DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Yu Y et al. DHA prevents altered 5-HT1A, 5-HT2A, CB1 and GABAA receptor binding densities in the brain of male rats fed a high-saturated-fat diet. 2013 J. Nutr. Biochem. pmid:23337348
Chen F et al. Fish oil attenuates liver injury caused by LPS in weaned pigs associated with inhibition of TLR4 and nucleotide-binding oligomerization domain protein signaling pathways. 2013 Innate Immun pmid:23339927
Tikhonenko M et al. N-3 polyunsaturated Fatty acids prevent diabetic retinopathy by inhibition of retinal vascular damage and enhanced endothelial progenitor cell reparative function. 2013 PLoS ONE pmid:23383097
Li H et al. Production of sophorolipids with eicosapentaenoic acid and docosahexaenoic acid from Wickerhamiella domercqiae var. sophorolipid using fish oil as a hydrophobic carbon source. 2013 Biotechnol. Lett. pmid:23386226
Wang TM et al. Docosahexaenoic acid and eicosapentaenoic acid reduce C-reactive protein expression and STAT3 activation in IL-6-treated HepG2 cells. 2013 Mol. Cell. Biochem. pmid:23361365
Suganuma H et al. Effect of hypoxic-ischemic insults on the composition of fatty acids in the brain of neonatal rats. 2013 Ann. Nutr. Metab. pmid:23364132
Casey JM et al. Effect of stearidonic acid-enriched soybean oil on fatty acid profile and metabolic parameters in lean and obese Zucker rats. 2013 Lipids Health Dis pmid:24139088
Chang CY et al. Docosahexaenoic acid reduces cellular inflammatory response following permanent focal cerebral ischemia in rats. 2013 J. Nutr. Biochem. pmid:24139673
Fernández-Iglesias A et al. DHA sensitizes FaO cells to tert-BHP-induced oxidative effects. Protective role of EGCG. 2013 Food Chem. Toxicol. pmid:24140970
Song YJ et al. Regulatory functions of docosahexaenoic acid on ion channels in rat ventricular myocytes. 2013 Eur Rev Med Pharmacol Sci pmid:24142611
Tai EK et al. An update on adding docosahexaenoic acid (DHA) and arachidonic acid (AA) to baby formula. 2013 Food Funct pmid:24150114
Miller BJ et al. Dietary supplements for preventing postnatal depression. 2013 Cochrane Database Syst Rev pmid:24158923
Larson MK et al. Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation. 2013 Am. J. Physiol., Cell Physiol. pmid:23174566
Mussi SV et al. New approach to improve encapsulation and antitumor activity of doxorubicin loaded in solid lipid nanoparticles. 2013 Eur J Pharm Sci pmid:23178339
Braga SF and Almgren MM Complementary therapies in cystic fibrosis: nutritional supplements and herbal products. 2013 J Pharm Pract pmid:23178411
Gurzell EA et al. DHA-enriched fish oil targets B cell lipid microdomains and enhances ex vivo and in vivo B cell function. 2013 J. Leukoc. Biol. pmid:23180828
Faber J et al. Rapid EPA and DHA incorporation and reduced PGE2 levels after one week intervention with a medical food in cancer patients receiving radiotherapy, a randomized trial. 2013 Clin Nutr pmid:23123043
Klingler M et al. Comparison of the incorporation of orally administered DHA into plasma, erythrocyte and cheek cell glycerophospholipids. 2013 Br. J. Nutr. pmid:22874641
Tu WC et al. Dietary alpha-linolenic acid does not enhance accumulation of omega-3 long-chain polyunsaturated fatty acids in barramundi (Lates calcarifer). 2013 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:23085323
Robinson DT et al. Docosahexaenoic and arachidonic acid levels in extremely low birth weight infants with prolonged exposure to intravenous lipids. 2013 J. Pediatr. pmid:22878111
Hsiao HM et al. A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation. 2013 PLoS ONE pmid:23484005
Hoshi T et al. Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca²⁺-dependent K⁺ channels. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23487785
Hoshi T et al. Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23487786
Betancor MB et al. Oxidative stress in sea bass Dicentrarchus labrax larvae: interaction of high dietary DHA contents and several antioxidant nutrients. 2013 Commun. Agric. Appl. Biol. Sci. pmid:25141617
Hagemann A et al. Content of essential fatty acids in cultivated Acartia tonsa nauplii fed a DHA-deficient Tetraselmis sp. concentrate. 2013 Commun. Agric. Appl. Biol. Sci. pmid:25141657
Lund I et al. Importance of DHA for first feeding pikeperch larvae--influence on behavioural responses. 2013 Commun. Agric. Appl. Biol. Sci. pmid:25141683
Mesa-Rodriguez A et al. Effect of increasing DHA content in new weaning diets for longfin yellowtail (Seriola rivoliana). 2013 Commun. Agric. Appl. Biol. Sci. pmid:25141689
Botelho PB et al. Effect of Echium oil compared with marine oils on lipid profile and inhibition of hepatic steatosis in LDLr knockout mice. 2013 Lipids Health Dis pmid:23510369
Rai AK et al. Bioefficacy of EPA-DHA from lipids recovered from fish processing wastes through biotechnological approaches. 2013 Food Chem pmid:23017395
van den Elsen LW et al. n-3 Long-chain PUFA reduce allergy-related mediator release by human mast cells in vitro via inhibition of reactive oxygen species. 2013 Br. J. Nutr. pmid:23021516
Bazan NG The docosanoid neuroprotectin D1 induces homeostatic regulation of neuroinflammation and cell survival. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23022417
Del Bó C et al. Horse meat consumption affects iron status, lipid profile and fatty acid composition of red blood cells in healthy volunteers. 2013 Int J Food Sci Nutr pmid:23025273
Lim SN et al. Improved outcome after spinal cord compression injury in mice treated with docosahexaenoic acid. 2013 Exp. Neurol. pmid:23026410
Kamolrat T and Gray SR The effect of eicosapentaenoic and docosahexaenoic acid on protein synthesis and breakdown in murine C2C12 myotubes. 2013 Biochem. Biophys. Res. Commun. pmid:23438435
Cieslik M et al. Docosahexaenoic acid and tetracyclines as promising neuroprotective compounds with poly(ADP-ribose) polymerase inhibitory activities for oxidative/genotoxic stress treatment. 2013 Neurochem. Int. pmid:23439385
Oken E et al. A pilot randomized controlled trial to promote healthful fish consumption during pregnancy: the Food for Thought Study. 2013 Nutr J pmid:23496848
Huang HL et al. Docosahexaenoic acid in maternal and neonatal plasma phospholipids and milk lipids of Taiwanese women in Kinmen: fatty acid composition of maternal blood, neonatal blood and breast milk. 2013 Lipids Health Dis pmid:23496882
Lau BY et al. Investigating the role of polyunsaturated fatty acids in bone development using animal models. 2013 Molecules pmid:24248147
Fahrmann JF and Hardman WE Omega 3 fatty acids increase the chemo-sensitivity of B-CLL-derived cell lines EHEB and MEC-2 and of B-PLL-derived cell line JVM-2 to anti-cancer drugs doxorubicin, vincristine and fludarabine. 2013 Lipids Health Dis pmid:23497075
Moate PJ et al. Effects of feeding algal meal high in docosahexaenoic acid on feed intake, milk production, and methane emissions in dairy cows. 2013 J. Dairy Sci. pmid:23498011
Ajami M et al. Effect of DHA+EPA on oxidative stress and apoptosis induced by ischemia-reperfusion in rat kidneys. 2013 Fundam Clin Pharmacol pmid:22943605
Scholtz SA et al. Clinical overview of effects of dietary long-chain polyunsaturated fatty acids during the perinatal period. 2013 Nestle Nutr Inst Workshop Ser pmid:24107504
McNamara RK et al. Low docosahexaenoic acid status is associated with reduced indices in cortical integrity in the anterior cingulate of healthy male children: a 1H MRS Study. 2013 Nutr Neurosci pmid:23582513
Koltsida O et al. Toll-like receptor 7 stimulates production of specialized pro-resolving lipid mediators and promotes resolution of airway inflammation. 2013 EMBO Mol Med pmid:23584892
Li J et al. Comparative metabolomics analysis of docosahexaenoic acid fermentation processes by Schizochytrium sp. under different oxygen availability conditions. 2013 OMICS pmid:23586678
Barros KV et al. Fatty acids in plasma, white and red blood cells, and tissues after oral or intravenous administration of fish oil in rats. 2013 Clin Nutr pmid:23541913
Bruins MJ et al. Plasma oxylipin profiling identifies polyunsaturated vicinal diols as responsive to arachidonic acid and docosahexaenoic acid intake in growing piglets. 2013 J. Lipid Res. pmid:23543770
Calder PC Editorial: Fat chance to enhance B cell function. 2013 J. Leukoc. Biol. pmid:23547174
Berman DR et al. Docosahexaenoic acid augments hypothermic neuroprotection in a neonatal rat asphyxia model. 2013 Neonatology pmid:23817197
Singhal A et al. Docosahexaenoic acid supplementation, vascular function and risk factors for cardiovascular disease: a randomized controlled trial in young adults. 2013 J Am Heart Assoc pmid:23817470
Hoss E et al. Control of late cornified envelope genes relevant to psoriasis risk: upregulation by 1,25-dihydroxyvitamin D3 and plant-derived delphinidin. 2013 Arch. Dermatol. Res. pmid:23839497
Zhang X et al. Resolvin D1 protects podocytes in adriamycin-induced nephropathy through modulation of 14-3-3β acetylation. 2013 PLoS ONE pmid:23840712
Shin S et al. The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROS-mediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53. 2013 Biomed Res Int pmid:23841076
Baillie JK and Digard P Influenza--time to target the host? 2013 N. Engl. J. Med. pmid:23841736
Meijerink J et al. N-Acyl amines of docosahexaenoic acid and other n-3 polyunsatured fatty acids - from fishy endocannabinoids to potential leads. 2013 Br. J. Pharmacol. pmid:23088259
Mozaffarian D et al. Plasma phospholipid long-chain ω-3 fatty acids and total and cause-specific mortality in older adults: a cohort study. 2013 Ann. Intern. Med. pmid:23546563
Sun YB et al. Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney. 2013 PLoS ONE pmid:24391884
Zhang X et al. Resolvin D1 reverts lipopolysaccharide-induced TJ proteins disruption and the increase of cellular permeability by regulating IκBα signaling in human vascular endothelial cells. 2013 Oxid Med Cell Longev pmid:24381712
Correia Bacarin C et al. Fish oil provides robust and sustained memory recovery after cerebral ischemia: influence of treatment regimen. 2013 Physiol. Behav. pmid:23770426
Jones ML et al. Maternal dietary omega-3 fatty acid intake increases resolvin and protectin levels in the rat placenta. 2013 J. Lipid Res. pmid:23723388
German OL et al. Retinoid X receptor activation is essential for docosahexaenoic acid protection of retina photoreceptors. 2013 J. Lipid Res. pmid:23723389
Hiratsuka S et al. Effects of dietary sialic acid in n-3 fatty acid-deficient dams during pregnancy and lactation on the learning abilities of their pups after weaning. 2013 J. Nutr. Sci. Vitaminol. pmid:23727644
Xie W et al. Resolvin D1 reduces deterioration of tight junction proteins by upregulating HO-1 in LPS-induced mice. 2013 Lab. Invest. pmid:23857007
Li Q et al. A comparative study: In vitro effects of EPA and DHA on immune functions of head-kidney macrophages isolated from large yellow croaker (Larmichthys crocea). 2013 Fish Shellfish Immunol. pmid:23859878
Chen S and Subbaiah PV Regioisomers of phosphatidylcholine containing DHA and their potential to deliver DHA to the brain: role of phospholipase specificities. 2013 Lipids pmid:23604781
Long SJ and Benton D A double-blind trial of the effect of docosahexaenoic acid and vitamin and mineral supplementation on aggression, impulsivity, and stress. 2013 Hum Psychopharmacol pmid:23625531
Das UN Polyunsaturated fatty acids in heart failure. 2013 Circ. J. pmid:23628915
Titova OE et al. Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly. 2013 Age (Dordr) pmid:22791395
Klek S et al. Four-week parenteral nutrition using a third generation lipid emulsion (SMOFlipid)--a double-blind, randomised, multicentre study in adults. 2013 Clin Nutr pmid:22796064
Barber E et al. Comparative actions of omega-3 fatty acids on in-vitro lipid droplet formation. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:24012207
Sheets KG et al. Microglial ramification and redistribution concomitant with the attenuation of choroidal neovascularization by neuroprotectin D1. 2013 Mol. Vis. pmid:23922492
Baselga-Escudero L et al. Chronic administration of proanthocyanidins or docosahexaenoic acid reverses the increase of miR-33a and miR-122 in dyslipidemic obese rats. 2013 PLoS ONE pmid:23922812
Bjorgvinsdottir L et al. Inflammatory response following heart surgery and association with n-3 and n-6 long-chain polyunsaturated fatty acids in plasma and red blood cell membrane lipids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23999253
Iwasaka H et al. Utilization of waste syrup for production of polyunsaturated fatty acids and xanthophylls by Aurantiochytrium. 2013 J Oleo Sci pmid:24005017
Liu Y et al. Fish oil alleviates activation of the hypothalamic-pituitary-adrenal axis associated with inhibition of TLR4 and NOD signaling pathways in weaned piglets after a lipopolysaccharide challenge. 2013 J. Nutr. pmid:24005609
Li X et al. Cyclooxygenase-2 induction in macrophages is modulated by docosahexaenoic acid via interactions with free fatty acid receptor 4 (FFA4). 2013 FASEB J. pmid:24005906
Cheng R et al. Cloning and functional analysis of putative malonyl-CoA:acyl-carrier protein transacylase gene from the docosahexaenoic acid-producer Schizochytrium sp. TIO1101. 2013 World J. Microbiol. Biotechnol. pmid:23292648
Chen J et al. Docosahexaenoic acid (DHA) attenuated paraquat induced lung damage in mice. 2013 Inhal Toxicol pmid:23293968
Figueroa JD et al. Dietary omega-3 polyunsaturated fatty acids improve the neurolipidome and restore the DHA status while promoting functional recovery after experimental spinal cord injury. 2013 J. Neurotrauma pmid:23294084
Lang JE et al. Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): rationale and methods. 2013 Contemp Clin Trials pmid:23298524
Hutchins-Wiese HL et al. The impact of supplemental n-3 long chain polyunsaturated fatty acids and dietary antioxidants on physical performance in postmenopausal women. 2013 J Nutr Health Aging pmid:23299384
Raza Shaikh S and Brown DA Models of plasma membrane organization can be applied to mitochondrial membranes to target human health and disease with polyunsaturated fatty acids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22464052
Gibson RA et al. Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22515943
Steffen BT et al. n-3 and n-6 Fatty acids are independently associated with lipoprotein-associated phospholipase A2 in the Multi-Ethnic Study of Atherosclerosis. 2013 Br. J. Nutr. pmid:23551952
Derogis PB et al. The development of a specific and sensitive LC-MS-based method for the detection and quantification of hydroperoxy- and hydroxydocosahexaenoic acids as a tool for lipidomic analysis. 2013 PLoS ONE pmid:24204871
Wang D et al. Organochlorine pesticides in fish from Taihu Lake, China, and associated human health risk assessment. 2013 Ecotoxicol. Environ. Saf. pmid:24125867
Hoshi T et al. A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid. 2013 J. Gen. Physiol. pmid:24127525
Latorre R and Contreras G Keeping you healthy: BK channel activation by omega-3 fatty acids. 2013 J. Gen. Physiol. pmid:24127527
Atwell K et al. Respiratory hospitalisation of infants supplemented with docosahexaenoic acid as preterm neonates. 2013 J Paediatr Child Health pmid:23279074
Barros KV et al. Supplemental intravenous n-3 fatty acids and n-3 fatty acid status and outcome in critically ill elderly patients in the ICU receiving enteral nutrition. 2013 Clin Nutr pmid:23260750
Ryu BG et al. Use of organic waste from the brewery industry for high-density cultivation of the docosahexaenoic acid-rich microalga, Aurantiochytrium sp. KRS101. 2013 Bioresour. Technol. pmid:23262011
Sato K et al. Selective and potent inhibitory effect of docosahexaenoic acid (DHA) on U46619-induced contraction in rat aorta. 2013 J Smooth Muscle Res pmid:24304639
Engel S et al. Docosahexaenoic acid status at 9 months is inversely associated with communicative skills in 3-year-old girls. 2013 Matern Child Nutr pmid:22642227
Gadaria-Rathod N et al. Red blood cell fatty acid analysis for determining compliance with omega3 supplements in dry eye disease trials. 2013 J Ocul Pharmacol Ther pmid:23971620
Weintraub H Update on marine omega-3 fatty acids: management of dyslipidemia and current omega-3 treatment options. 2013 Atherosclerosis pmid:24075771
Stulnig G et al. Docosahexaenoic acid (DHA)-induced heme oxygenase-1 attenuates cytotoxic effects of DHA in vascular smooth muscle cells. 2013 Atherosclerosis pmid:24075775
Nagachinta S and Akoh CC Spray-dried structured lipid containing long-chain polyunsaturated fatty acids for use in infant formulas. 2013 J. Food Sci. pmid:24024870
Kennedy DO Reply to MP Pase and C Stough. 2013 Am. J. Clin. Nutr. pmid:24027792
Gruszfeld D and Socha P Early nutrition and health: short- and long-term outcomes. 2013 World Rev Nutr Diet pmid:24029784
Przyrembel H and Agostoni C Growing-up milk: a necessity or marketing? 2013 World Rev Nutr Diet pmid:24029786