Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Young C et al. | Cancellation of low-frequency stimulation-induced long-term depression by docosahexaenoic acid in the rat hippocampus. | 1998 | Neurosci. Lett. | pmid:9655627 |
Vaidyanathan VV et al. | Regulation of diacylglycerol kinase in rat brain membranes by docosahexaenoic acid. | 1994 | Neurosci. Lett. | pmid:7845615 |
Wang X et al. | Neuroprotective effect of docosahexaenoic acid on glutamate-induced cytotoxicity in rat hippocampal cultures. | 2003 | Neuroreport | pmid:14663210 |
Wu A et al. | Dietary strategy to repair plasma membrane after brain trauma: implications for plasticity and cognition. | 2014 | Neurorehabil Neural Repair | pmid:23911971 |
Baldessarini RJ et al. | Fatty acid derivatives of clozapine: prolonged antidopaminergic activity of docosahexaenoylclozapine in the rat. | 2001 | Neuropsychopharmacology | pmid:11106876 |
Ethier I et al. | The transcription factor NGFI-B (Nur77) and retinoids play a critical role in acute neuroleptic-induced extrapyramidal effect and striatal neuropeptide gene expression. | 2004 | Neuropsychopharmacology | pmid:14603264 |
Lu DY et al. | Docosahexaenoic acid suppresses neuroinflammatory responses and induces heme oxygenase-1 expression in BV-2 microglia: implications of antidepressant effects for ω-3 fatty acids. | 2010 | Neuropsychopharmacology | pmid:20668435 |
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Tamim MK et al. | Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides. | 2010 | Neuropharmacology | pmid:19576910 |
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Bate C et al. | Docosahexaenoic and eicosapentaenoic acids increase neuronal death in response to HuPrP82-146 and Abeta 1-42. | 2008 | Neuropharmacology | pmid:18355880 |
Li Z et al. | Dehydroepiandrosterone sulfate prevents ischemia-induced impairment of long-term potentiation in rat hippocampal CA1 by up-regulating tyrosine phosphorylation of NMDA receptor. | 2006 | Neuropharmacology | pmid:16895729 |
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Pottala JV et al. | Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study. | 2014 | Neurology | pmid:24453077 |
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Jones CR et al. | Evidence for the involvement of docosahexaenoic acid in cholinergic stimulated signal transduction at the synapse. | 1997 | Neurochem. Res. | pmid:9178948 |
Ikemoto A et al. | Membrane fatty acid modifications of PC12 cells by arachidonate or docosahexaenoate affect neurite outgrowth but not norepinephrine release. | 1997 | Neurochem. Res. | pmid:9178949 |
Halapin NA and Bazan NG | NPD1 induction of retinal pigment epithelial cell survival involves PI3K/Akt phosphorylation signaling. | 2010 | Neurochem. Res. | pmid:21136150 |
Lee HJ et al. | Topiramate does not alter the kinetics of arachidonic or docosahexaenoic acid in brain phospholipids of the unanesthetized rat. | 2005 | Neurochem. Res. | pmid:16176072 |
Prasad MR et al. | Regional membrane phospholipid alterations in Alzheimer's disease. | 1998 | Neurochem. Res. | pmid:9482271 |
Chang MC et al. | Dynamics of docosahexaenoic acid metabolism in the central nervous system: lack of effect of chronic lithium treatment. | 1999 | Neurochem. Res. | pmid:10215514 |
Machová E et al. | The increase of choline acetyltransferase activity by docosahexaenoic acid in NG108-15 cells grown in serum-free medium is independent of its effect on cell growth. | 2006 | Neurochem. Res. | pmid:17004129 |
Alvarez-Nölting R et al. | Protection by DHA of early hippocampal changes in diabetes: possible role of CREB and NF-κB. | 2012 | Neurochem. Res. | pmid:21909958 |
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Brown J et al. | Binge ethanol-induced neurodegeneration in rat organotypic brain slice cultures: effects of PLA2 inhibitor mepacrine and docosahexaenoic acid (DHA). | 2009 | Neurochem. Res. | pmid:18592376 |
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Terrian DM et al. | Glutamate is the endogenous amino acid selectively released by rat hippocampal mossy fiber synaptosomes concomitantly with prodynorphin-derived peptides. | 1990 | Neurochem. Res. | pmid:1970130 |
Dagai L et al. | Docosahexaenoic acid significantly stimulates immediate early response genes and neurite outgrowth. | 2009 | Neurochem. Res. | pmid:18781386 |
Hashimoto M et al. | Prescription n-3 fatty acids, but not eicosapentaenoic acid alone, improve reference memory-related learning ability by increasing brain-derived neurotrophic factor levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model. | 2013 | Neurochem. Res. | pmid:23963508 |
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Petroni A et al. | Inhibition by n-3 fatty acids of arachidonic acid metabolism in a primary culture of astroglial cells. | 1994 | Neurochem. Res. | pmid:7824073 |
Giesing M and Zilliken F | Lipid metabolism of developing central nervous tissues in organotypic cultures. III. Ganglionic control of glycerolipids and fatty acids in cortex grey matter. | 1980 | Neurochem. Res. | pmid:6445512 |
Schonfeld E et al. | Docosahexaenoic acid enhances iron uptake by modulating iron transporters and accelerates apoptotic death in PC12 cells. | 2007 | Neurochem. Res. | pmid:17551831 |
Ouellet M et al. | Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: An in situ cerebral perfusion study. | 2009 | Neurochem. Int. | pmid:19442696 |
Ozsoy O et al. | The influence and the mechanism of docosahexaenoic acid on a mouse model of Parkinson's disease. | 2011 | Neurochem. Int. | pmid:21736911 |
Cieslik M et al. | Docosahexaenoic acid and tetracyclines as promising neuroprotective compounds with poly(ADP-ribose) polymerase inhibitory activities for oxidative/genotoxic stress treatment. | 2013 | Neurochem. Int. | pmid:23439385 |
Julien C et al. | Postmortem brain fatty acid profile of levodopa-treated Parkinson disease patients and parkinsonian monkeys. | 2006 | Neurochem. Int. | pmid:16442670 |
Grintal B et al. | Inhibition of astroglial glutamate transport by polyunsaturated fatty acids: evidence for a signalling role of docosahexaenoic acid. | 2009 | Neurochem. Int. | pmid:19428799 |
Boudrault C et al. | Cyclooxygenase-2 and n-6 PUFA are lower and DHA is higher in the cortex of fat-1 mice. | 2010 | Neurochem. Int. | pmid:20064570 |
Rosenberger TA et al. | Rat brain docosahexaenoic acid metabolism is not altered by a 6-day intracerebral ventricular infusion of bacterial lipopolysaccharide. | 2010 | Neurochem. Int. | pmid:20026368 |
Mathieu G et al. | DHA enhances the noradrenaline release by SH-SY5Y cells. | 2010 | Neurochem. Int. | pmid:19770016 |
Mahmoudi S et al. | Nur77 mRNA levels and L-Dopa-induced dyskinesias in MPTP monkeys treated with docosahexaenoic acid. | 2009 | Neurobiol. Dis. | pmid:19635563 |
De Felice C et al. | Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome. | 2014 | Neurobiol. Dis. | pmid:24769161 |
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Eady TN et al. | Docosahexaenoic acid complexed to albumin provides neuroprotection after experimental stroke in aged rats. | 2014 | Neurobiol. Dis. | pmid:24063996 |
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Favrelère S et al. | Age-related changes in ethanolamine glycerophospholipid fatty acid levels in rat frontal cortex and hippocampus. | 2000 Sep-Oct | Neurobiol. Aging | pmid:11016534 |
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