutr Diet pmid:9648512
Kyle DJ and Arterburn LM Single cell oil sources of docosahexaenoic acid: clinical studies. 1998 World Rev Nutr Diet pmid:9648509
Abril R and Barclay W Production of docosahexaenoic acid-enriched poultry eggs and meat using an algae-based feed ingredient. 1998 World Rev Nutr Diet pmid:9648506
Barclay W et al. Production of docosahexaenoic acid from microalgae and its benefits for use in animal feeds. 1998 World Rev Nutr Diet pmid:9648505
Hoffman DR and Birch DG Omega 3 fatty acid status in patients with retinitis pigmentosa. 1998 World Rev Nutr Diet pmid:9648504
Leaf A and Kang JX Omega 3 fatty acids and cardiovascular disease. 1998 World Rev Nutr Diet pmid:9648502
He Q et al. Reduction of 4-hydroxynonenal and 4-hydroxyhexenal by retinal aldose reductase. 1998 Biochem. Biophys. Res. Commun. pmid:9647760
Kimura S et al. Ameliorative effects of docosahexaenoic acid on serum lipid changes in stroke-prone spontaneously hypertensive rats. 1998 Res. Commun. Mol. Pathol. Pharmacol. pmid:9644719
Hibbeln JR Fish consumption and major depression. 1998 Lancet pmid:9643729
Cadroy Y et al. Arachidonic acid enhances the tissue factor expression of mononuclear cells by the cyclo-oxygenase-1 pathway: beneficial effect of n-3 fatty acids. 1998 J. Immunol. pmid:9637532
Williams EE et al. Docosahexaenoic acid (DHA) alters the structure and composition of membranous vesicles exfoliated from the surface of a murine leukemia cell line. 1998 Biochim. Biophys. Acta pmid:9630720
Henderson RJ et al. Effects of docosahexaenoic (22:6n-3), tetracosapentaenoic (24:5n-3) and tetracosahexaenoic (24:6n-3) acids on the desaturation and elongation of n-3 polyunsaturated fatty acids in trout liver microsomes. 1998 Biochim. Biophys. Acta pmid:9630696
Peterson LD et al. Low levels of eicosapentaenoic and docosahexaenoic acids mimic the effects of fish oil upon rat lymphocytes. 1998 Life Sci. pmid:9627080
Bojesen IN and Bojesen E Nature of the elements transporting long-chain fatty acids through the red cell membrane. 1998 J. Membr. Biol. pmid:9625774