DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Suganuma H et al. Effect of hypoxic-ischemic insults on the composition of fatty acids in the brain of neonatal rats. 2013 Ann. Nutr. Metab. pmid:23364132
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Schantz MM et al. Development of botanical and fish oil standard reference materials for fatty acids. 2013 Anal Bioanal Chem pmid:23371533
Teague H et al. Dendritic cell activation, phagocytosis and CD69 expression on cognate T cells are suppressed by n-3 long-chain polyunsaturated fatty acids. 2013 Immunology pmid:23373457
Soubias O and Gawrisch K Rhodopsin-lipid interactions studied by NMR. 2013 Meth. Enzymol. pmid:23374188
Daak AA et al. Docosahexaenoic and eicosapentaenoic acid supplementation does not exacerbate oxidative stress or intravascular haemolysis in homozygous sickle cell patients. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:24095588
Ishida T et al. Distinct regulation of plasma LDL cholesterol by eicosapentaenoic acid and docosahexaenoic acid in high fat diet-fed hamsters: participation of cholesterol ester transfer protein and LDL receptor. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23375839
Umhau JC et al. Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy. 2013 PLoS ONE pmid:24098376
Renganathan K et al. CEP biomarkers as potential tools for monitoring therapeutics. 2013 PLoS ONE pmid:24098476
Xu J et al. Expression of a type 2 diacylglycerol acyltransferase from Thalassiosira pseudonana in yeast leads to incorporation of docosahexaenoic acid β-oxidation intermediates into triacylglycerol. 2013 FEBS J. pmid:24128189
Teague H et al. DHA-fluorescent probe is sensitive to membrane order and reveals molecular adaptation of DHA in ordered lipid microdomains. 2013 J. Nutr. Biochem. pmid:22841541
Zong G et al. Effects of flaxseed supplementation on erythrocyte fatty acids and multiple cardiometabolic biomarkers among Chinese with risk factors of metabolic syndrome. 2013 Eur J Nutr pmid:23179200
Meher AP et al. Preconceptional omega-3 fatty acid supplementation on a micronutrient-deficient diet improves the reproductive cycle in Wistar rats. 2013 Reprod. Fertil. Dev. pmid:23137932
Betancor MB et al. Oxidative status and histological changes in sea bass larvae muscle in response to high dietary content of docosahexaenoic acid DHA. 2013 J. Fish Dis. pmid:23167568
Herba CM et al. Breastfeeding and early brain development: the Generation R study. 2013 Matern Child Nutr pmid:23167730
Rovito D et al. Omega-3 PUFA ethanolamides DHEA and EPEA induce autophagy through PPARγ activation in MCF-7 breast cancer cells. 2013 J. Cell. Physiol. pmid:23168911
Sato SB et al. Inhibition of constitutive Akt (PKB) phosphorylation by docosahexaenoic acid in the human breast cancer cell line MDA-MB-453. 2013 Biochim. Biophys. Acta pmid:23085420
Faizan M et al. Dietary alpha-tocopherol affects tissue vitamin e and malondialdehyde levels but does not change antioxidant enzymes and fatty acid composition in farmed Atlantic salmon (Salmo salar L.). 2013 Int J Vitam Nutr Res pmid:25008014
Al-Taan O et al. Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases. 2013 Lipids Health Dis pmid:23648075
Hoshi T et al. Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23487786
Gerstenblith AT et al. Electroretinographic effects of omega-3 Fatty Acid supplementation on dry age-related macular degeneration. 2013 JAMA Ophthalmol pmid:23494041
Ramos-Loyo J et al. Sex differences in lipid peroxidation and fatty acid levels in recent onset schizophrenia. 2013 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:23421976
Dallaire R et al. Exposure to organochlorines and mercury through fish and marine mammal consumption: associations with growth and duration of gestation among Inuit newborns. 2013 Environ Int pmid:23422685
Liu J et al. Screening and characterization of Isochrysis strains and optimization of culture conditions for docosahexaenoic acid production. 2013 Appl. Microbiol. Biotechnol. pmid:23423326
Metherel AH et al. Butylated hydroxytoluene can protect polyunsaturated fatty acids in dried blood spots from degradation for up to 8 weeks at room temperature. 2013 Lipids Health Dis pmid:23425563
Nordgren TM et al. Maresin-1 reduces the pro-inflammatory response of bronchial epithelial cells to organic dust. 2013 Respir. Res. pmid:23663457
Izquierdo MS et al. Effects of dietary DHA and α-tocopherol on bone development, early mineralisation and oxidative stress in Sparus aurata (Linnaeus, 1758) larvae. 2013 Br. J. Nutr. pmid:23046500
Hara M et al. Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction. 2013 Circ. J. pmid:23047296
McNamara RK et al. Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of adult depressed suicide victims compared with controls without cardiovascular disease. 2013 J Psychiatr Res pmid:23759469
Nielsen G et al. Alterations of N-3 polyunsaturated fatty acid-activated K2P channels in hypoxia-induced pulmonary hypertension. 2013 Basic Clin. Pharmacol. Toxicol. pmid:23724868
Moate PJ et al. Effects of feeding algal meal high in docosahexaenoic acid on feed intake, milk production, and methane emissions in dairy cows. 2013 J. Dairy Sci. pmid:23498011
Ajami M et al. Effect of DHA+EPA on oxidative stress and apoptosis induced by ischemia-reperfusion in rat kidneys. 2013 Fundam Clin Pharmacol pmid:22943605
Ruiz-Lopez N et al. Reconstitution of EPA and DHA biosynthesis in arabidopsis: iterative metabolic engineering for the synthesis of n-3 LC-PUFAs in transgenic plants. 2013 Metab. Eng. pmid:23500000
Recchiuti A Resolvin D1 and its GPCRs in resolution circuits of inflammation. 2013 Prostaglandins Other Lipid Mediat. pmid:23500003
Gladyshev MI et al. Production of EPA and DHA in aquatic ecosystems and their transfer to the land. 2013 Prostaglandins Other Lipid Mediat. pmid:23500063
Zhuang W et al. Omega-3 polyunsaturated fatty acids reduce vascular endothelial growth factor production and suppress endothelial wound repair. 2013 J Cardiovasc Transl Res pmid:22993129
Lu Y et al. Spinal injection of docosahexaenoic acid attenuates carrageenan-induced inflammatory pain through inhibition of microglia-mediated neuroinflammation in the spinal cord. 2013 Neuroscience pmid:23500096
Mozaffari-Khosravi H et al. Eicosapentaenoic acid versus docosahexaenoic acid in mild-to-moderate depression: a randomized, double-blind, placebo-controlled trial. 2013 Eur Neuropsychopharmacol pmid:22910528
Cardenia V et al. Health-related lipids components of sardine muscle as affected by photooxidation. 2013 Food Chem. Toxicol. pmid:23500769
Moallem U et al. Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil. 2013 Reproduction pmid:24062566
Dalli J et al. The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype. 2013 FASEB J. pmid:23504711
Hudson AG et al. Erythrocyte omega-6 and omega-3 fatty acids and mammographic breast density. 2013 Nutr Cancer pmid:23530640
Pacetti D et al. Effect of spawning on furan fatty acid profile of edible muscle and organ tissues from sardine (Sardina pilchardus) and anchovy (Engraulis encrasicolus). 2013 J. Agric. Food Chem. pmid:23531042
Mozurkewich EL et al. The Mothers, Omega-3, and Mental Health Study: a double-blind, randomized controlled trial. 2013 Am. J. Obstet. Gynecol. pmid:23531328
Romero VC et al. Developmental programming for allergy: a secondary analysis of the Mothers, Omega-3, and Mental Health Study. 2013 Am. J. Obstet. Gynecol. pmid:23531329
Bagley HN et al. Maternal docosahexaenoic acid increases adiponectin and normalizes IUGR-induced changes in rat adipose deposition. 2013 J Obes pmid:23533720
Miller E et al. A short-term n-3 DPA supplementation study in humans. 2013 Eur J Nutr pmid:22729967
Gao F et al. Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver. 2013 Age (Dordr) pmid:22388930
Erken HA et al. Exercise and DHA prevent the negative effects of hypoxia on EEG and nerve conduction velocity. 2013 High Alt. Med. Biol. pmid:24377343
Tapsell LC et al. Foods, nutrients or whole diets: effects of targeting fish and LCn3PUFA consumption in a 12mo weight loss trial. 2013 BMC Public Health pmid:24369765
van Valenberg HJ et al. Concentrations of n-3 and n-6 fatty acids in Dutch bovine milk fat and their contribution to human dietary intake. 2013 J. Dairy Sci. pmid:23664339
Baillie JK and Digard P Influenza--time to target the host? 2013 N. Engl. J. Med. pmid:23841736
Markhus MW et al. Low omega-3 index in pregnancy is a possible biological risk factor for postpartum depression. 2013 PLoS ONE pmid:23844041
Ribeiro T et al. Direct supplementation of diet is the most efficient way of enriching broiler meat with n-3 long-chain polyunsaturated fatty acids. 2013 Br. Poult. Sci. pmid:24397512
Singh A et al. Gene-metabolite expression in blood can discriminate allergen-induced isolated early from dual asthmatic responses. 2013 PLoS ONE pmid:23844124
Muldoon MF et al. Concurrent physical activity modifies the association between n3 long-chain fatty acids and cardiometabolic risk in midlife adults. 2013 J. Nutr. pmid:23884386
Rayapudi S et al. Vitamin A and fish oils for retinitis pigmentosa. 2013 Cochrane Database Syst Rev pmid:24357340
Azordegan N et al. Carcinogenesis alters fatty acid profile in breast tissue. 2013 Mol. Cell. Biochem. pmid:23180247
Brouwer IA et al. Effect of alpha linolenic acid supplementation on serum prostate specific antigen (PSA): results from the alpha omega trial. 2013 PLoS ONE pmid:24349086
Chang G et al. Improvement of docosahexaenoic acid production on glycerol by Schizochytrium sp. S31 with constantly high oxygen transfer coefficient. 2013 Bioresour. Technol. pmid:23747449
Zhang L et al. Improving docosahexaenoic acid productivity of Schizochytrium sp. by a two-stage AEMR/shake mixed culture mode. 2013 Bioresour. Technol. pmid:23751810
Janczyk W et al. Omega-3 fatty acids for treatment of non-alcoholic fatty liver disease: design and rationale of randomized controlled trial. 2013 BMC Pediatr pmid:23702094
Cortina MS et al. Neuroprotectin D1 restores corneal nerve integrity and function after damage from experimental surgery. 2013 Invest. Ophthalmol. Vis. Sci. pmid:23702780
Nyuar KB et al. Regular consumption of Nile river fish could ameliorate the low milk DHA of Southern Sudanese women living in Khartoum City area. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23706881
Terrando N et al. Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline. 2013 FASEB J. pmid:23709617
Das UN Polyunsaturated fatty acids in heart failure. 2013 Circ. J. pmid:23628915
Hara M and Sakata Y Polyunsaturated fatty acids in heart failure: reply. 2013 Circ. J. pmid:23628916
Chouinard-Watkins R et al. Disturbance in uniformly 13C-labelled DHA metabolism in elderly human subjects carrying the apoE ε4 allele. 2013 Br. J. Nutr. pmid:23631810
Laird BD et al. Dietary advice on Inuit traditional food use needs to balance benefits and risks of mercury, selenium, and n3 fatty acids. 2013 J. Nutr. pmid:23616502
Sala-Vila A et al. Eicosapentaenoic acid in serum phospholipids relates to a less atherogenic lipoprotein profile in subjects with familial hypercholesterolemia. 2013 J. Nutr. Biochem. pmid:23618530
Meyer BJ et al. Assessing long-chain ω-3 polyunsaturated fatty acids: a tailored food-frequency questionnaire is better. 2013 Nutrition pmid:22929186
Johnston DT et al. Red blood cell omega-3 fatty acid levels and neurocognitive performance in deployed U.S. Servicemembers. 2013 Nutr Neurosci pmid:22748167
Kusunoki C et al. Omega-3 polyunsaturated fatty acid has an anti-oxidant effect via the Nrf-2/HO-1 pathway in 3T3-L1 adipocytes. 2013 Biochem. Biophys. Res. Commun. pmid:23131562
Ravacci GR et al. Lipid raft disruption by docosahexaenoic acid induces apoptosis in transformed human mammary luminal epithelial cells harboring HER-2 overexpression. 2013 J. Nutr. Biochem. pmid:22749134
Li C et al. High efficient treatment of citric acid effluent by Chlorella vulgaris and potential biomass utilization. 2013 Bioresour. Technol. pmid:23131649
Nicholson T et al. The role of marine n-3 fatty acids in improving cardiovascular health: a review. 2013 Food Funct pmid:23325431
Hamaoka N et al. Oxidative stability of lipids rich in EPA and DHA extracted from fermented scallop ovary. 2013 J. Food Sci. pmid:23915081
Reinders I et al. Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study. 2013 Eur J Clin Nutr pmid:24084512
Takayama M et al. Association of marine-origin n-3 polyunsaturated fatty acids consumption and functional mobility in the community-dwelling oldest old. 2013 J Nutr Health Aging pmid:23299385
Lovegrove JA and Griffin BA The acute and long-term effects of dietary fatty acids on vascular function in health and disease. 2013 Curr Opin Clin Nutr Metab Care pmid:23299700
Santos VC et al. Effects of DHA-rich fish oil supplementation on lymphocyte function before and after a marathon race. 2013 Int J Sport Nutr Exerc Metab pmid:23239683
Raza Shaikh S and Brown DA Models of plasma membrane organization can be applied to mitochondrial membranes to target human health and disease with polyunsaturated fatty acids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22464052
Hoshi T et al. Reply to Harris et al.: Differential impacts of omega-3 fatty acids and their derivatives on blood pressure. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23940844
Sadli N et al. Effect of DHA and coenzymeQ10 against Aβ- and zinc-induced mitochondrial dysfunction in human neuronal cells. 2013 Cell. Physiol. Biochem. pmid:23942088
Rajasagi NK et al. Neuroprotectin D1 reduces the severity of herpes simplex virus-induced corneal immunopathology. 2013 Invest. Ophthalmol. Vis. Sci. pmid:23942967
Mühlroth A et al. Pathways of lipid metabolism in marine algae, co-expression network, bottlenecks and candidate genes for enhanced production of EPA and DHA in species of Chromista. 2013 Mar Drugs pmid:24284429
Chaung HC et al. Docosahexaenoic acid and phosphatidylserine improves the antioxidant activities in vitro and in vivo and cognitive functions of the developing brain. 2013 Food Chem pmid:23265497
Akanbi TO et al. Selective concentration of EPA and DHA using Thermomyces lanuginosus lipase is due to fatty acid selectivity and not regioselectivity. 2013 Food Chem pmid:23265531
Alicandro G et al. A randomized placebo-controlled study on high-dose oral algal docosahexaenoic acid supplementation in children with cystic fibrosis. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23266209
Fenton JI and McCaskey SJ Curcumin and docosahexaenoic acid block insulin-induced colon carcinoma cell proliferation. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23266210
Tam VC Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections. 2013 Semin. Immunol. pmid:24084369
Rogers LK et al. DHA supplementation: current implications in pregnancy and childhood. 2013 Pharmacol. Res. pmid:23266567
Orr SK et al. Unesterified docosahexaenoic acid is protective in neuroinflammation. 2013 J. Neurochem. pmid:23919613
Yusof HM et al. Limited impact of 2 g/day omega-3 fatty acid ethyl esters (Omacor®) on plasma lipids and inflammatory markers in patients awaiting carotid endarterectomy. 2013 Mar Drugs pmid:24065166
Stanley WC et al. Evaluation of docosahexaenoic acid in a dog model of hypertension induced left ventricular hypertrophy. 2013 J Cardiovasc Transl Res pmid:24065618
Xiao G et al. Eicosapentaenoic acid enhances heat stress-impaired intestinal epithelial barrier function in Caco-2 cells. 2013 PLoS ONE pmid:24066055
Lachance C et al. Fenretinide corrects the imbalance between omega-6 to omega-3 polyunsaturated fatty acids and inhibits macrophage inflammatory mediators via the ERK pathway. 2013 PLoS ONE pmid:24069363
Leggieri E et al. Clinical effects of diet supplementation with DHA in pediatric patients suffering from cystic fibrosis. 2013 Minerva Pediatr. pmid:24051972
Cunnane SC et al. Docosahexaenoic acid homeostasis, brain aging and Alzheimer's disease: Can we reconcile the evidence? 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22575581
Delplanque B et al. A dairy fat matrix providing alpha-linolenic acid (ALA) is better than a vegetable fat mixture to increase brain DHA accretion in young rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22884780