| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Crawford MA et al. | The inadequacy of the essential fatty acid content of present preterm feeds. | 1998 | Eur. J. Pediatr. | pmid:9462903 |
| Murphy MG et al. | Diets enriched in menhaden fish oil, seal oil, or shark liver oil have distinct effects on the lipid and fatty-acid composition of guinea pig heart. | 1997 | Mol. Cell. Biochem. | pmid:9450671 |
| Ding C et al. | Changes in fatty acid profile in plasma and very low density lipoprotein lipids after fish oil supplementation. | 1997 | Biochem. Soc. Trans. | pmid:9450114 |
| Nourooz-Zadeh J et al. | F4-isoprostanes: a novel class of prostanoids formed during peroxidation of docosahexaenoic acid (DHA). | 1998 | Biochem. Biophys. Res. Commun. | pmid:9446796 |
| Campan P et al. | Pilot study on n-3 polyunsaturated fatty acids in the treatment of human experimental gingivitis. | 1997 | J. Clin. Periodontol. | pmid:9442428 |
| Baur LA et al. | The fatty acid composition of skeletal muscle membrane phospholipid: its relationship with the type of feeding and plasma glucose levels in young children. | 1998 | Metab. Clin. Exp. | pmid:9440487 |
| Song JH et al. | Oxidative stability of docosahexaenoic acid-containing oils in the form of phospholipids, triacylglycerols, and ethyl esters. | 1997 | Biosci. Biotechnol. Biochem. | pmid:9438988 |
| Yasuda S et al. | Docosahexaenoic acid-rich fish oil does not enhance the elevation of serum transaminase and liver triacylglycerol induced by carbon tetrachloride in mice. | 1997 | Lipids | pmid:9438234 |
| Agren JJ et al. | Hemostatic factors and platelet aggregation after a fish-enriched diet or fish oil or docosahexaenoic acid supplementation. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9430389 |
| Frøyland L et al. | Hypotriacylglycerolemic component of fish oil. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9430383 |
| Achard F et al. | Eicosapentaenoic and docosahexaenoic acids reduce PGH synthase 1 expression in bovine aortic endothelial cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9425302 |
| Garcia MC et al. | Effect of docosahexaenoic acid on the synthesis of phosphatidylserine in rat brain in microsomes and C6 glioma cells. | 1998 | J. Neurochem. | pmid:9422343 |
| Kelso KA et al. | The effects of dietary supplementation with docosahexaenoic acid on the phospholipid fatty acid composition of avian spermatozoa. | 1997 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:9417994 |
| Anil K et al. | Effect of n-3 fatty acids on VLDL production by hepatocytes is mediated through prostaglandins. | 1997 | Biochem. Mol. Biol. Int. | pmid:9415816 |
| van Niel MH and Beynen AC | The intake of polyunsaturated fatty acids by cats is reflected in their adipose tissue. | 1997 | Vet Q | pmid:9413110 |
| Wu X et al. | Demonstration of biphasic effects of docosahexaenoic acid on apolipoprotein B secretion in HepG2 cells. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9409332 |
| Minami M et al. | Dietary docosahexaenoic acid increases cerebral acetylcholine levels and improves passive avoidance performance in stroke-prone spontaneously hypertensive rats. | 1997 | Pharmacol. Biochem. Behav. | pmid:9408223 |
| Nelson GJ et al. | The effect of dietary docosahexaenoic acid on plasma lipoproteins and tissue fatty acid composition in humans. | 1997 | Lipids | pmid:9397398 |
| Nelson GJ et al. | The effect of dietary docosahexaenoic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans. | 1997 | Lipids | pmid:9397397 |
| Greiner RC et al. | Brain docosahexaenoate accretion in fetal baboons: bioequivalence of dietary alpha-linolenic and docosahexaenoic acids. | 1997 | Pediatr. Res. | pmid:9396565 |
| Clandinin MT et al. | Assessment of the efficacious dose of arachidonic and docosahexaenoic acids in preterm infant formulas: fatty acid composition of erythrocyte membrane lipids. | 1997 | Pediatr. Res. | pmid:9396564 |
| Garcia MC et al. | Effects of chronic ethanol on the mobilization of arachidonate and docosahexaenoate stimulated by the type 2A serotonin receptor agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride in C6 glioma cells. | 1997 | Alcohol. Clin. Exp. Res. | pmid:9394119 |
| Kubo K et al. | Changes in susceptibility of tissues to lipid peroxidation after ingestion of various levels of docosahexaenoic acid and vitamin E. | 1997 | Br. J. Nutr. | pmid:9389890 |
| Suzuki I et al. | Inhibitory effects of oleic and docosahexaenoic acids on lung metastasis by colon-carcinoma-26 cells are associated with reduced matrix metalloproteinase-2 and -9 activities. | 1997 | Int. J. Cancer | pmid:9389579 |
| Minami M et al. | Effects of dietary docosahexaenoic acid on survival time and stroke-related behavior in stroke-prone spontaneously hypertensive rats. | 1997 | Gen. Pharmacol. | pmid:9378247 |
| Katan MB et al. | Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: an 18-month controlled study. | 1997 | J. Lipid Res. | pmid:9374124 |
| Raclot T et al. | Site-specific regulation of gene expression by n-3 polyunsaturated fatty acids in rat white adipose tissues. | 1997 | J. Lipid Res. | pmid:9374119 |
| Goldberg EM and Zidovetzki R | Effects of dipalmitoylglycerol and fatty acids on membrane structure and protein kinase C activity. | 1997 | Biophys. J. | pmid:9370455 |
| Garcia MC and Kim HY | Mobilization of arachidonate and docosahexaenoate by stimulation of the 5-HT2A receptor in rat C6 glioma cells. | 1997 | Brain Res. | pmid:9369299 |
| Mizutani M et al. | Omega-3 polyunsaturated fatty acids inhibit migration of human vascular smooth muscle cells in vitro. | 1997 | Life Sci. | pmid:9364203 |
| Takahashi M et al. | Reduction in formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced aberrant crypt foci in the rat colon by docosahexaenoic acid (DHA). | 1997 | Carcinogenesis | pmid:9364003 |
| Paulsen JE et al. | A fish oil derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl ester suppresses the formation and growth of intestinal polyps in the Min mouse. | 1997 | Carcinogenesis | pmid:9363998 |
| Schønberg SA et al. | Evidence that changes in Se-glutathione peroxidase levels affect the sensitivity of human tumour cell lines to n-3 fatty acids. | 1997 | Carcinogenesis | pmid:9363997 |
| Boehm G et al. | Docosahexaenoic and arachidonic acid absorption in preterm infants fed LCP-free or LCP-supplemented formula in comparison to infants fed fortified breast milk. | 1997 | Ann. Nutr. Metab. | pmid:9363295 |
| Herzberg GR and Skinner C | Differential accumulation and release of long-chain n-3 fatty acids from liver, muscle, and adipose tissue triacylglycerols. | 1997 | Can. J. Physiol. Pharmacol. | pmid:9360007 |
| Calviello G et al. | Low-dose eicosapentaenoic or docosahexaenoic acid administration modifies fatty acid composition and does not affect susceptibility to oxidative stress in rat erythrocytes and tissues. | 1997 | Lipids | pmid:9358434 |
| Dharmsthiti S and Ammaranond P | Purification and characterization of lipase from a raw-milk yeast (Trichosporon asteroides). | 1997 | Biotechnol. Appl. Biochem. | pmid:9357107 |
| Durot I et al. | Influence of phospholipid long chain polyunsaturated fatty acid composition on neonatal rat cardiomyocyte function in physiological conditions and during glucose-free hypoxia-reoxygenation. | 1997 | Mol. Cell. Biochem. | pmid:9350058 |
| Aguirre GD et al. | Diets enriched in docosahexaenoic acid fail to correct progressive rod-cone degeneration (prcd) phenotype. | 1997 | Invest. Ophthalmol. Vis. Sci. | pmid:9344362 |
| Atkinson TG et al. | DHA feeding provides host protection and prevents fibrosarcoma-induced hyperlipidemia while maintaining the tumor response to araC in Fischer 344 rats. | 1997 | Nutr Cancer | pmid:9343830 |
| Singh A and Ward OP | Microbial production of docosahexaenoic acid (DHA, C22:6). | 1997 | Adv. Appl. Microbiol. | pmid:9342829 |
| Scherer JM et al. | Spleen cell survival and proliferation are differentially altered by docosahexaenoic acid. | 1997 | Cell. Immunol. | pmid:9341745 |
| Yamada N et al. | Changes in blood coagulation, platelet aggregation, and lipid metabolism in rats given lipids containing docosahexaenoic acid. | 1997 | Biosci. Biotechnol. Biochem. | pmid:9339545 |
| Frøyland L et al. | Mitochondrion is the principal target for nutritional and pharmacological control of triglyceride metabolism. | 1997 | J. Lipid Res. | pmid:9323594 |
| Crawford MA et al. | Are deficits of arachidonic and docosahexaenoic acids responsible for the neural and vascular complications of preterm babies? | 1997 | Am. J. Clin. Nutr. | pmid:9322584 |
| Abran D et al. | Metabolism of 4,7,10,13,16,19-docosahexaenoic acid in isolated perfused adult and newborn pig eyes. | 1997 | Biol. Neonate | pmid:9313833 |
| Singh RB et al. | Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: the Indian experiment of infarct survival--4. | 1997 | Cardiovasc Drugs Ther | pmid:9310278 |
| Watanabe K et al. | Lipid and fatty acid compositions of a novel docosahexaenoic acid-producing marine bacterium. | 1997 | Lipids | pmid:9307940 |
| Ikeda I et al. | Effects of triolein or oleic acid on lymphatic recovery of docosahexaenoic acid given as ethyl ester and their intramolecular distribution in lymph triglyceride of rats. | 1997 | Lipids | pmid:9307935 |
| Halvorsen DS et al. | The effect of highly purified eicosapentaenoic and docosahexaenoic acids on monocyte phagocytosis in man. | 1997 | Lipids | pmid:9307933 |