DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Teague H et al. Dendritic cell activation, phagocytosis and CD69 expression on cognate T cells are suppressed by n-3 long-chain polyunsaturated fatty acids. 2013 Immunology pmid:23373457
Soubias O and Gawrisch K Rhodopsin-lipid interactions studied by NMR. 2013 Meth. Enzymol. pmid:23374188
Ishida T et al. Distinct regulation of plasma LDL cholesterol by eicosapentaenoic acid and docosahexaenoic acid in high fat diet-fed hamsters: participation of cholesterol ester transfer protein and LDL receptor. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23375839
Umhau JC et al. Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy. 2013 PLoS ONE pmid:24098376
Milic I et al. Simultaneous detection of low and high molecular weight carbonylated compounds derived from lipid peroxidation by electrospray ionization-tandem mass spectrometry. 2013 Anal. Chem. pmid:23186270
Renganathan K et al. CEP biomarkers as potential tools for monitoring therapeutics. 2013 PLoS ONE pmid:24098476
Mizwicki MT et al. 1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer's disease patients. 2013 J. Alzheimers Dis. pmid:23186989
Carlson SJ et al. The role of the ω-3 fatty acid DHA in the human life cycle. 2013 JPEN J Parenter Enteral Nutr pmid:23192455
Xu J et al. Expression of a type 2 diacylglycerol acyltransferase from Thalassiosira pseudonana in yeast leads to incorporation of docosahexaenoic acid β-oxidation intermediates into triacylglycerol. 2013 FEBS J. pmid:24128189
Kimura R et al. DHA attenuates postprandial hyperlipidemia via activating PPARα in intestinal epithelial cells. 2013 J. Lipid Res. pmid:24133194
Teague H et al. DHA-fluorescent probe is sensitive to membrane order and reveals molecular adaptation of DHA in ordered lipid microdomains. 2013 J. Nutr. Biochem. pmid:22841541
Betancor MB et al. Oxidative status and histological changes in sea bass larvae muscle in response to high dietary content of docosahexaenoic acid DHA. 2013 J. Fish Dis. pmid:23167568
Herba CM et al. Breastfeeding and early brain development: the Generation R study. 2013 Matern Child Nutr pmid:23167730
Rovito D et al. Omega-3 PUFA ethanolamides DHEA and EPEA induce autophagy through PPARγ activation in MCF-7 breast cancer cells. 2013 J. Cell. Physiol. pmid:23168911
Sato SB et al. Inhibition of constitutive Akt (PKB) phosphorylation by docosahexaenoic acid in the human breast cancer cell line MDA-MB-453. 2013 Biochim. Biophys. Acta pmid:23085420
Faizan M et al. Dietary alpha-tocopherol affects tissue vitamin e and malondialdehyde levels but does not change antioxidant enzymes and fatty acid composition in farmed Atlantic salmon (Salmo salar L.). 2013 Int J Vitam Nutr Res pmid:25008014
Al-Taan O et al. Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases. 2013 Lipids Health Dis pmid:23648075
Marze S et al. In vitro digestion of fish oils rich in n-3 polyunsaturated fatty acids studied in emulsion and at the oil-water interface. 2013 Food Funct pmid:23086175
Dallaire R et al. Exposure to organochlorines and mercury through fish and marine mammal consumption: associations with growth and duration of gestation among Inuit newborns. 2013 Environ Int pmid:23422685
Liu J et al. Screening and characterization of Isochrysis strains and optimization of culture conditions for docosahexaenoic acid production. 2013 Appl. Microbiol. Biotechnol. pmid:23423326
Metherel AH et al. Butylated hydroxytoluene can protect polyunsaturated fatty acids in dried blood spots from degradation for up to 8 weeks at room temperature. 2013 Lipids Health Dis pmid:23425563
Carlson SE et al. DHA supplementation and pregnancy outcomes. 2013 Am. J. Clin. Nutr. pmid:23426033
Cartiff SE et al. Eicosapentaenoic and docosahexaenoic acids increase insulin sensitivity in growing steers. 2013 J. Anim. Sci. pmid:23463554
Nordgren TM et al. Maresin-1 reduces the pro-inflammatory response of bronchial epithelial cells to organic dust. 2013 Respir. Res. pmid:23663457
Kataoka Y et al. Epanova(®) and hypertriglyceridemia: pharmacological mechanisms and clinical efficacy. 2013 Future Cardiol pmid:23463969
Hara M et al. Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction. 2013 Circ. J. pmid:23047296
McNamara RK et al. Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of adult depressed suicide victims compared with controls without cardiovascular disease. 2013 J Psychiatr Res pmid:23759469
Nielsen G et al. Alterations of N-3 polyunsaturated fatty acid-activated K2P channels in hypoxia-induced pulmonary hypertension. 2013 Basic Clin. Pharmacol. Toxicol. pmid:23724868
Mayer-Davis EJ et al. Nutritional factors and preservation of C-peptide in youth with recently diagnosed type 1 diabetes: SEARCH Nutrition Ancillary Study. 2013 Diabetes Care pmid:23801797
Recchiuti A Resolvin D1 and its GPCRs in resolution circuits of inflammation. 2013 Prostaglandins Other Lipid Mediat. pmid:23500003
Gladyshev MI et al. Production of EPA and DHA in aquatic ecosystems and their transfer to the land. 2013 Prostaglandins Other Lipid Mediat. pmid:23500063
Zhuang W et al. Omega-3 polyunsaturated fatty acids reduce vascular endothelial growth factor production and suppress endothelial wound repair. 2013 J Cardiovasc Transl Res pmid:22993129
Lu Y et al. Spinal injection of docosahexaenoic acid attenuates carrageenan-induced inflammatory pain through inhibition of microglia-mediated neuroinflammation in the spinal cord. 2013 Neuroscience pmid:23500096
Mozaffari-Khosravi H et al. Eicosapentaenoic acid versus docosahexaenoic acid in mild-to-moderate depression: a randomized, double-blind, placebo-controlled trial. 2013 Eur Neuropsychopharmacol pmid:22910528
Cardenia V et al. Health-related lipids components of sardine muscle as affected by photooxidation. 2013 Food Chem. Toxicol. pmid:23500769
Moallem U et al. Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil. 2013 Reproduction pmid:24062566
Dalli J et al. The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype. 2013 FASEB J. pmid:23504711
Arem H et al. Omega-3 and omega-6 fatty acid intakes and endometrial cancer risk in a population-based case-control study. 2013 Eur J Nutr pmid:22915050
Mickleborough TD Omega-3 polyunsaturated fatty acids in physical performance optimization. 2013 Int J Sport Nutr Exerc Metab pmid:23400626
Minihane AM Fish oil omega-3 fatty acids and cardio-metabolic health, alone or with statins. 2013 Eur J Clin Nutr pmid:23403872
Mozurkewich EL et al. The Mothers, Omega-3, and Mental Health Study: a double-blind, randomized controlled trial. 2013 Am. J. Obstet. Gynecol. pmid:23531328
Romero VC et al. Developmental programming for allergy: a secondary analysis of the Mothers, Omega-3, and Mental Health Study. 2013 Am. J. Obstet. Gynecol. pmid:23531329
Bagley HN et al. Maternal docosahexaenoic acid increases adiponectin and normalizes IUGR-induced changes in rat adipose deposition. 2013 J Obes pmid:23533720
Dangour AD and Allen E Do omega-3 fats boost brain function in adults? Are we any closer to an answer? 2013 Am. J. Clin. Nutr. pmid:23535110
Kitamura F et al. Oxidized trilinoleate and tridocosahexaenoate induce pica behavior and change locomotor activity. 2013 J Oleo Sci pmid:23535307
Miller E et al. A short-term n-3 DPA supplementation study in humans. 2013 Eur J Nutr pmid:22729967
Erken HA et al. Exercise and DHA prevent the negative effects of hypoxia on EEG and nerve conduction velocity. 2013 High Alt. Med. Biol. pmid:24377343
Tapsell LC et al. Foods, nutrients or whole diets: effects of targeting fish and LCn3PUFA consumption in a 12mo weight loss trial. 2013 BMC Public Health pmid:24369765
Markhus MW et al. Low omega-3 index in pregnancy is a possible biological risk factor for postpartum depression. 2013 PLoS ONE pmid:23844041
Ribeiro T et al. Direct supplementation of diet is the most efficient way of enriching broiler meat with n-3 long-chain polyunsaturated fatty acids. 2013 Br. Poult. Sci. pmid:24397512
Singh A et al. Gene-metabolite expression in blood can discriminate allergen-induced isolated early from dual asthmatic responses. 2013 PLoS ONE pmid:23844124
Zhang G et al. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23553837
Muldoon MF et al. Concurrent physical activity modifies the association between n3 long-chain fatty acids and cardiometabolic risk in midlife adults. 2013 J. Nutr. pmid:23884386
Watson AM et al. Taurine supplementation of plant derived protein and n-3 fatty acids are critical for optimal growth and development of cobia, Rachycentron canadum. 2013 Lipids pmid:23884630
Rayapudi S et al. Vitamin A and fish oils for retinitis pigmentosa. 2013 Cochrane Database Syst Rev pmid:24357340
Mocellin MC et al. Fish oil decreases C-reactive protein/albumin ratio improving nutritional prognosis and plasma fatty acid profile in colorectal cancer patients. 2013 Lipids pmid:23888317
Santos-Soto IJ et al. Voluntary running in young adult mice reduces anxiety-like behavior and increases the accumulation of bioactive lipids in the cerebral cortex. 2013 PLoS ONE pmid:24349072
Cortina MS et al. Neuroprotectin D1 restores corneal nerve integrity and function after damage from experimental surgery. 2013 Invest. Ophthalmol. Vis. Sci. pmid:23702780
Nyuar KB et al. Regular consumption of Nile river fish could ameliorate the low milk DHA of Southern Sudanese women living in Khartoum City area. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23706881
Terrando N et al. Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline. 2013 FASEB J. pmid:23709617
Fietkau R et al. A disease-specific enteral nutrition formula improves nutritional status and functional performance in patients with head and neck and esophageal cancer undergoing chemoradiotherapy: results of a randomized, controlled, multicenter trial. 2013 Cancer pmid:23765693
Jiang LH et al. Oral administration of docosahexaenoic acid activates the GDNF-MAPK-CERB pathway in hippocampus of natural aged rat. 2013 Pharm Biol pmid:23767459
Weiss GA et al. High levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactation. 2013 Lipids Health Dis pmid:23767972
Leino O et al. Effects of docosahexaenoic acid and methylmercury on child's brain development due to consumption of fish by Finnish mother during pregnancy: a probabilistic modeling approach. 2013 Food Chem. Toxicol. pmid:21723361
Alhazzaa R et al. Bioconversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation. 2013 PLoS ONE pmid:24040040
Laird BD et al. Dietary advice on Inuit traditional food use needs to balance benefits and risks of mercury, selenium, and n3 fatty acids. 2013 J. Nutr. pmid:23616502
Sala-Vila A et al. Eicosapentaenoic acid in serum phospholipids relates to a less atherogenic lipoprotein profile in subjects with familial hypercholesterolemia. 2013 J. Nutr. Biochem. pmid:23618530
Shida T et al. Colonic delivery of docosahexaenoic acid improves impaired glucose tolerance via GLP-1 secretion and suppresses pancreatic islet hyperplasia in diabetic KK-A(y) mice. 2013 Int J Pharm pmid:23618969
Berger H et al. SOCS3 transactivation by PPARγ prevents IL-17-driven cancer growth. 2013 Cancer Res. pmid:23619236
Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. 2013 JAMA pmid:23644932
Johnston DT et al. Red blood cell omega-3 fatty acid levels and neurocognitive performance in deployed U.S. Servicemembers. 2013 Nutr Neurosci pmid:22748167
Kusunoki C et al. Omega-3 polyunsaturated fatty acid has an anti-oxidant effect via the Nrf-2/HO-1 pathway in 3T3-L1 adipocytes. 2013 Biochem. Biophys. Res. Commun. pmid:23131562
Ravacci GR et al. Lipid raft disruption by docosahexaenoic acid induces apoptosis in transformed human mammary luminal epithelial cells harboring HER-2 overexpression. 2013 J. Nutr. Biochem. pmid:22749134
Li C et al. High efficient treatment of citric acid effluent by Chlorella vulgaris and potential biomass utilization. 2013 Bioresour. Technol. pmid:23131649
Nicholson T et al. The role of marine n-3 fatty acids in improving cardiovascular health: a review. 2013 Food Funct pmid:23325431
Hamaoka N et al. Oxidative stability of lipids rich in EPA and DHA extracted from fermented scallop ovary. 2013 J. Food Sci. pmid:23915081
Jing K et al. Omega-3 polyunsaturated fatty acids and cancer. 2013 Anticancer Agents Med Chem pmid:23919748
Santos VC et al. Effects of DHA-rich fish oil supplementation on lymphocyte function before and after a marathon race. 2013 Int J Sport Nutr Exerc Metab pmid:23239683
O'Sullivan BP et al. Evolution of pancreatic function during the first year in infants with cystic fibrosis. 2013 J. Pediatr. pmid:23245194
Rincón Cervera MÁ et al. Acyl migration evaluation in monoacylglycerols from Echium plantagineum seed oil and Marinol. 2013 J. Biosci. Bioeng. pmid:23287502
Rajasagi NK et al. Neuroprotectin D1 reduces the severity of herpes simplex virus-induced corneal immunopathology. 2013 Invest. Ophthalmol. Vis. Sci. pmid:23942967
Mühlroth A et al. Pathways of lipid metabolism in marine algae, co-expression network, bottlenecks and candidate genes for enhanced production of EPA and DHA in species of Chromista. 2013 Mar Drugs pmid:24284429
Harris WS et al. Omega-3 fatty acids and cardiovascular disease: new developments and applications. 2013 Postgrad Med pmid:24200766
Ding N et al. Short-term effects of different fish oil formulations on tissue absorption of docosahexaenoic acid in mice fed high- and low-fat diets. 2013 J Oleo Sci pmid:24200935
Akanbi TO et al. Selective concentration of EPA and DHA using Thermomyces lanuginosus lipase is due to fatty acid selectivity and not regioselectivity. 2013 Food Chem pmid:23265531
Alicandro G et al. A randomized placebo-controlled study on high-dose oral algal docosahexaenoic acid supplementation in children with cystic fibrosis. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23266209
Fenton JI and McCaskey SJ Curcumin and docosahexaenoic acid block insulin-induced colon carcinoma cell proliferation. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23266210
Rogers LK et al. DHA supplementation: current implications in pregnancy and childhood. 2013 Pharmacol. Res. pmid:23266567
Otsuka R et al. Higher serum EPA or DHA, and lower ARA compositions with age independent fatty acid intake in Japanese aged 40 to 79. 2013 Lipids pmid:23389403
Orr SK et al. Unesterified docosahexaenoic acid is protective in neuroinflammation. 2013 J. Neurochem. pmid:23919613
Barbadoro P et al. Fish oil supplementation reduces cortisol basal levels and perceived stress: a randomized, placebo-controlled trial in abstinent alcoholics. 2013 Mol Nutr Food Res pmid:23390041
Andrade-Vieira R et al. Omega-3 polyunsaturated fatty acid promotes the inhibition of glycolytic enzymes and mTOR signaling by regulating the tumor suppressor LKB1. 2013 Cancer Biol. Ther. pmid:24025358
Lachance C et al. Fenretinide corrects the imbalance between omega-6 to omega-3 polyunsaturated fatty acids and inhibits macrophage inflammatory mediators via the ERK pathway. 2013 PLoS ONE pmid:24069363
Leggieri E et al. Clinical effects of diet supplementation with DHA in pediatric patients suffering from cystic fibrosis. 2013 Minerva Pediatr. pmid:24051972
Cunnane SC et al. Docosahexaenoic acid homeostasis, brain aging and Alzheimer's disease: Can we reconcile the evidence? 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22575581
Zou Z et al. Inhibition of the HER2 pathway by n-3 polyunsaturated fatty acids prevents breast cancer in fat-1 transgenic mice. 2013 J. Lipid Res. pmid:24052576
Song X et al. Different impacts of short-chain fatty acids on saturated and polyunsaturated fatty acid biosynthesis in Aurantiochytrium sp. SD116. 2013 J. Agric. Food Chem. pmid:24053543
Kenchegowda S et al. Involvement of pigment epithelium-derived factor, docosahexaenoic acid and neuroprotectin D1 in corneal inflammation and nerve integrity after refractive surgery. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22579364
Nobili V et al. The I148M variant of PNPLA3 reduces the response to docosahexaenoic acid in children with non-alcoholic fatty liver disease. 2013 J Med Food pmid:24074360
Delplanque B et al. A dairy fat matrix providing alpha-linolenic acid (ALA) is better than a vegetable fat mixture to increase brain DHA accretion in young rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22884780