DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Ratnayake WM et al. Influence of dietary protein and fat on serum lipids and metabolism of essential fatty acids in rats. 1997 Br. J. Nutr. pmid:9306886
Gibson RA et al. Effect of increasing breast milk docosahexaenoic acid on plasma and erythrocyte phospholipid fatty acids and neural indices of exclusively breast fed infants. 1997 Eur J Clin Nutr pmid:9306083
Carvajal O and Angulo O Effect of n-3 polyunsaturated fatty acids on the lipidic profile of healthy Mexican volunteers. 1997 May-Jun Salud Publica Mex pmid:9304226
Colombo DT et al. Comparison of hexadecylphosphocholine with fish oil as an antitumor agent. 1997 J Lipid Mediat Cell Signal pmid:9302654
Lovegrove JA et al. Use of manufactured foods enriched with fish oils as a means of increasing long-chain n-3 polyunsaturated fatty acid intake. 1997 Br. J. Nutr. pmid:9301413
Brossard N et al. Human plasma albumin transports [13C]docosahexaenoic acid in two lipid forms to blood cells. 1997 J. Lipid Res. pmid:9300779
Van Elswyk ME Comparison of n-3 fatty acid sources in laying hen rations for improvement of whole egg nutritional quality: a review. 1997 Br. J. Nutr. pmid:9292775
Jensen CL et al. Effect of dietary linoleic/alpha-linolenic acid ratio on growth and visual function of term infants. 1997 J. Pediatr. pmid:9290604
Carlson SE Functional effects of increasing omega-3 fatty acid intake. 1997 J. Pediatr. pmid:9290597
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Grimsgaard S et al. Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids. 1997 Am. J. Clin. Nutr. pmid:9280188
Freese R and Mutanen M Alpha-linolenic acid and marine long-chain n-3 fatty acids differ only slightly in their effects on hemostatic factors in healthy subjects. 1997 Am. J. Clin. Nutr. pmid:9280178
Weete JD et al. Lipids and ultrastructure of Thraustochytrium sp. ATCC 26185. 1997 Lipids pmid:9270975
Khalfoun B et al. Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte proliferation induced by allogenic cells. 1997 Transplant. Proc. pmid:9270778
Hishinuma T et al. Microdetermination of the thromboxane B3 gas chromatography-selected-ion monitoring using [18O]thromboxane B3 as an internal standard. 1997 Prostaglandins pmid:9261859
Kanazawa A et al. Increased hepatic beta-oxidation of docosahexaenoic acid, elongation of eicosapentaenoic acid, and acylation of lysophosphatidate in rats fed a docosahexaenoic acid-enriched diet. 1997 Lipids pmid:9252962
Vidgren HM et al. Incorporation of n-3 fatty acids into plasma lipid fractions, and erythrocyte membranes and platelets during dietary supplementation with fish, fish oil, and docosahexaenoic acid-rich oil among healthy young men. 1997 Lipids pmid:9252957
Oliveira FL et al. Triglyceride hydrolysis of soy oil vs fish oil emulsions. 1997 Jul-Aug JPEN J Parenter Enteral Nutr pmid:9252949
Schønberg SA and Skorpen F Paracetamol counteracts docosahexaenoic acid-induced growth inhibition of A-427 lung carcinoma cells and enhances tumor cell proliferation in vitro. 1997 Jul-Aug Anticancer Res. pmid:9252660
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Takahashi M et al. Suppression of azoxymethane-induced rat colon carcinoma development by a fish oil component, docosahexaenoic acid (DHA). 1997 Carcinogenesis pmid:9230276
Huang ZH et al. N-6 and n-3 polyunsaturated fatty acids stimulate translocation of protein kinase Calpha, -betaI, -betaII and -epsilon and enhance agonist-induced NADPH oxidase in macrophages. 1997 Biochem. J. pmid:9230140
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Reynaud D and Pace-Asciak CR Docosahexaenoic acid causes accumulation of free arachidonic acid in rat pineal gland and hippocampus to form hepoxilins from both substrates. 1997 Biochim. Biophys. Acta pmid:9219915
Murakami T et al. Suppressive action of docosahexaenoic acid enriched-Euglena on reduction of endothelium-dependent relaxation in stroke-prone spontaneously hypertensive rats (SHRSP). 1997 J. Nutr. Sci. Vitaminol. pmid:9219094
Petrukhina GN et al. [The effect of the chronic internal administration of the new Russian n-3 polyunsaturated fatty acid concentrate--epaden--on blood coagulation system indices in rabbits]. 1997 Mar-Apr Eksp Klin Farmakol pmid:9206567
Innis SM and Dyer R Dietary triacylglycerols with palmitic acid (16:0) in the 2-position increase 16:0 in the 2-position of plasma and chylomicron triacylglycerols, but reduce phospholipid arachidonic and docosahexaenoic acids, and alter cholesteryl ester metabolism in formula-Fed piglets. 1997 J. Nutr. pmid:9202085
Terano T et al. Eicosapentaenoic acid and docosahexaenoic acid inhibit DNA synthesis through inhibiting cdk2 kinase in vascular smooth muscle cells. 1997 Ann. N. Y. Acad. Sci. pmid:9186612
Ding ST and Lilburn MS Changes in fatty acid profiles in different lipid classes during late development of turkey embryos from two genetic lines. 1997 Poult. Sci. pmid:9181615
Ikemoto A et al. Membrane fatty acid modifications of PC12 cells by arachidonate or docosahexaenoate affect neurite outgrowth but not norepinephrine release. 1997 Neurochem. Res. pmid:9178949
Jones CR et al. Evidence for the involvement of docosahexaenoic acid in cholinergic stimulated signal transduction at the synapse. 1997 Neurochem. Res. pmid:9178948
Shimura T et al. Docosahexanoic acid (DHA) improved glucose and lipid metabolism in KK-Ay mice with genetic non-insulin-dependent diabetes mellitus (NIDDM). 1997 Biol. Pharm. Bull. pmid:9178930
Connor WE et al. Biochemical markers for puberty in the monkey testis: desmosterol and docosahexaenoic acid. 1997 J. Clin. Endocrinol. Metab. pmid:9177405
Davidson MH et al. Effects of docosahexaenoic acid on serum lipoproteins in patients with combined hyperlipidemia: a randomized, double-blind, placebo-controlled trial. 1997 J Am Coll Nutr pmid:9176830
Allard JP et al. Lipid peroxidation during n-3 fatty acid and vitamin E supplementation in humans. 1997 Lipids pmid:9168460
Bell JG et al. The effect of dietary lipid on polyunsaturated fatty acid metabolism in Atlantic salmon (Salmo salar) undergoing parr-smolt transformation. 1997 Lipids pmid:9168458
Stillwell W et al. Effect of docosahexaenoic acid on mouse mitochondrial membrane properties. 1997 Lipids pmid:9168456
Jumpsen J et al. Small changes of dietary (n-6) and (n-3)/fatty acid content ration alter phosphatidylethanolamine and phosphatidylcholine fatty acid composition during development of neuronal and glial cells in rats. 1997 J. Nutr. pmid:9164993
Benassayag C et al. High polyunsaturated fatty acid, thromboxane A2, and alpha-fetoprotein concentrations at the human feto-maternal interface. 1997 J. Lipid Res. pmid:9162747
Green P et al. Replenishment of docosahexaenoic acid in n-3 fatty acid-deficient fetal rats by intraamniotic ethyl-docosahexaenoate administration. 1997 J. Neurosci. Res. pmid:9160249
Buzzi M et al. Biosynthesis of docosahexaenoic acid in trout hepatocytes proceeds via 24-carbon intermediates. 1997 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:9159889
Andreassen AK et al. Hypertension prophylaxis with omega-3 fatty acids in heart transplant recipients. 1997 J. Am. Coll. Cardiol. pmid:9137231
Gordon N Nutrition and cognitive function. 1997 Brain Dev. pmid:9134186
Oski FA What we eat may determine who we can be. 1997 Nutrition pmid:9131682
Harris WS n-3 fatty acids and serum lipoproteins: human studies. 1997 Am. J. Clin. Nutr. pmid:9129504
Tamura M and Suzuki H Effect of docosahexaenoic acid and linoleic acid diets on the ultrastructure of liver cells in adult mice. 1997 Int J Vitam Nutr Res pmid:9129257
Heird WC et al. Docosahexaenoic acid and the development and function of the infant retina. 1997 Curr. Opin. Lipidol. pmid:9127705
Khalfoun B et al. In vitro effects of docosahexaenoic and eicosapentaenoic acids in association with cyclosporine A on human lymphocyte proliferation. 1997 Feb-Mar Transplant. Proc. pmid:9123309
Kikugawa K et al. beta-Carotene effectively scavenges toxic nitrogen oxides: nitrogen dioxide and peroxynitrous acid. 1997 FEBS Lett. pmid:9119059
Ndiaye J and Hayashi S Effect of docosahexaenoic acid on lipoprotein synthesis and secretion by cultured eel hepatocytes. 1996 Cell Struct. Funct. pmid:9118236
Mandell IB et al. Effects of fish meal in beef cattle diets on growth performance, carcass characteristics, and fatty acid composition of longissimus muscle. 1997 J. Anim. Sci. pmid:9110201
McKeone BJ et al. Alterations in serum phosphatidylcholine fatty acyl species by eicosapentaenoic and docosahexaenoic ethyl esters in patients with severe hypertriglyceridemia. 1997 J. Lipid Res. pmid:9101424
Rodriguez de Turco EB et al. Post-Golgi vesicles cotransport docosahexaenoyl-phospholipids and rhodopsin during frog photoreceptor membrane biogenesis. 1997 J. Biol. Chem. pmid:9099692
Mohan IK and Das UN Oxidant stress, anti-oxidants and essential fatty acids in systemic lupus erythematosus. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9089797
Bouglé D et al. Relationships between red blood cell vitamin E and polyunsaturated fatty acid in the premature infant. 1996 Ann. Nutr. Metab. pmid:9087310
Conquer JA and Holub BJ Dietary docosahexaenoic acid as a source of eicosapentaenoic acid in vegetarians and omnivores. 1997 Lipids pmid:9076673
Atkinson TG et al. Incorporation of long-chain n-3 fatty acids in tissues and enhanced bone marrow cellularity with docosahexaenoic acid feeding in post-weanling Fischer 344 rats. 1997 Lipids pmid:9076666
Kimura S et al. Dietary docosahexaenoic acid (22: 6n-3) prevents the development of hypertension in SHRSP. 1995 Clin Exp Pharmacol Physiol Suppl pmid:9072405
Horimoto N et al. Arachidonic acid activation of potassium channels in rat visual cortex neurons. 1997 Neuroscience pmid:9070743
Kelso KA et al. Lipid and antioxidant changes in spermatozoa and seminal plasma throughout the reproductive period of bulls. 1997 J. Reprod. Fertil. pmid:9068407
Yamane M and Abe A Properties of the omega-hydroxylation system of docosahexaenoic or arachidonic acid in brain or liver homogenate of rat. 1995 Neurosci. Lett. pmid:9064612
Infante JP and Huszagh VA On the molecular etiology of decreased arachidonic (20:4n-6), docosapentaenoic (22:5n-6) and docosahexaenoic (22:6n-3) acids in Zellweger syndrome and other peroxisomal disorders. 1997 Mol. Cell. Biochem. pmid:9062899
Orth M and Luley C Diagnostic pitfalls during therapy for extreme hypertriglyceridaemia. 1997 Eur J Clin Chem Clin Biochem pmid:9056751
Dacremont G and Vincent G Assay of plasmalogens and polyunsaturated fatty acids (PUFA) in erythrocytes and fibroblasts. 1995 J. Inherit. Metab. Dis. pmid:9053558
Iigo M et al. Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung. 1997 Br. J. Cancer pmid:9043019
Wainwright PE et al. Arachidonic acid offsets the effects on mouse brain and behavior of a diet with a low (n-6):(n-3) ratio and very high levels of docosahexaenoic acid. 1997 J. Nutr. pmid:9040564
Kresiun VI et al. [The membrane-protective action of a new preparation of n-3 polyenic acids in the adrenaline-damaged myocardium]. 1996 Mar-Apr Lik. Sprava pmid:9035880
Delton-Vandenbroucke I et al. Polyunsaturated fatty acid metabolism in retinal and cerebral microvascular endothelial cells. 1997 J. Lipid Res. pmid:9034209
Sauerwald TU et al. Intermediates in endogenous synthesis of C22:6 omega 3 and C20:4 omega 6 by term and preterm infants. 1997 Pediatr. Res. pmid:9029636
Badalamenti S et al. Lack of renal effects of fish oil administration in patients with advanced cirrhosis and impaired glomerular filtration. 1997 Hepatology pmid:9021940
Noguchi M et al. Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA. 1997 Br. J. Cancer pmid:9020478
Sheaff Greiner RC et al. Linoleate, alpha-linolenate, and docosahexaenoate recycling into saturated and monounsaturated fatty acids is a major pathway in pregnant or lactating adults and fetal or infant rhesus monkeys. 1996 J. Lipid Res. pmid:9017518
Tamura M and Suzuki H Effects of docosahexaenoic acid and sardine oil diets on the ultrastructure of jejunal absorptive cells in adult mice. 1996 Ann. Nutr. Metab. pmid:9001686
Conquer JA and Holub BJ Supplementation with an algae source of docosahexaenoic acid increases (n-3) fatty acid status and alters selected risk factors for heart disease in vegetarian subjects. 1996 J. Nutr. pmid:9001371
Herber SM and Van Elswyk ME Dietary marine algae promotes efficient deposition of n-3 fatty acids for the production of enriched shell eggs. 1996 Poult. Sci. pmid:9000275
Liutova LV et al. [Effect of docanol on the status of hemostasis and fibrinolysis systems, as well as lipid spectrum in patients with ischemic heart disease depending on the initial level of fibrinolytic activity]. 1996 Jan-Mar Vopr. Med. Khim. pmid:8999661
Taugbøl O et al. An experimental study on transcutaneous absorption of ethylesters of eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) in pigs. 1996 Acta Vet. Scand. pmid:8996873
Pregnolato P et al. Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8981629
Fritsche KL and Cassity NA Metabolism of [3H]arachidonic acid by n-3 polyunsaturated fatty acid-enriched piglet alveolar macrophages. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8981628
Martin DD et al. The fatty acid composition of human gliomas differs from that found in nonmalignant brain tissue. 1996 Lipids pmid:8972462
Khalfoun B et al. Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte-endothelial cell adhesion. 1996 Transplantation pmid:8970622
Brossard N et al. Metabolic fate of an oral tracer dose of [13C]docosahexaenoic acid triglycerides in the rat. 1996 Am. J. Physiol. pmid:8967415
Futamura Y Toxicity of amiodarone on mouse pulmonary endothelial cells cultured with or without alveolar macrophages. 1996 J Toxicol Sci pmid:8959650
Foreman-van Drongelen MM et al. Influence of feeding artificial-formula milks containing docosahexaenoic and arachidonic acids on the postnatal long-chain polyunsaturated fatty acid status of healthy preterm infants. 1996 Br. J. Nutr. pmid:8958000
Garratt JC et al. Blockade of two voltage-dependent potassium channels, mKv1.1 and mKv1.2, by docosahexaenoic acid. 1996 Eur. J. Pharmacol. pmid:8957264
Ohira T et al. Improvement by eicosanoids in cancer cachexia induced by LLC-IL6 transplantation. 1996 J. Cancer Res. Clin. Oncol. pmid:8954167
Awad AB et al. The effect of unsaturated fatty acids on membrane composition and signal transduction in HT-29 human colon cancer cells. 1996 Cancer Lett. pmid:8950205
Reinboth JJ et al. Light elicits the release of docosahexaenoic acid from membrane phospholipids in the rat retina in vitro. 1996 Exp. Eye Res. pmid:8943700
Katoku Y et al. Effect of the cholesterol content of a formula on the lipid compositions of plasma lipoproteins and red blood cell membranes in early infancy. 1996 Am. J. Clin. Nutr. pmid:8942411
Suzuki Y et al. Trial of docosahexaenoic acid supplementation on a Japanese patient with a peroxisome biogenesis defect. 1996 Acta Paediatr Jpn pmid:8942014
Poling JS et al. Docosahexaenoic acid block of neuronal voltage-gated K+ channels: subunit selective antagonism by zinc. 1996 Neuropharmacology pmid:8938727
Krämer HJ et al. Fish oil fatty acids and human platelets: dose-dependent decrease in dienoic and increase in trienoic thromboxane generation. 1996 Biochem. Pharmacol. pmid:8937428
De Craemer D et al. Dietary docosahexaenoic acid has little effect on peroxisomes in healthy mice. 1996 Lipids pmid:8934448
Santos GA and Silversides FG Utilization of the sex-linked gene for imperfect albinism (S*ALS). 1. Effect of early weight loss on chick metabolism. 1996 Poult. Sci. pmid:8933584
Agren JJ et al. Fish diet, fish oil and docosahexaenoic acid rich oil lower fasting and postprandial plasma lipid levels. 1996 Eur J Clin Nutr pmid:8933125
Santos FF et al. Alterations in rabbit retina lipid metabolism induced by detachment. Decreased incorporation of [3H]DHA into phospholipids. 1995-1996 Int Ophthalmol pmid:8926126
Carballeira NM et al. Phospholipid fatty acid composition of gorgonians of the genus Pseudopterogorgia: identification of tetracosapolyenoic acids. 1996 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:8925444
Zerouga M et al. Phospholipid class as a determinant in docosahexaenoic acid's effect on tumor cell viability. 1996 Sep-Oct Anticancer Res. pmid:8917399