Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Liu J and Ma DW | The role of n-3 polyunsaturated fatty acids in the prevention and treatment of breast cancer. | 2014 | Nutrients | pmid:25412153 |
Cruz-Hernandez C et al. | Benefits of structured and free monoacylglycerols to deliver eicosapentaenoic (EPA) in a model of lipid malabsorption. | 2012 | Nutrients | pmid:23201848 |
Valenzuela R et al. | Modification of Docosahexaenoic Acid Composition of Milk from Nursing Women Who Received Alpha Linolenic Acid from Chia Oil during Gestation and Nursing. | 2015 | Nutrients | pmid:26247968 |
Givens I | Animal nutrition and lipids in animal products and their contribution to human intake and health. | 2009 | Nutrients | pmid:22253968 |
Lee MS et al. | Effects of eicosapentaenoic acid and docosahexaenoic acid on uncoupling protein 3 gene expression in C(2)C(12) muscle cells. | 2013 | Nutrients | pmid:23698161 |
Calder PC | Omega-3 fatty acids and inflammatory processes. | 2010 | Nutrients | pmid:22254027 |
von Schacky C | Omega-3 Index and sudden cardiac death. | 2010 | Nutrients | pmid:22254028 |
GarcÃa-Layana A et al. | Effects of lutein and docosahexaenoic Acid supplementation on macular pigment optical density in a randomized controlled trial. | 2013 | Nutrients | pmid:23434908 |
Emmett R et al. | Expanding awareness of docosahexaenoic acid during pregnancy. | 2013 | Nutrients | pmid:23549329 |
Fekete K and Decsi T | Long-chain polyunsaturated fatty acids in inborn errors of metabolism. | 2010 | Nutrients | pmid:22254065 |
Cerf ME and Herrera E | High Fat Diet Administration during Specific Periods of Pregnancy Alters Maternal Fatty Acid Profiles in the Near-Term Rat. | 2016 | Nutrients | pmid:26742067 |
Cheatham CL and Sheppard KW | Synergistic Effects of Human Milk Nutrients in the Support of Infant Recognition Memory: An Observational Study. | 2015 | Nutrients | pmid:26540073 |
Bradbury J | Docosahexaenoic acid (DHA): an ancient nutrient for the modern human brain. | 2011 | Nutrients | pmid:22254110 |
Juman S et al. | Effects of long-term oral administration of arachidonic acid and docosahexaenoic acid on the immune functions of young rats. | 2013 | Nutrients | pmid:23760060 |
Abeywardena MY et al. | Rise in DPA Following SDA-Rich Dietary Echium Oil Less Effective in Affording Anti-Arrhythmic Actions Compared to High DHA Levels Achieved with Fish Oil in Sprague-Dawley Rats. | 2016 | Nutrients | pmid:26742064 |
Tabbaa M et al. | Docosahexaenoic acid, inflammation, and bacterial dysbiosis in relation to periodontal disease, inflammatory bowel disease, and the metabolic syndrome. | 2013 | Nutrients | pmid:23966110 |
Lefort N et al. | Dietary Buglossoides Arvensis Oil Increases Circulating n-3 Polyunsaturated Fatty Acids in a Dose-Dependent Manner and Enhances Lipopolysaccharide-Stimulated Whole Blood Interleukin-10-A Randomized Placebo-Controlled Trial. | 2017 | Nutrients | pmid:28287415 |
Akiyama M et al. | Impact of docosahexaenoic acid on gene expression during osteoclastogenesis in vitro--a comprehensive analysis. | 2013 | Nutrients | pmid:23945674 |
Senftleber NK et al. | Marine Oil Supplements for Arthritis Pain: A Systematic Review and Meta-Analysis of Randomized Trials. | 2017 | Nutrients | pmid:28067815 |
von Schacky C | Omega-3 index and cardiovascular health. | 2014 | Nutrients | pmid:24566438 |
Minihane AM | Impact of Genotype on EPA and DHA Status and Responsiveness to Increased Intakes. | 2016 | Nutrients | pmid:26950146 |
Cinelli G et al. | Influence of Maternal Obesity and Gestational Weight Gain on Maternal and Foetal Lipid Profile. | 2016 | Nutrients | pmid:27314385 |
Flock MR et al. | Long-chain omega-3 fatty acids: time to establish a dietary reference intake. | 2013 | Nutr. Rev. | pmid:24117792 |
Cole GM et al. | Dietary fatty acids and the aging brain. | 2010 | Nutr. Rev. | pmid:21091943 |
Wurtman RJ et al. | Nutritional modifiers of aging brain function: use of uridine and other phosphatide precursors to increase formation of brain synapses. | 2010 | Nutr. Rev. | pmid:21091953 |
Sarris J et al. | Major depressive disorder and nutritional medicine: a review of monotherapies and adjuvant treatments. | 2009 | Nutr. Rev. | pmid:19239627 |
Brownawell AM et al. | Assessing the environment for regulatory change for eicosapentaenoic acid and docosahexaenoic acid nutrition labeling. | 2009 | Nutr. Rev. | pmid:19566599 |
Dietary fish oil increases omega-3 long-chain polyunsaturated fatty acids in human milk. | 1985 | Nutr. Rev. | pmid:2934649 | |
Musa-Veloso K et al. | Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid dose-dependently reduce fasting serum triglycerides. | 2010 | Nutr. Rev. | pmid:20384846 |
Maki KC and Rains TM | Low-dose eicosapentaenoic acid and/or docosahexaenoic acid and triglyceride lowering. | 2010 | Nutr. Rev. | pmid:20796222 |
Neuringer M | Cerebral cortex docosahexaenoic acid is lower in formula-fed than in breast-fed infants. | 1993 | Nutr. Rev. | pmid:8302494 |
Studies of docosahexaenoic and eicosapentaenoic acids in trout and frogs. | 1982 | Nutr. Rev. | pmid:6289203 | |
Cruz-Hernandez C et al. | Lipase inhibitor orlistat decreases incorporation of eicosapentaenoic and docosahexaenoic acids in rat tissues. | 2010 | Nutr Res | pmid:20226999 |
An WS et al. | Omega-3 fatty acid supplementation increases 1,25-dihydroxyvitamin D and fetuin-A levels in dialysis patients. | 2012 | Nutr Res | pmid:22901557 |
Suchy J et al. | Dietary supplementation with a combination of alpha-lipoic acid, acetyl-L-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain and improves cognitive performance. | 2009 | Nutr Res | pmid:19185780 |
Courville AB et al. | Plasma or red blood cell phospholipids can be used to assess docosahexaenoic acid status in women during pregnancy. | 2009 | Nutr Res | pmid:19358928 |
Zhang J et al. | Different intakes of n-3 fatty acids among pregnant women in 3 regions of China with contrasting dietary patterns are reflected in maternal but not in umbilical erythrocyte phosphatidylcholine fatty acid composition. | 2013 | Nutr Res | pmid:23890350 |
Shiraishi M et al. | Estimation of eicosapentaenoic acid and docosahexaenoic acid intakes in pregnant Japanese women without nausea by using a self-administered diet history questionnaire. | 2013 | Nutr Res | pmid:23746563 |
Broughton KS et al. | High α-linolenic acid and fish oil ingestion promotes ovulation to the same extent in rats. | 2010 | Nutr Res | pmid:21056289 |
Lohner S et al. | Lower n-3 long-chain polyunsaturated fatty acid values in patients with phenylketonuria: a systematic review and meta-analysis. | 2013 | Nutr Res | pmid:23827125 |
Kelly OJ et al. | Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis. | 2013 | Nutr Res | pmid:23827126 |
Schnebelen C et al. | Dietary polyunsaturated fatty acids reduce retinal stress induced by an elevation of intraocular pressure in rats. | 2011 | Nutr Res | pmid:21530802 |
Harden CJ et al. | Long-chain polyunsaturated fatty acid supplementation had no effect on body weight but reduced energy intake in overweight and obese women. | 2014 | Nutr Res | pmid:24418242 |
Lora KR et al. | Validity and reliability of an omega-3 fatty acid food frequency questionnaire for first-generation Midwestern Latinas. | 2010 | Nutr Res | pmid:20851309 |
Nobre ME et al. | Eicosapentaenoic acid and docosahexaenoic acid exert anti-inflammatory and antinociceptive effects in rodents at low doses. | 2013 | Nutr Res | pmid:23684444 |
Broughton KS et al. | Docosahexaenoic acid and eicosapentaenoic acid affect ovarian prostaglandin levels differently in rats. | 2009 | Nutr Res | pmid:19700039 |
Poudel-Tandukar K et al. | Dietary intakes of alpha-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men. | 2009 | Nutr Res | pmid:19628101 |
Kim M et al. | Erythrocyte α-linolenic acid is associated with the risk for mild dementia in Korean elderly. | 2010 | Nutr Res | pmid:21130294 |
Park Y et al. | Dietary n-3 polyunsaturated fatty acids increase oxidative stress in rats with intracerebral hemorrhagic stroke. | 2009 | Nutr Res | pmid:19932870 |
Rasmussen LE et al. | The content of docosahexaenoic acid in serum phospholipid is inversely correlated with plasma homocysteine levels in patients with end-stage renal disease. | 2010 | Nutr Res | pmid:20851307 |
Maki KC et al. | Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. | 2009 | Nutr Res | pmid:19854375 |
Zhang J et al. | Inclusion of Atlantic salmon in the Chinese diet reduces cardiovascular disease risk markers in dyslipidemic adult men. | 2010 | Nutr Res | pmid:20797476 |
Sala-Vila A et al. | The intramolecular position of docosahexaenoic acid in the triacylglycerol sources used for pediatric nutrition has a minimal effect on its metabolic use. | 2008 | Nutr Res | pmid:19083399 |
Fukunaga K et al. | Marine phosphatidylcholine suppresses 1,2-dimethylhydrazine-induced colon carcinogenesis in rats by inducing apoptosis. | 2008 | Nutr Res | pmid:19083470 |
Fernandes JS et al. | Long-term treatment with fish oil prevents memory impairments but not hippocampal damage in rats subjected to transient, global cerebral ischemia. | 2008 | Nutr Res | pmid:19083490 |
Rondanelli M et al. | Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment. | 2012 | Nutr Neurosci | pmid:22334085 |
Carey AN et al. | The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. | 2013 | Nutr Neurosci | pmid:23321679 |
Johnson EJ et al. | Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women. | 2008 | Nutr Neurosci | pmid:18510807 |
McNamara RK et al. | Low docosahexaenoic acid status is associated with reduced indices in cortical integrity in the anterior cingulate of healthy male children: a 1H MRS Study. | 2013 | Nutr Neurosci | pmid:23582513 |
Naliwaiko K et al. | Effects of fish oil on the central nervous system: a new potential antidepressant? | 2004 | Nutr Neurosci | pmid:15279495 |
Davis PF et al. | Dopamine receptor alterations in female rats with diet-induced decreased brain docosahexaenoic acid (DHA): interactions with reproductive status. | 2010 | Nutr Neurosci | pmid:20670471 |
Kennedy DO et al. | Cognitive and mood effects of 8 weeks' supplementation with 400 mg or 1000 mg of the omega-3 essential fatty acid docosahexaenoic acid (DHA) in healthy children aged 10-12 years. | 2009 | Nutr Neurosci | pmid:19356306 |
Martin DA et al. | Prenatal dietary docosahexaenoic acid supplementation in combination with protein restriction does not affect blood pressure in adult Wistar rats. | 2004 | Nutr Neurosci | pmid:15526988 |
Johnston DT et al. | Red blood cell omega-3 fatty acid levels and neurocognitive performance in deployed U.S. Servicemembers. | 2013 | Nutr Neurosci | pmid:22748167 |
Auestad N et al. | Auditory brainstem evoked response in juvenile rats fed rat milk formulas with high docosahexaenoic acid. | 2003 | Nutr Neurosci | pmid:14744037 |
Liu Z et al. | Determination of fatty acid levels in erythrocyte membranes of patients with chronic fatigue syndrome. | 2003 | Nutr Neurosci | pmid:14744043 |
Hamazaki T et al. | The effect of docosahexaenoic acid on aggression in elderly Thai subjects--a placebo-controlled double-blind study. | 2002 | Nutr Neurosci | pmid:11929196 |
Sahin N et al. | A novel nutritional supplement containing chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron activates the antioxidant pathway Nrf2/HO-1 and protects the brain against oxidative stress in high-fat-fed rats. | 2012 | Nutr Neurosci | pmid:23232054 |
Yavin E et al. | Docosahexaenoic acid abundance in the brain: a biodevice to combat oxidative stress. | 2002 | Nutr Neurosci | pmid:12041873 |
Amiano P et al. | Intake of total omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid and risk of coronary heart disease in the Spanish EPIC cohort study. | 2014 | Nutr Metab Cardiovasc Dis | pmid:24360762 |
Eschen O et al. | Soluble adhesion molecules in healthy subjects: a dose-response study using n-3 fatty acids. | 2004 | Nutr Metab Cardiovasc Dis | pmid:15553594 |
Weber P and Raederstorff D | Triglyceride-lowering effect of omega-3 LC-polyunsaturated fatty acids--a review. | 2000 | Nutr Metab Cardiovasc Dis | pmid:10812585 |
Bragt MC and Mensink RP | Comparison of the effects of n-3 long chain polyunsaturated fatty acids and fenofibrate on markers of inflammation and vascular function, and on the serum lipoprotein profile in overweight and obese subjects. | 2012 | Nutr Metab Cardiovasc Dis | pmid:21429719 |
Madden J et al. | Altered monocyte CD44 expression in peripheral arterial disease is corrected by fish oil supplementation. | 2009 | Nutr Metab Cardiovasc Dis | pmid:18804988 |
Oelrich B et al. | Effect of fish oil supplementation on serum triglycerides, LDL cholesterol and LDL subfractions in hypertriglyceridemic adults. | 2013 | Nutr Metab Cardiovasc Dis | pmid:21924882 |
Sirot V et al. | A restricted cubic spline approach to assess the association between high fat fish intake and red blood cell EPA + DHA content. | 2012 | Nutr Metab Cardiovasc Dis | pmid:20875947 |
Rein P et al. | Omega-3 fatty acids significantly reduce postprandial triglyceridemia in male smokers: a pilot study. | 2009 | Nutr Metab Cardiovasc Dis | pmid:19073364 |
Nobili V et al. | Docosahexaenoic acid for the treatment of fatty liver: randomised controlled trial in children. | 2013 | Nutr Metab Cardiovasc Dis | pmid:23220074 |
Phang M et al. | Gender-specific inhibition of platelet aggregation following omega-3 fatty acid supplementation. | 2012 | Nutr Metab Cardiovasc Dis | pmid:20708391 |
Bogl LH et al. | Association between habitual dietary intake and lipoprotein subclass profile in healthy young adults. | 2013 | Nutr Metab Cardiovasc Dis | pmid:23333726 |
Danthiir V et al. | The older people, omega-3, and cognitive health (EPOCH) trial design and methodology: a randomised, double-blind, controlled trial investigating the effect of long-chain omega-3 fatty acids on cognitive ageing and wellbeing in cognitively healthy older adults. | 2011 | Nutr J | pmid:22011460 |
Beezhold BL et al. | Vegetarian diets are associated with healthy mood states: a cross-sectional study in seventh day adventist adults. | 2010 | Nutr J | pmid:20515497 |
Papanikolaou Y et al. | U.S. adults are not meeting recommended levels for fish and omega-3 fatty acid intake: results of an analysis using observational data from NHANES 2003-2008. | 2014 | Nutr J | pmid:24694001 |
Burns-Whitmore B et al. | Effects of supplementing n-3 fatty acid enriched eggs and walnuts on cardiovascular disease risk markers in healthy free-living lacto-ovo-vegetarians: a randomized, crossover, free-living intervention study. | 2014 | Nutr J | pmid:24673793 |
Sorgi PJ et al. | Effects of an open-label pilot study with high-dose EPA/DHA concentrates on plasma phospholipids and behavior in children with attention deficit hyperactivity disorder. | 2007 | Nutr J | pmid:17629918 |
Beezhold BL and Johnston CS | Restriction of meat, fish, and poultry in omnivores improves mood: a pilot randomized controlled trial. | 2012 | Nutr J | pmid:22333737 |
Oken E et al. | A pilot randomized controlled trial to promote healthful fish consumption during pregnancy: the Food for Thought Study. | 2013 | Nutr J | pmid:23496848 |
Bermudez OI et al. | Dietary intakes and food sources of fat and fatty acids in Guatemalan schoolchildren: a cross-sectional study. | 2010 | Nutr J | pmid:20416064 |
Dangour AD et al. | A randomised controlled trial investigating the effect of n-3 long-chain polyunsaturated fatty acid supplementation on cognitive and retinal function in cognitively healthy older people: the Older People And n-3 Long-chain polyunsaturated fatty acids (OPAL) study protocol [ISRCTN72331636]. | 2006 | Nutr J | pmid:16945130 |
Huang T et al. | Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism. | 2012 | Nutr J | pmid:22260268 |
Holub BJ et al. | Correlation of omega-3 levels in serum phospholipid from 2053 human blood samples with key fatty acid ratios. | 2009 | Nutr J | pmid:20034401 |
Gruber JF et al. | Associations between toenail arsenic concentration and dietary factors in a New Hampshire population. | 2012 | Nutr J | pmid:22747713 |
Garneau V et al. | Omega-3 fatty acids status in human subjects estimated using a food frequency questionnaire and plasma phospholipids levels. | 2012 | Nutr J | pmid:22775977 |
Kawakami Y et al. | Flaxseed oil intake reduces serum small dense low-density lipoprotein concentrations in Japanese men: a randomized, double blind, crossover study. | 2015 | Nutr J | pmid:25896182 |
Castro González MI et al. | [Renal patient's diet: Can fish be included?]. | 2012 Sep-Oct | Nutr Hosp | pmid:23478696 |
Sanz ParÃs A et al. | [Proposed profile of omega 3 fatty acids in enteral nutrition]. | 2012 Nov-Dec | Nutr Hosp | pmid:23588426 |
Piñeiro-Corrales G et al. | [Role of omega-3 fatty acids in cardiovascular disease prevention]. | 2013 Jan-Feb | Nutr Hosp | pmid:23808424 |
Vilaseca MA et al. | Long-chain polyunsaturated fatty acid concentration in patients with inborn errors of metabolism. | 2011 Jan-Feb | Nutr Hosp | pmid:21519739 |
Johnson B | Consciousness reinstated using the certainty principle--a better mental health strategy. | 2011 | Nutr Health | pmid:22141192 |
Moodley T et al. | Arachidonic and docosahexaenoic acid deficits in preterm neonatal mononuclear cell membranes. Implications for the immune response at birth. | 2009 | Nutr Health | pmid:19835110 |