DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
de Urquiza AM et al. Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. 2000 Science pmid:11118147
Stockard JE et al. Effect of docosahexaenoic acid content of maternal diet on auditory brainstem conduction times in rat pups. 2000 Sep-Dec Dev. Neurosci. pmid:11111168
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Song JH et al. Polyunsaturated (n-3) fatty acids susceptible to peroxidation are increased in plasma and tissue lipids of rats fed docosahexaenoic acid-containing oils. 2000 J. Nutr. pmid:11110863
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Baldessarini RJ et al. Fatty acid derivatives of clozapine: prolonged antidopaminergic activity of docosahexaenoylclozapine in the rat. 2001 Neuropsychopharmacology pmid:11106876
Decsi T et al. Fatty acid composition of human milk in Hungary. 2000 Acta Paediatr. pmid:11106060
Ikemoto A et al. Effect of n-3 fatty acid deficiency on fatty acid composition and metabolism of aminophospholipids in rat brain synaptosomes. 2000 Lipids pmid:11104017
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Lapillonne A et al. The use of low-EPA fish oil for long-chain polyunsaturated fatty acid supplementation of preterm infants. 2000 Pediatr. Res. pmid:11102555
Freedman SD et al. Fatty acids in cystic fibrosis. 2000 Curr Opin Pulm Med pmid:11100964
Rissanen T et al. Fish oil-derived fatty acids, docosahexaenoic acid and docosapentaenoic acid, and the risk of acute coronary events: the Kuopio ischaemic heart disease risk factor study. 2000 Circulation pmid:11094031
Otto SJ et al. The effect of supplementation with docosahexaenoic and arachidonic acid derived from single cell oils on plasma and erythrocyte fatty acids of pregnant women in the second trimester. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090260
Chen ZY and Istfan NW Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090257
Fokkema MR et al. Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090255
Louw L and Dannhauser A Keloids in rural black South Africans. Part 2: dietary fatty acid intake and total phospholipid fatty acid profile in the blood of keloid patients. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090250
Diep QN et al. Docosahexaenoic acid, a peroxisome proliferator-activated receptor-alpha ligand, induces apoptosis in vascular smooth muscle cells by stimulation of p38 mitogen-activated protein kinase. 2000 Hypertension pmid:11082155
Moriguchi T et al. Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration. 2000 J. Neurochem. pmid:11080210
Contreras MA et al. Nutritional deprivation of alpha-linolenic acid decreases but does not abolish turnover and availability of unacylated docosahexaenoic acid and docosahexaenoyl-CoA in rat brain. 2000 J. Neurochem. pmid:11080190
Totland GK et al. Proliferation of mitochondria and gene expression of carnitine palmitoyltransferase and fatty acyl-CoA oxidase in rat skeletal muscle, heart and liver by hypolipidemic fatty acids. 2000 Biol. Cell pmid:11071041
Lim SY and Suzuki H Effect of dietary docosahexaenoic acid and phosphatidylcholine on maze behavior and fatty acid composition of plasma and brain lipids in mice. 2000 Int J Vitam Nutr Res pmid:11068705
Lopez-Alarcon M et al. Illness-induced anorexia in the breast-fed infants. Role of IL-1beta and TNF-alpha. 2000 Adv. Exp. Med. Biol. pmid:11065112
Decsi T et al. Low contribution of docosahexaenoic acid to the fatty acid composition of mature human milk in Hungary. 2000 Adv. Exp. Med. Biol. pmid:11065108
Savino F et al. Arachidonic (AA) and docosahexaenoic (DHA) acid content in healthy infants fed with an HA milk formula supplemented with LCPUFA and in breast fed infants. 2000 Adv. Exp. Med. Biol. pmid:11065107
Lauritizen L et al. Dietary fish and the docosahexaenoic acid (DHA) content of human milk. 2000 Adv. Exp. Med. Biol. pmid:11065103
Smit EN et al. Docosahexaenoic acid (DHA) status of breastfed malnourished infants and their mothers in North Pakistan. 2000 Adv. Exp. Med. Biol. pmid:11065099
Granot E et al. Breast-fed and formula-fed infants do not differ in immunocompetent cell cytokine production despite differences in cell membrane fatty acid composition. 2000 Am. J. Clin. Nutr. pmid:11063450
Sherman MP Human milk, fatty acids, and the immune response: a new glimpse. 2000 Am. J. Clin. Nutr. pmid:11063429
Salem ML et al. N-3 polyunsaturated fatty acids accentuate B16 melanoma growth and metastasis through suppression of tumoricidal function of T cells and macrophages. 2000 Sep-Oct Anticancer Res. pmid:11062743
Pakala R et al. Vascular smooth muscle cells preloaded with eicosapentaenoic acid and docosahexaenoic acid fail to respond to serotonin stimulation. 2000 Atherosclerosis pmid:11058699
Surai PF et al. Effect of long-term supplementation with arachidonic or docosahexaenoic acids on sperm production in the broiler chicken. 2000 J. Reprod. Fertil. pmid:11058441
Hosokawa M et al. Conversion to docosahexaenoic acid-containing phosphatidylserine from squid skin lecithin by phospholipase D-mediated transphosphatidylation. 2000 J. Agric. Food Chem. pmid:11052698
Gerber MJ et al. Profiles of a healthful diet and its relationship to biomarkers in a population sample from Mediterranean southern France. 2000 J Am Diet Assoc pmid:11043701
Garcia HS et al. Synthesis of glycerides containing n-3 fatty acids and conjugated linoleic acid by solvent-free acidolysis of fish oil. 2000 Biotechnol. Bioeng. pmid:11042555
Luquain C et al. Bis(monoacylglycerol) phosphate in rat uterine stromal cells: structural characterization and specific esterification of docosahexaenoic acid. 2000 Biochem. J. pmid:11042136
Arterburn LM et al. In vitro genotoxicity testing of ARASCO and DHASCO oils. 2000 Food Chem. Toxicol. pmid:11038233
Jenski LJ et al. Docosahexaenoic acid-containing phosphatidylcholine affects the binding of monoclonal antibodies to purified Kb reconstituted into liposomes. 2000 Biochim. Biophys. Acta pmid:11030589
House S Stages in reproduction particularly vulnerable to xenobiotic hazards and nutritional deficits. 2000 Nutr Health pmid:11028931
Qian SY et al. EPR detection of lipid-derived free radicals from PUFA, LDL, and cell oxidations. 2000 Free Radic. Biol. Med. pmid:11025200
Glozman S et al. Docosahexaenoic acid-deficient phosphatidyl serine and high alpha-tocopherol in a fetal mouse brain over-expressing Cu/Zn-superoxide dismutase. 2000 Biochim. Biophys. Acta pmid:11018466
Favrelère S et al. Age-related changes in ethanolamine glycerophospholipid fatty acid levels in rat frontal cortex and hippocampus. 2000 Sep-Oct Neurobiol. Aging pmid:11016534
Petrik MB et al. Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice. 2000 J. Nutr. pmid:11015469
Martínez-Cayuela M et al. Metabolism of palmitic and docosahexaenoic acids in Reuber H35 hepatoma cells. 2000 J. Biochem. pmid:11011136
Xi S et al. 15-hydroxyeicosatrienoic acid (15-HETrE) suppresses epidermal hyperproliferation via the modulation of nuclear transcription factor (AP-1) and apoptosis. 2000 Arch. Dermatol. Res. pmid:10994774
Cunnane SC Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10991770
Wijendran V et al. Fetal erythrocyte phospholipid polyunsaturated fatty acids are altered in pregnancy complicated with gestational diabetes mellitus. 2000 Lipids pmid:10984116
Hamilton L et al. n-3 fatty acid deficiency decreases phosphatidylserine accumulation selectively in neuronal tissues. 2000 Lipids pmid:10984109
Hsu FF et al. Electrospray ionization mass spectrometric analyses of changes in tissue phospholipid molecular species during the evolution of hyperlipidemia and hyperglycemia in Zucker diabetic fatty rats. 2000 Lipids pmid:10984107
Mori TA et al. Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men. 2000 Circulation pmid:10982541
Kajita M et al. Enhanced enteral bioavailability of vancomycin using water-in-oil-in-water multiple emulsion incorporating highly purified unsaturated fatty acid. 2000 J Pharm Sci pmid:10980499
Fidler N et al. Docosahexaenoic acid transfer into human milk after dietary supplementation: a randomized clinical trial. 2000 J. Lipid Res. pmid:10974044
Dagnelie G et al. Lutein improves visual function in some patients with retinal degeneration: a pilot study via the Internet. 2000 Optometry pmid:10970259
Wander RC and Du SH Oxidation of plasma proteins is not increased after supplementation with eicosapentaenoic and docosahexaenoic acids. 2000 Am. J. Clin. Nutr. pmid:10966891
Higdon JV et al. Supplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as assessed by plasma malondialdehyde and F(2)-isoprostanes. 2000 Am. J. Clin. Nutr. pmid:10966889
Marangoni F et al. Polyunsaturated fatty acid concentrations in human hindmilk are stable throughout 12-months of lactation and provide a sustained intake to the infant during exclusive breastfeeding: an Italian study. 2000 Br. J. Nutr. pmid:10961166
Liu QY and Tan BK Effects of cis-unsaturated fatty acids on doxorubicin sensitivity in P388/DOX resistant and P388 parental cell lines. 2000 Life Sci. pmid:10954054
Kohno H et al. Modifying effect of tuna orbital oil rich in docosahexaenoic acid and vitamin D3 on azoxymethane-induced colonic aberrant crypt foci in rats. 2000 Sep-Oct Oncol. Rep. pmid:10948340
Surai PF and Sparks NH Tissue-specific fatty acid and alpha-tocopherol profiles in male chickens depending on dietary tuna oil and vitamin E provision. 2000 Poult. Sci. pmid:10947182
Retterstøl K et al. Metabolism of some radiolabeled essential fatty acids in isolated rat hepatocytes is affected by dietary ethanol. 2000 Alcohol pmid:10946154
Guo X and Ota Y Incorporation of eicosapentaenoic and docosahexaenoic acids by a yeast (FO726A). 2000 J. Appl. Microbiol. pmid:10945786
Albino AP et al. Cell cycle arrest and apoptosis of melanoma cells by docosahexaenoic acid: association with decreased pRb phosphorylation. 2000 Cancer Res. pmid:10945621
Fritsche KL et al. Consumption of eicosapentaenoic acid and docosahexaenoic acid impair murine interleukin-12 and interferon-gamma production in vivo. 2000 J. Infect. Dis. pmid:10944484
Vanderhoof J et al. A multicenter long-term safety and efficacy trial of preterm formula supplemented with long-chain polyunsaturated fatty acids. 2000 J. Pediatr. Gastroenterol. Nutr. pmid:10941962
Healy DA et al. Effect of low-to-moderate amounts of dietary fish oil on neutrophil lipid composition and function. 2000 Lipids pmid:10941877
Arterburn LM et al. A developmental safety study in rats using DHA- and ARA-rich single-cell oils. 2000 Food Chem. Toxicol. pmid:10930697
Kimura S [Antihypertensive effect of docosahexaenoic acid in stroke-prone spontaneously hypertensive rats]. 2000 Yakugaku Zasshi pmid:10920715
Everts S and Davis JH 1H and (13)C NMR of multilamellar dispersions of polyunsaturated (22:6) phospholipids. 2000 Biophys. J. pmid:10920020
Mukhopadhyay S et al. Preferential distribution of long chain polyunsaturated fatty acids in phospatidyl ethanolamine fraction of guinea pig alveolar apical membranes. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10913226
Smit EN et al. Effect of supplementation of arachidonic acid (AA) or a combination of AA plus docosahexaenoic acid on breastmilk fatty acid composition. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10913225
Matthews KR et al. Effect of whole linseed (Linum usitatissimum) in the diet of finishing pigs on growth performance and on the quality and fatty acid composition of various tissues. 2000 Br. J. Nutr. pmid:10911772
Ando Y et al. Reinvestigation of positional distribution of fatty acids in docosahexaenoic acid-rich fish oil triacyl-sn-glycerols. 2000 Lipids pmid:10907794
Ghebremeskel K et al. Blood fatty acid composition of pregnant and nonpregnant Korean women: red cells may act as a reservoir of arachidonic acid and docosahexaenoic acid for utilization by the developing fetus. 2000 Lipids pmid:10907792
Martin RE et al. Uptake and incorporation of docosahexaenoic acid (DHA) into neuronal cell body and neurite/nerve growth cone lipids: evidence of compartmental DHA metabolism in nerve growth factor-differentiated PC12 cells. 2000 Neurochem. Res. pmid:10905634
de Turco EB et al. Strong association of unesterified [3H]docosahexaenoic acid and [3H-docosahexaenoyl]phosphatidate to rhodopsin during in vivo labeling of frog retinal rod outer segments. 2000 Neurochem. Res. pmid:10905632
Kim HY et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. 2000 J. Biol. Chem. pmid:10903316
Xiao YF et al. Coexpression with beta(1)-subunit modifies the kinetics and fatty acid block of hH1(alpha) Na(+) channels. 2000 Am. J. Physiol. Heart Circ. Physiol. pmid:10899039
Kontogiannea M et al. omega-3 fatty acids decrease endothelial adhesion of human colorectal carcinoma cells. 2000 J. Surg. Res. pmid:10896822
Young C et al. Docosahexaenoic acid inhibits synaptic transmission and epileptiform activity in the rat hippocampus. 2000 Synapse pmid:10881029
Lesage F et al. Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors. 2000 J. Biol. Chem. pmid:10880510
de la Presa Owens S and Innis SM Diverse, region-specific effects of addition of arachidonic and docosahexanoic acids to formula with low or adequate linoleic and alpha-linolenic acids on piglet brain monoaminergic neurotransmitters. 2000 Pediatr. Res. pmid:10879811
Morishita M et al. The dose-related hypoglycemic effects of insulin emulsions incorporating highly purified EPA and DHA. 2000 Int J Pharm pmid:10878324
Kumar KV et al. Oxidant stress and essential fatty acids in patients with risk and established ARDS. 2000 Clin. Chim. Acta pmid:10876008
Gao YC and Charter EA Nutritionally important fatty acids in hen egg yolks from different sources. 2000 Poult. Sci. pmid:10875777
Narita K et al. Therapeutic time window in the penumbra during permanent focal ischemia in rats: changes of free fatty acids and glycerophospholipids. 2000 Neurol. Res. pmid:10874689
Mantzioris E et al. Biochemical effects of a diet containing foods enriched with n-3 fatty acids. 2000 Am. J. Clin. Nutr. pmid:10871559
Decsi T and Koletzko B Effects of protein-energy malnutrition and human immunodeficiency virus-1 infection on essential fatty acid metabolism in children. 2000 Nutrition pmid:10869902
Kubo K et al. Preferential incorporation of docosahexaenoic acid into nonphosphorus lipids and phosphatidylethanolamine protects rats from dietary DHA-stimulated lipid peroxidation. 2000 J. Nutr. pmid:10867046
Torres IC et al. Study of the effects of dietary fish intake on serum lipids and lipoproteins in two populations with different dietary habits. 2000 Br. J. Nutr. pmid:10858695
Kosugi Y et al. Esterification of polyunsaturated fatty acids by various forms of immobilized lipase from Rhizomucor miehei. 2000 Lipids pmid:10858032
Morris S et al. Utilization of docosahexaenoic acid from intravenous egg yolk phospholipid. 2000 Lipids pmid:10858022
Giusto NM et al. Lipid metabolism in vertebrate retinal rod outer segments. 2000 Prog. Lipid Res. pmid:10856601
Kielar ML et al. Docosahexaenoic acid decreases IRF-1 mRNA and thus inhibits activation of both the IRF-E and NFkappa d response elements of the iNOS promoter. 2000 Transplantation pmid:10852612
Marx N et al. Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells. 2000 J. Immunol. pmid:10843708
Watanabe S et al. Dietary docosahexaenoic acid but not eicosapentaenoic acid suppresses lipopolysaccharide-induced interleukin-1 beta mRNA induction in mouse spleen leukocytes. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10841036
Jahangiri A et al. Termination of asynchronous contractile activity in rat atrial myocytes by n-3 polyunsaturated fatty acids. 2000 Mol. Cell. Biochem. pmid:10839192
Smit EN et al. Breast milk docosahexaenoic acid (DHA) correlates with DHA status of malnourished infants. 2000 Arch. Dis. Child. pmid:10833187
Huster D et al. Strength of Ca(2+) binding to retinal lipid membranes: consequences for lipid organization. 2000 Biophys. J. pmid:10827979
Lim SY and Suzuki H Intakes of dietary docosahexaenoic acid ethyl ester and egg phosphatidylcholine improve maze-learning ability in young and old mice. 2000 J. Nutr. pmid:10827221
Farkas T et al. Docosahexaenoic acid-containing phospholipid molecular species in brains of vertebrates. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10823917