| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pomponi M et al. | Fatty aspirin: a new perspective in the prevention of dementia of Alzheimer's type? | 2008 | Curr Alzheimer Res | pmid:18855583 |
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| Davidson MH et al. | Marine oil capsule therapy for the treatment of hyperlipidemia. | 1991 | Arch. Intern. Med. | pmid:1888238 |
| Glew RH et al. | Low docosahexaenoic acid in the diet and milk of women in New Mexico. | 2008 | J Am Diet Assoc | pmid:18926136 |
| Thienprasert A et al. | Fish oil n-3 polyunsaturated fatty acids selectively affect plasma cytokines and decrease illness in Thai schoolchildren: a randomized, double-blind, placebo-controlled intervention trial. | 2009 | J. Pediatr. | pmid:18930251 |
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| Vanderhoof JA | Hypoallergenicity and effects on growth and tolerance of a new amino acid-based formula with DHA and ARA. | 2008 | J. Pediatr. Gastroenterol. Nutr. | pmid:18931605 |
| Weseler AR et al. | Dietary arachidonic acid dose-dependently increases the arachidonic acid concentration in human milk. | 2008 | J. Nutr. | pmid:18936218 |
| Chi Z et al. | Study of a two-stage growth of DHA-producing marine algae Schizochytrium limacinum SR21 with shifting dissolved oxygen level. | 2009 | Appl. Microbiol. Biotechnol. | pmid:18936938 |
| Harris WS et al. | Intakes of long-chain omega-3 fatty acid associated with reduced risk for death from coronary heart disease in healthy adults. | 2008 | Curr Atheroscler Rep | pmid:18937898 |
| Lapenna D et al. | Inhibitory activity of salicylic acid on lipoxygenase-dependent lipid peroxidation. | 2009 | Biochim. Biophys. Acta | pmid:18950686 |
| Brouwer IA | Omega-3 PUFA: good or bad for prostate cancer? | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18951003 |
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| Ozogul Y et al. | Fat content and fatty acid compositions of 34 marine water fish species from the Mediterranean Sea. | 2009 | Int J Food Sci Nutr | pmid:18972241 |
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| Nodari S et al. | The role of n-3 PUFAs in preventing the arrhythmic risk in patients with idiopathic dilated cardiomyopathy. | 2009 | Cardiovasc Drugs Ther | pmid:18982439 |
| Arai Y et al. | Effect of dietary Lorenzo's oil and docosahexaenoic acid treatment for Zellweger syndrome. | 2008 | Congenit Anom (Kyoto) | pmid:18983586 |
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| Noffs MD et al. | Dietary fish oil replacement with lard and soybean oil affects triacylglycerol and phospholipid muscle and liver docosahexaenoic acid content but not in the brain and eyes of surubim juveniles Pseudoplatystoma sp. | 2009 | Fish Physiol. Biochem. | pmid:18989742 |
| McNamara RK et al. | Chronic risperidone treatment preferentially increases rat erythrocyte and prefrontal cortex omega-3 fatty acid composition: evidence for augmented biosynthesis. | 2009 | Schizophr. Res. | pmid:18993032 |
| Wu H et al. | Docosahexaenoic acid induces ERK1/2 activation and neuritogenesis via intracellular reactive oxygen species production in human neuroblastoma SH-SY5Y cells. | 2009 | Biochim. Biophys. Acta | pmid:18996496 |
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| Tobin KA et al. | Long-chain polyunsaturated fatty acid transport across human placental choriocarcinoma (BeWo) cells. | 2009 | Placenta | pmid:19010540 |
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| Hashimoto M et al. | Docosahexaenoic acid disrupts in vitro amyloid beta(1-40) fibrillation and concomitantly inhibits amyloid levels in cerebral cortex of Alzheimer's disease model rats. | 2008 | J. Neurochem. | pmid:19014387 |
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| Wassall SR and Stillwell W | Polyunsaturated fatty acid-cholesterol interactions: domain formation in membranes. | 2009 | Biochim. Biophys. Acta | pmid:19014904 |
| Zhuo Z et al. | The effect of combination treatment with docosahexaenoic acid and 5-fluorouracil on the mRNA expression of apoptosis-related genes, including the novel gene BCL2L12, in gastric cancer cells. | 2009 Jan-Feb | In Vitro Cell. Dev. Biol. Anim. | pmid:19015929 |
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| Fernandes JS et al. | Long-term treatment with fish oil prevents memory impairments but not hippocampal damage in rats subjected to transient, global cerebral ischemia. | 2008 | Nutr Res | pmid:19083490 |
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| Lucas M et al. | Validation of an FFQ for evaluation of EPA and DHA intake. | 2009 | Public Health Nutr | pmid:19102810 |
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| Zeisel SH | Is maternal diet supplementation beneficial? Optimal development of infant depends on mother's diet. | 2009 | Am. J. Clin. Nutr. | pmid:19116319 |
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| Gliozzi TM et al. | Quality and lipid composition of spermatozoa in rabbits fed DHA and vitamin E rich diets. | 2009 | Theriogenology | pmid:19121864 |
| Cui HS et al. | Berberine exerts neuroprotective actions against in vitro ischemia-induced neuronal cell damage in organotypic hippocampal slice cultures: involvement of B-cell lymphoma 2 phosphorylation suppression. | 2009 | Biol. Pharm. Bull. | pmid:19122285 |
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| Hooijmans CR et al. | DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice. | 2009 | Neurobiol. Dis. | pmid:19130883 |
| Valdivielso P et al. | Omega 3 fatty acids induce a marked reduction of apolipoprotein B48 when added to fluvastatin in patients with type 2 diabetes and mixed hyperlipidemia: a preliminary report. | 2009 | Cardiovasc Diabetol | pmid:19133114 |
| Jirapinyo P et al. | Fatty acid composition in breast milk from 4 regions of Thailand. | 2008 | J Med Assoc Thai | pmid:19133517 |
| Phivilay A et al. | High dietary consumption of trans fatty acids decreases brain docosahexaenoic acid but does not alter amyloid-beta and tau pathologies in the 3xTg-AD model of Alzheimer's disease. | 2009 | Neuroscience | pmid:19135506 |
| Mayer K et al. | Acute lung injury is reduced in fat-1 mice endogenously synthesizing n-3 fatty acids. | 2009 | Am. J. Respir. Crit. Care Med. | pmid:19136374 |
| Simopoulos AP | Omega-6/omega-3 essential fatty acids: biological effects. | 2009 | World Rev Nutr Diet | pmid:19136835 |
| Hibbeln JR | Depression, suicide and deficiencies of omega-3 essential fatty acids in modern diets. | 2009 | World Rev Nutr Diet | pmid:19136836 |
| Niemoller TD et al. | Omega-3 fatty acid docosahexaenoic acid is the precursor of neuroprotectin D1 in the nervous system. | 2009 | World Rev Nutr Diet | pmid:19136838 |
| Lukiw WJ | Docosahexaenoic acid and amyloid-beta peptide signaling in Alzheimer's disease. | 2009 | World Rev Nutr Diet | pmid:19136839 |
| Wurtman RJ et al. | Administration of docosahexaenoic acid, uridine and choline increases levels of synaptic membranes and dendritic spines in rodent brain. | 2009 | World Rev Nutr Diet | pmid:19136840 |