DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Mori TA Dietary n-3 PUFA and CVD: a review of the evidence. 2014 Proc Nutr Soc pmid:24119287
Hua J et al. The resolvin D1 analogue controls maturation of dendritic cells and suppresses alloimmunity in corneal transplantation. 2014 Invest. Ophthalmol. Vis. Sci. pmid:25146982
Navarro-Guillén C et al. Effect of varying dietary levels of LC-PUFA and vegetable oil sources on performance and fatty acids of Senegalese sole post larvae: puzzling results suggest complete biosynthesis pathway from C18 PUFA to DHA. 2014 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:24120522
Fedorova-Dahms I et al. A 3-week dietary bioequivalence study in preweaning farm piglets of two sources of docosahexaenoic acid produced from two different organisms. 2014 Food Chem. Toxicol. pmid:24333867
Huang X et al. Serum and adipose tissue fatty acid composition as biomarkers of habitual dietary fat intake in elderly men with chronic kidney disease. 2014 Nephrol. Dial. Transplant. pmid:23229929
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Keelan JA Letter to the editor: "fatty acids and placental transport: insight or in vitro artifact?". 2014 Am. J. Physiol., Cell Physiol. pmid:25452382
Wales KM et al. N-3 PUFAs protect against aortic inflammation and oxidative stress in angiotensin II-infused apolipoprotein E-/- mice. 2014 PLoS ONE pmid:25398022
Hsiao HM et al. Resolvin D1 attenuates polyinosinic-polycytidylic acid-induced inflammatory signaling in human airway epithelial cells via TAK1. 2014 J. Immunol. pmid:25320283
Hiram R et al. Resolvin D1 reverses reactivity and Ca2+ sensitivity induced by ET-1, TNF-α, and IL-6 in the human pulmonary artery. 2014 Am. J. Physiol. Heart Circ. Physiol. pmid:25281570
Arnardottir HH et al. Aging delays resolution of acute inflammation in mice: reprogramming the host response with novel nano-proresolving medicines. 2014 J. Immunol. pmid:25217168
Bremer AA et al. Fish oil supplementation ameliorates fructose-induced hypertriglyceridemia and insulin resistance in adult male rhesus macaques. 2014 J. Nutr. pmid:24108131
Zhu G et al. Enhanced production of docosahexaenoic acid in mammalian cells. 2014 PLoS ONE pmid:24788769
Rodrigues PO et al. Influence of feeding graded levels of canned sardines on the inflammatory markers and tissue fatty acid composition of Wistar rats. 2014 Br. J. Nutr. pmid:24775714
Torok VA et al. Influence of dietary docosahexaenoic acid supplementation on the overall rumen microbiota of dairy cows and linkages with production parameters. 2014 Can. J. Microbiol. pmid:24779577
Burns-Whitmore B et al. Effects of supplementing n-3 fatty acid enriched eggs and walnuts on cardiovascular disease risk markers in healthy free-living lacto-ovo-vegetarians: a randomized, crossover, free-living intervention study. 2014 Nutr J pmid:24673793
Martin CR et al. Resolvin D1 and lipoxin A4 improve alveolarization and normalize septal wall thickness in a neonatal murine model of hyperoxia-induced lung injury. 2014 PLoS ONE pmid:24892762
Al-Zaubai N et al. Resolvin D2 supports MCF-7 cell proliferation via activation of estrogen receptor. 2014 J. Pharmacol. Exp. Ther. pmid:25077525
Makrides M et al. Four-year follow-up of children born to women in a randomized trial of prenatal DHA supplementation. 2014 JAMA pmid:24794375
Jung JY et al. Effect of dietary supplementation with omega-3 fatty acid and gamma-linolenic acid on acne vulgaris: a randomised, double-blind, controlled trial. 2014 Acta Derm. Venereol. pmid:24553997
Mirakaj V et al. Vagus nerve controls resolution and pro-resolving mediators of inflammation. 2014 J. Exp. Med. pmid:24863066
Chen R et al. [Effects of docosahexaenoic acid on hypoxia-induced pulmonary arterial hypertension]. 2014 Zhonghua Jie He He Hu Xi Za Zhi pmid:24796591
Djoussé L et al. Repeated versus single measurement of plasma omega-3 fatty acids and risk of heart failure. 2014 Eur J Nutr pmid:24395612
Ooi SY and Andrews JM Commentary: The association between high dietary intake of docosahexaenoic acid and reduced risk of Crohn's disease. 2014 Aliment. Pharmacol. Ther. pmid:24803245
Chan SS and Hart AR Commentary: The association between high dietary intake of docosahexaenoic acid and reduced risk of Crohn's disease--authors' reply. 2014 Aliment. Pharmacol. Ther. pmid:24803246
Ramon S et al. The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant? 2014 J. Immunol. pmid:25392529
Heemskerk MM et al. Prolonged niacin treatment leads to increased adipose tissue PUFA synthesis and anti-inflammatory lipid and oxylipin plasma profile. 2014 J. Lipid Res. pmid:25320342
Mulder KA et al. Omega-3 fatty acid deficiency in infants before birth identified using a randomized trial of maternal DHA supplementation in pregnancy. 2014 PLoS ONE pmid:24427279
Portillo-Reyes V et al. Clinical significance of neuropsychological improvement after supplementation with omega-3 in 8-12 years old malnourished Mexican children: a randomized, double-blind, placebo and treatment clinical trial. 2014 Res Dev Disabil pmid:24508294
Oh DY et al. A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. 2014 Nat. Med. pmid:24997608
Hughbanks-Wheaton DK et al. Safety assessment of docosahexaenoic acid in X-linked retinitis pigmentosa: the 4-year DHAX trial. 2014 Invest. Ophthalmol. Vis. Sci. pmid:25015354
Velten M et al. Maternal dietary docosahexaenoic acid supplementation attenuates fetal growth restriction and enhances pulmonary function in a newborn mouse model of perinatal inflammation. 2014 J. Nutr. pmid:24453131
Mereghetti P et al. A Fourier transform infrared spectroscopy study of cell membrane domain modifications induced by docosahexaenoic acid. 2014 Biochim. Biophys. Acta pmid:25018005
Lager S et al. Differential regulation of placental amino acid transport by saturated and unsaturated fatty acids. 2014 Am. J. Physiol., Cell Physiol. pmid:25143349
Purushothaman D et al. Flaxseed oil supplementation alters the expression of inflammatory-related genes in dogs. 2014 Genet. Mol. Res. pmid:25078588
Domenichiello AF et al. Whole body synthesis rates of DHA from α-linolenic acid are greater than brain DHA accretion and uptake rates in adult rats. 2014 J. Lipid Res. pmid:24212299
Sato K et al. Pharmacological evidence showing significant roles for potassium channels and CYP epoxygenase metabolites in the relaxant effects of docosahexaenoic acid on the rat aorta contracted with U46619. 2014 Biol. Pharm. Bull. pmid:24369179
Nishinaka T et al. Involvement of the long-chain fatty acid receptor GPR40 in depression-related behavior. 2014 J. Pharmacol. Sci. pmid:24758921
Nagao K et al. Comparison of the lipid-lowering effects of four different n-3 highly unsaturated fatty acids in HepG2 cells. 2014 J Oleo Sci pmid:25213447
Aursnes M et al. Total synthesis of the lipid mediator PD1n-3 DPA: configurational assignments and anti-inflammatory and pro-resolving actions. 2014 J. Nat. Prod. pmid:24576195
Brasky TM et al. Associations of long-chain ω-3 fatty acids and fish intake with endometrial cancer risk in the VITamins And Lifestyle cohort. 2014 Am. J. Clin. Nutr. pmid:24500149
Nobili V et al. Role of docosahexaenoic acid treatment in improving liver histology in pediatric nonalcoholic fatty liver disease. 2014 PLoS ONE pmid:24505350
Tateishi N et al. Dietary supplementation of arachidonic acid increases arachidonic acid and lipoxin Aâ‚„ contents in colon, but does not affect severity or prostaglandin Eâ‚‚ content in murine colitis model. 2014 Lipids Health Dis pmid:24507383
Zhang M et al. Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1. 2014 J. Neurosci. pmid:24478369
Kabeya N et al. Modification of the n-3 HUFA biosynthetic pathway by transgenesis in a marine teleost, nibe croaker. 2014 J. Biotechnol. pmid:24389067
Casanova E et al. Epigallocatechin gallate counteracts oxidative stress in docosahexaenoxic acid-treated myocytes. 2014 Biochim. Biophys. Acta pmid:24486445
Taltavull N et al. Eicosapentaenoic acid/docosahexaenoic acid 1:1 ratio improves histological alterations in obese rats with metabolic syndrome. 2014 Lipids Health Dis pmid:24512213
Nanjappa D et al. Oxylipin diversity in the diatom family Leptocylindraceae reveals DHA derivatives in marine diatoms. 2014 Mar Drugs pmid:24445306
Begum G et al. Docosahexaenoic acid reduces ER stress and abnormal protein accumulation and improves neuronal function following traumatic brain injury. 2014 J. Neurosci. pmid:24599472
Koppenol A et al. Effect of the ratio of dietary n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid on broiler breeder performance, egg quality, and yolk fatty acid composition at different breeder ages. 2014 Poult. Sci. pmid:24604849
Gil-Zamorano J et al. Docosahexaenoic acid modulates the enterocyte Caco-2 cell expression of microRNAs involved in lipid metabolism. 2014 J. Nutr. pmid:24623846
Dayaker G et al. Total synthesis of neuroprotectin D1 analogues derived from omega-6 docosapentaenoic acid (DPA) and adrenic acid (AdA) from a common pivotal, late-stage intermediate. 2014 J. Org. Chem. pmid:24571431
Røsjø E et al. Increasing serum levels of vitamin A, D and E are associated with alterations of different inflammation markers in patients with multiple sclerosis. 2014 J. Neuroimmunol. pmid:24713402
Koizumi K et al. Lipid and fatty acids of three edible myctophids, Diaphus watasei, Diaphus suborbitalis, and Benthosema pterotum: high levels of icosapentaenoic and docosahexaenoic acids. 2014 J Oleo Sci pmid:24717543
Xue M et al. Docosahexaenoic acid inhibited the Wnt/β-catenin pathway and suppressed breast cancer cells in vitro and in vivo. 2014 J. Nutr. Biochem. pmid:24290517
Kim W et al. Dietary fish oil and DHA down-regulate antigen-activated CD4+ T-cells while promoting the formation of liquid-ordered mesodomains. 2014 Br. J. Nutr. pmid:23962659
Levy BD and Serhan CN Resolution of acute inflammation in the lung. 2014 Annu. Rev. Physiol. pmid:24313723
Dendelé B et al. Protective action of n-3 fatty acids on benzo[a]pyrene-induced apoptosis through the plasma membrane remodeling-dependent NHE1 pathway. 2014 Chem. Biol. Interact. pmid:24246761
Zanfini A et al. GC-EI-MS analysis of fatty acid composition in brain and serum of twitcher mouse. 2014 Lipids pmid:25208498
Sertoglu E et al. Comparison of plasma and erythrocyte membrane fatty acid compositions in patients with end-stage renal disease and type 2 diabetes mellitus. 2014 Chem. Phys. Lipids pmid:24384240
Stoffel W et al. Obesity resistance and deregulation of lipogenesis in Δ6-fatty acid desaturase (FADS2) deficiency. 2014 EMBO Rep. pmid:24378641
Shinohara M et al. Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1. 2014 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:25217660
Hutchins-Wiese HL et al. High-dose eicosapentaenoic acid and docosahexaenoic acid supplementation reduces bone resorption in postmenopausal breast cancer survivors on aromatase inhibitors: a pilot study. 2014 Nutr Cancer pmid:24274259
Yao QH et al. ω-3 polyunsaturated fatty acids inhibit the proliferation of the lung adenocarcinoma cell line A549 in vitro. 2014 Mol Med Rep pmid:24276408
Jiang M et al. Isolation and characterization of the diatom Phaeodactylum Δ5-elongase gene for transgenic LC-PUFA production in Pichia pastoris. 2014 Mar Drugs pmid:24608969
Luxwolda MF et al. Interrelationships between maternal DHA in erythrocytes, milk and adipose tissue. Is 1 wt% DHA the optimal human milk content? Data from four Tanzanian tribes differing in lifetime stable intakes of fish. 2014 Br. J. Nutr. pmid:24175990
Gladine C et al. Lipid profiling following intake of the omega 3 fatty acid DHA identifies the peroxidized metabolites F4-neuroprostanes as the best predictors of atherosclerosis prevention. 2014 PLoS ONE pmid:24558496
Hixson SM et al. Changes in tissue lipid and fatty acid composition of farmed rainbow trout in response to dietary camelina oil as a replacement of fish oil. 2014 Lipids pmid:24264359
Chang D et al. Serum free fatty acids level in senile cataract. 2014 J Am Coll Nutr pmid:25079310
Purcell R et al. High-fat meals rich in EPA plus DHA compared with DHA only have differential effects on postprandial lipemia and plasma 8-isoprostane F2α concentrations relative to a control high-oleic acid meal: a randomized controlled trial. 2014 Am. J. Clin. Nutr. pmid:25099540
Hernández E et al. Prenatal determinants of cord blood total immunoglobulin E levels in Mexican newborns. 2013 Sep-Oct Allergy Asthma Proc pmid:23998234
Harris WS et al. Comparative effects of an acute dose of fish oil on omega-3 fatty acid levels in red blood cells versus plasma: implications for clinical utility. 2013 Sep-Oct J Clin Lipidol pmid:24079284
Tatsuno I et al. Long-term safety and efficacy of TAK-085 in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized long-term (ORL) study. 2013 Nov-Dec J Clin Lipidol pmid:24314359
Igarashi M et al. Kinetics of eicosapentaenoic acid in brain, heart and liver of conscious rats fed a high n-3 PUFA containing diet. 2013 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:24209500
Fenton JI et al. Immunomodulation by dietary long chain omega-3 fatty acids and the potential for adverse health outcomes. 2013 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:24183073
Docosahexaenoic and arachidonic acid levels in ELBW infants with prolonged exposure to intravenous lipids. 2013 May-Jun Neonatal Netw pmid:23807965
Tatsuno I et al. Efficacy and safety of TAK-085 compared with eicosapentaenoic acid in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized double-blind (ORD) study. 2013 May-Jun J Clin Lipidol pmid:23725919
Nishimura RY et al. Breast milk fatty acid composition of women living far from the coastal area in Brazil. 2013 May-Jun J Pediatr (Rio J) pmid:23669215
Zajdel A et al. Polyunsaturated fatty acids inhibit melanoma cell growth in vitro. 2013 Mar-Apr Acta Pol Pharm pmid:23614295
Bohr S et al. Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. 2013 Jan-Feb Wound Repair Regen pmid:23110665
Piñeiro-Corrales G et al. [Role of omega-3 fatty acids in cardiovascular disease prevention]. 2013 Jan-Feb Nutr Hosp pmid:23808424
Lindberg M et al. Long-term tracking of plasma phospholipid fatty acid concentrations and their correlation with the dietary intake of marine foods in newly diagnosed diabetic patients: results from a follow-up of the HUNT Study, Norway. 2013 Br. J. Nutr. pmid:22846205
Hu Y et al. 15-Lipoxygenase-1-mediated metabolism of docosahexaenoic acid is required for syndecan-1 signaling and apoptosis in prostate cancer cells. 2013 Carcinogenesis pmid:23066085
Gillingham LG et al. Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. 2013 Am. J. Clin. Nutr. pmid:23221573
Maskrey BH et al. Emerging importance of omega-3 fatty acids in the innate immune response: molecular mechanisms and lipidomic strategies for their analysis. 2013 Mol Nutr Food Res pmid:23417926
Lee MS et al. Effects of eicosapentaenoic acid and docosahexaenoic acid on uncoupling protein 3 gene expression in C(2)C(12) muscle cells. 2013 Nutrients pmid:23698161
Correia M et al. Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid. 2013 PLoS ONE pmid:23577140
Araújo JR et al. Gestational diabetes mellitus decreases placental uptake of long-chain polyunsaturated fatty acids: involvement of long-chain acyl-CoA synthetase. 2013 J. Nutr. Biochem. pmid:23790250
Russell KL et al. Low brain DHA content worsens sensorimotor outcomes after TBI and decreases TBI-induced Timp1 expression in juvenile rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23796971
Haller MJ et al. Autologous umbilical cord blood infusion followed by oral docosahexaenoic acid and vitamin D supplementation for C-peptide preservation in children with Type 1 diabetes. 2013 Biol. Blood Marrow Transplant. pmid:23611977
Rashid MA et al. N-Docosahexaenoylethanolamine is a potent neurogenic factor for neural stem cell differentiation. 2013 J. Neurochem. pmid:23570577
Decsi T and Boehm G trans Isomeric fatty acids are inversely related to the availability of long-chain PUFAs in the perinatal period. 2013 Am. J. Clin. Nutr. pmid:23824720
Taha AY et al. A minimum of 3 months of dietary fish oil supplementation is required to raise amygdaloid afterdischarge seizure thresholds in rats--implications for treating complex partial seizures. 2013 Epilepsy Behav pmid:23376336
Nobre ME et al. Eicosapentaenoic acid and docosahexaenoic acid exert anti-inflammatory and antinociceptive effects in rodents at low doses. 2013 Nutr Res pmid:23684444
Begum G et al. ER stress and effects of DHA as an ER stress inhibitor. 2013 Transl Stroke Res pmid:24323417
Lee AL and Park Y The association between n-3 polyunsaturated fatty acid levels in erythrocytes and the risk of rheumatoid arthritis in Korean women. 2013 Ann. Nutr. Metab. pmid:23949659
van der Merwe LF et al. Long-chain PUFA supplementation in rural African infants: a randomized controlled trial of effects on gut integrity, growth, and cognitive development. 2013 Am. J. Clin. Nutr. pmid:23221579
Marcon R et al. Maresin 1, a proresolving lipid mediator derived from omega-3 polyunsaturated fatty acids, exerts protective actions in murine models of colitis. 2013 J. Immunol. pmid:24038091
Neuhofer A et al. Impaired local production of proresolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation. 2013 Diabetes pmid:23349501