DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Igarashi M et al. Dietary n-6 polyunsaturated fatty acid deprivation increases docosahexaenoic acid metabolism in rat brain. 2012 J. Neurochem. pmid:22117540
Lim SJ et al. Docosahexaenoic acid sensitizes colon cancer cells to sulindac sulfide-induced apoptosis. 2012 Oncol. Rep. pmid:22395735
Sørensen IM et al. Serum long chain n-3 fatty acids (EPA and DHA) in the pregnant mother are independent of risk of type 1 diabetes in the offspring. 2012 Diabetes Metab. Res. Rev. pmid:22396195
Hutchins-Wiese HL et al. Hind limb suspension and long-chain omega-3 PUFA increase mRNA endocannabinoid system levels in skeletal muscle. 2012 J. Nutr. Biochem. pmid:22051448
Petrie JR et al. Metabolic engineering plant seeds with fish oil-like levels of DHA. 2012 PLoS ONE pmid:23145108
Cruz-Hernandez C et al. Benefits of structured and free monoacylglycerols to deliver eicosapentaenoic (EPA) in a model of lipid malabsorption. 2012 Nutrients pmid:23201848
Noreen EE and Brandauer J The effects of supplemental fish oil on blood pressure and morning cortisol in normotensive adults: a pilot study. 2012 J Complement Integr Med pmid:23104856
Skulas-Ray AC et al. Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress: a dose-response study. 2012 Ann Behav Med pmid:22865498
Le HD et al. Docosahexaenoic acid and arachidonic acid prevent essential fatty acid deficiency and hepatic steatosis. 2012 JPEN J Parenter Enteral Nutr pmid:22038210
Towhidi A and Parks JE Effect of n-3 fatty acids and α-tocopherol on post-thaw parameters and fatty acid composition of bovine sperm. 2012 J. Assist. Reprod. Genet. pmid:22869241
Tillman EM et al. Eicosapentaenoic acid and docosahexaenoic acid synergistically attenuate bile acid-induced hepatocellular apoptosis. 2012 JPEN J Parenter Enteral Nutr pmid:22038211
Fasano E et al. DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. 2012 Biochim. Biophys. Acta pmid:22898250
Jackson PA et al. DHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: a near IR spectroscopy pilot study. 2012 Br. J. Nutr. pmid:22018509
Tyburczy C et al. Growth, clinical chemistry and immune function in domestic piglets fed varying ratios of arachidonic acid and DHA. 2012 Br. J. Nutr. pmid:22040360
Schmitt D et al. Toxicologic evaluation of DHA-rich algal oil: Genotoxicity, acute and subchronic toxicity in rats. 2012 Food Chem. Toxicol. pmid:22898615
Serini S et al. DHA induces apoptosis and differentiation in human melanoma cells in vitro: involvement of HuR-mediated COX-2 mRNA stabilization and β-catenin nuclear translocation. 2012 Carcinogenesis pmid:22045024
Jackson PA et al. Docosahexaenoic acid-rich fish oil modulates the cerebral hemodynamic response to cognitive tasks in healthy young adults. 2012 Biol Psychol pmid:22020134
An WS et al. Omega-3 fatty acid supplementation increases 1,25-dihydroxyvitamin D and fetuin-A levels in dialysis patients. 2012 Nutr Res pmid:22901557
Li N et al. Arginyl-glutamine dipeptide or docosahexaenoic acid attenuates hyperoxia-induced small intestinal injury in neonatal mice. 2012 J. Pediatr. Gastroenterol. Nutr. pmid:22020559
Morris MC Nutritional determinants of cognitive aging and dementia. 2012 Proc Nutr Soc pmid:22067138
Berson EL et al. ω-3 intake and visual acuity in patients with retinitis pigmentosa receiving vitamin A. 2012 Arch. Ophthalmol. pmid:22332205
Beezhold BL and Johnston CS Restriction of meat, fish, and poultry in omnivores improves mood: a pilot randomized controlled trial. 2012 Nutr J pmid:22333737
Rondanelli M et al. Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment. 2012 Nutr Neurosci pmid:22334085
Rockett BD et al. Fish oil increases raft size and membrane order of B cells accompanied by differential effects on function. 2012 J. Lipid Res. pmid:22315394
Hjorth E and Freund-Levi Y Immunomodulation of microglia by docosahexaenoic acid and eicosapentaenoic acid. 2012 Curr Opin Clin Nutr Metab Care pmid:22316559
Liu RZ et al. A fatty acid-binding protein 7/RXRβ pathway enhances survival and proliferation in triple-negative breast cancer. 2012 J. Pathol. pmid:22322885
Deckelbaum RJ et al. Conclusions and recommendations from the symposium, Heart Healthy Omega-3s for Food: Stearidonic Acid (SDA) as a Sustainable Choice. 2012 J. Nutr. pmid:22323767
Harden CJ et al. Effect of different long-chain fatty acids on cholecystokinin release in vitro and energy intake in free-living healthy males. 2012 Br. J. Nutr. pmid:22313587
Liu Y et al. Fish oil enhances intestinal integrity and inhibits TLR4 and NOD2 signaling pathways in weaned pigs after LPS challenge. 2012 J. Nutr. pmid:23014495
Saito H and Ishikawa S Characteristic of lipids and fatty acid compositions of the neon flying squid, Ommastrephes bartramii. 2012 J Oleo Sci pmid:23018852
Lopez HL Nutritional interventions to prevent and treat osteoarthritis. Part I: focus on fatty acids and macronutrients. 2012 PM R pmid:22632694
O'Flaherty JT et al. 15-lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival. 2012 PLoS ONE pmid:23029040
Felbinger TW et al. Supplementation in acute lung injury. 2012 JAMA pmid:22235078
Bistrian BR Supplementation in acute lung injury. 2012 JAMA pmid:22235079
König K et al. Supplementation in acute lung injury. 2012 JAMA pmid:22235080
Xue C et al. Differences in lipid characteristics among populations: low-temperature adaptability of ayu, Plecoglossus altivelis. 2012 Lipids pmid:22120618
Schmitt D et al. Toxicologic evaluations of DHA-rich algal oil in rats: developmental toxicity study and 3-month dietary toxicity study with an in utero exposure phase. 2012 Food Chem. Toxicol. pmid:22960629
Huang TY et al. A fermentation strategy for producing docosahexaenoic acid in Aurantiochytrium limacinum SR21 and increasing C22:6 proportions in total fatty acid. 2012 Bioresour. Technol. pmid:22929740
Browning LM et al. Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish. 2012 Am. J. Clin. Nutr. pmid:22932281
Pan XX et al. Efficient display of active Geotrichum sp. lipase on Pichia pastoris cell wall and its application as a whole-cell biocatalyst to enrich EPA and DHA in fish oil. 2012 J. Agric. Food Chem. pmid:22934819
Zhao M et al. Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women. 2012 J. Nutr. pmid:22955512
Bazan NG Neuroinflammation and proteostasis are modulated by endogenously biosynthesized neuroprotectin D1. 2012 Mol. Neurobiol. pmid:22956271
Feng Z et al. Maternal docosahexaenoic acid feeding protects against impairment of learning and memory and oxidative stress in prenatally stressed rats: possible role of neuronal mitochondria metabolism. 2012 Antioxid. Redox Signal. pmid:21905985
Moreno-Indias I et al. The effect of diet and DHA addition on the sensory quality of goat kid meat. 2012 Meat Sci. pmid:21907501
Alvarez-Nölting R et al. Protection by DHA of early hippocampal changes in diabetes: possible role of CREB and NF-κB. 2012 Neurochem. Res. pmid:21909958
Pifferi F et al. Fatty acid composition of the brain, retina, liver and adipose tissue of the grey mouse lemur (Microcebus murinus, primate). 2012 Lipids pmid:22684890
Cortina MS et al. Recovery of corneal sensitivity, calcitonin gene-related peptide-positive nerves, and increased wound healing induced by pigment epithelial-derived factor plus docosahexaenoic acid after experimental surgery. 2012 Arch. Ophthalmol. pmid:21911652
Heinze VM and Actis AB Dietary conjugated linoleic acid and long-chain n-3 fatty acids in mammary and prostate cancer protection: a review. 2012 Int J Food Sci Nutr pmid:21762028
Ribeiro P et al. Effect of fish oil supplementation in pregnancy on the fatty acid composition of erythrocyte phospholipids and breast milk lipids. 2012 Int J Food Sci Nutr pmid:21707451
Steffen BT et al. Ethnicity, plasma phospholipid fatty acid composition and inflammatory/endothelial activation biomarkers in the Multi-Ethnic Study of Atherosclerosis (MESA). 2012 Eur J Clin Nutr pmid:22215136
Peters BS et al. The effect of a 12-week course of omega-3 polyunsaturated fatty acids on lipid parameters in hypertriglyceridemic adult HIV-infected patients undergoing HAART: a randomized, placebo-controlled pilot trial. 2012 Clin Ther pmid:22212377
Munro IA and Garg ML Dietary supplementation with n-3 PUFA does not promote weight loss when combined with a very-low-energy diet. 2012 Br. J. Nutr. pmid:22214842
Basselin M et al. Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans. 2012 Brain Res. Bull. pmid:22178644
van der Meij BS et al. Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT. 2012 Eur J Clin Nutr pmid:22234041
Chen HF and Su HM Fish oil supplementation of maternal rats on an n-3 fatty acid-deficient diet prevents depletion of maternal brain regional docosahexaenoic acid levels and has a postpartum anxiolytic effect. 2012 J. Nutr. Biochem. pmid:21543216
Odusanwo O et al. Resolvin D1 prevents TNF-α-mediated disruption of salivary epithelial formation. 2012 Am. J. Physiol., Cell Physiol. pmid:22237406
Deike E et al. The effects of fish oil supplementation on markers of inflammation in chronic kidney disease patients. 2012 J Ren Nutr pmid:22285316
Trépanier MO et al. Increases in seizure latencies induced by subcutaneous docosahexaenoic acid are lost at higher doses. 2012 Epilepsy Res. pmid:22285511
Signori C et al. Administration of omega-3 fatty acids and Raloxifene to women at high risk of breast cancer: interim feasibility and biomarkers analysis from a clinical trial. 2012 Eur J Clin Nutr pmid:22669332
Wu MH et al. Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10. 2012 J. Nutr. Biochem. pmid:22285823
Han CY et al. NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes. 2012 J. Biol. Chem. pmid:22287546
Rasic-Milutinovic Z et al. Lower serum paraoxonase-1 activity is related to linoleic and docosahexanoic fatty acids in type 2 diabetic patients. 2012 Arch. Med. Res. pmid:22222492
Kitson AP et al. Enzymes in brain phospholipid docosahexaenoic acid accretion: a PL-ethora of potential PL-ayers. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22749739
Johnson M et al. Fatty acids in ADHD: plasma profiles in a placebo-controlled study of Omega 3/6 fatty acids in children and adolescents. 2012 Atten Defic Hyperact Disord pmid:22753087
Quinn EA and Kuzawa CW A dose-response relationship between fish consumption and human milk DHA content among Filipino women in Cebu City, Philippines. 2012 Acta Paediatr. pmid:22759234
Turk HF et al. Alteration of EGFR spatiotemporal dynamics suppresses signal transduction. 2012 PLoS ONE pmid:22761867
Hacioglu G et al. Docosahexaenoic acid provides protective mechanism in bilaterally MPTP-lesioned rat model of Parkinson's disease. 2012 Folia Histochem. Cytobiol. pmid:22763967
Scheltens P et al. Efficacy of Souvenaid in mild Alzheimer's disease: results from a randomized, controlled trial. 2012 J. Alzheimers Dis. pmid:22766770
Moreno-Indias I et al. Docosahexaenoic acid in the goat kid diet: effects on immune system and meat quality. 2012 J. Anim. Sci. pmid:22665635
Holly LT et al. Dietary therapy to promote neuroprotection in chronic spinal cord injury. 2012 J Neurosurg Spine pmid:22735048
Moallem U and Zachut M Short communication: the effects of supplementation of various n-3 fatty acids to late-pregnant dairy cows on plasma fatty acid composition of the newborn calves. 2012 J. Dairy Sci. pmid:22720961
Maqbool A et al. Relation between dietary fat intake type and serum fatty acid status in children with cystic fibrosis. 2012 J. Pediatr. Gastroenterol. Nutr. pmid:22699835
Oblozinský M et al. New pharmaceutical insights related to the pathways of PUFAs. 2012 Ceska Slov Farm pmid:23251954
Liu SH et al. Docosahexaenoic acid and phosphatidylserine supplementations improve antioxidant activities and cognitive functions of the developing brain on pentylenetetrazol-induced seizure model. 2012 Brain Res. pmid:22440676
Turchini GM et al. Jumping on the omega-3 bandwagon: distinguishing the role of long-chain and short-chain omega-3 fatty acids. 2012 Crit Rev Food Sci Nutr pmid:22698270
Trikalinos TA et al. Concordance of randomized and nonrandomized studies was unrelated to translational patterns of two nutrient-disease associations. 2012 J Clin Epidemiol pmid:22047889
Passos PP et al. Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. 2012 J. Chem. Neuroanat. pmid:22687395
Bianchini F et al. 22 : 6n-3 DHA inhibits differentiation of prostate fibroblasts into myofibroblasts and tumorigenesis. 2012 Br. J. Nutr. pmid:22390897
Tu WC et al. An alternative n-3 fatty acid elongation pathway utilising 18:3n-3 in barramundi (Lates calcarifer). 2012 Biochem. Biophys. Res. Commun. pmid:22640739
Itakura H et al. The change in low-density lipoprotein cholesterol concentration is positively related to plasma docosahexaenoic acid but not eicosapentaenoic acid. 2012 J. Atheroscler. Thromb. pmid:22653220
Lorenzetti A et al. Improving sperm quality and spermatogenesis through a bioactive marine compound: an experimental study. 2012 Acta Biomed pmid:23393918
Glover KE et al. Effect of feeding fresh forage and marine algae on the fatty acid composition and oxidation of milk and butter. 2012 J. Dairy Sci. pmid:22612917
Corsetto PA et al. Chemical-physical changes in cell membrane microdomains of breast cancer cells after omega-3 PUFA incorporation. 2012 Cell Biochem. Biophys. pmid:22622660
Bell S et al. The effect of omega-3 fatty acids on the atherogenic lipoprotein phenotype in patients with nephrotic range proteinuria. 2012 Clin. Nephrol. pmid:22595386
Hajjaji N et al. Tumor and non-tumor tissues differential oxidative stress response to supplemental DHA and chemotherapy in rats. 2012 Cancer Chemother. Pharmacol. pmid:22610354
Campoy C et al. Omega 3 fatty acids on child growth, visual acuity and neurodevelopment. 2012 Br. J. Nutr. pmid:22591907
Njoroge SW et al. DHA and EPA reverse cystic fibrosis-related FA abnormalities by suppressing FA desaturase expression and activity. 2012 J. Lipid Res. pmid:22095831
Angulo J et al. Dietary fatty acid intervention of lactating cows simultaneously affects lipid profiles of meat and milk. 2012 J. Sci. Food Agric. pmid:22549272
Wielinga PY et al. Arachidonic acid/docosahexaenoic acid-supplemented diet in early life reduces body weight gain, plasma lipids, and adiposity in later life in ApoE*3Leiden mice. 2012 Mol Nutr Food Res pmid:22611002
Zhou SJ et al. Fish-oil supplementation in pregnancy does not reduce the risk of gestational diabetes or preeclampsia. 2012 Am. J. Clin. Nutr. pmid:22552037
Correia M et al. Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization. 2012 PLoS ONE pmid:22529974
Calder PC Long-chain fatty acids and inflammation. 2012 Proc Nutr Soc pmid:22369781
Drzymała-Czyż S et al. Discrepancy between clinical and histological effects of DHA supplementation in a rat model of pouchitis. 2012 Folia Histochem. Cytobiol. pmid:22532147
Kelley DS and Adkins Y Similarities and differences between the effects of EPA and DHA on markers of atherosclerosis in human subjects. 2012 Proc Nutr Soc pmid:22369859
Bernstein AM et al. A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease. 2012 J. Nutr. pmid:22113870
Daud ZA et al. Effects of protein and omega-3 supplementation, provided during regular dialysis sessions, on nutritional and inflammatory indices in hemodialysis patients. 2012 Vasc Health Risk Manag pmid:22536073
Yui K et al. Effects of large doses of arachidonic acid added to docosahexaenoic acid on social impairment in individuals with autism spectrum disorders: a double-blind, placebo-controlled, randomized trial. 2012 J Clin Psychopharmacol pmid:22370992
Finocchiaro C et al. Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study. 2012 Br. J. Nutr. pmid:22114792
Crnkovic S et al. Docosahexaenoic acid-induced unfolded protein response, cell cycle arrest, and apoptosis in vascular smooth muscle cells are triggered by Ca²⁺-dependent induction of oxidative stress. 2012 Free Radic. Biol. Med. pmid:22391221
Aisen PS et al. Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease. 2012 Cold Spring Harb Perspect Med pmid:22393531