Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Raederstorff D et al. | Anti-inflammatory properties of docosahexaenoic and eicosapentaenoic acids in phorbol-ester-induced mouse ear inflammation. | 1996 | Int. Arch. Allergy Immunol. | pmid:8917124 |
Hamazaki T et al. | Docosahexaenoic acid-rich fish oil does not affect serum lipid concentrations of normolipidemic young adults. | 1996 | J. Nutr. | pmid:8914949 |
Marignani PA and Sebaldt RJ | The formation of diradylglycerol molecular species in murine peritoneal macrophages varies dose-dependently with dietary purified eicosapentaenoic and docosahexaenoic ethyl esters. | 1996 | J. Nutr. | pmid:8914943 |
Woods J et al. | Is docosahexaenoic acid necessary in infant formula? Evaluation of high linolenate diets in the neonatal rat. | 1996 | Pediatr. Res. | pmid:8910933 |
Crosby AJ et al. | Modulation of glutathione peroxidase activity in human vascular endothelial cells by fatty acids and the cytokine interleukin-1 beta. | 1996 | Biochim. Biophys. Acta | pmid:8908152 |
Retterstøl K et al. | The metabolism of 22:5(-6) and of docosahexaenoic acid [22:6(-3)] compared in rat hepatocytes. | 1996 | Biochim. Biophys. Acta | pmid:8908151 |
Chambon M et al. | Influence of orthotopic liver transplantation on docosehexaenoic acid deficiency in cholestatic children. | 1996 | Transplant. Proc. | pmid:8908096 |
Yamada K et al. | Effects of fatty acids on accumulation and secretion of histamine in RBL-2H3 cells and leukotriene release from peritoneal exudate cells isolated from Wistar rats. | 1996 | J. Nutr. Sci. Vitaminol. | pmid:8906631 |
Vreugdenhil M et al. | Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8901621 |
Farkas K et al. | Changes in the size and docosahexaenoic acid content of adipocytes during chick embryo development. | 1996 | Lipids | pmid:8900461 |
Ohno T et al. | Fatty acid profiles of phospholipids in brown adipose tissue from rats during cold acclimation and repetitive intermittent immobilization: with special reference to docosahexaenoic acid. | 1996 | Jpn. J. Physiol. | pmid:8899494 |
Farkas K et al. | Developmental changes in the levels of molecular species of triacylglycerol that contain docosahexaenoic acid in adipose tissue of the chick embryo. | 1996 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:8896327 |
Luukkainen P et al. | Impact of solid food on plasma arachidonic and docosahexaenoic acid status of term infants at 8 months of age. | 1996 | J. Pediatr. Gastroenterol. Nutr. | pmid:8890071 |
Abbate R et al. | n-3 PUFA supplementation, monocyte PCA expression and interleukin-6 production. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888356 |
Peet M et al. | Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888126 |
Glen AI et al. | Membrane fatty acids, niacin flushing and clinical parameters. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888117 |
Horrobin DF | Schizophrenia as a membrane lipid disorder which is expressed throughout the body. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888116 |
Dahlan W et al. | Fish meal lecithin as alternative precursor of docosahexaenoate and choline. | 1996 | Biomed. Environ. Sci. | pmid:8886341 |
Lambert MS et al. | Modification of the fatty acid composition of dietary oils and fats on incorporation into chylomicrons and chylomicron remnants. | 1996 | Br. J. Nutr. | pmid:8881715 |
Alessandri JM et al. | Polyunsaturated fatty acids status in blood, heart, liver, intestine, retina and brain of newborn piglets fed either sow milk or a milk replacer diet. | 1996 | Reprod. Nutr. Dev. | pmid:8881596 |
Hughes DA and Pinder AC | Influence of n-3 polyunsaturated fatty acids (PUFA) on the antigen-presenting function of human monocytes. | 1996 | Biochem. Soc. Trans. | pmid:8878933 |
Schjøtt J et al. | Effects of eicosapentaenoic acid and docosahexaenoic acid diet supplement on tolerance to the cardiotoxicity of epirubicin and to ischaemia reperfusion in the isolated rat heart. | 1996 | Pharmacol. Toxicol. | pmid:8878248 |
Berkenboom G et al. | Effect of dietary supplementation with fish oil on cyclosporine A-induced vascular toxicity. | 1996 | Cardiovasc Drugs Ther | pmid:8877082 |
Oski FA | Making the public and pediatric community aware of the importance of fatty acids in infant nutrition. | 1996 | Nutrition | pmid:8875527 |
Stillwell W et al. | Cholesterol versus alpha-tocopherol: effects on properties of bilayers made from heteroacid phosphatidylcholines. | 1996 | Biochemistry | pmid:8873602 |
Liu W et al. | Docosahexaenoic acid ethyl ester and its ultraviolet degradation products showed DNA-breaking activity in vitro and cytotoxic effects on the HSC-4 cell line. | 1995 | Kobe J Med Sci | pmid:8869009 |
Hamano H et al. | Docosahexaenoic acid reduces GABA response in substantia nigra neuron of rat. | 1996 | J. Neurophysiol. | pmid:8867135 |
Saito M et al. | An assessment of docosahexaenoic acid (DHA) intake with special reference to lipid metabolism in rats. | 1996 | J. Nutr. Sci. Vitaminol. | pmid:8866256 |
Baskaya MK et al. | Enhanced accumulation of free fatty acids in experimental focal cerebral ischemia. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8860103 |
Reithmann C et al. | Exposure to the n-3 polyunsaturated fatty acid docosahexaenoic acid impairs alpha 1-adrenoceptor-mediated contractile responses and inositol phosphate formation in rat cardiomyocytes. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8857587 |
Karmali RA | Historical perspective and potential use of n-3 fatty acids in therapy of cancer cachexia. | 1996 | Nutrition | pmid:8850210 |
Organisciak DT et al. | Retinal light damage in rats with altered levels of rod outer segment docosahexaenoate. | 1996 | Invest. Ophthalmol. Vis. Sci. | pmid:8843911 |
Leaf A et al. | Long chain polyunsaturated fatty acids and visual function in preterm infants. | 1996 | Early Hum. Dev. | pmid:8842638 |
Brossard N et al. | Retroconversion and metabolism of [13C]22:6n-3 in humans and rats after intake of a single dose of [13C]22:6n-3-triacylglycerols. | 1996 | Am. J. Clin. Nutr. | pmid:8839503 |
Frøyland L et al. | Chronic administration of eicosapentaenoic acid and docosahexaenoic acid as ethyl esters reduced plasma cholesterol and changed the fatty acid composition in rat blood and organs. | 1996 | Lipids | pmid:8835405 |
Okada M et al. | The chronic administration of docosahexaenoic acid reduces the spatial cognitive deficit following transient forebrain ischemia in rats. | 1996 | Neuroscience | pmid:8834389 |
Khair-el-Din TA et al. | Inhibition of macrophage nitric-oxide production and Ia-expression by docosahexaenoic acid, a constituent of fetal and neonatal serum. | 1996 | Am. J. Reprod. Immunol. | pmid:8831896 |
Ku K et al. | The effects of omega-3 polyunsaturated (correction of polyunsatulated) fatty acids on the recovery of cardiac function following cold preservation and reperfusion in hyperlipidemic rats. | 1996 | Transplantation | pmid:8824469 |
Polette A et al. | N-3 fatty acid-induced lipid peroxidation in human platelets is prevented by catechins. | 1996 | Thromb. Haemost. | pmid:8822591 |
Bayorh MA et al. | Effects of MaxEPA on salt-induced hypertension: relationship to [3H]nitrobenzylthioinosine binding sites. | 1996 | Clin. Exp. Hypertens. | pmid:8822232 |
Pöschl JM et al. | Dietary docosahexaenoic acid improves red blood cell deformability in rats. | 1996 | Thromb. Res. | pmid:8822144 |
Huang MC and Craig-Schmidt MC | Arachidonate and docosahexaenoate added to infant formula influence fatty acid composition and subsequent eicosanoid production in neonatal pigs. | 1996 | J. Nutr. | pmid:8814208 |
Fernández-Bañares F et al. | Changes of the mucosal n3 and n6 fatty acid status occur early in the colorectal adenoma-carcinoma sequence. | 1996 | Gut | pmid:8801207 |
Xu LZ et al. | Ligand specificity of brain lipid-binding protein. | 1996 | J. Biol. Chem. | pmid:8798739 |
Carnielli VP et al. | The very low birth weight premature infant is capable of synthesizing arachidonic and docosahexaenoic acids from linoleic and linolenic acids. | 1996 | Pediatr. Res. | pmid:8798265 |
Simonelli F et al. | Evaluation of fatty acids in membrane phospholipids of erythrocytes in retinitis pigmentosa patients. | 1996 | Ophthalmic Res. | pmid:8792359 |
Mitjavila MT et al. | Effect of degree of unsaturation in dietary fatty acids on arachidonic acid mobilization by peritoneal macrophages. | 1996 | Lipids | pmid:8784749 |
Dembitsky VM and Rezanka T | Unusually high levels of eicosatetraenoic, eicosapentaenoic, and docosahexaenoic fatty acids in Palestinian freshwater sponges. | 1996 | Lipids | pmid:8784746 |
Innis SM et al. | Blood lipid docosahexaenoic and arachidonic acid in term gestation infants fed formulas with high docosahexaenoic acid, low eicosapentaenoic acid fish oil. | 1996 | Lipids | pmid:8784742 |
Willumsen N et al. | Eicosapentaenoic acid, but not docosahexaenoic acid, increases mitochondrial fatty acid oxidation and upregulates 2,4-dienoyl-CoA reductase gene expression in rats. | 1996 | Lipids | pmid:8784738 |
Minami M and Noguchi M | Effects of low-dose eicosapentaenoic acid, docosahexaenoic acid and dietary fat on the incidence, growth and cell kinetics of mammary carcinomas in rats. | 1996 Sep-Oct | Oncology | pmid:8784475 |
Palozza P et al. | n-3 fatty acids induce oxidative modifications in human erythrocytes depending on dose and duration of dietary supplementation. | 1996 | Am. J. Clin. Nutr. | pmid:8780337 |
Lecomte M et al. | Docosahexaenoic acid is a major n-3 polyunsaturated fatty acid in bovine retinal microvessels. | 1996 | J. Neurochem. | pmid:8780049 |
Rotstein NP et al. | Docosahexaenoic acid is required for the survival of rat retinal photoreceptors in vitro. | 1996 | J. Neurochem. | pmid:8780010 |
Maccoll AJ et al. | Erythrocyte morphology and filterability in rats fed on diets containing different fats and oils. | 1996 | Br. J. Nutr. | pmid:8774223 |
Weisinger HS et al. | Effect of dietary n-3 deficiency on the electroretinogram in the guinea pig. | 1996 | Ann. Nutr. Metab. | pmid:8773733 |
Boswell K et al. | Preclinical evaluation of single-cell oils that are highly enriched with arachidonic acid and docosahexaenoic acid. | 1996 | Food Chem. Toxicol. | pmid:8761351 |
Yamada Y et al. | Effect of eicosapentaenoic acid and docosahexaenoic acid on diabetic osteopenia. | 1995 | Diabetes Res. Clin. Pract. | pmid:8745204 |
Degrace P et al. | Intestinal lymph absorption of butter, corn oil, cod liver oil, menhaden oil, and eicosapentaenoic and docosahexaenoic acid ethyl esters in rats. | 1996 | Lipids | pmid:8743053 |
Sasaki H et al. | [Immunosuppressive effect of intravenously injected docosahexaenoic acid on single lung allotransplantation in the rat]. | 1996 | Nihon Kyobu Geka Gakkai Zasshi | pmid:8741552 |
McLennan P et al. | The cardiovascular protective role of docosahexaenoic acid. | 1996 | Eur. J. Pharmacol. | pmid:8741170 |
Boehm G et al. | Docosahexaenoic and arachidonic acid content of serum and red blood cell membrane phospholipids of preterm infants fed breast milk, standard formula or formula supplemented with n-3 and n-6 long-chain polyunsaturated fatty acids. | 1996 | Eur. J. Pediatr. | pmid:8741041 |
Cerolini S et al. | Preferential mobilisation of docosahexaenoic acid from adipose tissue triacylglycerol of the chick embryo. | 1996 | Biochem. Soc. Trans. | pmid:8736823 |
Green P and Yavin E | Natural and accelerated docosahexaenoic acid accumulation in the prenatal rat brain. | 1996 | Lipids | pmid:8729125 |
Connor WE et al. | Increased docosahexaenoic acid levels in human newborn infants by administration of sardines and fish oil during pregnancy. | 1996 | Lipids | pmid:8729116 |
Gibson RA et al. | Effect of dietary docosahexaenoic acid on brain composition and neural function in term infants. | 1996 | Lipids | pmid:8729115 |
Martinez M | Docosahexaenoic acid therapy in docosahexaenoic acid-deficient patients with disorders of peroxisomal biogenesis. | 1996 | Lipids | pmid:8729110 |
Croset M et al. | In vivo compartmental metabolism of 13C-docosahexaenoic acid, studied by gas chromatography-combustion isotope ratio mass spectrometry. | 1996 | Lipids | pmid:8729104 |
De Caterina R and Libby P | Control of endothelial leukocyte adhesion molecules by fatty acids. | 1996 | Lipids | pmid:8729095 |
Carlson SE et al. | Visual acuity and fatty acid status of term infants fed human milk and formulas with and without docosahexaenoate and arachidonate from egg yolk lecithin. | 1996 | Pediatr. Res. | pmid:8726246 |
Hammes HP et al. | Acceleration of experimental diabetic retinopathy in the rat by omega-3 fatty acids. | 1996 | Diabetologia | pmid:8721768 |
Chen Y et al. | Docosahexaenoic acid modulates the interactions of the interphotoreceptor retinoid-binding protein with 11-cis-retinal. | 1996 | J. Biol. Chem. | pmid:8702792 |
Lim BO et al. | Effects of n-3 polyunsaturated fatty acids and lectins on immunoglobulin production by spleen lymphocytes of Sprague-Dawley rats. | 1996 | Biosci. Biotechnol. Biochem. | pmid:8695902 |
Innis SM and Hansen JW | Plasma fatty acid responses, metabolic effects, and safety of microalgal and fungal oils rich in arachidonic and docosahexaenoic acids in healthy adults. | 1996 | Am. J. Clin. Nutr. | pmid:8694015 |
Yamane M et al. | Subcellular localization of docosahexaenoic acid and arachidonic acid omega-hydroxylation activity in the brain, liver and colonic adenocarcinoma. | 1996 | J Chromatogr A | pmid:8680600 |
Tamura M and Suzuki H | Effect of docosahexaenoic acid and sardine oil diets on the ultrastructure of hepatocytes in adult mice. | 1995 | J. Nutr. Sci. Vitaminol. | pmid:8676220 |
Lagarde M | [Biosynthesis and functions of eicosanoids. Recent data]. | 1995 | C. R. Seances Soc. Biol. Fil. | pmid:8673630 |
Rotstein NP et al. | Active synthesis of C24:5, n-3 fatty acid in retina. | 1996 | Biochem. J. | pmid:8670163 |
Innis SM et al. | Feeding formula without arachidonic acid and docosahexaenoic acid has no effect on preferential looking acuity or recognition memory in healthy full-term infants at 9 mo of age. | 1996 | Am. J. Clin. Nutr. | pmid:8669412 |
Marzo I et al. | Biosynthesis of docosahexaenoic acid in human cells: evidence that two different delta 6-desaturase activities may exist. | 1996 | Biochim. Biophys. Acta | pmid:8664338 |
Luthria DL et al. | Regulation of the biosynthesis of 4,7,10,13,16,19-docosahexaenoic acid. | 1996 | J. Biol. Chem. | pmid:8663162 |
Moore SA et al. | Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid. | 1995 | J. Lipid Res. | pmid:8656081 |
Beijers RJ and Schaafsma A | Long-chain polyunsaturated fatty acid content in Dutch preterm breast milk; differences in the concentrations of docosahexaenoic acid and arachidonic acid due to length of gestation. | 1996 | Early Hum. Dev. | pmid:8654314 |
Balestrieri GP et al. | Fish oil supplementation in patients with heterozygous familial hypercholesterolemia. | 1996 | Recenti Prog Med | pmid:8650428 |
Jørgensen MH et al. | Visual acuity and erythrocyte docosahexaenoic acid status in breast-fed and formula-fed term infants during the first four months of life. | 1996 | Lipids | pmid:8649242 |
Werkman SH and Carlson SE | A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until nine months. | 1996 | Lipids | pmid:8649241 |
Carlson SE and Werkman SH | A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until two months. | 1996 | Lipids | pmid:8649239 |
Weisinger HS et al. | The effect of docosahexaenoic acid on the electroretinogram of the guinea pig. | 1996 | Lipids | pmid:8649236 |
Makrides M et al. | Is dietary docosahexaenoic acid essential for term infants? | 1996 | Lipids | pmid:8649228 |
Prisco D et al. | Effect of n-3 polyunsaturated fatty acid intake on phospholipid fatty acid composition in plasma and erythrocytes. | 1996 | Am. J. Clin. Nutr. | pmid:8644688 |
Khair-El-Din T et al. | Transcription of the murine iNOS gene is inhibited by docosahexaenoic acid, a major constituent of fetal and neonatal sera as well as fish oils. | 1996 | J. Exp. Med. | pmid:8642266 |
Engler MB and Engler MM | Influence of aging on the relaxant responses to omega-3 fatty acids in Fischer 344 rat aorta. | 1996 | Gerontology | pmid:8641598 |
Serhiienko OO | [The experimental and clinical aspects of eicosapentaenoic amd docosahexaenoic acids (a review of the literature and the author's own data)]. | 1995 May-Jun | Lik. Sprava | pmid:8630815 |
Pageaux JF et al. | Biogenesis and metabolic fate of docosahexaenoic and arachidonic acids in rat uterine stromal cells in culture. | 1996 | Arch. Biochem. Biophys. | pmid:8615684 |
Carlson SE et al. | Effect of long-chain n-3 fatty acid supplementation on visual acuity and growth of preterm infants with and without bronchopulmonary dysplasia. | 1996 | Am. J. Clin. Nutr. | pmid:8615350 |
Shashoua VE and Hesse GW | N-docosahexaenoyl, 3 hydroxytyramine: a dopaminergic compound that penetrates the blood-brain barrier and suppresses appetite. | 1996 | Life Sci. | pmid:8614292 |
Hamazaki T et al. | The effect of docosahexaenoic acid on aggression in young adults. A placebo-controlled double-blind study. | 1996 | J. Clin. Invest. | pmid:8613538 |
Khalfoun B et al. | Docosahexaenoic and eicosapentaenoic acids inhibit human lymphoproliferative responses in vitro but not the expression of T cell surface activation markers. | 1996 | Scand. J. Immunol. | pmid:8602457 |
Hughes DA et al. | (n-3) Polyunsaturated fatty acids modulate the expression of functionally associated molecules on human monocytes in vitro. | 1996 | J. Nutr. | pmid:8598544 |
Christensen JH et al. | Effect of fish oil on heart rate variability in survivors of myocardial infarction: a double blind randomised controlled trial. | 1996 | BMJ | pmid:8597736 |