DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Kotani S et al. Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction. 2006 Neurosci. Res. pmid:16905216
Bays H Clinical overview of Omacor: a concentrated formulation of omega-3 polyunsaturated fatty acids. 2006 Am. J. Cardiol. pmid:16919519
Hall JA et al. The (n-3) fatty acid dose, independent of the (n-6) to (n-3) fatty acid ratio, affects the plasma fatty acid profile of normal dogs. 2006 J. Nutr. pmid:16920851
Mori TA Omega-3 fatty acids and hypertension in humans. 2006 Clin. Exp. Pharmacol. Physiol. pmid:16922818
German OL et al. Docosahexaenoic acid prevents apoptosis of retina photoreceptors by activating the ERK/MAPK pathway. 2006 J. Neurochem. pmid:16923163
Helland IB et al. Supplementation of n-3 fatty acids during pregnancy and lactation reduces maternal plasma lipid levels and provides DHA to the infants. 2006 J. Matern. Fetal. Neonatal. Med. pmid:16923694
Burdge GC et al. Lack of effect of meal fatty acid composition on postprandial lipid, glucose and insulin responses in men and women aged 50-65 years consuming their habitual diets. 2006 Br. J. Nutr. pmid:16925854
Serhan CN Novel chemical mediators in the resolution of inflammation: resolvins and protectins. 2006 Anesthesiol Clin pmid:16927933
McNamara RK The emerging role of omega-3 fatty acids in psychiatry. 2006 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:16930969
Freeman MP Omega-3 fatty acids and perinatal depression: a review of the literature and recommendations for future research. 2006 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:16930971
Isbilen B et al. Docosahexaenoic acid (omega-3) blocks voltage-gated sodium channel activity and migration of MDA-MB-231 human breast cancer cells. 2006 Int. J. Biochem. Cell Biol. pmid:16931105
Hashimoto M et al. Docosahexaenoic acid but not eicosapentaenoic acid withstands dietary cholesterol-induced decreases in platelet membrane fluidity. 2006 Mol. Cell. Biochem. pmid:16933035
Kojima Y et al. Different specificity of two types of Pseudomonas lipases for C20 fatty acids with a Delta5 unsaturated double bond and their application for selective concentration of fatty acids. 2006 J. Biosci. Bioeng. pmid:16935251
Mollard RC and Weiler HA Dietary arachidonic acid and docosahexaenoic acid elevate femur calcium and reduce zinc content in piglets. 2006 Pediatr. Res. pmid:16940244
Dangour AD et al. A randomised controlled trial investigating the effect of n-3 long-chain polyunsaturated fatty acid supplementation on cognitive and retinal function in cognitively healthy older people: the Older People And n-3 Long-chain polyunsaturated fatty acids (OPAL) study protocol [ISRCTN72331636]. 2006 Nutr J pmid:16945130
McNamara RK and Carlson SE Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology. 2006 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:16949263
Morris T et al. New perspectives on aspirin and the endogenous control of acute inflammatory resolution. 2006 ScientificWorldJournal pmid:16951898
Xu Y et al. Di-(2-ethylhexyl)-phthalate affects lipid profiling in fetal rat brain upon maternal exposure. 2007 Arch. Toxicol. pmid:16951938
Nieminen LR et al. Relationship between omega-3 fatty acids and plasma neuroactive steroids in alcoholism, depression and controls. 2006 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:16959481
Sanders TA et al. Effect of varying the ratio of n-6 to n-3 fatty acids by increasing the dietary intake of alpha-linolenic acid, eicosapentaenoic and docosahexaenoic acid, or both on fibrinogen and clotting factors VII and XII in persons aged 45-70 y: the OPTILIP study. 2006 Am. J. Clin. Nutr. pmid:16960164
Tavilani H et al. Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males. 2006 Andrologia pmid:16961570
Lee M and Bae MA Docosahexaenoic acid induces apoptosis in CYP2E1-containing HepG2 cells by activating the c-Jun N-terminal protein kinase related mitochondrial damage. 2007 J. Nutr. Biochem. pmid:16963249
Yonezawa Y et al. Inhibitory action of C22-fatty acids on DNA polymerases and DNA topoisomerases. 2006 Int. J. Mol. Med. pmid:16964408
Egert S et al. Influence of three rapeseed oil-rich diets, fortified with alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid on the composition and oxidizability of low-density lipoproteins: results of a controlled study in healthy volunteers. 2007 Eur J Clin Nutr pmid:16969378
Pappas AC et al. Maternal organo-selenium compounds and polyunsaturated fatty acids affect progeny performance and levels of selenium and docosahexaenoic acid in the chick tissues. 2006 Poult. Sci. pmid:16977847
Yao HT et al. The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes. 2006 Life Sci. pmid:16978661
Hacioglu G et al. Beneficial effects of docosahexaenoic acid on active avoidance performance in 1K-1C hypertensive rats. 2007 Neurobiol Learn Mem pmid:16979916
Marosvölgyi T et al. [Fatty acid composition of human milk in mothers of preterm and full-term infants in the first three weeks of lactation]. 2006 Orv Hetil pmid:16981419
Kao BT et al. Mice raised on milk transgenically enriched with n-3 PUFA have increased brain docosahexaenoic acid. 2006 Lipids pmid:16981432
Erkkilä AT et al. Higher plasma docosahexaenoic acid is associated with reduced progression of coronary atherosclerosis in women with CAD. 2006 J. Lipid Res. pmid:16983146
Rao JS et al. n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism. 2007 Mol. Psychiatry pmid:16983391
Rao JS et al. Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex. 2007 Mol. Psychiatry pmid:16983392
Orikasa Y et al. Recombinant production of docosahexaenoic acid in a polyketide biosynthesis mode in Escherichia coli. 2006 Biotechnol. Lett. pmid:16988784
[Start of insulin therapy. How to ensure patient compliance?]. 2006 MMW Fortschr Med pmid:16995354
Hashimoto M et al. Docosahexaenoic acid-induced protective effect against impaired learning in amyloid beta-infused rats is associated with increased synaptosomal membrane fluidity. 2006 Clin. Exp. Pharmacol. Physiol. pmid:17002670
Machová E et al. The increase of choline acetyltransferase activity by docosahexaenoic acid in NG108-15 cells grown in serum-free medium is independent of its effect on cell growth. 2006 Neurochem. Res. pmid:17004129
Zlatanos S et al. Proximate composition, fatty acid analysis and protein digestibility-corrected amino acid score of three Mediterranean cephalopods. 2006 Mol Nutr Food Res pmid:17009215
Rupp H [Omega-3 fatty acids in secondary prevention after myocardial infarct]. 2006 Clin Res Cardiol pmid:17013579
Lau CS Collateral benefits of fish oil therapy for rheumatoid arthritis. 2006 J. Rheumatol. pmid:17014011
Sunada S et al. Effect of docosahexaenoic acid intake on lipid peroxidation in diabetic rat retina under oxidative stress. 2006 Free Radic. Res. pmid:17015262
Massaro M et al. The omega-3 fatty acid docosahexaenoate attenuates endothelial cyclooxygenase-2 induction through both NADP(H) oxidase and PKC epsilon inhibition. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:17018645
Colas S et al. Sensitization by dietary docosahexaenoic acid of rat mammary carcinoma to anthracycline: a role for tumor vascularization. 2006 Clin. Cancer Res. pmid:17020996
Larqué E et al. Docosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteins. 2006 Am. J. Clin. Nutr. pmid:17023713
Serna-Saldivar SO et al. Effect of DHA containing oils and powders on baking performance and quality of white pan bread. 2006 Plant Foods Hum Nutr pmid:17031604
Abuzaytoun R and Shahidi F Oxidative stability of algal oils as affected by their minor components. 2006 J. Agric. Food Chem. pmid:17032036
Puglia C et al. Protective effect of Mediterranean fish oil extracts on heat-induced denaturation of albumin. 2006 J. Pharm. Pharmacol. pmid:17034666
Kuriki K et al. Risk of colorectal cancer is linked to erythrocyte compositions of fatty acids as biomarkers for dietary intakes of fish, fat, and fatty acids. 2006 Cancer Epidemiol. Biomarkers Prev. pmid:17035384
Pastor N et al. Infants fed docosahexaenoic acid- and arachidonic acid-supplemented formula have decreased incidence of bronchiolitis/bronchitis the first year of life. 2006 Clin Pediatr (Phila) pmid:17041174
Igarashi M et al. Upregulated liver conversion of alpha-linolenic acid to docosahexaenoic acid in rats on a 15 week n-3 PUFA-deficient diet. 2007 J. Lipid Res. pmid:17050905
Horia E and Watkins BA Complementary actions of docosahexaenoic acid and genistein on COX-2, PGE2 and invasiveness in MDA-MB-231 breast cancer cells. 2007 Carcinogenesis pmid:17052999
Cao J et al. Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids. 2006 Clin. Chem. pmid:17053155
Hong S et al. Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms. 2007 J. Am. Soc. Mass Spectrom. pmid:17055291
Duffield JS et al. Resolvin D series and protectin D1 mitigate acute kidney injury. 2006 J. Immunol. pmid:17056514
González-Périz A et al. Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S-hydroxy-DHA. 2006 FASEB J. pmid:17056761
Søgaard R et al. GABA(A) receptor function is regulated by lipid bilayer elasticity. 2006 Biochemistry pmid:17059229
Tang XH et al. Cell proliferation inhibition and alterations in retinol esterification induced by phytanic acid and docosahexaenoic acid. 2007 J. Lipid Res. pmid:17068359
Osako K et al. Docosahexaenoic acid levels in the lipids of spotted mackerel Scomber australasicus. 2006 Lipids pmid:17069355
Krabbendam L et al. Relationship between DHA status at birth and child problem behaviour at 7 years of age. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17074476
Hulbert AJ et al. Oxidation-resistant membrane phospholipids can explain longevity differences among the longest-living rodents and similarly-sized mice. 2006 J. Gerontol. A Biol. Sci. Med. Sci. pmid:17077193
Brown M et al. Emodin and DHA potently increase arsenic trioxide interferon-alpha-induced cell death of HTLV-I-transformed cells by generation of reactive oxygen species and inhibition of Akt and AP-1. 2007 Blood pmid:17077332
Luczaj W and Skrzydlewska E [The present-day look at lipid peroxidation]. 2006 Postepy Biochem. pmid:17078507
Tanaka H et al. Promotive effects of hyperthermia on the inhibition of DNA synthesis in ehrlich ascites tumor cells by eicosapentaenoic and docosahexaenoic acids. 2006 Exp. Oncol. pmid:17080013
Hall JA et al. Maternal dietary n-3 fatty acids alter immune cell fatty acid composition and leukotriene production in growing chicks. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17081738
White NM et al. Altered cholesterol homeostasis in cultured and in vivo models of cystic fibrosis. 2007 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:17085523
Hamaad A et al. Oral omega n3-PUFA therapy (Omacor) has no impact on indices of heart rate variability in stable post myocardial infarction patients. 2006 Cardiovasc Drugs Ther pmid:17089085
Serhan CN Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways. 2007 Annu. Rev. Immunol. pmid:17090225
Beharry S et al. Long-term docosahexaenoic acid therapy in a congenic murine model of cystic fibrosis. 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17095751
Almendingen K et al. Familial adenomatous polyposis patients have high levels of arachidonic acid and docosahexaenoic acid and low levels of linoleic acid and alpha-linolenic acid in serum phospholipids. 2007 Int. J. Cancer pmid:17096349
Eto K et al. Modulation of ATP-induced inward currents by docosahexaenoic acid and other fatty acids in rat nodose ganglion neurons. 2006 J. Pharmacol. Sci. pmid:17099292
Morris MC Docosahexaenoic acid and Alzheimer disease. 2006 Arch. Neurol. pmid:17101820
Schaefer EJ et al. Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. 2006 Arch. Neurol. pmid:17101822
Buydens-Branchey L and Branchey M n-3 polyunsaturated fatty acids decrease anxiety feelings in a population of substance abusers. 2006 J Clin Psychopharmacol pmid:17110827
Berdeaux O et al. Isolation and structural analysis of the cyclic fatty acid monomers formed from eicosapentaenoic and docosahexaenoic acids during fish oil deodorization. 2007 J Chromatogr A pmid:17113094
Coetzee M et al. Effects of arachidonic acid, docosahexaenoic acid and prostaglandin E(2) on cell proliferation and morphology of MG-63 and MC3T3-E1 osteoblast-like cells. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17113274
Hartong DT et al. Retinitis pigmentosa. 2006 Lancet pmid:17113430
Mathur SN et al. Regulation of intestinal NPC1L1 expression by dietary fish oil and docosahexaenoic acid. 2007 J. Lipid Res. pmid:17114806
Coronel R et al. Dietary n-3 fatty acids promote arrhythmias during acute regional myocardial ischemia in isolated pig hearts. 2007 Cardiovasc. Res. pmid:17116294
Kim HK et al. Docosahexaenoic acid inhibits adipocyte differentiation and induces apoptosis in 3T3-L1 preadipocytes. 2006 J. Nutr. pmid:17116704
Okuyama H et al. Bacterial genes responsible for the biosynthesis of eicosapentaenoic and docosahexaenoic acids and their heterologous expression. 2007 Appl. Environ. Microbiol. pmid:17122401
Harris WS et al. Effects of omega-3 fatty acids on heart rate in cardiac transplant recipients. 2006 Am. J. Cardiol. pmid:17134636
Miller MR et al. Replacement of dietary fish oil for Atlantic salmon parr (Salmo salar L.) with a stearidonic acid containing oil has no effect on omega-3 long-chain polyunsaturated fatty acid concentrations. 2007 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:17134928
Alimuddin G et al. Expression of masu salmon delta5-desaturase-like gene elevated EPA and DHA biosynthesis in zebrafish. 2007 Jan-Feb Mar. Biotechnol. pmid:17136489
Kanayasu T et al. Eicosapentaenoic acid inhibits tube formation of vascular endothelial cells in vitro. 1991 Lipids pmid:1714032
van Beelen VA et al. A comparative study on the effect of algal and fish oil on viability and cell proliferation of Caco-2 cells. 2007 Food Chem. Toxicol. pmid:17141934
Shirai N and Suzuki H Effect of docosahexaenoic acid on brain 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in male ICR mice. 2007 J. Nutr. Biochem. pmid:17142030
Yuhas R et al. Human milk fatty acid composition from nine countries varies most in DHA. 2006 Lipids pmid:17152922
Champeil-Potokar G et al. Docosahexaenoic acid (22:6n-3) enrichment of membrane phospholipids increases gap junction coupling capacity in cultured astrocytes. 2006 Eur. J. Neurosci. pmid:17156369
Griffin MD et al. Effects of altering the ratio of dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45-70 y: the OPTILIP Study. 2006 Am. J. Clin. Nutr. pmid:17158408
Philibert A et al. Fish intake and serum fatty acid profiles from freshwater fish. 2006 Am. J. Clin. Nutr. pmid:17158409
Kamphuis MH et al. Depression and cardiovascular mortality: a role for n-3 fatty acids? 2006 Am. J. Clin. Nutr. pmid:17158437
Demonty I et al. Fish-oil esters of plant sterols improve the lipid profile of dyslipidemic subjects more than do fish-oil or sunflower oil esters of plant sterols. 2006 Am. J. Clin. Nutr. pmid:17158440
Carlson BA and Kingston JD Docosahexaenoic acid, the aquatic diet, and hominin encephalization: difficulties in establishing evolutionary links. 2007 Jan-Feb Am. J. Hum. Biol. pmid:17160979
Domingo JL et al. Benefits and risks of fish consumption Part I. A quantitative analysis of the intake of omega-3 fatty acids and chemical contaminants. 2007 Toxicology pmid:17161894
Narayanan BA Chemopreventive agents alters global gene expression pattern: predicting their mode of action and targets. 2006 Curr Cancer Drug Targets pmid:17168675
Broersen K et al. Alpha-synuclein adopts an alpha-helical conformation in the presence of polyunsaturated fatty acids to hinder micelle formation. 2006 Biochemistry pmid:17176082
De Truchis P et al. Reduction in triglyceride level with N-3 polyunsaturated fatty acids in HIV-infected patients taking potent antiretroviral therapy: a randomized prospective study. 2007 J. Acquir. Immune Defic. Syndr. pmid:17179770
Cole GM and Frautschy SA Docosahexaenoic acid protects from amyloid and dendritic pathology in an Alzheimer's disease mouse model. 2006 Nutr Health pmid:17180870
Yavin E Docosahexaenoic acid: a pluripotent molecule acting as a membrane fluidizer, a cellular antioxidant and a modulator of gene expression. 2006 Nutr Health pmid:17180871
Crawford MA Docosahexaenoic acid in neural signaling systems. 2006 Nutr Health pmid:17180872
Levy BD et al. Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness. 2007 J. Immunol. pmid:17182589