DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kraffe E et al. | Evidence of a tetradocosahexaenoic cardiolipin in some marine bivalves. | 2002 | Lipids | pmid:12056594 |
| Meesapyodsuk D and Qiu X | The front-end desaturase: structure, function, evolution and biotechnological use. | 2012 | Lipids | pmid:22009657 |
| Li HX et al. | Increasing DHA and EPA concentrations prolong action potential durations and reduce transient outward potassium currents in rat ventricular myocytes. | 2011 | Lipids | pmid:21140236 |
| Denys A et al. | Docosahexaenoic acid modulates phorbol ester-induced activation of extracellular signal-regulated kinases 1 and 2 in NIH/3T3 cells. | 2001 | Lipids | pmid:11592732 |
| Thomson AB et al. | Influence of dietary fat composition on intestinal absorption in the rat. | 1989 | Lipids | pmid:2549323 |
| Nauroth JM et al. | Docosahexaenoic acid (DHA) and docosapentaenoic acid (DPAn-6) algal oils reduce inflammatory mediators in human peripheral mononuclear cells in vitro and paw edema in vivo. | 2010 | Lipids | pmid:20364438 |
| Kraffe E et al. | Docosahexaenoic acid- and eicosapentaenoic acid-enriched cardiolipin in the Manila clam Ruditapes philippinarum. | 2005 | Lipids | pmid:16149741 |
| Grandgirard A et al. | Occurrence of geometrical isomers of eicosapentaenoic and docosahexaenoic acids in liver lipids of rats fed heated linseed oil. | 1989 | Lipids | pmid:2555649 |
| Garrido A et al. | Ingestion of high doses of fish oil increases the susceptibility of cellular membranes to the induction of oxidative stress. | 1989 | Lipids | pmid:2555651 |
| Devlin AM and Innis SM | Dietary phospholipid alters biliary lipid composition in formula-fed piglets. | 1999 | Lipids | pmid:10652991 |
| Polette A et al. | Synthesis of acetyl,docosahexaenoyl-glycerophosphocholine and its characterization using nuclear magnetic resonance. | 1999 | Lipids | pmid:10652994 |
| Lu FS et al. | Oxidative stability of marine phospholipids in the liposomal form and their applications. | 2011 | Lipids | pmid:21088919 |
| Paschoal VA et al. | Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid differentially modulate rat neutrophil function in vitro. | 2013 | Lipids | pmid:23086551 |
| Tardivel S et al. | Protective effects of EPA and deleterious effects of DHA on eNOS activity in Ea hy 926 cultured with lysophosphatidylcholine. | 2009 | Lipids | pmid:19190950 |
| Betancor MB et al. | Vitamin C enhances vitamin E status and reduces oxidative stress indicators in sea bass larvae fed high DHA microdiets. | 2012 | Lipids | pmid:23086553 |
| Pasquier E et al. | Effects of delta5 polyunsaturated fatty acids of maritime pine (Pinus pinaster) seed oil on the fatty acid profile of the developing brain of rats. | 2001 | Lipids | pmid:11485159 |
| Makrides M et al. | Is dietary docosahexaenoic acid essential for term infants? | 1996 | Lipids | pmid:8649228 |
| Miller C et al. | Guinea pig epidermis generates putative anti-inflammatory metabolites from fish oil polyunsaturated fatty acids. | 1989 | Lipids | pmid:2559281 |
| Weisinger HS et al. | The effect of docosahexaenoic acid on the electroretinogram of the guinea pig. | 1996 | Lipids | pmid:8649236 |
| Carlson SE and Werkman SH | A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until two months. | 1996 | Lipids | pmid:8649239 |
| Gilbert M et al. | Opposite regulation of prostaglandin H synthase isoforms by eicosapentaenoic and docosahexaenoic acids. | 1999 | Lipids | pmid:10419156 |
| Werkman SH and Carlson SE | A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until nine months. | 1996 | Lipids | pmid:8649241 |
| Løchsen T et al. | Effects of fish oil and n-3 fatty acids on the regulation of delta9-fatty acid desaturase mRNA and -activity in rat liver. | 1999 | Lipids | pmid:10419157 |
| Jensen CL et al. | Effects of maternal docosahexaenoic acid supplementation on visual function and growth of breast-fed term infants. | 1999 | Lipids | pmid:10419159 |
| Otto SJ et al. | The postpartum docosahexaenoic acid status of lactating and nonlactating mothers. | 1999 | Lipids | pmid:10419160 |
| van Houwelingen AC et al. | The female docosahexaenoic acid status related to the number of completed pregnancies. | 1999 | Lipids | pmid:10419161 |
| Borod E et al. | Effects of third trimester consumption of eggs high in docosahexaenoic acid on docosahexaenoic acid status and pregnancy. | 1999 | Lipids | pmid:10419162 |
| Anderson RE et al. | A hypothesis to explain the reduced blood levels of docosahexaenoic acid in inherited retinal degenerations caused by mutations in genes encoding retina-specific proteins. | 1999 | Lipids | pmid:10419164 |
| Greiner RS et al. | Rats with low levels of brain docosahexaenoic acid show impaired performance in olfactory-based and spatial learning tasks. | 1999 | Lipids | pmid:10419165 |
| Kyle DJ et al. | Low serum docosahexaenoic acid is a significant risk factor for Alzheimer's dementia. | 1999 | Lipids | pmid:10419166 |
| Størvold GL et al. | Docosahexaenoic acid activates some SREBP-2 targets independent of cholesterol and ER stress in SW620 colon cancer cells. | 2009 | Lipids | pmid:19582494 |
| Glozman S et al. | Ethyl docosahexaenoic acid administration during intrauterine life enhances prostanoid production and reduces free radicals generation in the fetal rat brain. | 1999 | Lipids | pmid:10419167 |
| Kim HY and Edsall L | The role of docosahexaenoic acid (22:6n-3) in neuronal signaling. | 1999 | Lipids | pmid:10419168 |
| Patten GS et al. | Dietary fish oil dose-response effects on ileal phospholipid fatty acids and contractility. | 2005 | Lipids | pmid:16329465 |
| Harris WS | n-3 fatty acids and human lipoprotein metabolism: an update. | 1999 | Lipids | pmid:10419172 |
| Saito H et al. | High docosahexaenoic acid levels in both neutral and polar lipids of a highly migratory fish: Thunnus tonggol (Bleeker). | 2005 | Lipids | pmid:16329467 |
| Howe PR et al. | Equal antithrombotic and triglyceride-lowering effectiveness of eicosapentaenoic acid-rich and docosahexaenoic acid-rich fish oil supplements. | 1999 | Lipids | pmid:10419186 |
| Lyberg AM et al. | Monitoring the oxidation of docosahexaenoic acid in lipids. | 2005 | Lipids | pmid:16329470 |
| Horrocks LA and Yeo YK | Docosahexaenoic acid-enriched foods: production and effects on blood lipids. | 1999 | Lipids | pmid:10419189 |
| Terano T et al. | Docosahexaenoic acid supplementation improves the moderately severe dementia from thrombotic cerebrovascular diseases. | 1999 | Lipids | pmid:10419198 |
| Frøyland L et al. | Chronic administration of eicosapentaenoic acid and docosahexaenoic acid as ethyl esters reduced plasma cholesterol and changed the fatty acid composition in rat blood and organs. | 1996 | Lipids | pmid:8835405 |
| Xue C et al. | Differences in lipid characteristics among populations: low-temperature adaptability of ayu, Plecoglossus altivelis. | 2012 | Lipids | pmid:22120618 |
| Reicks M et al. | Recovery of fish oil-derived fatty acids in lymph of thoracic duct-cannulated Wistar rats. | 1990 | Lipids | pmid:2139156 |
| Boeynaems JM et al. | Iodination of docosahexaenoic acid by lactoperoxidase and thyroid gland in vitro: formation of an lodolactone. | 1981 | Lipids | pmid:6153054 |
| Gaudette DC and Holub BJ | Albumin-bound docosahexaenoic acid and collagen-induced human platelet reactivity. | 1990 | Lipids | pmid:2139712 |
| Sørensen BM et al. | Storage lipid accumulation and acyltransferase action in developing flaxseed. | 2005 | Lipids | pmid:16382576 |
| Waldron MK et al. | Plasma phospholipid fatty acid and ex vivo neutrophil responses are differentially altered in dogs fed fish- and linseed-oil containing diets at the same n-6:n-3 fatty acid ratio. | 2012 | Lipids | pmid:22252853 |
| Degrace P et al. | Intestinal lymph absorption of butter, corn oil, cod liver oil, menhaden oil, and eicosapentaenoic and docosahexaenoic acid ethyl esters in rats. | 1996 | Lipids | pmid:8743053 |
| McLennan PL | Myocardial membrane fatty acids and the antiarrhythmic actions of dietary fish oil in animal models. | 2001 | Lipids | pmid:11837983 |
| Hamazaki T et al. | Docosahexaenoic acid does not affect aggression of normal volunteers under nonstressful conditions. A randomized, placebo-controlled, double-blind study. | 1998 | Lipids | pmid:9688168 |
| Kitson AP et al. | Elevated production of docosahexaenoic acid in females: potential molecular mechanisms. | 2010 | Lipids | pmid:20151220 |
| Pifferi F et al. | Fatty acid composition of the brain, retina, liver and adipose tissue of the grey mouse lemur (Microcebus murinus, primate). | 2012 | Lipids | pmid:22684890 |
| Huang LS et al. | Lysophosphatidylcholine containing docosahexaenoic acid at the sn-1 position is anti-inflammatory. | 2010 | Lipids | pmid:20165929 |
| Seeger DR and Murphy EJ | Mouse Strain Impacts Fatty Acid Uptake and Trafficking in Liver, Heart, and Brain: A Comparison of C57BL/6 and Swiss Webster Mice. | 2016 | Lipids | pmid:26797754 |
| Hsu FF et al. | Electrospray ionization mass spectrometric analyses of changes in tissue phospholipid molecular species during the evolution of hyperlipidemia and hyperglycemia in Zucker diabetic fatty rats. | 2000 | Lipids | pmid:10984107 |
| Hamilton L et al. | n-3 fatty acid deficiency decreases phosphatidylserine accumulation selectively in neuronal tissues. | 2000 | Lipids | pmid:10984109 |
| Ratledge C et al. | Production of docosahexaenoic acid by Crypthecodinium cohnii grown in a pH-auxostat culture with acetic acid as principal carbon source. | 2001 | Lipids | pmid:11795857 |
| Wijendran V et al. | Fetal erythrocyte phospholipid polyunsaturated fatty acids are altered in pregnancy complicated with gestational diabetes mellitus. | 2000 | Lipids | pmid:10984116 |
| Healy DA et al. | Effect of low-to-moderate amounts of dietary fish oil on neutrophil lipid composition and function. | 2000 | Lipids | pmid:10941877 |
| Cunnane SC et al. | Detection of [U-13C]eicosapentaenoic acid in rat liver lipids using 13C nuclear magnetic resonance spectroscopy. | 1993 | Lipids | pmid:8487618 |
| Schnebelen C et al. | Dietary n-3 and n-6 PUFA enhance DHA incorporation in retinal phospholipids without affecting PGE(1) and PGE (2) levels. | 2009 | Lipids | pmid:19242743 |
| Geppert J et al. | Docosahexaenoic acid supplementation in vegetarians effectively increases omega-3 index: a randomized trial. | 2005 | Lipids | pmid:16296399 |
| Rotstein NP et al. | Effects of aging on the composition and metabolism of docosahexaenoate-containing lipids of retina. | 1987 | Lipids | pmid:2955190 |
| Baybutt RC et al. | The effects of dietary fish oil on alveolar type II cell fatty acids and lung surfactant phospholipids. | 1993 | Lipids | pmid:8464346 |
| Hoffman D et al. | Soy-based infant formula supplemented with DHA and ARA supports growth and increases circulating levels of these fatty acids in infants. | 2008 | Lipids | pmid:17912568 |
| Young GS et al. | Blood phospholipid fatty acid analysis of adults with and without attention deficit/hyperactivity disorder. | 2004 | Lipids | pmid:15134138 |
| Kao BT et al. | Mice raised on milk transgenically enriched with n-3 PUFA have increased brain docosahexaenoic acid. | 2006 | Lipids | pmid:16981432 |
| Osako K et al. | Docosahexaenoic acid levels in the lipids of spotted mackerel Scomber australasicus. | 2006 | Lipids | pmid:17069355 |
| Ewaschuk JB et al. | Docosahexanoic acid improves chemotherapy efficacy by inducing CD95 translocation to lipid rafts in ER(-) breast cancer cells. | 2012 | Lipids | pmid:23054549 |
| Morris S et al. | Utilization of docosahexaenoic acid from intravenous egg yolk phospholipid. | 2000 | Lipids | pmid:10858022 |
| Nøding R et al. | Effects of polyunsaturated fatty acids and their n-6 hydroperoxides on growth of five malignant cell lines and the significance of culture media. | 1998 | Lipids | pmid:9560803 |
| Kosugi Y et al. | Esterification of polyunsaturated fatty acids by various forms of immobilized lipase from Rhizomucor miehei. | 2000 | Lipids | pmid:10858032 |
| Xu Y et al. | Different ratios of docosahexaenoic and eicosapentaenoic acids do not alter growth, nucleic acid and fatty acids of juvenile cobia (Rachycentron canadum). | 2009 | Lipids | pmid:19760445 |
| Hirano R et al. | Regulation by long-chain fatty acids of the expression of cholesteryl ester transfer protein in HepG2 cells. | 2001 | Lipids | pmid:11383693 |
| Tomobe YI et al. | Dietary docosahexaenoic acid suppresses inflammation and immunoresponses in contact hypersensitivity reaction in mice. | 2000 | Lipids | pmid:10695925 |
| Calviello G et al. | Low-dose eicosapentaenoic or docosahexaenoic acid administration modifies fatty acid composition and does not affect susceptibility to oxidative stress in rat erythrocytes and tissues. | 1997 | Lipids | pmid:9358434 |
| Clayton EH et al. | Long-chain omega-3 polyunsaturated fatty acids in the blood of children and adolescents with juvenile bipolar disorder. | 2008 | Lipids | pmid:18781353 |
| Kanayasu T et al. | Eicosapentaenoic acid inhibits tube formation of vascular endothelial cells in vitro. | 1991 | Lipids | pmid:1714032 |
| Stark KD | The percentage of n-3 highly unsaturated fatty acids in total HUFA as a biomarker for omega-3 fatty acid status in tissues. | 2008 | Lipids | pmid:17985169 |
| Metherel AH et al. | EPA and DHA levels in whole blood decrease more rapidly when stored at -20 °C as compared with room temperature, 4 and -75 °C. | 2013 | Lipids | pmid:23949919 |
| Zanfini A et al. | GC-EI-MS analysis of fatty acid composition in brain and serum of twitcher mouse. | 2014 | Lipids | pmid:25208498 |
| Harris WS et al. | Stearidonic acid increases the red blood cell and heart eicosapentaenoic acid content in dogs. | 2007 | Lipids | pmid:17406927 |
| Bell MV et al. | Dietary deficiency of docosahexaenoic acid impairs vision at low light intensities in juvenile herring (Clupea harengus L.). | 1995 | Lipids | pmid:7637565 |
| Hwang I et al. | N-3 polyunsaturated fatty acids and atopy in Korean preschoolers. | 2007 | Lipids | pmid:17406929 |
| Oikawa D et al. | Dietary CLA and DHA modify skin properties in mice. | 2003 | Lipids | pmid:12934670 |
| Huang LS et al. | Oxygenation of 1-docosahexaenoyl lysophosphatidylcholine by lipoxygenases; conjugated hydroperoxydiene and dihydroxytriene derivatives. | 2007 | Lipids | pmid:17879105 |
| Meyer BJ et al. | Dose-dependent effects of docosahexaenoic acid supplementation on blood lipids in statin-treated hyperlipidaemic subjects. | 2007 | Lipids | pmid:17393216 |
| Judge MP et al. | A docosahexaenoic acid-functional food during pregnancy benefits infant visual acuity at four but not six months of age. | 2007 | Lipids | pmid:17393217 |
| Sciotto C and Mjøs SA | Trans isomers of EPA and DHA in omega-3 products on the European market. | 2012 | Lipids | pmid:22566205 |
| Takkunen M et al. | Dietary fat in relation to erythrocyte fatty acid composition in men. | 2013 | Lipids | pmid:23975575 |
| Alessandri JM et al. | Estradiol favors the formation of eicosapentaenoic acid (20:5n-3) and n-3 docosapentaenoic acid (22:5n-3) from alpha-linolenic acid (18:3n-3) in SH-SY5Y neuroblastoma cells. | 2008 | Lipids | pmid:17912567 |
| Zheng JS et al. | Low docosahexaenoic acid content in plasma phospholipids is associated with increased non-alcoholic fatty liver disease in China. | 2012 | Lipids | pmid:22527845 |
| Aldai N et al. | Evaluating the in vitro metabolism of docosahexaenoic acid in sheep rumen fluid. | 2012 | Lipids | pmid:22695744 |
| Itoh T et al. | Efficient synthesis of the very-long-chain n-3 fatty acids, tetracosahexaenoic acid (C24:6n-3) and tricosahexaenoic acid (C23:6n-3). | 2011 | Lipids | pmid:21347745 |
| Du ZY et al. | Alteration of 20:5n-3 and 22:6n-3 fat contents and liver peroxisomal activities in fenofibrate-treated rainbow trout. | 2004 | Lipids | pmid:15669760 |
| Hixson SM et al. | Changes in tissue lipid and fatty acid composition of farmed rainbow trout in response to dietary camelina oil as a replacement of fish oil. | 2014 | Lipids | pmid:24264359 |
| Zhang ZJ et al. | Metabolism of n-3 polyunsaturated fatty acids by the isolated perfused rat liver. | 1991 | Lipids | pmid:1834902 |
| Kelley DS et al. | Dietary docosahexaenoic acid and immunocompetence in young healthy men. | 1998 | Lipids | pmid:9655370 |
| Bryan DL et al. | Polyunsaturated fatty acids regulate cytokine and prostaglandin E2 production by respiratory cells in response to mast cell mediators. | 2006 | Lipids | pmid:17269555 |
| Elvevoll EO et al. | Enhanced incorporation of n-3 fatty acids from fish compared with fish oils. | 2006 | Lipids | pmid:17269556 |