| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Le HD et al. | The effect of varying ratios of docosahexaenoic acid and arachidonic acid in the prevention and reversal of biochemical essential fatty acid deficiency in a murine model. | 2013 | Metab. Clin. Exp. | pmid:23151438 |
| Huang LL et al. | Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23474173 |
| Mozaffarian D et al. | Plasma phospholipid long-chain ω-3 fatty acids and total and cause-specific mortality in older adults: a cohort study. | 2013 | Ann. Intern. Med. | pmid:23546563 |
| Correia Bacarin C et al. | Fish oil provides robust and sustained memory recovery after cerebral ischemia: influence of treatment regimen. | 2013 | Physiol. Behav. | pmid:23770426 |
| Stulnig G et al. | Docosahexaenoic acid (DHA)-induced heme oxygenase-1 attenuates cytotoxic effects of DHA in vascular smooth muscle cells. | 2013 | Atherosclerosis | pmid:24075775 |
| Dalal JJ et al. | Role of omega-3 ethyl ester concentrate in reducing sudden cardiac death following myocardial infarction and in management of hypertriglyceridemia: an Indian consensus statement. | 2012 Sep-Oct | Indian Heart J | pmid:23102390 |
| Baum SJ | EPA and DHA: distinct yet essential n-3 fatty acids. | 2012 Sep-Oct | J Clin Lipidol | pmid:23009786 |
| Castro González MI et al. | [Renal patient's diet: Can fish be included?]. | 2012 Sep-Oct | Nutr Hosp | pmid:23478696 |
| Block RC et al. | The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23017325 |
| Kartikasari LR et al. | Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22925778 |
| Ma L et al. | Arginyl-glutamine dipeptide or docosahexaenoic acid attenuate hyperoxia-induced lung injury in neonatal mice. | 2012 Nov-Dec | Nutrition | pmid:23044165 |
| Sanz ParÃs A et al. | [Proposed profile of omega 3 fatty acids in enteral nutrition]. | 2012 Nov-Dec | Nutr Hosp | pmid:23588426 |
| Brown WV | From the editor. | 2012 Nov-Dec | J Clin Lipidol | pmid:23312044 |
| Derosa G et al. | Effects of n-3 PUFAs on postprandial variation of metalloproteinases, and inflammatory and insulin resistance parameters in dyslipidemic patients: evaluation with euglycemic clamp and oral fat load. | 2012 Nov-Dec | J Clin Lipidol | pmid:23312051 |
| Davidson MH et al. | A novel omega-3 free fatty acid formulation has dramatically improved bioavailability during a low-fat diet compared with omega-3-acid ethyl esters: the ECLIPSE (Epanova(®) compared to Lovaza(®) in a pharmacokinetic single-dose evaluation) study. | 2012 Nov-Dec | J Clin Lipidol | pmid:23312053 |
| Abad S and Turon X | Valorization of biodiesel derived glycerol as a carbon source to obtain added-value metabolites: Focus on polyunsaturated fatty acids. | 2012 May-Jun | Biotechnol. Adv. | pmid:22261015 |
| An WS et al. | Effect of omega-3 fatty acids on the modification of erythrocyte membrane fatty acid content including oleic acid in peritoneal dialysis patients. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22071008 |
| Jacobson TA et al. | Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: a review. | 2012 Jan-Feb | J Clin Lipidol | pmid:22264569 |
| Widgerow AD | Cellular resolution of inflammation--catabasis. | 2012 Jan-Feb | Wound Repair Regen | pmid:22276585 |
| Kuipers RS et al. | Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22115845 |
| Brenna T | Tissue-specific LCPUFA accretion in fetal humans. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22078006 |
| Helmersson-Karlqvist J et al. | Enhanced prostaglandin F2α formation in human pregnancy and the effect of increased oily fish intake: results from the Salmon in Pregnancy Study. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22047909 |
| Kuipers RS et al. | Gestational age dependent content, composition and intrauterine accretion rates of fatty acids in fetal white adipose tissue. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22093549 |
| Jackson PA et al. | DHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: a near IR spectroscopy pilot study. | 2012 | Br. J. Nutr. | pmid:22018509 |
| Tyburczy C et al. | Growth, clinical chemistry and immune function in domestic piglets fed varying ratios of arachidonic acid and DHA. | 2012 | Br. J. Nutr. | pmid:22040360 |
| Schmitt D et al. | Toxicologic evaluation of DHA-rich algal oil: Genotoxicity, acute and subchronic toxicity in rats. | 2012 | Food Chem. Toxicol. | pmid:22898615 |
| Serini S et al. | DHA induces apoptosis and differentiation in human melanoma cells in vitro: involvement of HuR-mediated COX-2 mRNA stabilization and β-catenin nuclear translocation. | 2012 | Carcinogenesis | pmid:22045024 |
| An WS et al. | Omega-3 fatty acid supplementation increases 1,25-dihydroxyvitamin D and fetuin-A levels in dialysis patients. | 2012 | Nutr Res | pmid:22901557 |
| Hjorth E and Freund-Levi Y | Immunomodulation of microglia by docosahexaenoic acid and eicosapentaenoic acid. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:22316559 |
| Liu RZ et al. | A fatty acid-binding protein 7/RXRβ pathway enhances survival and proliferation in triple-negative breast cancer. | 2012 | J. Pathol. | pmid:22322885 |
| Browning LM et al. | Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish. | 2012 | Am. J. Clin. Nutr. | pmid:22932281 |
| Alvarez-Nölting R et al. | Protection by DHA of early hippocampal changes in diabetes: possible role of CREB and NF-κB. | 2012 | Neurochem. Res. | pmid:21909958 |
| Pifferi F et al. | Fatty acid composition of the brain, retina, liver and adipose tissue of the grey mouse lemur (Microcebus murinus, primate). | 2012 | Lipids | pmid:22684890 |
| Cortina MS et al. | Recovery of corneal sensitivity, calcitonin gene-related peptide-positive nerves, and increased wound healing induced by pigment epithelial-derived factor plus docosahexaenoic acid after experimental surgery. | 2012 | Arch. Ophthalmol. | pmid:21911652 |
| Heinze VM and Actis AB | Dietary conjugated linoleic acid and long-chain n-3 fatty acids in mammary and prostate cancer protection: a review. | 2012 | Int J Food Sci Nutr | pmid:21762028 |
| Basselin M et al. | Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans. | 2012 | Brain Res. Bull. | pmid:22178644 |
| van der Meij BS et al. | Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT. | 2012 | Eur J Clin Nutr | pmid:22234041 |
| Trépanier MO et al. | Increases in seizure latencies induced by subcutaneous docosahexaenoic acid are lost at higher doses. | 2012 | Epilepsy Res. | pmid:22285511 |
| Signori C et al. | Administration of omega-3 fatty acids and Raloxifene to women at high risk of breast cancer: interim feasibility and biomarkers analysis from a clinical trial. | 2012 | Eur J Clin Nutr | pmid:22669332 |
| Wu MH et al. | Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10. | 2012 | J. Nutr. Biochem. | pmid:22285823 |
| Rasic-Milutinovic Z et al. | Lower serum paraoxonase-1 activity is related to linoleic and docosahexanoic fatty acids in type 2 diabetic patients. | 2012 | Arch. Med. Res. | pmid:22222492 |
| Hacioglu G et al. | Docosahexaenoic acid provides protective mechanism in bilaterally MPTP-lesioned rat model of Parkinson's disease. | 2012 | Folia Histochem. Cytobiol. | pmid:22763967 |
| Scheltens P et al. | Efficacy of Souvenaid in mild Alzheimer's disease: results from a randomized, controlled trial. | 2012 | J. Alzheimers Dis. | pmid:22766770 |
| Trikalinos TA et al. | Concordance of randomized and nonrandomized studies was unrelated to translational patterns of two nutrient-disease associations. | 2012 | J Clin Epidemiol | pmid:22047889 |
| Angulo J et al. | Dietary fatty acid intervention of lactating cows simultaneously affects lipid profiles of meat and milk. | 2012 | J. Sci. Food Agric. | pmid:22549272 |
| Zhou SJ et al. | Fish-oil supplementation in pregnancy does not reduce the risk of gestational diabetes or preeclampsia. | 2012 | Am. J. Clin. Nutr. | pmid:22552037 |
| Bernstein AM et al. | A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease. | 2012 | J. Nutr. | pmid:22113870 |
| Yui K et al. | Effects of large doses of arachidonic acid added to docosahexaenoic acid on social impairment in individuals with autism spectrum disorders: a double-blind, placebo-controlled, randomized trial. | 2012 | J Clin Psychopharmacol | pmid:22370992 |
| Finocchiaro C et al. | Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study. | 2012 | Br. J. Nutr. | pmid:22114792 |
| Crnkovic S et al. | Docosahexaenoic acid-induced unfolded protein response, cell cycle arrest, and apoptosis in vascular smooth muscle cells are triggered by Ca²âº-dependent induction of oxidative stress. | 2012 | Free Radic. Biol. Med. | pmid:22391221 |