DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Gelsomino G et al. Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition. 2013 Mol. Cancer pmid:24225025
Cederholm T et al. ω-3 fatty acids in the prevention of cognitive decline in humans. 2013 Adv Nutr pmid:24228198
Amminger GP et al. Omega-3 fatty acid supplementation in adolescents with borderline personality disorder and ultra-high risk criteria for psychosis: a post hoc subgroup analysis of a double-blind, randomized controlled trial. 2013 Can J Psychiatry pmid:23870722
Lotrich FE et al. Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids. 2013 J Psychosom Res pmid:24182638
Pande G et al. Enzymatic synthesis of extra virgin olive oil based infant formula fat analogues containing ARA and DHA: one-stage and two-stage syntheses. 2013 J. Agric. Food Chem. pmid:24117100
Murphy EJ A lipid neurochemist's siren: docosahexaenoic acid and its elusive function in the central nervous system. 2013 J. Neurochem. pmid:24117623
Flock MR et al. Long-chain omega-3 fatty acids: time to establish a dietary reference intake. 2013 Nutr. Rev. pmid:24117792
Carlson SJ et al. The role of the ω-3 fatty acid DHA in the human life cycle. 2013 JPEN J Parenter Enteral Nutr pmid:23192455
Le HD et al. The effect of varying ratios of docosahexaenoic acid and arachidonic acid in the prevention and reversal of biochemical essential fatty acid deficiency in a murine model. 2013 Metab. Clin. Exp. pmid:23151438
Lecchi C et al. Effects of EPA and DHA on lipid droplet accumulation and mRNA abundance of PAT proteins in caprine monocytes. 2013 Res. Vet. Sci. pmid:23102647
Brenna T et al. Docosahexaenoic acid in translational medicine: the Tenth Fatty Acids and Cell Signaling meeting (FACS-10). 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23103099
Lee LK et al. The role of long chain omega-3 polyunsaturated fatty acids in reducing lipid peroxidation among elderly patients with mild cognitive impairment: a case-control study. 2013 J. Nutr. Biochem. pmid:22898566
Nozue T et al. Effects of statins on serum n-3 to n-6 polyunsaturated fatty acid ratios in patients with coronary artery disease. 2013 J. Cardiovasc. Pharmacol. Ther. pmid:23324995
Yang YC et al. Docosahexaenoic acid inhibition of inflammation is partially via cross-talk between Nrf2/heme oxygenase 1 and IKK/NF-κB pathways. 2013 J. Nutr. Biochem. pmid:22901690
Walker CG et al. Stearidonic acid as a supplemental source of ω-3 polyunsaturated fatty acids to enhance status for improved human health. 2013 Nutrition pmid:23102888
Cao AH et al. Composition of long chain polyunsaturated fatty acids (LC-PUFAs) in different encephalic regions and its association with behavior in spontaneous hypertensive rat (SHR). 2013 Brain Res. pmid:23811335
Tu WC et al. Dietary alpha-linolenic acid does not enhance accumulation of omega-3 long-chain polyunsaturated fatty acids in barramundi (Lates calcarifer). 2013 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:23085323
Paschoal VA et al. Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid differentially modulate rat neutrophil function in vitro. 2013 Lipids pmid:23086551
Kataoka Y et al. Epanova(®) and hypertriglyceridemia: pharmacological mechanisms and clinical efficacy. 2013 Future Cardiol pmid:23463969
Cedernaes J et al. Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet. 2013 Lipids Health Dis pmid:23298201
Mocking RJ et al. Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression. 2013 Psychoneuroendocrinology pmid:23465556
Gao M et al. Isolation and characterization of Aurantiochytrium species: high docosahexaenoic acid (DHA) production by the newly isolated microalga, Aurantiochytrium sp. SD116. 2013 J Oleo Sci pmid:23470441
Dobson EP et al. Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase. 2013 J. Lipid Res. pmid:23471029
Drover JR et al. Addendum to "Cognitive function in 18-month-old term infants of the DIAMOND study: a randomized, controlled clinical trial with multiple dietary levels of docosahexaenoic acid" [Early Hum. Dev. 87 (2011) 223-230]. 2013 Early Hum. Dev. pmid:23411369
Sundrani D et al. Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases-1, -2 in placentas from preterm pregnancies and their association with one-carbon metabolites. 2013 Reproduction pmid:23412981
McNamara RK Deciphering the role of docosahexaenoic acid in brain maturation and pathology with magnetic resonance imaging. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22521863
Lagarde M et al. Dose-effect and metabolism of docosahexaenoic acid: pathophysiological relevance in blood platelets. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22520055
Hong WK et al. Production of lipids containing high levels of docosahexaenoic acid from empty palm fruit bunches by Aurantiochytrium sp. KRS101. 2013 Bioprocess Biosyst Eng pmid:23053417
Lohner S et al. Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. 2013 Ann. Nutr. Metab. pmid:23327902
MacIntosh BA et al. Low-n-6 and low-n-6 plus high-n-3 diets for use in clinical research. 2013 Br. J. Nutr. pmid:23328113
Carey AN et al. The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. 2013 Nutr Neurosci pmid:23321679
Usami M et al. Analysis of fecal microbiota, organic acids and plasma lipids in hepatic cancer patients with or without liver cirrhosis. 2013 Clin Nutr pmid:23068014
Kimura AK and Kim HY Phosphatidylserine synthase 2: high efficiency for synthesizing phosphatidylserine containing docosahexaenoic acid. 2013 J. Lipid Res. pmid:23071296
Kang JX and Gleason ED Omega-3 Fatty acids and hippocampal neurogenesis in depression. 2013 CNS Neurol Disord Drug Targets pmid:23574158
Kim HY and Spector AA Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22959887
Minihane AM Fish oil omega-3 fatty acids and cardio-metabolic health, alone or with statins. 2013 Eur J Clin Nutr pmid:23403872
Miyahara T et al. D-series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury. 2013 FASEB J. pmid:23407709
Huang LL et al. Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23474173
Morita M et al. The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. 2013 Cell pmid:23477864
Lee LK et al. Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial. 2013 Psychopharmacology (Berl.) pmid:22932777
Berberovic E et al. Arachidonic and docosahexaenoic acid in the blood of a mother and umbilical vein in diabetic pregnant women. 2013 J. Matern. Fetal. Neonatal. Med. pmid:23480524
Khaled M et al. Effects of resolvin D1 on cell survival and cytokine expression of human gingival fibroblasts. 2013 J. Periodontol. pmid:23398023
Pettit LK et al. Modulating the inflammatory properties of activated microglia with Docosahexaenoic acid and Aspirin. 2013 Lipids Health Dis pmid:23398903
Montes R et al. Fatty-acid composition of maternal and umbilical cord plasma and early childhood atopic eczema in a Spanish cohort. 2013 Eur J Clin Nutr pmid:23549201
Tu WC et al. Correlations between blood and tissue omega-3 LCPUFA status following dietary ALA intervention in rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22521090
Friedman AN et al. Fatty acids and other risk factors for sudden cardiac death in patients starting hemodialysis. 2013 Am. J. Nephrol. pmid:23816975
Zulyniak MA et al. Fish oil supplementation alters circulating eicosanoid concentrations in young healthy men. 2013 Metab. Clin. Exp. pmid:23522836
Qadhi R et al. Differential responses to docosahexaenoic acid in primary and immortalized cardiac cells. 2013 Toxicol. Lett. pmid:23523905
Gódor-Kacsándi A et al. Developmental docosahexaenoic and arachidonic acid supplementation improves adult learning and increases resistance against excitotoxicity in the brain. 2013 Acta Physiol Hung pmid:23524180
Meijerink J et al. N-Acyl amines of docosahexaenoic acid and other n-3 polyunsatured fatty acids - from fishy endocannabinoids to potential leads. 2013 Br. J. Pharmacol. pmid:23088259
Simões T et al. Seasonal variation in proximate composition and fatty acid profile of grey triggerfish (Balistes capriscus) captured along the coast of Portugal. 2013 J. Food Sci. pmid:23551246
Guihéneuf F et al. Use of radiolabeled substrates to determine the desaturase and elongase activities involved in eicosapentaenoic acid and docosahexaenoic acid biosynthesis in the marine microalga Pavlova lutheri. 2013 Phytochemistry pmid:23528573
Devaraj S et al. Modulation of endothelial progenitor cell number and function with n-3 polyunsaturated fatty acids. 2013 Atherosclerosis pmid:23528830
Zhang J et al. Different intakes of n-3 fatty acids among pregnant women in 3 regions of China with contrasting dietary patterns are reflected in maternal but not in umbilical erythrocyte phosphatidylcholine fatty acid composition. 2013 Nutr Res pmid:23890350
Yao C et al. Neuroprotectin D1 attenuates brain damage induced by transient middle cerebral artery occlusion in rats through TRPC6/CREB pathways. 2013 Mol Med Rep pmid:23799606
Davidson MH Omega-3 fatty acids: new insights into the pharmacology and biology of docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid. 2013 Curr. Opin. Lipidol. pmid:24184945
Al-Farsi YM et al. Impact of nutrition on serum levels of docosahexaenoic acid among Omani children with autism. 2013 Nutrition pmid:23800562
Samieri C et al. Relationship between diet and plasma long-chain n-3 PUFAs in older people: impact of apolipoprotein E genotype. 2013 J. Lipid Res. pmid:23801662
Wu JH et al. Plasma phospholipid omega-3 fatty acids and incidence of postoperative atrial fibrillation in the OPERA trial. 2013 J Am Heart Assoc pmid:24145742
Végran F et al. Socs3 induction by PPARγ restrains cancer-promoting inflammation. 2013 Cell Cycle pmid:23803735
Bruno MJ et al. Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonation. 2013 Faraday Discuss. pmid:23805753
Leino O et al. Effects of docosahexaenoic acid and methylmercury on child's brain development due to consumption of fish by Finnish mother during pregnancy: a probabilistic modeling approach. 2013 Food Chem. Toxicol. pmid:21723361
Mizia-Stec K et al. N-3 polyunsaturated fatty acids do not influence the efficacy of dual antiplatelet therapy in stable angina pectoris patients after percutaneous coronary intervention. 2013 Cardiol J pmid:24469870
Juman S et al. Effects of long-term oral administration of arachidonic acid and docosahexaenoic acid on the immune functions of young rats. 2013 Nutrients pmid:23760060
Merendino N et al. Dietary ω -3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer. 2013 Biomed Res Int pmid:23762838
Hunina LM et al. [Effectiveness of use of omega-3 polyunsaturated fatty acids at physical loads]. 2013 Fiziol Zh pmid:23713352
Dangour AD et al. N-3 fatty acids and retinal function. 2013 Ophthalmology pmid:23714605
Qu L et al. Batch, fed-batch and repeated fed-batch fermentation processes of the marine thraustochytrid Schizochytrium sp. for producing docosahexaenoic acid. 2013 Bioprocess Biosyst Eng pmid:23673897
Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. 2013 JAMA pmid:23644932
Veszelka S et al. Docosahexaenoic acid reduces amyloid-β induced toxicity in cells of the neurovascular unit. 2013 J. Alzheimers Dis. pmid:23645098
Stephenson JA et al. Unsaturated fatty acids differ between hepatic colorectal metastases and liver tissue without tumour in humans: results from a randomised controlled trial of intravenous eicosapentaenoic and docosahexaenoic acids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23647811
Nishinaka T et al. [Elucidation of mechanisms underlying docosahexaenoic acid-induced antinociception]. 2013 Yakugaku Zasshi pmid:23649389
Giroud S et al. Membrane phospholipid fatty acid composition regulates cardiac SERCA activity in a hibernator, the Syrian hamster (Mesocricetus auratus). 2013 PLoS ONE pmid:23650545
Ostapchenko VG et al. Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease. 2013 J. Neurochem. pmid:23651058
Rapoport SI Translational studies on regulation of brain docosahexaenoic acid (DHA) metabolism in vivo. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22766388
Ramprasath VR et al. Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil. 2013 Lipids Health Dis pmid:24304605
Fecchio C et al. α-Synuclein oligomers induced by docosahexaenoic acid affect membrane integrity. 2013 PLoS ONE pmid:24312431
Szklenar M et al. Eicosanoids and docosanoids in plasma and aorta of healthy and atherosclerotic rabbits. 2013 J. Vasc. Res. pmid:23969947
Dabkowski ER et al. Docosahexaenoic acid supplementation alters key properties of cardiac mitochondria and modestly attenuates development of left ventricular dysfunction in pressure overload-induced heart failure. 2013 Cardiovasc Drugs Ther pmid:24013804
Porta A et al. Biology and chemistry of neuroprostanes. First total synthesis of 17-A4-NeuroP: validation of a convergent strategy to a number of cyclopentenone neuroprostanes. 2013 Chem. Phys. Lipids pmid:23895793
Costa S et al. The emerging farmed fish species meagre (Argyrosomus regius): how culinary treatment affects nutrients and contaminants concentration and associated benefit-risk balance. 2013 Food Chem. Toxicol. pmid:23900006
Akiyama M et al. Impact of docosahexaenoic acid on gene expression during osteoclastogenesis in vitro--a comprehensive analysis. 2013 Nutrients pmid:23945674
Rosa A et al. Potential anti-tumor effects of Mugil cephalus processed roe extracts on colon cancer cells. 2013 Food Chem. Toxicol. pmid:23948356
Chen HW et al. Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells. 2013 Arch. Toxicol. pmid:23288142
Matsuoka Y et al. Tachikawa project for prevention of posttraumatic stress disorder with polyunsaturated fatty acid (TPOP): study protocol for a randomized controlled trial. 2013 BMC Psychiatry pmid:23289548
Gibson RA et al. Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22515943
Ritter JC et al. Quality analysis of commercial fish oil preparations. 2013 J. Sci. Food Agric. pmid:23255124
Fogagnolo Mauricio A et al. Effects of fish oil containing eicosapentaenoic acid and docosahexaenoic acid on dystrophic mdx mice. 2013 Clin Nutr pmid:23218947
Nobili V et al. Docosahexaenoic acid for the treatment of fatty liver: randomised controlled trial in children. 2013 Nutr Metab Cardiovasc Dis pmid:23220074
Takkunen M et al. Dietary fat in relation to erythrocyte fatty acid composition in men. 2013 Lipids pmid:23975575
Qu L et al. Biomass composition, lipid characterization, and metabolic profile analysis of the fed-batch fermentation process of two different docosahexanoic acid producing Schizochytrium sp. strains. 2013 Appl. Biochem. Biotechnol. pmid:24061873
Wu D et al. Novel biphasic role of resolvin D1 on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts is partly through PI3K/AKT and ERK2 pathways. 2013 Mediators Inflamm. pmid:24174713
Spite M Deciphering the role of n-3 polyunsaturated fatty acid-derived lipid mediators in health and disease. 2013 Proc Nutr Soc pmid:23991833
Siddiqui RA et al. Characterization of synergistic anti-cancer effects of docosahexaenoic acid and curcumin on DMBA-induced mammary tumorigenesis in mice. 2013 BMC Cancer pmid:24034496
Borghetti G et al. Tumor growth reduction is regulated at the gene level in Walker 256 tumor-bearing rats supplemented with fish oil rich in EPA and DHA. 2013 Braz. J. Med. Biol. Res. pmid:24036940
Phang M et al. Eicosapentaenoic and docosahexaenoic acid supplementations reduce platelet aggregation and hemostatic markers differentially in men and women. 2013 J. Nutr. pmid:23390192
Nikolakopoulou Z et al. The induction of apoptosis in pre-malignant keratinocytes by omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) is inhibited by albumin. 2013 Toxicol. Lett. pmid:23391486
Souied EH et al. Oral docosahexaenoic acid in the prevention of exudative age-related macular degeneration: the Nutritional AMD Treatment 2 study. 2013 Ophthalmology pmid:23395546
Denis I et al. Omega-3 fatty acids and brain resistance to ageing and stress: body of evidence and possible mechanisms. 2013 Ageing Res. Rev. pmid:23395782
Yan Y et al. Enhanced catalysis of Yarrowia lipolytica lipase LIP2 immobilized on macroporous resin and its application in enrichment of polyunsaturated fatty acids. 2013 Bioresour. Technol. pmid:23347925