DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ozogul Y et al. | The effects of extraction methods on the contents of fatty acids, especially EPA and DHA in marine lipids. | 2012 | Int J Food Sci Nutr | pmid:22010951 |
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| Kelley DS et al. | Docosahexaenoic acid supplementation improved lipocentric but not glucocentric markers of insulin sensitivity in hypertriglyceridemic men. | 2012 | Metab Syndr Relat Disord | pmid:21999398 |
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| Larsen BM et al. | Pre-treatment with an intravenous lipid emulsion containing fish oil (eicosapentaenoic and docosahexaenoic acid) decreases inflammatory markers after open-heart surgery in infants: a randomized, controlled trial. | 2012 | Clin Nutr | pmid:22136963 |
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| Phang M et al. | Acute supplementation with eicosapentaenoic acid reduces platelet microparticle activity in healthy subjects. | 2012 | J. Nutr. Biochem. | pmid:22137256 |
| Ortiz-Alvarado O et al. | Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid in the management of hypercalciuric stone formers. | 2012 | Urology | pmid:22000931 |
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| Hall JC et al. | Docosahexaenoic acid, but not eicosapentaenoic acid, reduces the early inflammatory response following compression spinal cord injury in the rat. | 2012 | J. Neurochem. | pmid:22404382 |
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| Ji A et al. | n-3 polyunsaturated fatty acids inhibit lipopolysaccharide-induced microglial activation and dopaminergic injury in rats. | 2012 | Neurotoxicology | pmid:22406923 |
| Betancor MB et al. | Selenium inclusion decreases oxidative stress indicators and muscle injuries in sea bass larvae fed high-DHA microdiets. | 2012 | Br. J. Nutr. | pmid:22409905 |
| Kim HW et al. | Effects of chronic clozapine administration on markers of arachidonic acid cascade and synaptic integrity in rat brain. | 2012 | Psychopharmacology (Berl.) | pmid:22414961 |
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| Jørgensen MH et al. | Long-chain PUFA in granulocytes, mononuclear cells, and RBC in patients with cystic fibrosis: relation to liver disease. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22241510 |
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| Shabrani NC et al. | Polyunsaturated fatty acids confer cryoresistance on megakaryocytes generated from cord blood and also enhance megakaryocyte production from cryopreserved cord blood cells. | 2012 | Cytotherapy | pmid:22250991 |
| Shearer GC et al. | Effects of prescription niacin and omega-3 fatty acids on lipids and vascular function in metabolic syndrome: a randomized controlled trial. | 2012 | J. Lipid Res. | pmid:22892157 |
| Lauritzen L et al. | Fish intake, erythrocyte n-3 fatty acid status and metabolic health in Danish adolescent girls and boys. | 2012 | Br. J. Nutr. | pmid:21736784 |
| Yetimler B et al. | Differential effect of age on the brain fatty acid levels and their correlation with animal cognitive status in mice. | 2012 | Pharmacol. Biochem. Behav. | pmid:22878041 |
| Brown SP et al. | Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist. | 2012 | ACS Med Chem Lett | pmid:24900539 |
| Kitson AP et al. | Tissue-specific sex differences in docosahexaenoic acid and Δ6-desaturase in rats fed a standard chow diet. | 2012 | Appl Physiol Nutr Metab | pmid:23050796 |
| Quan-Xin F et al. | Resolvin D1 reverses chronic pancreatitis-induced mechanical allodynia, phosphorylation of NMDA receptors, and cytokines expression in the thoracic spinal dorsal horn. | 2012 | BMC Gastroenterol | pmid:23092159 |
| Ritter JC and Budge SM | Key lipid oxidation products can be used to predict sensory quality of fish oils with different levels of EPA and DHA. | 2012 | Lipids | pmid:23096224 |
| Jackson KG et al. | Dietary fat manipulation has a greater impact on postprandial lipid metabolism than the apolipoprotein E (epsilon) genotype-insights from the SATgenε study. | 2012 | Mol Nutr Food Res | pmid:23097177 |
| Liu Y et al. | Fish oil enhances intestinal integrity and inhibits TLR4 and NOD2 signaling pathways in weaned pigs after LPS challenge. | 2012 | J. Nutr. | pmid:23014495 |
| Damsgaard CT et al. | The effects of n-3 long-chain polyunsaturated fatty acids on bone formation and growth factors in adolescent boys. | 2012 | Pediatr. Res. | pmid:22337227 |
| Saito H and Ishikawa S | Characteristic of lipids and fatty acid compositions of the neon flying squid, Ommastrephes bartramii. | 2012 | J Oleo Sci | pmid:23018852 |
| Burillo E et al. | Omega-3 fatty acids and HDL. How do they work in the prevention of cardiovascular disease? | 2012 | Curr Vasc Pharmacol | pmid:22339302 |
| Serhan CN et al. | Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain. | 2012 | FASEB J. | pmid:22253477 |
| Sundrani DP et al. | Matrix metalloproteinase-1 and -9 in human placenta during spontaneous vaginal delivery and caesarean sectioning in preterm pregnancy. | 2012 | PLoS ONE | pmid:22253805 |
| Tian H et al. | 14S,21R-dihydroxy-docosahexaenoic acid treatment enhances mesenchymal stem cell amelioration of renal ischemia/reperfusion injury. | 2012 | Stem Cells Dev. | pmid:21846180 |
| Ruan D and So SP | Screening and identification of dietary oils and unsaturated fatty acids in inhibiting inflammatory prostaglandin E2 signaling in fat stromal cells. | 2012 | BMC Complement Altern Med | pmid:22938033 |
| Park Y et al. | N-3 polyunsaturated fatty acid consumption produces neurobiological effects associated with prevention of depression in rats after the forced swimming test. | 2012 | J. Nutr. Biochem. | pmid:21852084 |
| Finlin BS et al. | DHA reduces the atrophy-associated Fn14 protein in differentiated myotubes during coculture with macrophages. | 2012 | J. Nutr. Biochem. | pmid:21852085 |
| Norris PC and Dennis EA | Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22586114 |
| Ramadeen A et al. | Docosahexaenoic acid, but not eicosapentaenoic acid, supplementation reduces vulnerability to atrial fibrillation. | 2012 | Circ Arrhythm Electrophysiol | pmid:22923273 |
| Martin N et al. | Primary human airway epithelial cell-dependent inhibition of human lung mast cell degranulation. | 2012 | PLoS ONE | pmid:22970103 |
| Richardson AJ et al. | Docosahexaenoic acid for reading, cognition and behavior in children aged 7-9 years: a randomized, controlled trial (the DOLAB Study). | 2012 | PLoS ONE | pmid:22970149 |
| Rasti B et al. | Comparative study of the oxidative and physical stability of liposomal and nanoliposomal polyunsaturated fatty acids prepared with conventional and Mozafari methods. | 2012 | Food Chem | pmid:22980870 |
| Moore RL et al. | Oxidative stability of an extended shelf-life dairy-based beverage system designed to contribute to heart health. | 2012 | J. Dairy Sci. | pmid:22981572 |
| Adolph S et al. | Unsaturated fatty acids promote the phagocytosis of P. aeruginosa and R. equi by RAW264.7 macrophages. | 2012 | Curr. Microbiol. | pmid:22903555 |
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| Valentine CJ | Maternal dietary DHA supplementation to improve inflammatory outcomes in the preterm infant. | 2012 | Adv Nutr | pmid:22585914 |
| Yakunin E et al. | Α-synuclein neuropathology is controlled by nuclear hormone receptors and enhanced by docosahexaenoic acid in a mouse model for Parkinson's disease. | 2012 | Brain Pathol. | pmid:21929559 |
| Chen HF and Su HM | Fish oil supplementation of maternal rats on an n-3 fatty acid-deficient diet prevents depletion of maternal brain regional docosahexaenoic acid levels and has a postpartum anxiolytic effect. | 2012 | J. Nutr. Biochem. | pmid:21543216 |
| Alessandri JM et al. | Influence of gender on DHA synthesis: the response of rat liver to low dietary α-linolenic acid evidences higher ω3 ∆4-desaturation index in females. | 2012 | Eur J Nutr | pmid:21647669 |
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| Angulo J et al. | Effects of polyunsaturated fatty acids from plant oils and algae on milk fat yield and composition are associated with mammary lipogenic and SREBF1 gene expression. | 2012 | Animal | pmid:22717104 |
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| Dornstauder B et al. | Dietary docosahexaenoic acid supplementation prevents age-related functional losses and A2E accumulation in the retina. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22427551 |
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| Tanigai T et al. | Docosahexaenoic acid exerts anti-inflammatory action on human eosinophils through peroxisome proliferator-activated receptor-independent mechanisms. | 2012 | Int. Arch. Allergy Immunol. | pmid:22487606 |
| Jiang LH et al. | Pure docosahexaenoic acid can improve depression behaviors and affect HPA axis in mice. | 2012 | Eur Rev Med Pharmacol Sci | pmid:23208960 |
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| Rossmeisl M et al. | Metabolic effects of n-3 PUFA as phospholipids are superior to triglycerides in mice fed a high-fat diet: possible role of endocannabinoids. | 2012 | PLoS ONE | pmid:22701720 |
| Xiong A et al. | Distinct roles of different forms of vitamin E in DHA-induced apoptosis in triple-negative breast cancer cells. | 2012 | Mol Nutr Food Res | pmid:22707267 |
| Carter JR et al. | Fish oil and neurovascular control in humans. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22707560 |
| Milte CM et al. | Eicosapentaenoic and docosahexaenoic acids, cognition, and behavior in children with attention-deficit/hyperactivity disorder: a randomized controlled trial. | 2012 | Nutrition | pmid:22541055 |
| Sharma S et al. | High-fat diet transition reduces brain DHA levels associated with altered brain plasticity and behaviour. | 2012 | Sci Rep | pmid:22666534 |
| Tang X et al. | Short term effects of different omega-3 fatty acid formulation on lipid metabolism in mice fed high or low fat diet. | 2012 | Lipids Health Dis | pmid:22676394 |
| Settimio R et al. | Resolvin D1 reduces the immunoinflammatory response of the rat eye following uveitis. | 2012 | Mediators Inflamm. | pmid:23304060 |