DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Davidson MH et al. Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study. 2007 Clin Ther pmid:17825687
Yang DY et al. Detrimental effects of post-treatment with fatty acids on brain injury in ischemic rats. 2007 Neurotoxicology pmid:17854901
Wittwer J and Hersberger M The two faces of the 15-lipoxygenase in atherosclerosis. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17869078
Block RC et al. EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls. 2008 Atherosclerosis pmid:17875307
Wright SA et al. A randomised interventional trial of omega-3-polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosus. 2008 Ann. Rheum. Dis. pmid:17875549
Shah AP et al. Cardiovascular and endothelial effects of fish oil supplementation in healthy volunteers. 2007 J. Cardiovasc. Pharmacol. Ther. pmid:17875948
Aires V et al. Docosahexaenoic acid induces increases in [Ca2+]i via inositol 1,4,5-triphosphate production and activates protein kinase C gamma and -delta via phosphatidylserine binding site: implication in apoptosis in U937 cells. 2007 Mol. Pharmacol. pmid:17878267
Huang LS et al. Oxygenation of 1-docosahexaenoyl lysophosphatidylcholine by lipoxygenases; conjugated hydroperoxydiene and dihydroxytriene derivatives. 2007 Lipids pmid:17879105
Andersson C et al. Alterations in immune response and PPAR/LXR regulation in cystic fibrosis macrophages. 2008 J. Cyst. Fibros. pmid:17889625
Pignier C et al. Direct protective effects of poly-unsaturated fatty acids, DHA and EPA, against activation of cardiac late sodium current: a mechanism for ischemia selectivity. 2007 Basic Res. Cardiol. pmid:17891522
Takenaka A et al. Unsaturated phosphatidylethanolamine as effective synergist in combination with alpha-tocopherol. 2007 J Oleo Sci pmid:17898457
Barre DE The role of consumption of alpha-linolenic, eicosapentaenoic and docosahexaenoic acids in human metabolic syndrome and type 2 diabetes--a mini-review. 2007 J Oleo Sci pmid:17898498
Ando Y and Nozaki M Lipid profile of mysid Neomysis intermedia and its changes by feeding DHA-rich marine lipids. 2007 J Oleo Sci pmid:17898515
Buydens-Branchey L and Branchey M Long-chain n-3 polyunsaturated fatty acids decrease feelings of anger in substance abusers. 2008 Psychiatry Res pmid:17900705
Huang WL et al. A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury. 2007 Brain pmid:17901087
Polozova A and Salem N Role of liver and plasma lipoproteins in selective transport of n-3 fatty acids to tissues: a comparative study of 14C-DHA and 3H-oleic acid tracers. 2007 J. Mol. Neurosci. pmid:17901547
Watkins PA and Hamilton JA Roundtable discussion of session 2: lipoproteins and polyunsaturated fatty acids. 2007 J. Mol. Neurosci. pmid:17901549
Watkins PA and Hamilton JA Roundtable discussion of session 4: fatty acids and lipids in brain disorders. 2007 J. Mol. Neurosci. pmid:17901556
Colombo C Liver disease in cystic fibrosis. 2007 Curr Opin Pulm Med pmid:17901760
Li CC et al. DHA down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes by attenuating CAR translocation. 2007 Toxicol. Appl. Pharmacol. pmid:17904175
Mollard RC and Weiler HA Bone resorption varies as a function of time of day and quantity of dietary long chain polyunsaturated fatty acids. 2008 J. Nutr. Biochem. pmid:17904343
Chen S and Subbaiah PV Phospholipid and fatty acid specificity of endothelial lipase: potential role of the enzyme in the delivery of docosahexaenoic acid (DHA) to tissues. 2007 Biochim. Biophys. Acta pmid:17905648
Yagil C and Yagil Y Peroxisome proliferator-activated receptor alpha: friend or foe? 2007 Hypertension pmid:17909117
Alessandri JM et al. Estradiol favors the formation of eicosapentaenoic acid (20:5n-3) and n-3 docosapentaenoic acid (22:5n-3) from alpha-linolenic acid (18:3n-3) in SH-SY5Y neuroblastoma cells. 2008 Lipids pmid:17912567
Hoffman D et al. Soy-based infant formula supplemented with DHA and ARA supports growth and increases circulating levels of these fatty acids in infants. 2008 Lipids pmid:17912568
Song WL et al. Neurofurans, novel indices of oxidant stress derived from docosahexaenoic acid. 2008 J. Biol. Chem. pmid:17921521
Cerchietti LC et al. Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and preferential Cox-2 inhibition on systemic syndromes in patients with advanced lung cancer. 2007 Nutr Cancer pmid:17927497
Little SJ et al. Docosahexaenoic acid-induced changes in phospholipids in cortex of young and aged rats: a lipidomic analysis. 2007 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:17928211
Rahman MM et al. Docosahexaenoic acid is more potent inhibitor of osteoclast differentiation in RAW 264.7 cells than eicosapentaenoic acid. 2008 J. Cell. Physiol. pmid:17929247
Blum R et al. Genotoxicity and subchronic toxicity studies of DHA-rich oil in rats. 2007 Regul. Toxicol. Pharmacol. pmid:17933446
Salvati S et al. Eicosapentaenoic acid stimulates the expression of myelin proteins in rat brain. 2008 J. Neurosci. Res. pmid:17941053
Pazirandeh S et al. Supplementation of arachidonic acid plus docosahexaenoic acid in cirrhotic patients awaiting liver transplantation: a preliminary study. 2007 Nov-Dec JPEN J Parenter Enteral Nutr pmid:17947609
Chen S and Li KW Mass spectrometric identification of molecular species of phosphatidylcholine and lysophosphatidylcholine extracted from shark liver. 2007 J. Agric. Food Chem. pmid:17949052
Schaefer MB et al. Fatty acids differentially influence phosphatidylinositol 3-kinase signal transduction in endothelial cells: impact on adhesion and apoptosis. 2008 Atherosclerosis pmid:17950294
Sakamoto T et al. Oral supplementation with docosahexaenoic acid and uridine-5'-monophosphate increases dendritic spine density in adult gerbil hippocampus. 2007 Brain Res. pmid:17950710
Schiavone A et al. Breast meat traits of Muscovy ducks fed on a microalga (Crypthecodinium cohnii) meal supplemented diet. 2007 Br. Poult. Sci. pmid:17952729
Xia Y et al. [Effects of EPA, DHA on the secretion of NO, expression of iNOS mRNA and DNA-binding activity of NFkappaB in human monocyte]. 2007 Wei Sheng Yan Jiu pmid:17953212
Serhan CN et al. Mediator lipidomics: search algorithms for eicosanoids, resolvins, and protectins. 2007 Meth. Enzymol. pmid:17954222
Arneson KO and Roberts LJ Measurement of products of docosahexaenoic acid peroxidation, neuroprostanes, and neurofurans. 2007 Meth. Enzymol. pmid:17954232
von Schacky C [Omega-3 fatty acids in cardiology. Latest developments]. 2007 MMW Fortschr Med pmid:17955786
Rogers PJ et al. No effect of n-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: a randomised controlled trial. 2008 Br. J. Nutr. pmid:17956647
Dunstan JA et al. The effects of fish oil supplementation in pregnancy on breast milk fatty acid composition over the course of lactation: a randomized controlled trial. 2007 Pediatr. Res. pmid:17957152
Muthayya S et al. The effect of fish and omega-3 LCPUFA intake on low birth weight in Indian pregnant women. 2009 Eur J Clin Nutr pmid:17957193
Bazan NG Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture. 2007 Invest. Ophthalmol. Vis. Sci. pmid:17962433
Chucair AJ et al. Lutein and zeaxanthin protect photoreceptors from apoptosis induced by oxidative stress: relation with docosahexaenoic acid. 2007 Invest. Ophthalmol. Vis. Sci. pmid:17962470
Serhan CN and Chiang N Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus. 2008 Br. J. Pharmacol. pmid:17965751
Sugihara S et al. An EntD-like phosphopantetheinyl transferase gene from Photobacterium profundum SS9 complements pfa genes of Moritella marina strain MP-1 involved in biosynthesis of docosahexaenoic acid. 2008 Biotechnol. Lett. pmid:17973084
Blum R et al. One-generation reproductive toxicity study of DHA-rich oil in rats. 2007 Regul. Toxicol. Pharmacol. pmid:17976878
Milte CM et al. Dose-dependent effects of docosahexaenoic acid-rich fish oil on erythrocyte docosahexaenoic acid and blood lipid levels. 2008 Br. J. Nutr. pmid:17977469
Delarue J et al. Fish oil attenuates adrenergic overactivity without altering glucose metabolism during an oral glucose load in haemodialysis patients. 2008 Br. J. Nutr. pmid:17977474
Haworth O and Levy BD Endogenous lipid mediators in the resolution of airway inflammation. 2007 Eur. Respir. J. pmid:17978156
Gajewski BJ et al. Predicting accrual in clinical trials with Bayesian posterior predictive distributions. 2008 Stat Med pmid:17979152
Krauss-Etschmann S et al. Decreased cord blood IL-4, IL-13, and CCR4 and increased TGF-beta levels after fish oil supplementation of pregnant women. 2008 J. Allergy Clin. Immunol. pmid:17980419
Wu KT et al. Vasodilator action of docosahexaenoic acid (DHA) in human coronary arteries in vitro. 2007 Chin J Physiol pmid:17982914
Stark KD The percentage of n-3 highly unsaturated fatty acids in total HUFA as a biomarker for omega-3 fatty acid status in tissues. 2008 Lipids pmid:17985169
Sublette ME et al. Plasma free polyunsaturated fatty acid levels are associated with symptom severity in acute mania. 2007 Bipolar Disord pmid:17988367
Carnielli VP et al. Synthesis of long-chain polyunsaturated fatty acids in preterm newborns fed formula with long-chain polyunsaturated fatty acids. 2007 Am. J. Clin. Nutr. pmid:17991642
Conklin SM et al. High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. 2007 Psychosom Med pmid:17991818
Siahanidou T et al. Oxidative stress in preterm infants fed a formula containing long-chain polyunsaturated fatty acids (LCPUFA). 2007 Am J Perinatol pmid:17992715
Zanoni G et al. Asymmetric synthesis of 14-A4t-neuroprostane: hunting for a suitable biomarker for neurodegenerative diseases. 2007 J. Org. Chem. pmid:17994761
Moriya H et al. Combination effect of herring roe lipids and proteins on plasma lipids and abdominal fat weight of mouse. 2007 J. Food Sci. pmid:17995707
Borneo R et al. Stability and consumer acceptance of long-chain omega-3 fatty acids (eicosapentaenoic acid, 20:5, n-3 and docosahexaenoic acid, 22:6, n-3) in cream-filled sandwich cookies. 2007 J. Food Sci. pmid:17995897
Kale A et al. Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patients. 2008 Schizophr. Res. pmid:17997280
Rühl R et al. Fatty acid composition of serum lipid classes in mice following allergic sensitisation with or without dietary docosahexaenoic acid-enriched fish oil substitution. 2008 Br. J. Nutr. pmid:18005485
Kuriki K et al. Gastric cancer risk and erythrocyte composition of docosahexaenoic acid with anti-inflammatory effects. 2007 Cancer Epidemiol. Biomarkers Prev. pmid:18006930
Poulsen RC et al. Specific effects of gamma-linolenic, eicosapentaenoic, and docosahexaenoic ethyl esters on bone post-ovariectomy in rats. 2007 Calcif. Tissue Int. pmid:18008020
De Smedt-Peyrusse V et al. Docosahexaenoic acid prevents lipopolysaccharide-induced cytokine production in microglial cells by inhibiting lipopolysaccharide receptor presentation but not its membrane subdomain localization. 2008 J. Neurochem. pmid:18021297
Brenna JT and Diau GY The influence of dietary docosahexaenoic acid and arachidonic acid on central nervous system polyunsaturated fatty acid composition. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18023566
Mitchell TW et al. Membrane phospholipid composition may contribute to exceptional longevity of the naked mole-rat (Heterocephalus glaber): a comparative study using shotgun lipidomics. 2007 Exp. Gerontol. pmid:18029129
Walkowiak J et al. Polyunsaturated fatty acids in cystic fibrosis are related to nutrition and clinical expression of the disease. 2007 J. Pediatr. Gastroenterol. Nutr. pmid:18030219
Calder PC Immunomodulation by omega-3 fatty acids. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18032006
Bhale SD et al. Oregano and rosemary extracts inhibit oxidation of long-chain n-3 fatty acids in menhaden oil. 2007 J. Food Sci. pmid:18034711
Taha AY et al. Seizure resistance in fat-1 transgenic mice endogenously synthesizing high levels of omega-3 polyunsaturated fatty acids. 2008 J. Neurochem. pmid:18036191
Al-Turkmani MR et al. Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18036797
Calderon F and Kim HY Role of RXR in neurite outgrowth induced by docosahexaenoic acid. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18036800
Michael-Titus AT Omega-3 fatty acids and neurological injury. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18036801
Plourde M et al. Unresolved issues in the link between docosahexaenoic acid and Alzheimer's disease. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18036804
Calon F and Cole G Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18037281
Pomponi M and Pomponi M DHA deficiency and Alzheimer's disease. 2008 Clin Nutr pmid:18037538
Pifferi F et al. n-3 Fatty acids modulate brain glucose transport in endothelial cells of the blood-brain barrier. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18042368
Palmblad J et al. [Omega-3-fatty acids protect against dementia. Also early symptoms of mild Alzheimer disease seem to be inhibited]. 2007 Oct 31-Nov 6 Lakartidningen pmid:18050989
Armah CK et al. Fish oil fatty acids improve postprandial vascular reactivity in healthy men. 2008 Clin. Sci. pmid:18052925
Das UN Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer's disease--but how and why? 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18054217
Tamai T et al. Effects of supplemented diacylglycerol rich in docosahexaenoic acid on serum triacylglycerol in a diet-induced hyperlipidemic model of rats are essentially equivalent to those of triacylglycerol rich in docosahexaenoic acid. 2007 Biol. Pharm. Bull. pmid:18057730
Zhang W et al. Modulatory effects of EPA and DHA on proliferation and apoptosis of pancreatic cancer cells. 2007 J. Huazhong Univ. Sci. Technol. Med. Sci. pmid:18060632
Buydens-Branchey L et al. Associations between increases in plasma n-3 polyunsaturated fatty acids following supplementation and decreases in anger and anxiety in substance abusers. 2008 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:18060675
Rapoport SI et al. Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18060754
Mukherjee PK et al. Docosanoids are multifunctional regulators of neural cell integrity and fate: significance in aging and disease. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18060755
Maes M et al. Why fish oils may not always be adequate treatments for depression or other inflammatory illnesses: docosahexaenoic acid, an omega-3 polyunsaturated fatty acid, induces a Th-1-like immune response. 2007 Neuro Endocrinol. Lett. pmid:18063921
Harris WS et al. Comparison of the effects of fish and fish-oil capsules on the n 3 fatty acid content of blood cells and plasma phospholipids. 2007 Am. J. Clin. Nutr. pmid:18065578
Muskiet FA et al. The basis of recommendations for docosahexaenoic and arachidonic acids in infant formula: absolute or relative standards? 2007 Am. J. Clin. Nutr. pmid:18065601
Okuyama H et al. Significance of antioxidative functions of eicosapentaenoic and docosahexaenoic acids in marine microorganisms. 2008 Appl. Environ. Microbiol. pmid:18065628
Lyberg AM and Adlercreutz P Lipase specificity towards eicosapentaenoic acid and docosahexaenoic acid depends on substrate structure. 2008 Biochim. Biophys. Acta pmid:18067872
Chapkin RS et al. Docosahexaenoic acid alters the size and distribution of cell surface microdomains. 2008 Biochim. Biophys. Acta pmid:18068112
Yuen AW et al. Erythrocyte and plasma fatty acid profiles in patients with epilepsy: does carbamazepine affect omega-3 fatty acid concentrations? 2008 Epilepsy Behav pmid:18068523
Kidd PM Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids. 2007 Altern Med Rev pmid:18072818
Yi L et al. [Role of Rho GTPase in inhibiting metastatic ability of human prostate cancer cell line PC-3 by omega-3 polyunsaturated fatty acid]. 2007 Ai Zheng pmid:18076787
Nah SY et al. Ginsenosides: are any of them candidates for drugs acting on the central nervous system? 2007 CNS Drug Rev pmid:18078425
Hirunpanich V et al. Inhibitory effect of docosahexaenoic acid (DHA) on the intestinal metabolism of midazolam: in vitro and in vivo studies in rats. 2008 Int J Pharm pmid:18082981
Peltier S et al. Preferential enrichment of liver phospholipids in docosahexaenoate relative to eicosapentaenoate in omega-3-depleted rats injected with a medium-chain triglyceride: fish oil emulsion. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18083359