DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Gani OA and Sylte I Molecular recognition of docosahexaenoic acid by peroxisome proliferator-activated receptors and retinoid-X receptor alpha. 2008 J. Mol. Graph. Model. pmid:18547851
Gani OA and Sylte I Ligand-induced stabilization and activation of peroxisome proliferator-activated receptor gamma. 2008 Chem Biol Drug Des pmid:18554251
Buckley JD et al. DHA-rich fish oil lowers heart rate during submaximal exercise in elite Australian Rules footballers. 2009 J Sci Med Sport pmid:18555744
Li P et al. Dietary supplementation with cholesterol and docosahexaenoic acid increases the activity of the arginine-nitric oxide pathway in tissues of young pigs. 2008 Nitric Oxide pmid:18555806
Aarsetøy H et al. Low levels of cellular omega-3 increase the risk of ventricular fibrillation during the acute ischaemic phase of a myocardial infarction. 2008 Resuscitation pmid:18556107
Merched AJ et al. Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators. 2008 FASEB J. pmid:18559988
Jakobsen AN et al. Accumulation of docosahexaenoic acid-rich lipid in thraustochytrid Aurantiochytrium sp. strain T66: effects of N and P starvation and O2 limitation. 2008 Appl. Microbiol. Biotechnol. pmid:18560831
Wilding TJ et al. Amino acid substitutions in the pore helix of GluR6 control inhibition by membrane fatty acids. 2008 J. Gen. Physiol. pmid:18562501
Andersen G et al. Dietary eicosapentaenoic acid and docosahexaenoic acid are more effective than alpha-linolenic acid in improving insulin sensitivity in rats. 2008 Ann. Nutr. Metab. pmid:18562792
Walser B and Stebbins CL Omega-3 fatty acid supplementation enhances stroke volume and cardiac output during dynamic exercise. 2008 Eur. J. Appl. Physiol. pmid:18563435
Jakobsen CH et al. DHA induces ER stress and growth arrest in human colon cancer cells: associations with cholesterol and calcium homeostasis. 2008 J. Lipid Res. pmid:18566476
Zand H et al. Docosahexaenoic acid sensitizes Ramos cells to Gamma-irradiation-induced apoptosis through involvement of PPAR-gamma activation and NF-kappaB suppression. 2008 Mol. Cell. Biochem. pmid:18566752
Koletzko B Prenatal supply of docosahexaenoic acid (DHA): should we be worried? 2008 J Perinat Med pmid:18576939
Hirunpanich V et al. Ethyl docosahexaenoate decreased Neoral absorption due to particle size enlargement. 2008 Int J Pharm pmid:18577438
Sontrop J et al. Depressive symptoms during pregnancy in relation to fish consumption and intake of n-3 polyunsaturated fatty acids. 2008 Paediatr Perinat Epidemiol pmid:18578753
Mathieu G et al. Synergistic effects of stress and omega-3 fatty acid deprivation on emotional response and brain lipid composition in adult rats. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18579362
Meguid NA et al. Role of polyunsaturated fatty acids in the management of Egyptian children with autism. 2008 Clin. Biochem. pmid:18582451
Bonham MP et al. Habitual fish consumption does not prevent a decrease in LCPUFA status in pregnant women (the Seychelles Child Development Nutrition Study). 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18585023
Hamazaki K et al. The effects of docosahexaenoic acid-rich fish oil on behavior, school attendance rate and malaria infection in school children--a double-blind, randomized, placebo-controlled trial in Lampung, Indonesia. 2008 Asia Pac J Clin Nutr pmid:18586645
Arterburn LM et al. Algal-oil capsules and cooked salmon: nutritionally equivalent sources of docosahexaenoic acid. 2008 J Am Diet Assoc pmid:18589030
Coates AM et al. Regular consumption of n-3 fatty acid-enriched pork modifies cardiovascular risk factors. 2009 Br. J. Nutr. pmid:18590592
Brown J et al. Binge ethanol-induced neurodegeneration in rat organotypic brain slice cultures: effects of PLA2 inhibitor mepacrine and docosahexaenoic acid (DHA). 2009 Neurochem. Res. pmid:18592376
Orr SK and Bazinet RP The emerging role of docosahexaenoic acid in neuroinflammation. 2008 Curr Opin Investig Drugs pmid:18600579
Shi Y and Pestka JJ Mechanisms for suppression of interleukin-6 expression in peritoneal macrophages from docosahexaenoic acid-fed mice. 2009 J. Nutr. Biochem. pmid:18602807
Holguin S et al. Dietary uridine enhances the improvement in learning and memory produced by administering DHA to gerbils. 2008 FASEB J. pmid:18606862
Dirix CE et al. Associations between neonatal birth dimensions and maternal essential and trans fatty acid contents during pregnancy and at delivery. 2009 Br. J. Nutr. pmid:18613984
Manna S et al. Dietary fish oil associated with increased apoptosis and modulated expression of Bax and Bcl-2 during 7,12-dimethylbenz(alpha)anthracene-induced mammary carcinogenesis in rats. 2008 Jul-Aug Prostaglandins Leukot. Essent. Fatty Acids pmid:18614344
Sun Q et al. Blood concentrations of individual long-chain n-3 fatty acids and risk of nonfatal myocardial infarction. 2008 Am. J. Clin. Nutr. pmid:18614744
Kaur P et al. Docosahexaenoic acid may act as a neuroprotector for methylmercury-induced neurotoxicity in primary neural cell cultures. 2008 Neurotoxicology pmid:18619488
Wu A et al. Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. 2008 Neuroscience pmid:18620024
Robson LG et al. Omega-3 polyunsaturated fatty acids increase the neurite outgrowth of rat sensory neurones throughout development and in aged animals. 2010 Neurobiol. Aging pmid:18620782
Saedisomeolia A et al. Anti-inflammatory effects of long-chain n-3 PUFA in rhinovirus-infected cultured airway epithelial cells. 2009 Br. J. Nutr. pmid:18631417
Cansev M et al. Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses. 2008 Alzheimers Dement pmid:18631994
Zapata-Gonzalez F et al. Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPAR(gamma):RXR heterodimers: comparison with other polyunsaturated fatty acids. 2008 J. Leukoc. Biol. pmid:18632990
Willis S et al. Eicosapentaenoic and docosahexaenoic acids are not anticonvulsant or neuroprotective in acute mouse seizure models. 2009 Epilepsia pmid:18637828
Hanebutt FL et al. Long-chain polyunsaturated fatty acid (LC-PUFA) transfer across the placenta. 2008 Clin Nutr pmid:18639956
Dinan T et al. Investigating the inflammatory phenotype of major depression: focus on cytokines and polyunsaturated fatty acids. 2009 J Psychiatr Res pmid:18640689
Tanaka K et al. Does breastfeeding in the neonatal period influence the cognitive function of very-low-birth-weight infants at 5 years of age? 2009 Brain Dev. pmid:18640798
Streppel MT et al. Long-term fish consumption and n-3 fatty acid intake in relation to (sudden) coronary heart disease death: the Zutphen study. 2008 Eur. Heart J. pmid:18641046
Shaikh IA et al. Docosahexaenoic acid enhances the efficacy of docetaxel in prostate cancer cells by modulation of apoptosis: the role of genes associated with the NF-kappaB pathway. 2008 Prostate pmid:18668525
Onuki Y et al. Specific effect of polyunsaturated fatty acids on the cholesterol-poor membrane domain in a model membrane. 2008 Chem. Pharm. Bull. pmid:18670110
Serhan CN Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators. 2008 J. Periodontol. pmid:18673006
van Goor SA et al. Milk of women with lifetime consumption of the recommended daily intake of fish fatty acids should constitute the basis for the DHA contents of infant formula. 2008 J Perinat Med pmid:18673085
Dujardin KS et al. Ultrafast sodium channel block by dietary fish oil prevents dofetilide-induced ventricular arrhythmias in rabbit hearts. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18676685
Yu YH et al. Docosahexaenoic acid regulates adipogenic genes in myoblasts via porcine peroxisome proliferator-activated receptor gamma. 2008 J. Anim. Sci. pmid:18676720
Serini S et al. Docosahexaenoic acid induces apoptosis in lung cancer cells by increasing MKP-1 and down-regulating p-ERK1/2 and p-p38 expression. 2008 Apoptosis pmid:18679798
Shaw DI et al. LIPGENE food-exchange model for alteration of dietary fat quantity and quality in free-living participants from eight European countries. 2009 Br. J. Nutr. pmid:18680629
Stebbins CL et al. Effects of dietary decosahexaenoic acid (DHA) on eNOS in human coronary artery endothelial cells. 2008 J. Cardiovasc. Pharmacol. Ther. pmid:18682551
Ferraro PM et al. Combined treatment with renin-angiotensin system blockers and polyunsaturated fatty acids in proteinuric IgA nephropathy: a randomized controlled trial. 2009 Nephrol. Dial. Transplant. pmid:18685141
Bourre JM and Paquotte PM Contributions (in 2005) of marine and fresh water products (finfish and shellfish, seafood, wild and farmed) to the French dietary intakes of vitamins D and B12, selenium, iodine and docosahexaenoic acid: impact on public health. 2008 Int J Food Sci Nutr pmid:18686110
Augood C et al. Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration. 2008 Am. J. Clin. Nutr. pmid:18689376
Rosenfeld E et al. IPD meta-analysis shows no effect of LC-PUFA supplementation on infant growth at 18 months. 2009 Acta Paediatr. pmid:18691337
Levant B et al. Decreased brain docosahexaenoic acid content produces neurobiological effects associated with depression: Interactions with reproductive status in female rats. 2008 Psychoneuroendocrinology pmid:18707812
Lau BY et al. Femur EPA and DHA are correlated with femur biomechanical strength in young fat-1 mice. 2009 J. Nutr. Biochem. pmid:18708283
Mebarek S et al. Effects of increasing docosahexaenoic acid intake in human healthy volunteers on lymphocyte activation and monocyte apoptosis. 2009 Br. J. Nutr. pmid:18710607
Novak EM et al. High dietary omega-6 fatty acids contribute to reduced docosahexaenoic acid in the developing brain and inhibit secondary neurite growth. 2008 Brain Res. pmid:18710653
Raghukumar S Thraustochytrid Marine Protists: production of PUFAs and Other Emerging Technologies. 2008 Nov-Dec Mar. Biotechnol. pmid:18712565
McNamara RK et al. Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder. 2008 Psychiatry Res pmid:18715653
Schobert R et al. Conjugates of the fungal cytotoxin illudin M with improved tumour specificity. 2008 Bioorg. Med. Chem. pmid:18715789
Annuzzi G et al. A controlled study on the effects of n-3 fatty acids on lipid and glucose metabolism in non-insulin-dependent diabetic patients. 1991 Atherosclerosis pmid:1872925
Huang J et al. Expressed sequence tag analysis of marine fungus Schizochytrium producing docosahexaenoic acid. 2008 J. Biotechnol. pmid:18755227
Cansev M et al. Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease. 2008 Neurosci. Res. pmid:18761383
Scheja L et al. Liver TAG transiently decreases while PL n-3 and n-6 fatty acids are persistently elevated in insulin resistant mice. 2008 Lipids pmid:18763007
De Groote G et al. Improvement in the plasma omega-3 index by the use of a fish oil-enriched spread. 2008 Ann. Nutr. Metab. pmid:18772586
D Guillén M et al. Characterization of cod liver oil by spectroscopic techniques. New approaches for the determination of compositional parameters, acyl groups, and cholesterol from 1h nuclear magnetic resonance and Fourier transform infrared spectral data. 2008 J. Agric. Food Chem. pmid:18778030
van de Rest O et al. Effect of fish-oil supplementation on mental well-being in older subjects: a randomized, double-blind, placebo-controlled trial. 2008 Am. J. Clin. Nutr. pmid:18779287
Lindberg M et al. Long-chain n-3 fatty acids and mortality in elderly patients. 2008 Am. J. Clin. Nutr. pmid:18779289
Barceló-Coblijn G et al. Flaxseed oil and fish-oil capsule consumption alters human red blood cell n-3 fatty acid composition: a multiple-dosing trial comparing 2 sources of n-3 fatty acid. 2008 Am. J. Clin. Nutr. pmid:18779299
SanGiovanni JP et al. The relationship of dietary omega-3 long-chain polyunsaturated fatty acid intake with incident age-related macular degeneration: AREDS report no. 23. 2008 Arch. Ophthalmol. pmid:18779490
Trattner S et al. Sesamin supplementation increases white muscle docosahexaenoic acid (DHA) levels in rainbow trout (Oncorhynchus mykiss) fed high alpha-linolenic acid (ALA) containing vegetable oil: metabolic actions. 2008 Lipids pmid:18781351
Clayton EH et al. Long-chain omega-3 polyunsaturated fatty acids in the blood of children and adolescents with juvenile bipolar disorder. 2008 Lipids pmid:18781353
Dagai L et al. Docosahexaenoic acid significantly stimulates immediate early response genes and neurite outgrowth. 2009 Neurochem. Res. pmid:18781386
Trattner S et al. Sesamin increases alpha-linolenic acid conversion to docosahexaenoic acid in atlantic salmon (Salmo salar L.) hepatocytes: role of altered gene expression. 2008 Lipids pmid:18784949
Engelbrecht AM et al. Differential induction of apoptosis and inhibition of the PI3-kinase pathway by saturated, monounsaturated and polyunsaturated fatty acids in a colon cancer cell model. 2008 Apoptosis pmid:18785011
Bate C et al. Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells. 2008 BMC Biol. pmid:18789130
Hardman WE and Ion G Suppression of implanted MDA-MB 231 human breast cancer growth in nude mice by dietary walnut. 2008 Nutr Cancer pmid:18791931
Vandal M et al. Plasma omega-3 fatty acid response to a fish oil supplement in the healthy elderly. 2008 Lipids pmid:18795357
McNamara RK et al. Perinatal n-3 fatty acid deficiency selectively reduces myo-inositol levels in the adult rat PFC: an in vivo (1)H-MRS study. 2009 J. Lipid Res. pmid:18802197
Lu CY et al. Docosahexaenoic acid downregulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes via the c-Jun NH2-terminal kinase mitogen-activated protein kinase pathway. 2009 Mol Nutr Food Res pmid:18803253
Wurtman RJ Synapse formation and cognitive brain development: effect of docosahexaenoic acid and other dietary constituents. 2008 Metab. Clin. Exp. pmid:18803968
Morishita M et al. Usefulness of colon targeted DHA and EPA as novel diabetes medications that promote intrinsic GLP-1 secretion. 2008 J Control Release pmid:18804128
Chang CT et al. Eicosapentaenoic-acid-derived isoprostanes: synthesis and discovery of two major isoprostanes. 2008 Bioorg. Med. Chem. Lett. pmid:18804370
Madden J et al. Altered monocyte CD44 expression in peripheral arterial disease is corrected by fish oil supplementation. 2009 Nutr Metab Cardiovasc Dis pmid:18804988
Pan HC et al. Protective effect of docosahexaenoic acid against brain injury in ischemic rats. 2009 J. Nutr. Biochem. pmid:18805685
Qian J et al. [Technology investigation of extracting fish oil by enzymolysising ocean wild fish]. 2008 Sheng Wu Gong Cheng Xue Bao pmid:18807986
Bouvier J et al. Selective decrease of bis(monoacylglycero)phosphate content in macrophages by high supplementation with docosahexaenoic acid. 2009 J. Lipid Res. pmid:18809971
Carsia RV et al. Long-term dietary lipid regimen alters adrenocortical function at the cellular level. 2008 Horm. Metab. Res. pmid:18810711
Krieglstein J et al. Influence of various fatty acids on the activity of protein phosphatase type 2C and apoptosis of endothelial cells and macrophages. 2008 Eur J Pharm Sci pmid:18812221
Alexander JW et al. Influence of long chain polyunsaturated fatty acids and ornithine concentrations on complications after renal transplant. 2008 Exp Clin Transplant pmid:18816238
Jin X et al. Dietary fats altered nephrotoxicity profile of methylmercury in rats. 2009 J Appl Toxicol pmid:18821721
Kafanova TV et al. [Marine fungus Stilbella aciculosa as a potential producer of prostaglandins]. 2008 Jul-Aug Mikrobiologiia pmid:18825978
Buretić-Tomljanović A et al. Phospholipid membrane abnormalities and reduced niacin skin flush response in schizophrenia. 2008 Psychiatr Danub pmid:18827766
Xu Y et al. Maternal di-(2-ethylhexyl)-phthalate exposure influences essential fatty acid homeostasis in rat placenta. 2008 Placenta pmid:18829104
Jiang LH et al. The influence of orally administered docosahexaenoic acid on cognitive ability in aged mice. 2009 J. Nutr. Biochem. pmid:18829287
Koumura A et al. A novel calpain inhibitor, ((1S)-1((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl) carbamic acid 5-methoxy-3-oxapentyl ester, protects neuronal cells from cerebral ischemia-induced damage in mice. 2008 Neuroscience pmid:18835333
Larson MK et al. Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects. 2008 Thromb. Haemost. pmid:18841286
Wang S et al. Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse. 2009 Atherosclerosis pmid:18842266
Amin AA et al. Acute coronary syndrome patients with depression have low blood cell membrane omega-3 fatty acid levels. 2008 Psychosom Med pmid:18842751
Smithers LG et al. Higher dose of docosahexaenoic acid in the neonatal period improves visual acuity of preterm infants: results of a randomized controlled trial. 2008 Am. J. Clin. Nutr. pmid:18842793
Patterson AC and Stark KD Direct determinations of the fatty acid composition of daily dietary intakes incorporating nutraceuticals and functional food strategies to increase n-3 highly unsaturated fatty acids. 2008 J Am Coll Nutr pmid:18845703