DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mocking RJ et al. | Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression. | 2013 | Psychoneuroendocrinology | pmid:23465556 |
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| Buretić-Tomljanović A et al. | Phospholipid membrane abnormalities and reduced niacin skin flush response in schizophrenia. | 2008 | Psychiatr Danub | pmid:18827766 |
| Shaikh IA et al. | Docosahexaenoic acid enhances the efficacy of docetaxel in prostate cancer cells by modulation of apoptosis: the role of genes associated with the NF-kappaB pathway. | 2008 | Prostate | pmid:18668525 |
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| Yuan J et al. | The effects of polyunsaturated fatty acids and their metabolites on osteoclastogenesis in vitro. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20394833 |
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| Zhang J et al. | Characteristics of fatty acid distribution is associated with colorectal cancer prognosis. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23465412 |
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| Cunnane SC | Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10991770 |
| Burdge GC | Metabolism of alpha-linolenic acid in humans. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16828546 |
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| Kris-Etherton PM et al. | Dietary reference intakes for DHA and EPA. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19525100 |
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| Du Plooy WJ et al. | The cumulative dose response effect of eicosapentaenoic and docosahexaenoic acid on blood pressure, plasma lipid profile and diet pattern in mild to moderate essential hypertensive black patients. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1409770 |
| Pakala R et al. | Serotonin-induced endothelial cell proliferation is blocked by omega-3 fatty acids. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10328332 |
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| Maki KC et al. | Prescription omega-3-acid ethyl esters reduce fasting and postprandial triglycerides and modestly reduce pancreatic β-cell response in subjects with primary hypertriglyceridemia. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21775113 |
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| Xi S et al. | Suppression of proto-oncogene (AP-1) in a model of skin epidermal hyperproliferation is reversed by topical application of 13-hydroxyoctadecadienoic acid and 15-hydroxyeicosatrienoic acid. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10765974 |
| Gustafson KM et al. | Docosahexaenoic acid and cognitive function: Is the link mediated by the autonomic nervous system? | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18930644 |
| Bazan NG | The docosanoid neuroprotectin D1 induces homeostatic regulation of neuroinflammation and cell survival. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23022417 |
| Saldanha LG et al. | Workshop on DHA as a required nutrient: overview. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19643589 |
| Brenna JT and Diau GY | The influence of dietary docosahexaenoic acid and arachidonic acid on central nervous system polyunsaturated fatty acid composition. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18023566 |
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| Qin Q et al. | Neuroprotectin D1 inhibits retinal ganglion cell death following axotomy. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19019647 |
| Kim HW et al. | Regulation of rat brain polyunsaturated fatty acid (PUFA) metabolism during graded dietary n-3 PUFA deprivation. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21880477 |
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| Serhan CN | Systems approach with inflammatory exudates uncovers novel anti-inflammatory and pro-resolving mediators. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19008087 |
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| Sethom MM et al. | Polyunsaturated fatty acids deficits are associated with psychotic state and negative symptoms in patients with schizophrenia. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20667702 |
| Alnajjar A et al. | Effect of n-3 and n-6 polyunsaturated fatty acids on lymphocyte proliferation, interleukin production and phospholipid fatty acids composition in type 2 diabetic and healthy subjects in Jordan people. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16650969 |
| Storck Lindholm E et al. | Different fatty acid pattern in breast milk of obese compared to normal-weight mothers. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23273824 |
| Gregor JI et al. | Does enteral nutrition of dietary polyunsaturated fatty acids promote oxidative stress and tumour growth in ductal pancreatic cancer? Experimental trial in Syrian Hamster. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16226437 |
| Alicandro G et al. | A randomized placebo-controlled study on high-dose oral algal docosahexaenoic acid supplementation in children with cystic fibrosis. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23266209 |
| Fenton JI and McCaskey SJ | Curcumin and docosahexaenoic acid block insulin-induced colon carcinoma cell proliferation. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23266210 |
| Das UN et al. | Can tumour cell drug resistance be reversed by essential fatty acids and their metabolites? | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9482165 |
| van Goor SA et al. | Human milk arachidonic acid and docosahexaenoic acid contents increase following supplementation during pregnancy and lactation. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19118992 |
| Meldrum SJ et al. | Determinants of DHA levels in early infancy: differential effects of breast milk and direct fish oil supplementation. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22572105 |
| Louw L and Dannhauser A | Keloids in rural black South Africans. Part 2: dietary fatty acid intake and total phospholipid fatty acid profile in the blood of keloid patients. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090250 |
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