| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shomonov-Wagner L et al. | Alpha linolenic acid in maternal diet halts the lipid disarray due to saturated fatty acids in the liver of mice offspring at weaning. | 2015 | Lipids Health Dis | pmid:25889505 |
| Wu A et al. | Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders. | 2015 | Biochim. Biophys. Acta | pmid:25550171 |
| Hsiao HM et al. | Resolvin D1 Reduces Emphysema and Chronic Inflammation. | 2015 | Am. J. Pathol. | pmid:26468975 |
| Maekawa T et al. | Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway. | 2015 | Nat Commun | pmid:26374165 |
| Herrera BS et al. | LXA4 actions direct fibroblast function and wound closure. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26188508 |
| Rossi S et al. | Interplay between Intravitreal RvD1 and Local Endogenous Sirtuin-1 in the Protection from Endotoxin-Induced Uveitis in Rats. | 2015 | Mediators Inflamm. | pmid:26180376 |
| Shevalye H et al. | Effect of enriching the diet with menhaden oil or daily treatment with resolvin D1 on neuropathy in a mouse model of type 2 diabetes. | 2015 | J. Neurophysiol. | pmid:25925322 |
| Fiala M et al. | ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairment. | 2015 | FASEB J. | pmid:25805829 |
| Guichardant M et al. | Omega-3 polyunsaturated fatty acids and oxygenated metabolism in atherothrombosis. | 2015 | Biochim. Biophys. Acta | pmid:25263947 |
| Cox R et al. | Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25647402 |
| Saito H et al. | Variation of Lipids and Fatty Acids of the Japanese Freshwater Eel, Anguilla japonica, during Spawning Migration. | 2015 | J Oleo Sci | pmid:26028326 |
| Gavzan H et al. | Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models. | 2015 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:26018398 |
| Chiang N et al. | Identification of resolvin D2 receptor mediating resolution of infections and organ protection. | 2015 | J. Exp. Med. | pmid:26195725 |
| Marinho GS et al. | Lipids and Composition of Fatty Acids of Saccharina latissima Cultivated Year-Round in Integrated Multi-Trophic Aquaculture. | 2015 | Mar Drugs | pmid:26184241 |
| Koh AS et al. | The association between dietary omega-3 fatty acids and cardiovascular death: the Singapore Chinese Health Study. | 2015 | Eur J Prev Cardiol | pmid:24343844 |
| Wang X et al. | Resolution of inflammation is altered in Alzheimer's disease. | 2015 | Alzheimers Dement | pmid:24530025 |
| Calandria JM et al. | NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival. | 2015 | Cell Death Differ. | pmid:25633199 |
| Kanan Y et al. | Neuroprotectin D1 is synthesized in the cone photoreceptor cell line 661W and elicits protection against light-induced stress. | 2015 | Cell. Mol. Neurobiol. | pmid:25212825 |
| Orban T et al. | Serum levels of lipid metabolites in age-related macular degeneration. | 2015 | FASEB J. | pmid:26187344 |
| Serhan CN et al. | Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome. | 2015 | Biochim. Biophys. Acta | pmid:25139562 |
| Wang CW et al. | Maresin 1 Biosynthesis and Proresolving Anti-infective Functions with Human-Localized Aggressive Periodontitis Leukocytes. | 2015 | Infect. Immun. | pmid:26667839 |
| Nordgren TM et al. | Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust. | 2015 | Transl Res | pmid:25655838 |
| Hashim RB et al. | Fatty acid compositions of silver catfish, Pangasius sp. farmed in several rivers of Pahang, Malaysia. | 2015 | J Oleo Sci | pmid:25748380 |
| Tyurina YY et al. | LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: Implication for mitochondrial dysfunction in Parkinson's disease. | 2015 | Free Radic. Res. | pmid:25740198 |
| Clouard C et al. | Dietary linoleic and α-linolenic acids affect anxiety-related responses and exploratory activity in growing pigs. | 2015 | J. Nutr. | pmid:25644359 |
| Hsieh JC et al. | High-Oleic Ready-to-Use Therapeutic Food Maintains Docosahexaenoic Acid Status in Severe Malnutrition. | 2015 | J. Pediatr. Gastroenterol. Nutr. | pmid:25633498 |
| Wang Y et al. | Mesoscale Simulations and Experimental Studies of pH-Sensitive Micelles for Controlled Drug Delivery. | 2015 | ACS Appl Mater Interfaces | pmid:26539742 |
| Ercan S et al. | Induction of omega 6 inflammatory pathway by sodium metabisulfite in rat liver and its attenuation by ghrelin. | 2015 | Lipids Health Dis | pmid:25889219 |
| Talvas J et al. | Immunonutrition stimulates immune functions and antioxidant defense capacities of leukocytes in radiochemotherapy-treated head & neck and esophageal cancer patients: A double-blind randomized clinical trial. | 2015 | Clin Nutr | pmid:25575640 |
| Sekhon-Loodu S et al. | Docosahexaenoic acid ester of phloridzin inhibit lipopolysaccharide-induced inflammation in THP-1 differentiated macrophages. | 2015 | Int. Immunopharmacol. | pmid:25637769 |
| Wang Y et al. | Mesoscopic simulation studies on the formation mechanism of drug loaded polymeric micelles. | 2015 | Colloids Surf B Biointerfaces | pmid:26454543 |
| Maciejewska D et al. | Fatty acid changes help to better understand regression of nonalcoholic fatty liver disease. | 2015 | World J. Gastroenterol. | pmid:25574105 |
| Berge RK et al. | Krill oil reduces plasma triacylglycerol level and improves related lipoprotein particle concentration, fatty acid composition and redox status in healthy young adults - a pilot study. | 2015 | Lipids Health Dis | pmid:26666303 |
| Morin C et al. | Eicosapentaenoic acid and docosapentaenoic acid monoglycerides are more potent than docosahexaenoic acid monoglyceride to resolve inflammation in a rheumatoid arthritis model. | 2015 | Arthritis Res. Ther. | pmid:26022389 |
| Yoshinaga K et al. | Differential effects of triacylglycerol positional isomers containing n-3 series highly unsaturated fatty acids on lipid metabolism in C57BL/6J mice. | 2015 | J. Nutr. Biochem. | pmid:25448607 |
| Hiram R et al. | Resolvin E1 normalizes contractility, Ca2+ sensitivity and smooth muscle cell migration rate in TNF-α- and IL-6-pretreated human pulmonary arteries. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26320154 |
| Cheatham CL and Sheppard KW | Synergistic Effects of Human Milk Nutrients in the Support of Infant Recognition Memory: An Observational Study. | 2015 | Nutrients | pmid:26540073 |
| Lucena CF et al. | Omega-3 supplementation improves pancreatic islet redox status: in vivo and in vitro studies. | 2015 | Pancreas | pmid:25426612 |
| Harrison JL et al. | Resolvins AT-D1 and E1 differentially impact functional outcome, post-traumatic sleep, and microglial activation following diffuse brain injury in the mouse. | 2015 | Brain Behav. Immun. | pmid:25585137 |
| Brigandi SA et al. | Autistic children exhibit decreased levels of essential Fatty acids in red blood cells. | 2015 | Int J Mol Sci | pmid:25946342 |
| Ossani GP et al. | Short-term menhaden oil rich diet changes renal lipid profile in acute kidney injury. | 2015 | J Oleo Sci | pmid:25948137 |
| Samokhvalov V et al. | PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. | 2015 | Toxicol. Lett. | pmid:25300478 |
| Honda KL et al. | Docosahexaenoic acid differentially affects TNFα and IL-6 expression in LPS-stimulated RAW 264.7 murine macrophages. | 2015 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:25921297 |
| Wang Y et al. | Maresin 1 Inhibits Epithelial-to-Mesenchymal Transition in Vitro and Attenuates Bleomycin Induced Lung Fibrosis in Vivo. | 2015 | Shock | pmid:26196843 |
| Block RC et al. | The effects of aspirin on platelet function and lysophosphatidic acids depend on plasma concentrations of EPA and DHA. | 2015 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:25555354 |
| Yang S et al. | Effect of thermal processing on astaxanthin and astaxanthin esters in pacific white shrimp Litopenaeus vannamei. | 2015 | J Oleo Sci | pmid:25757428 |
| Véricel E et al. | Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients. | 2015 | Thromb. Haemost. | pmid:25832443 |
| Wijendran V et al. | Long-chain polyunsaturated fatty acids attenuate the IL-1β-induced proinflammatory response in human fetal intestinal epithelial cells. | 2015 | Pediatr. Res. | pmid:26270575 |
| Mansara PP et al. | Differential Ratios of Omega Fatty Acids (AA/EPA+DHA) Modulate Growth, Lipid Peroxidation and Expression of Tumor Regulatory MARBPs in Breast Cancer Cell Lines MCF7 and MDA-MB-231. | 2015 | PLoS ONE | pmid:26325577 |
| Mason JK et al. | α-linolenic acid and docosahexaenoic acid, alone and combined with trastuzumab, reduce HER2-overexpressing breast cancer cell growth but differentially regulate HER2 signaling pathways. | 2015 | Lipids Health Dis | pmid:26282560 |