DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Florent S et al. Docosahexaenoic acid prevents neuronal apoptosis induced by soluble amyloid-beta oligomers. 2006 J. Neurochem. pmid:16300635
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Yanagita T et al. Conjugated linoleic acid-induced fatty liver can be attenuated by combination with docosahexaenoic acid in C57BL/6N mice. 2005 J. Agric. Food Chem. pmid:16302788
Taber DF and Jackson Roberts L Nomenclature systems for the neuroprostanes and for the neurofurans. 2005 Prostaglandins Other Lipid Mediat. pmid:16303600
Hong S et al. Rainbow trout (Oncorhynchus mykiss) brain cells biosynthesize novel docosahexaenoic acid-derived resolvins and protectins-Mediator lipidomic analysis. 2005 Prostaglandins Other Lipid Mediat. pmid:16303609
Xiang M et al. Long-chain polyunsaturated fatty acids in Chinese and Swedish mothers: diet, breast milk and infant growth. 2005 Acta Paediatr. pmid:16303692
Quilty MC et al. Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection. 2006 Exp. Neurol. pmid:16310772
Patch CS et al. The use of novel foods enriched with long-chain n-3 fatty acids to increase dietary intake: a comparison of methodologies assessing nutrient intake. 2005 J Am Diet Assoc pmid:16321598
Sala-Vila A et al. Influence of dietary source of docosahexaenoic and arachidonic acids on their incorporation into membrane phospholipids of red blood cells in term infants. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16326086
Patten GS et al. Dietary fish oil dose-response effects on ileal phospholipid fatty acids and contractility. 2005 Lipids pmid:16329465
Saito H et al. High docosahexaenoic acid levels in both neutral and polar lipids of a highly migratory fish: Thunnus tonggol (Bleeker). 2005 Lipids pmid:16329467
Lyberg AM et al. Monitoring the oxidation of docosahexaenoic acid in lipids. 2005 Lipids pmid:16329470
Min Y et al. Unfavorable effect of type 1 and type 2 diabetes on maternal and fetal essential fatty acid status: a potential marker of fetal insulin resistance. 2005 Am. J. Clin. Nutr. pmid:16332647
Kuratko C et al. Importance of arachidonic acid in long-chain polyunsaturated fatty acid-supplemented infant formula. 2005 Am. J. Clin. Nutr. pmid:16332670
Ishigamori H et al. Docosahexaenoic acid-containing phosphatidylethanolamine enhances HL-60 cell differentiation by regulation of c-jun and c-myc expression. 2005 Mol. Cell. Biochem. pmid:16335792
Li T et al. In vivo delivery of a XIAP (BIR3-RING) fusion protein containing the protein transduction domain protects against neuronal death induced by seizures. 2006 Exp. Neurol. pmid:16336964
Bazinet RP et al. Valproic acid selectively inhibits conversion of arachidonic acid to arachidonoyl-CoA by brain microsomal long-chain fatty acyl-CoA synthetases: relevance to bipolar disorder. 2006 Psychopharmacology (Berl.) pmid:16344985
Joardar A et al. Docosahexaenoic acid facilitates cell maturation and beta-adrenergic transmission in astrocytes. 2006 J. Lipid Res. pmid:16352524
Lindskog M et al. Neuroblastoma cell death in response to docosahexaenoic acid: sensitization to chemotherapy and arsenic-induced oxidative stress. 2006 Int. J. Cancer pmid:16353135
Agostoni C et al. Reduced docosahexaenoic acid synthesis may contribute to growth restriction in infants born to mothers who smoke. 2005 J. Pediatr. pmid:16356447
Song C et al. Existence of lipid microdomains in bilayer of dipalmitoyl phosphatidylcholine (DPPC) and 1-stearoyl-2-docosahexenoyl phosphatidylserine (SDPS) and their perturbation by chlorpromazine: a 13C and 31P solid-state NMR study. 2006 Biophys. Chem. pmid:16356624
Vaughan DK et al. Light-induced exacerbation of retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome. 2006 Exp. Eye Res. pmid:16360150
Robert SS Production of eicosapentaenoic and docosahexaenoic acid-containing oils in transgenic land plants for human and aquaculture nutrition. 2006 Mar-Apr Mar. Biotechnol. pmid:16372159
Birch DG A randomized placebo-controlled clinical trial of docosahexaenoic acid (DHA) supplementation for X-linked retinitis pigmentosa. 2005 Retina (Philadelphia, Pa.) pmid:16374336
Kumon Y et al. A new labyrinthulid isolate that produces only docosahexaenoic acid. 2006 Mar-Apr Mar. Biotechnol. pmid:16380808
Hussar DA New drugs: pregabalin and omega-3-acid ethyl esters. 2005 Nov-Dec J Am Pharm Assoc (2003) pmid:16381426
Bryan DL et al. Modulation of respiratory syncytial virus-induced prostaglandin E2 production by n-3 long-chain polyunsaturated fatty acids in human respiratory epithelium. 2005 Lipids pmid:16382572
Sørensen BM et al. Storage lipid accumulation and acyltransferase action in developing flaxseed. 2005 Lipids pmid:16382576
Fang PC et al. The effect of supplementation of docosahexaenoic acid and arachidonic acid on visual acuity and neurodevelopment in larger preterm infants. 2005 Chang Gung Med J pmid:16382755
Kulkarni A et al. Successful outcome of pregnancy in a patient with familial hypertriglyceridaemia. 2006 J Obstet Gynaecol pmid:16390715
Butovich IA A one-step method of 10,17-dihydro(pero)xydocosahexa-4Z,7Z,11E,13Z,15E,19Z-enoic acid synthesis by soybean lipoxygenase. 2006 J. Lipid Res. pmid:16391324
Higuchi T et al. Reduction in plasma glucose after lipid changes in mice fed fish oil, docosahexaenoic acid, and eicosapentaenoic acid diets. 2006 Ann. Nutr. Metab. pmid:16391470
Onuki Y et al. Docosahexaenoic acid and eicosapentaenoic acid induce changes in the physical properties of a lipid bilayer model membrane. 2006 Chem. Pharm. Bull. pmid:16394552
Flachs P et al. Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet. 2006 Diabetologia pmid:16397791
Akbar M et al. Ethanol promotes neuronal apoptosis by inhibiting phosphatidylserine accumulation. 2006 J. Neurosci. Res. pmid:16397898
Bourre JM et al. Fatty acid alterations in liver peroxisomes from n-3-deficient mice. 2006 Ann. Nutr. Metab. pmid:16407648
Ren H et al. Primary open-angle glaucoma patients have reduced levels of blood docosahexaenoic and eicosapentaenoic acids. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16410047
Alexander JW et al. Can immunonutrients reduce rejection rates in African Americans? 2005 Exp Clin Transplant pmid:16417441
Jia Q et al. Docosahexaenoic acid consumption inhibits deoxynivalenol-induced CREB/ATF1 activation and IL-6 gene transcription in mouse macrophages. 2006 J. Nutr. pmid:16424113
Serhan CN et al. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes. 2006 J. Immunol. pmid:16424216
Tsuzuki T et al. Conjugated docosahexaenoic acid inhibits lipid accumulation in rats. 2006 J. Nutr. Biochem. pmid:16426831
Hashimoto M et al. Docosahexaenoic acid-induced amelioration on impairment of memory learning in amyloid beta-infused rats relates to the decreases of amyloid beta and cholesterol levels in detergent-insoluble membrane fractions. 2005 Biochim. Biophys. Acta pmid:16427803
Christensen JH et al. Prostate tissue and leukocyte levels of n-3 polyunsaturated fatty acids in men with benign prostate hyperplasia or prostate cancer. 2006 BJU Int. pmid:16430627
Haugaard SB et al. Dietary intervention increases n-3 long-chain polyunsaturated fatty acids in skeletal muscle membrane phospholipids of obese subjects. Implications for insulin sensitivity. 2006 Clin. Endocrinol. (Oxf) pmid:16430716
Samadi P et al. Docosahexaenoic acid reduces levodopa-induced dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine monkeys. 2006 Ann. Neurol. pmid:16437566
Burdge GC et al. Docosahexaenoic acid is selectively enriched in plasma phospholipids during pregnancy in Trinidadian women--results of a pilot study. 2006 Jan-Feb Reprod. Nutr. Dev. pmid:16438916
Mayes C et al. Variation in [U-13C] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula. 2006 Pediatr. Res. pmid:16439591
Arab K et al. Docosahexaenoic acid enhances the antioxidant response of human fibroblasts by upregulating gamma-glutamyl-cysteinyl ligase and glutathione reductase. 2006 Br. J. Nutr. pmid:16441913
Tapia-Salazar M et al. Effect of DHA supplementation on digestible starch utilization by rainbow trout. 2006 Br. J. Nutr. pmid:16441919
Williams CM and Burdge G Long-chain n-3 PUFA: plant v. marine sources. 2006 Proc Nutr Soc pmid:16441943
Julien C et al. Postmortem brain fatty acid profile of levodopa-treated Parkinson disease patients and parkinsonian monkeys. 2006 Neurochem. Int. pmid:16442670
Perez MA et al. Dietary docosahexaenoic acid alters pregnant rat reproductive tissue prostaglandin and matrix metalloproteinase production. 2006 J. Nutr. Biochem. pmid:16457997
Poulos A et al. Effect of 22-32 carbon n-3 polyunsaturated fatty acids on superoxide production in human neutrophils: synergism of docosahexaenoic acid with f-met-leu-phe and phorbol ester. 1991 Immunology pmid:1646160
Mamalakis G et al. Depression and long chain n-3 fatty acids in adipose tissue in adults from Crete. 2006 Eur J Clin Nutr pmid:16465199
Gough NR Focus issue: signaling lipids. 2006 Sci. STKE pmid:16467192
Glomset JA Role of docosahexaenoic acid in neuronal plasma membranes. 2006 Sci. STKE pmid:16467193
Delarue J et al. Interaction of fish oil and a glucocorticoid on metabolic responses to an oral glucose load in healthy human subjects. 2006 Br. J. Nutr. pmid:16469141
Seo J et al. Docosahexaenoic acid selectively inhibits plasma membrane targeting of lipidated proteins. 2006 FASEB J. pmid:16469846
Sekine S et al. Dietary docosahexaenoic acid-induced generation of liver lipid peroxides is not suppressed further by elevated levels of glutathione in ODS rats. 2006 Nutrition pmid:16472975
Pfrommer CA et al. Docosahexaenoic acid induces ciap1 mRNA and protects human endothelial cells from stress-induced apoptosis. 2006 Am. J. Physiol. Heart Circ. Physiol. pmid:16473961
Hubbard AF et al. Association of adipose and red blood cell lipids with severity of dominant Stargardt macular dystrophy (STGD3) secondary to an ELOVL4 mutation. 2006 Arch. Ophthalmol. pmid:16476896
Mori TA and Woodman RJ The independent effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors in humans. 2006 Curr Opin Clin Nutr Metab Care pmid:16477172
Hossain Z et al. Docosahexaenoic acid and eicosapentaenoic acid-enriched phosphatidylcholine liposomes enhance the permeability, transportation and uptake of phospholipids in Caco-2 cells. 2006 Mol. Cell. Biochem. pmid:16477371
Park YS et al. Prolyl endopeptidase inhibitory activity of unsaturated fatty acids. 2006 J. Agric. Food Chem. pmid:16478242
Mamalakis G et al. Depression and adipose and serum cholesteryl ester polyunsaturated fatty acids in the survivors of the seven countries study population of Crete. 2006 Eur J Clin Nutr pmid:16482070
Goyens PL and Mensink RP Effects of alpha-linolenic acid versus those of EPA/DHA on cardiovascular risk markers in healthy elderly subjects. 2006 Eur J Clin Nutr pmid:16482073
Bauch A et al. Dietary intake and sources of long-chain n-3 PUFAs in German adults. 2006 Eur J Clin Nutr pmid:16482078
Arachchige PG et al. Dietary sesamin and docosahexaenoic and eicosapentaenoic acids synergistically increase the gene expression of enzymes involved in hepatic peroxisomal fatty acid oxidation in rats. 2006 Metab. Clin. Exp. pmid:16483883
Perveen Z et al. Isolation and characterization of a novel thraustochytrid-like microorganism that efficiently produces docosahexaenoic acid. 2006 Biotechnol. Lett. pmid:16489498
López-Alarcón M et al. [The effect of docosahexaenoic acid on the loss of appetite in pediatric patients with pneumonia]. 2006 Jan-Feb Rev Med Inst Mex Seguro Soc pmid:16497254
Levant B et al. Reduced brain DHA content after a single reproductive cycle in female rats fed a diet deficient in N-3 polyunsaturated fatty acids. 2006 Biol. Psychiatry pmid:16499882
Ramaprasad TR et al. Spray-dried milk supplemented with alpha-linolenic acid or eicosapentaenoic acid and docosahexaenoic acid decreases HMG Co A reductase activity and increases biliary secretion of lipids in rats. 2006 Steroids pmid:16499938
Parker GB et al. Low levels of docosahexaenoic acid identified in acute coronary syndrome patients with depression. 2006 Psychiatry Res pmid:16499974
da Silva TL et al. Effect of n-dodecane on Crypthecodinium cohnii fermentations and DHA production. 2006 J. Ind. Microbiol. Biotechnol. pmid:16501933
Chattipakorn N et al. Effects of n-3 polyunsaturated fatty acid on upper limit of vulnerability shocks. 2006 Int. J. Cardiol. pmid:16503251
Ko WC et al. Efficient hydrolysis of tuna oil by a surfactant-coated lipase in a two-phase system. 2006 J. Agric. Food Chem. pmid:16506843
Heinemann KM and Bauer JE Docosahexaenoic acid and neurologic development in animals. 2006 J. Am. Vet. Med. Assoc. pmid:16506930
Jumpsen JA et al. Fatty acids in blood and intestine following docosahexaenoic acid supplementation in adults with cystic fibrosis. 2006 J. Cyst. Fibros. pmid:16507353
Chiu LC et al. Cytostatic and cytotoxic effects of cyclooxygenase inhibitors and their synergy with docosahexaenoic acid on the growth of human skin melanoma A-375 cells. 2005 Biomed. Pharmacother. pmid:16507396
Sanders TA et al. Influence of an algal triacylglycerol containing docosahexaenoic acid (22 : 6n-3) and docosapentaenoic acid (22 : 5n-6) on cardiovascular risk factors in healthy men and women. 2006 Br. J. Nutr. pmid:16512939
Abedin M et al. N-3 fatty acids inhibit vascular calcification via the p38-mitogen-activated protein kinase and peroxisome proliferator-activated receptor-gamma pathways. 2006 Circ. Res. pmid:16514067
Scambi C et al. Can 5-methyltetrahydrofolate modify the phospholipid fatty acid pattern in cystic fibrosis pediatric patients? 2006 J. Cyst. Fibros. pmid:16516563
Li CC et al. n-6 and n-3 polyunsaturated fatty acids down-regulate cytochrome P-450 2B1 gene expression induced by phenobarbital in primary rat hepatocytes. 2006 J. Nutr. Biochem. pmid:16517146
Shoji H et al. Effect of docosahexaenoic acid and eicosapentaenoic acid supplementation on oxidative stress levels during pregnancy. 2006 Free Radic. Res. pmid:16517502
Usami M et al. Phospholipid fatty acid composition and diamine oxidase activity of intestinal mucosa from rats treated with irinotecan hydrochloride (CPT-11) under vegetable oil-enriched diets: comparison between perilla oil and corn oil. 2006 Mar-Apr JPEN J Parenter Enteral Nutr pmid:16517957
Qiu C et al. Erythrocyte omega-3 and omega-6 polyunsaturated fatty acids and preeclampsia risk in Peruvian women. 2006 Arch. Gynecol. Obstet. pmid:16520922
Shi Y and Pestka JJ Attenuation of mycotoxin-induced IgA nephropathy by eicosapentaenoic acid in the mouse: dose response and relation to IL-6 expression. 2006 J. Nutr. Biochem. pmid:16524712
Kawakita E et al. Docosahexaenoic acid promotes neurogenesis in vitro and in vivo. 2006 Neuroscience pmid:16527422
Cerolini S et al. Effect of docosahexaenoic acid and alpha-tocopherol enrichment in chicken sperm on semen quality, sperm lipid composition and susceptibility to peroxidation. 2006 Theriogenology pmid:16530814
Tian Q et al. Peroxisome proliferator-activated receptor alpha agonist, clofibrate, has profound influence on myocardial fatty acid composition. 2006 Chem. Biol. Interact. pmid:16540100
Pall H et al. Decreased peroxisome proliferator activated receptor alpha is associated with bile duct injury in cystic fibrosis transmembrane conductance regulator-/- mice. 2006 J. Pediatr. Gastroenterol. Nutr. pmid:16540796
Hoffman DR et al. Docosahexaenoic acid in red blood cells of term infants receiving two levels of long-chain polyunsaturated fatty acids. 2006 J. Pediatr. Gastroenterol. Nutr. pmid:16540798
Straarup EM et al. The stereospecific triacylglycerol structures and Fatty Acid profiles of human milk and infant formulas. 2006 J. Pediatr. Gastroenterol. Nutr. pmid:16540799
Li Q et al. Effect of docosahexaenoic acid on interleukin-2 receptor signaling pathway in lipid rafts. 2006 Sci. China, C, Life Sci. pmid:16544577
Fer M et al. Determination of polyunsaturated fatty acid monoepoxides by high performance liquid chromatography-mass spectrometry. 2006 J Chromatogr A pmid:16545829
Wang WP et al. Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons. 2006 Brain Res. pmid:16546145
Lyberg AM and Adlercreutz P Monitoring monohydroperoxides in docosahexaenoic acid using high-performance liquid chromatography. 2006 Lipids pmid:16555474
Li D et al. A significant inverse relationship between concentrations of plasma homocysteine and phospholipid docosahexaenoic acid in healthy male subjects. 2006 Lipids pmid:16555476
Strokin M et al. Neuroprotection of rat hippocampal slices exposed to oxygen-glucose deprivation by enrichment with docosahexaenoic acid and by inhibition of hydrolysis of docosahexaenoic acid-containing phospholipids by calcium independent phospholipase A2. 2006 Neuroscience pmid:16563639
Bhattacharya A et al. Different ratios of eicosapentaenoic and docosahexaenoic omega-3 fatty acids in commercial fish oils differentially alter pro-inflammatory cytokines in peritoneal macrophages from C57BL/6 female mice. 2007 J. Nutr. Biochem. pmid:16563716