DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Crawford MA et al. | Docosahexaenoic acid and cerebral evolution. | 2001 | World Rev Nutr Diet | pmid:11935972 |
| Suzuki H et al. | Effect of DHA oil supplementation on intelligence and visual acuity in the elderly. | 2001 | World Rev Nutr Diet | pmid:11935973 |
| Nestel P | Fish oil fatty acids beneficially modulate vascular function. | 2001 | World Rev Nutr Diet | pmid:11935976 |
| Legrand P et al. | Update of French nutritional recommendations for fatty acids. | 2011 | World Rev Nutr Diet | pmid:21865827 |
| Barclay W et al. | Production of docosahexaenoic acid from microalgae and its benefits for use in animal feeds. | 1998 | World Rev Nutr Diet | pmid:9648505 |
| Abril R and Barclay W | Production of docosahexaenoic acid-enriched poultry eggs and meat using an algae-based feed ingredient. | 1998 | World Rev Nutr Diet | pmid:9648506 |
| Kyle DJ and Arterburn LM | Single cell oil sources of docosahexaenoic acid: clinical studies. | 1998 | World Rev Nutr Diet | pmid:9648509 |
| Wright T et al. | Docosahexaenoic acid-enriched milk. | 1998 | World Rev Nutr Diet | pmid:9648512 |
| Bazan NG et al. | Docosahexaenoic acid supply to the retina and its conservation in photoreceptor cells by active retinal pigment epithelium-mediated recycling. | 1994 | World Rev Nutr Diet | pmid:7871812 |
| Anderson RE et al. | The accretion of docosahexaenoic acid in the retina. | 1994 | World Rev Nutr Diet | pmid:7871813 |
| von Houwelingen AC and Hornstra G | Trans fatty acids in early human development. | 1994 | World Rev Nutr Diet | pmid:7871822 |
| Martinez M | Polyunsaturated fatty acids in the developing human brain, red cells and plasma: influence of nutrition and peroxisomal disease. | 1994 | World Rev Nutr Diet | pmid:7871835 |
| Bohr S et al. | Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. | 2013 Jan-Feb | Wound Repair Regen | pmid:23110665 |
| Widgerow AD | Cellular resolution of inflammation--catabasis. | 2012 Jan-Feb | Wound Repair Regen | pmid:22276585 |
| McDaniel JC et al. | Omega-3 fatty acids effect on wound healing. | 2008 May-Jun | Wound Repair Regen | pmid:18471252 |
| McDaniel JC et al. | Fish oil supplementation alters levels of lipid mediators of inflammation in microenvironment of acute human wounds. | 2011 Mar-Apr | Wound Repair Regen | pmid:21362086 |
| Kimura S | [Antihypertensive effect of docosahexaenoic acid in stroke-prone spontaneously hypertensive rats]. | 2000 | Yakugaku Zasshi | pmid:10920715 |
| Nishinaka T et al. | [Elucidation of mechanisms underlying docosahexaenoic acid-induced antinociception]. | 2013 | Yakugaku Zasshi | pmid:23649389 |
| Okuyama H | [Need to change the direction of cholesterol-related medication--a problem of great urgency]. | 2005 | Yakugaku Zasshi | pmid:16272805 |
| Ishiguro J et al. | [Effects of ethyl eicosapentaenoate (EPA-E) and its metabolite on the drug and fatty acid metabolizing enzyme systems in rat liver]. | 1988 | Yakugaku Zasshi | pmid:2841446 |
| Li QC et al. | [Determination of docosahexenoic acid in human serum by capillary gas chromatography]. | 1997 | Yao Xue Xue Bao | pmid:11596318 |
| Qi AD et al. | [Effects of arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid on tension of rabbit aortic strips]. | 1992 | Yao Xue Xue Bao | pmid:1442036 |
| Schmitt Y and Schneider H | [The effect of highly unsaturated fatty acids on the parameters of lipoprotein metabolism and rheology during their administration to patients undergoing chronic hemodialysis treatment]. | 1993 | Z Ernahrungswiss | pmid:8237080 |
| Wechsler JG et al. | [Effect of omega-3-fatty acids on biliary lipids and lithogenicity]. | 1989 | Z Gastroenterol | pmid:2756729 |
| Gohlke H | [Prevention of coronary disease and sudden death by nutrition]. | 2004 | Z Kardiol | pmid:15021992 |
| Obukhova GP et al. | [A neuromorphological analysis of the motor area of the cerebral cortex in rat pups subjected to prenatal exposure to normal and pathological blood serum]. | 1992 Jul-Aug | Zh. Evol. Biokhim. Fiziol. | pmid:1455957 |
| Wu Q et al. | [Effect of combination of docosahexaenoic acid and fluorouracil on human gastric carcinoma cell strain MGC803]. | 2010 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:20236591 |
| Chen R et al. | [Effects of docosahexaenoic acid on hypoxia-induced pulmonary arterial hypertension]. | 2014 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:24796591 |
| Wang RX et al. | [Mechanism related to docosahexaenoic acid induced large conductance calcium-activated potassium channel currents increase in coronary smooth muscle cells]. | 2011 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:21624312 |
| Lai LH et al. | [Effects of docosahexaenoic acid on sodium channel current and transient outward potassium channel current in rat ventricular myocytes]. | 2011 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:21781602 |
| Dong PS et al. | [Effects of docosahexaenoic acid on ion channels of rat coronary artery smooth muscle cells]. | 2012 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:22883096 |
| Wang RX et al. | [Effects of docosahexaenoic acid on action potential and transient outward potassium current on ventricular myocytes of Sprague-Dawley rat]. | 2009 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:19719983 |
| Lu G | [The role of n-3 polyunsaturated fatty acid on coronary heart disease]. | 1990 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:2150806 |
| Hu SX and Yang JN | [Biological effects of docosahexaenoic acid on the retina]. | 2003 | Zhonghua Yan Ke Za Zhi | pmid:12894762 |
| Yu XJ et al. | [Effect of omega-3 long-chain polyunsaturated fatty acids on the cultured oligodendrocyte precursor cells]. | 2009 | Zhonghua Yi Xue Za Zhi | pmid:19563717 |
| Feng XG et al. | [Antitumor effect of DHA compound in vitro and in vivo and its mechanism]. | 2010 | Zhonghua Zhong Liu Za Zhi | pmid:20819480 |