Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Brouwer IA et al. | Association between n-3 fatty acid status in blood and electrocardiographic predictors of arrhythmia risk in healthy volunteers. | 2002 | Am. J. Cardiol. | pmid:11867059 |
Birch EE et al. | A randomized controlled trial of long-chain polyunsaturated fatty acid supplementation of formula in term infants after weaning at 6 wk of age. | 2002 | Am. J. Clin. Nutr. | pmid:11864865 |
Champoux M et al. | Fatty acid formula supplementation and neuromotor development in rhesus monkey neonates. | 2002 | Pediatr. Res. | pmid:11861930 |
Qi K et al. | Long-chain polyunsaturated fatty acid accretion in brain. | 2002 | Curr Opin Clin Nutr Metab Care | pmid:11844978 |
Takeuchi T et al. | Influence of a dietary n-3 fatty acid deficiency on the cerebral catecholamine contents, EEG and learning ability in rat. | 2002 | Behav. Brain Res. | pmid:11844586 |
Marchioli R et al. | Efficacy of n-3 polyunsaturated fatty acids after myocardial infarction: results of GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico. | 2001 | Lipids | pmid:11837985 |
McLennan PL | Myocardial membrane fatty acids and the antiarrhythmic actions of dietary fish oil in animal models. | 2001 | Lipids | pmid:11837983 |
Bell JG et al. | Substituting fish oil with crude palm oil in the diet of Atlantic salmon (Salmo salar) affects muscle fatty acid composition and hepatic fatty acid metabolism. | 2002 | J. Nutr. | pmid:11823582 |
Buznikov GA et al. | [Cholinergic regulation of the sea urchin embryonic and larval development]. | 2001 | Ross Fiziol Zh Im I M Sechenova | pmid:11822358 |
Qi B et al. | Identification of a cDNA encoding a novel C18-Delta(9) polyunsaturated fatty acid-specific elongating activity from the docosahexaenoic acid (DHA)-producing microalga, Isochrysis galbana. | 2002 | FEBS Lett. | pmid:11801246 |
Ratledge C et al. | Production of docosahexaenoic acid by Crypthecodinium cohnii grown in a pH-auxostat culture with acetic acid as principal carbon source. | 2001 | Lipids | pmid:11795857 |
Schiefermeier M and Yavin E | n-3 Deficient and docosahexaenoic acid-enriched diets during critical periods of the developing prenatal rat brain. | 2002 | J. Lipid Res. | pmid:11792731 |
Whelan J | Targeted taxane therapy for cancer. | 2002 | Drug Discov. Today | pmid:11790612 |
Neschen S et al. | Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:11788372 |
Gibson RA and Makrides M | Long-chain polyunsaturated fatty acids in breast milk: are they essential? | 2001 | Adv. Exp. Med. Biol. | pmid:11787705 |
Agostoni C et al. | Prolonged breast-feeding (six months or more) and milk fat content at six months are associated with higher developmental scores at one year of age within a breast-fed population. | 2001 | Adv. Exp. Med. Biol. | pmid:11787675 |
Huber T et al. | Structure of docosahexaenoic acid-containing phospholipid bilayers as studied by (2)H NMR and molecular dynamics simulations. | 2002 | J. Am. Chem. Soc. | pmid:11782182 |
Pawlosky RJ et al. | Ethanol consumption alters electroretinograms and depletes neural tissues of docosahexaenoic acid in rhesus monkeys: nutritional consequences of a low n-3 fatty acid diet. | 2001 | Alcohol. Clin. Exp. Res. | pmid:11781509 |
Valenzuela A and Nieto MS | [Docosahexaenoic acid (DHA) in fetal development and in infant nutrition]. | 2001 | Rev Med Chil | pmid:11775350 |
Wu FC et al. | Docosahexaenoic acid is superior to eicosapentaenoic acid as the essential fatty acid for growth of grouper, Epinephelus malabaricus. | 2002 | J. Nutr. | pmid:11773511 |
Hawkes JS et al. | Transforming growth factor beta in human milk does not change in response to modest intakes of docosahexaenoic acid. | 2001 | Lipids | pmid:11768164 |
Bell MV et al. | Biosynthesis and tissue deposition of docosahexaenoic acid (22:6n-3) in rainbow trout (Oncorhynchus mykiss). | 2001 | Lipids | pmid:11768160 |
Reich EE et al. | Quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease. | 2001 | Adv. Exp. Med. Biol. | pmid:11764949 |
de Swaaf ME et al. | Characterisation of extracellular polysaccharides produced by Crypthecodinium cohnii. | 2001 | Appl. Microbiol. Biotechnol. | pmid:11759692 |
Siddiqui RA et al. | Prevention of docosahexaenoic acid-induced cytotoxicity by phosphatidic acid in Jurkat leukemic cells: the role of protein phosphatase-1. | 2001 | Biochim. Biophys. Acta | pmid:11755213 |
Noguchi R et al. | Dietary effects of bitter gourd oil on blood and liver lipids of rats. | 2001 | Arch. Biochem. Biophys. | pmid:11747298 |
Petrache HI et al. | Structural properties of docosahexaenoyl phospholipid bilayers investigated by solid-state 2H NMR spectroscopy. | 2001 | J. Am. Chem. Soc. | pmid:11741426 |
Contreras MA et al. | Chronic nutritional deprivation of n-3 alpha-linolenic acid does not affect n-6 arachidonic acid recycling within brain phospholipids of awake rats. | 2001 | J. Neurochem. | pmid:11739623 |
Pradalier A et al. | Failure of omega-3 polyunsaturated fatty acids in prevention of migraine: a double-blind study versus placebo. | 2001 | Cephalalgia | pmid:11737007 |
Fernández-Real JM et al. | Circulating granulocyte-macrophage colony-stimulating factor and serum fatty acid composition in men and women. | 2001 | Metab. Clin. Exp. | pmid:11735097 |
Denys A et al. | Eicosapentaenoic acid and docosahexaenoic acid modulate MAP kinase (ERK1/ERK2) signaling in human T cells. | 2001 | J. Lipid Res. | pmid:11734574 |
Ferdinandusse S et al. | Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid. | 2001 | J. Lipid Res. | pmid:11734571 |
Mizejewski GJ and Pass KA | Fatty acids, alpha-fetoprotein, and cystic fibrosis. | 2001 | Pediatrics | pmid:11731663 |
Das UN et al. | Effect of corticosteroids and eicosapentaenoic acid/docosahexaenoic acid on pro-oxidant and anti-oxidant status and metabolism of essential fatty acids in patients with glomerular disorders. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728172 |
Salem N et al. | Mechanisms of action of docosahexaenoic acid in the nervous system. | 2001 | Lipids | pmid:11724467 |
Politi L et al. | Effects of docosahexaenoic acid on retinal development: cellular and molecular aspects. | 2001 | Lipids | pmid:11724465 |
Jeffrey BG et al. | The role of docosahexaenoic acid in retinal function. | 2001 | Lipids | pmid:11724458 |
Rousseau D et al. | Dietary n-3 polyunsaturated fatty acids affect the development of renovascular hypertension in rats. | 2001 | Mol. Cell. Biochem. | pmid:11716352 |
Narayanan BA et al. | Docosahexaenoic acid regulated genes and transcription factors inducing apoptosis in human colon cancer cells. | 2001 | Int. J. Oncol. | pmid:11713597 |
Strandvik B et al. | Essential fatty acid deficiency in relation to genotype in patients with cystic fibrosis. | 2001 | J. Pediatr. | pmid:11713441 |
Roque ME et al. | Effect of surfactants and natural detergents on phosphatidylcholine synthesis in photoreceptor membranes. | 2001 | Membr Cell Biol | pmid:11699863 |
Wang JY and Saito M | Dietary supplementation of N-3 fatty acids and hydroperoxide levels in rat retinas. | 2001 | Free Radic. Res. | pmid:11697133 |
Helland IB et al. | Similar effects on infants of n-3 and n-6 fatty acids supplementation to pregnant and lactating women. | 2001 | Pediatrics | pmid:11694666 |
Lampen A et al. | Phytanic acid and docosahexaenoic acid increase the metabolism of all-trans-retinoic acid and CYP26 gene expression in intestinal cells. | 2001 | Biochim. Biophys. Acta | pmid:11690641 |
Fan KW et al. | Eicosapentaenoic and docosahexaenoic acids production by and okara-utilizing potential of thraustochytrids. | 2001 | J. Ind. Microbiol. Biotechnol. | pmid:11687930 |
Politi LE et al. | Effect of GDNF on neuroblast proliferation and photoreceptor survival: additive protection with docosahexaenoic acid. | 2001 | Invest. Ophthalmol. Vis. Sci. | pmid:11687549 |
Dewailly E E et al. | Relations between n-3 fatty acid status and cardiovascular disease risk factors among Quebecers. | 2001 | Am. J. Clin. Nutr. | pmid:11684528 |
Innis SM et al. | Are human milk long-chain polyunsaturated fatty acids related to visual and neural development in breast-fed term infants? | 2001 | J. Pediatr. | pmid:11598600 |
Ruiz-Sanz JI et al. | Polyunsaturated fatty acid deficiency during dietary treatment of very long-chain acyl-CoA dehydrogenase deficiency. Rescue with soybean oil. | 2001 | J. Inherit. Metab. Dis. | pmid:11596652 |
Li QC et al. | [Determination of docosahexenoic acid in human serum by capillary gas chromatography]. | 1997 | Yao Xue Xue Bao | pmid:11596318 |
Bradley MO et al. | Tumor targeting by covalent conjugation of a natural fatty acid to paclitaxel. | 2001 | Clin. Cancer Res. | pmid:11595719 |
Bézaire V et al. | Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice. | 2001 | Am. J. Physiol. Endocrinol. Metab. | pmid:11595653 |
Rump P and Hornstra G | Relation between arachidonic acid and docosahexaenoic acid in maternal and neonatal blood. | 2001 | Eur J Clin Nutr | pmid:11593355 |
Denys A et al. | Docosahexaenoic acid modulates phorbol ester-induced activation of extracellular signal-regulated kinases 1 and 2 in NIH/3T3 cells. | 2001 | Lipids | pmid:11592732 |
Ikemoto A et al. | Reversibility of n-3 fatty acid deficiency-induced alterations of learning behavior in the rat: level of n-6 fatty acids as another critical factor. | 2001 | J. Lipid Res. | pmid:11590222 |
Ozawa I et al. | Purification of docosahexaenoic acid ethyl ester using a silver-ion-immobilized porous hollow-fiber membrane module. | 2001 Sep-Oct | Biotechnol. Prog. | pmid:11587581 |
Cha SH et al. | Chronic docosahexaenoic acid intake enhances expression of the gene for uncoupling protein 3 and affects pleiotropic mRNA levels in skeletal muscle of aged C57BL/6NJcl mice. | 2001 | J. Nutr. | pmid:11584083 |
Brand A and Yavin E | Early ethanolamine phospholipid translocation marks stress-induced apoptotic cell death in oligodendroglial cells. | 2001 | J. Neurochem. | pmid:11579130 |
Yoshida H et al. | Effect of dietary seal and fish oils on lipid metabolism in hamsters. | 2001 | J. Nutr. Sci. Vitaminol. | pmid:11575580 |
Miller RR et al. | Ethanol- and nicotine-induced membrane changes in embryonic and neonatal chick brains. | 2001 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:11574286 |
Infante JP et al. | High levels of docosahexaenoic acid (22:6n-3)-containing phospholipids in high-frequency contraction muscles of hummingbirds and rattlesnakes. | 2001 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:11567891 |
Hirafuji M et al. | Inhibition by docosahexaenoic acid of receptor-mediated Ca(2+) influx in rat vascular smooth muscle cells stimulated with 5-hydroxytryptamine. | 2001 | Eur. J. Pharmacol. | pmid:11567649 |
Costabile M et al. | A novel long chain polyunsaturated fatty acid, beta-Oxa 21:3n-3, inhibits T lymphocyte proliferation, cytokine production, delayed-type hypersensitivity, and carrageenan-induced paw reaction and selectively targets intracellular signals. | 2001 | J. Immunol. | pmid:11564817 |
Moore NG et al. | Omega-3 fatty acids decrease protein kinase expression in human breast cancer cells. | 2001 | Breast Cancer Res. Treat. | pmid:11561774 |
Moya M et al. | Fatty acid absorption in preterms on formulas with and without long-chain polyunsaturated fatty acids and in terms on formulas without these added. | 2001 | Eur J Clin Nutr | pmid:11528489 |
Ollero M et al. | Characterization of subsets of human spermatozoa at different stages of maturation: implications in the diagnosis and treatment of male infertility. | 2001 | Hum. Reprod. | pmid:11527898 |
Kuroda Y et al. | Desmutagenic and bio-antimutagenic activity of docosahexaenoic acid and eicosapentaenoic acid in cultured Chinese hamster V79 cells. | 2001 | Mutat. Res. | pmid:11525914 |
Poisson L and Ergan F | Docosahexaenoic acid ethyl esters from Isochrysis galbana. | 2001 | J. Biotechnol. | pmid:11522364 |
Ando Y and Oomi Y | Positional distribution of highly unsaturated fatty acids in triacyl-sn-glycerols of Artemia nauplii enriched with docosahexaenoic acid ethyl ester. | 2001 | Lipids | pmid:11521972 |
Shaikh SR et al. | Formation of inverted hexagonal phase in SDPE as observed by solid-state (31)P NMR. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11520062 |
Luquain C et al. | High-performance liquid chromatography determination of bis(monoacylglycerol) phosphate and other lysophospholipids. | 2001 | Anal. Biochem. | pmid:11520030 |
Hoffman DR et al. | Impaired synthesis of DHA in patients with X-linked retinitis pigmentosa. | 2001 | J. Lipid Res. | pmid:11518758 |
Williard DE et al. | Docosahexaenoic acid synthesis from n-3 polyunsaturated fatty acids in differentiated rat brain astrocytes. | 2001 | J. Lipid Res. | pmid:11518755 |
De Nys K et al. | Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase. | 2001 | Biochim. Biophys. Acta | pmid:11514237 |
Reynolds LM et al. | Phospholipid fatty acids and neurotoxicity in human neuroblastoma SH-SY5Y cells. | 2001 | Neurosci. Lett. | pmid:11514074 |
Aidos I et al. | Upgrading of maatjes herring byproducts: production of crude fish oil. | 2001 | J. Agric. Food Chem. | pmid:11513650 |
Araya J et al. | Red wine raises plasma HDL and preserves long-chain polyunsaturated fatty acids in rat kidney and erythrocytes. | 2001 | Br. J. Nutr. | pmid:11502232 |
Su HM et al. | Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis. | 2001 | J. Biol. Chem. | pmid:11500517 |
Grobas S et al. | Influence of source and percentage of fat added to diet on performance and fatty acid composition of egg yolks of two strains of laying hens. | 2001 | Poult. Sci. | pmid:11495470 |
Bradley MO et al. | Tumor targeting by conjugation of DHA to paclitaxel. | 2001 | J Control Release | pmid:11489499 |
Voigt RG et al. | A randomized, double-blind, placebo-controlled trial of docosahexaenoic acid supplementation in children with attention-deficit/hyperactivity disorder. | 2001 | J. Pediatr. | pmid:11487742 |
Reich EE et al. | Interactions between apolipoprotein E gene and dietary alpha-tocopherol influence cerebral oxidative damage in aged mice. | 2001 | J. Neurosci. | pmid:11487622 |
Harris MA et al. | Effects of conjugated linoleic acids and docosahexaenoic acid on rat liver and reproductive tissue fatty acids, prostaglandins and matrix metalloproteinase production. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487304 |
Urquhart P et al. | Profile of eicosanoids produced by human saphenous vein endothelial cells and the effect of dietary fatty acids. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487303 |
Pasquier E et al. | Effects of delta5 polyunsaturated fatty acids of maritime pine (Pinus pinaster) seed oil on the fatty acid profile of the developing brain of rats. | 2001 | Lipids | pmid:11485159 |
Auestad N et al. | Growth and development in term infants fed long-chain polyunsaturated fatty acids: a double-masked, randomized, parallel, prospective, multivariate study. | 2001 | Pediatrics | pmid:11483802 |
O'Connor DL et al. | Growth and development in preterm infants fed long-chain polyunsaturated fatty acids: a prospective, randomized controlled trial. | 2001 | Pediatrics | pmid:11483801 |
Pawlosky RJ et al. | Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. | 2001 | J. Lipid Res. | pmid:11483627 |
Le Petit-Thévenin J et al. | Effects of arachidonic and docosahexaenoic acids on secretion and degradation of bile salt-dependent lipase in AR4-2J cells. | 2001 | J. Lipid Res. | pmid:11483623 |
Watkins PA et al. | Brain uptake and utilization of fatty acids: applications to peroxisomal biogenesis diseases. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478388 |
Katz R et al. | Brain uptake and utilization of fatty acids: recommendations for future research. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478387 |
Martinez M | Restoring the DHA levels in the brains of Zellweger patients. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478386 |
Salem N et al. | Alterations in brain function after loss of docosahexaenoate due to dietary restriction of n-3 fatty acids. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478385 |
Faust PL et al. | The peroxisome deficient PEX2 Zellweger mouse: pathologic and biochemical correlates of lipid dysfunction. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478384 |
Farooqui AA and Horrocks LA | Plasmalogens, phospholipase A2, and docosahexaenoic acid turnover in brain tissue. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478381 |
Litman BJ et al. | The role of docosahexaenoic acid containing phospholipids in modulating G protein-coupled signaling pathways: visual transduction. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478379 |
Yavin E et al. | Docosahexaenoic acid accumulation in the prenatal brain: prooxidant and antioxidant features. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478378 |
Kim HY et al. | Inhibition of neuronal apoptosis by polyunsaturated fatty acids. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478377 |
Li F et al. | Biosynthesis of docosahexaenoate-containing glycerolipid molecular species in the retina. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478376 |
Lagarde M et al. | Lysophosphatidylcholine as a preferred carrier form of docosahexaenoic acid to the brain. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478375 |