Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kelley DS et al. | Docosahexaenoic acid supplementation improved lipocentric but not glucocentric markers of insulin sensitivity in hypertriglyceridemic men. | 2012 | Metab Syndr Relat Disord | pmid:21999398 |
Ortiz-Alvarado O et al. | Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid in the management of hypercalciuric stone formers. | 2012 | Urology | pmid:22000931 |
Nakamoto K et al. | Involvement of the long-chain fatty acid receptor GPR40 as a novel pain regulatory system. | 2012 | Brain Res. | pmid:22137657 |
Ling PR et al. | Arachidonic acid and docosahexaenoic acid supplemented to an essential fatty acid-deficient diet alters the response to endotoxin in rats. | 2012 | Metab. Clin. Exp. | pmid:21944266 |
Ji A et al. | n-3 polyunsaturated fatty acids inhibit lipopolysaccharide-induced microglial activation and dopaminergic injury in rats. | 2012 | Neurotoxicology | pmid:22406923 |
Betancor MB et al. | Selenium inclusion decreases oxidative stress indicators and muscle injuries in sea bass larvae fed high-DHA microdiets. | 2012 | Br. J. Nutr. | pmid:22409905 |
Kornfeld S et al. | Reducing endothelial NOS activation and interstitial fluid pressure with n-3 PUFA offset tumor chemoresistance. | 2012 | Carcinogenesis | pmid:22114075 |
Kim HW et al. | Effects of chronic clozapine administration on markers of arachidonic acid cascade and synaptic integrity in rat brain. | 2012 | Psychopharmacology (Berl.) | pmid:22414961 |
Liang W and Chikritzhs T | Does light alcohol consumption during pregnancy improve offspring's cognitive development? | 2012 | Med. Hypotheses | pmid:21985759 |
Sinn N et al. | Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial. | 2012 | Br. J. Nutr. | pmid:21929835 |
Drover JR et al. | A randomized trial of DHA intake during infancy: school readiness and receptive vocabulary at 2-3.5 years of age. | 2012 | Early Hum. Dev. | pmid:22835597 |
Chew EY et al. | The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1). | 2012 | Ophthalmology | pmid:22840421 |
Carvalho-Wells AL et al. | APOE genotype influences triglyceride and C-reactive protein responses to altered dietary fat intake in UK adults. | 2012 | Am. J. Clin. Nutr. | pmid:23134888 |
Stanley WC et al. | Update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:22248591 |
Damiano F et al. | Citrate carrier promoter is target of peroxisome proliferator-activated receptor alpha and gamma in hepatocytes and adipocytes. | 2012 | Int. J. Biochem. Cell Biol. | pmid:22249025 |
Shabrani NC et al. | Polyunsaturated fatty acids confer cryoresistance on megakaryocytes generated from cord blood and also enhance megakaryocyte production from cryopreserved cord blood cells. | 2012 | Cytotherapy | pmid:22250991 |
Shearer GC et al. | Effects of prescription niacin and omega-3 fatty acids on lipids and vascular function in metabolic syndrome: a randomized controlled trial. | 2012 | J. Lipid Res. | pmid:22892157 |
Lauritzen L et al. | Fish intake, erythrocyte n-3 fatty acid status and metabolic health in Danish adolescent girls and boys. | 2012 | Br. J. Nutr. | pmid:21736784 |
Isobe Y et al. | Identification and structure determination of novel anti-inflammatory mediator resolvin E3, 17,18-dihydroxyeicosapentaenoic acid. | 2012 | J. Biol. Chem. | pmid:22275352 |
Yetimler B et al. | Differential effect of age on the brain fatty acid levels and their correlation with animal cognitive status in mice. | 2012 | Pharmacol. Biochem. Behav. | pmid:22878041 |
Mozaffarian D and Wu JH | (n-3) fatty acids and cardiovascular health: are effects of EPA and DHA shared or complementary? | 2012 | J. Nutr. | pmid:22279134 |
Macášek J et al. | Plasma fatty acid composition in patients with pancreatic cancer: correlations to clinical parameters. | 2012 | Nutr Cancer | pmid:23061902 |
Maki KC and Rains TM | Stearidonic acid raises red blood cell membrane eicosapentaenoic acid. | 2012 | J. Nutr. | pmid:22279138 |
Whelan J et al. | Effects of dietary stearidonic acid on biomarkers of lipid metabolism. | 2012 | J. Nutr. | pmid:22279143 |
Wu JH et al. | Association of plasma phospholipid long-chain ω-3 fatty acids with incident atrial fibrillation in older adults: the cardiovascular health study. | 2012 | Circulation | pmid:22282329 |
Pineda-Peña EA et al. | Docosahexaenoic acid, an omega-3 polyunsaturated acid protects against indomethacin-induced gastric injury. | 2012 | Eur. J. Pharmacol. | pmid:23063544 |
Giudetti AM and Cagnazzo R | Beneficial effects of n-3 PUFA on chronic airway inflammatory diseases. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:23064030 |
Vedtofte MS et al. | The role of essential fatty acids in the control of coronary heart disease. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:23037902 |
Molloy C et al. | Docosahexaenoic acid and visual functioning in preterm infants: a review. | 2012 | Neuropsychol Rev | pmid:23065239 |
Kim YJ et al. | Plasma phospholipid fatty acid composition in ischemic stroke: importance of docosahexaenoic acid in the risk for intracranial atherosclerotic stenosis. | 2012 | Atherosclerosis | pmid:23044095 |
Chang YL et al. | Docosahexaenoic acid promotes dopaminergic differentiation in induced pluripotent stem cells and inhibits teratoma formation in rats with Parkinson-like pathology. | 2012 | Cell Transplant | pmid:21669041 |
Tanaka T et al. | Oral supplementation with dihomo-γ-linolenic acid (DGLA)-enriched oil increases serum DGLA content in healthy adults. | 2012 | Lipids | pmid:22411689 |
Ruan D and So SP | Screening and identification of dietary oils and unsaturated fatty acids in inhibiting inflammatory prostaglandin E2 signaling in fat stromal cells. | 2012 | BMC Complement Altern Med | pmid:22938033 |
Lin PY et al. | A meta-analytic review of polyunsaturated fatty acid compositions in dementia. | 2012 | J Clin Psychiatry | pmid:22938939 |
Park Y et al. | N-3 polyunsaturated fatty acid consumption produces neurobiological effects associated with prevention of depression in rats after the forced swimming test. | 2012 | J. Nutr. Biochem. | pmid:21852084 |
Shi T et al. | Identification of a novel C22-∆4-producing docosahexaenoic acid (DHA) specific polyunsaturated fatty acid desaturase gene from Isochrysis galbana and its expression in Saccharomyces cerevisiae. | 2012 | Biotechnol. Lett. | pmid:22941368 |
Finlin BS et al. | DHA reduces the atrophy-associated Fn14 protein in differentiated myotubes during coculture with macrophages. | 2012 | J. Nutr. Biochem. | pmid:21852085 |
D'Vaz N et al. | Postnatal fish oil supplementation in high-risk infants to prevent allergy: randomized controlled trial. | 2012 | Pediatrics | pmid:22945403 |
Francescato G et al. | Early retinol-binding protein levels are associated with growth changes in infants born to diabetic mothers. | 2012 | Pediatr Obes | pmid:22991250 |
Cortie CH and Else PL | Dietary docosahexaenoic Acid (22:6) incorporates into cardiolipin at the expense of linoleic Acid (18:2): analysis and potential implications. | 2012 | Int J Mol Sci | pmid:23203135 |
Sauerwald UC et al. | Effect of different levels of docosahexaenoic acid supply on fatty acid status and linoleic and α-linolenic acid conversion in preterm infants. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22008957 |
Mitchell DC et al. | Quantifying the differential effects of DHA and DPA on the early events in visual signal transduction. | 2012 | Chem. Phys. Lipids | pmid:22405878 |
Adolph S et al. | Unsaturated fatty acids promote the phagocytosis of P. aeruginosa and R. equi by RAW264.7 macrophages. | 2012 | Curr. Microbiol. | pmid:22903555 |
Dalli J and Serhan CN | Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators. | 2012 | Blood | pmid:22904297 |
Dong PS et al. | [Effects of docosahexaenoic acid on ion channels of rat coronary artery smooth muscle cells]. | 2012 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:22883096 |
Kuang YL et al. | Regulation of the expression of key genes involved in HDL metabolism by unsaturated fatty acids. | 2012 | Br. J. Nutr. | pmid:22221450 |
Whyte C et al. | N-3 long-chain polyunsaturated fatty acids inhibit smooth muscle cell migration by modulating urokinase plasminogen activator receptor through MEK/ERK-dependent and -independent mechanisms. | 2012 | J. Nutr. Biochem. | pmid:22221673 |
de Velasco PC et al. | Nutritional restriction of omega-3 fatty acids alters topographical fine tuning and leads to a delay in the critical period in the rodent visual system. | 2012 | Exp. Neurol. | pmid:22227060 |
Bonatto SJ et al. | Fish oil supplementation improves neutrophil function during cancer chemotherapy. | 2012 | Lipids | pmid:22160495 |
de Batlle J et al. | Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. | 2012 | J. Nutr. Biochem. | pmid:21889886 |
Castro-González MI et al. | [Evaluation of ten fish species to be included as part of renal diet, due to their protein, phosphorus and fatty acids content]. | 2012 | Arch Latinoam Nutr | pmid:23610899 |
Motter AL and Ahern GP | TRPA1 is a polyunsaturated fatty acid sensor in mammals. | 2012 | PLoS ONE | pmid:22723860 |
Ma Y et al. | DHA derivatives of fish oil as dietary supplements: a nutrition-based drug discovery approach for therapies to prevent metabolic cardiotoxicity. | 2012 | Expert Opin Drug Discov | pmid:22724444 |
Harris WS et al. | Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study. | 2012 | Atherosclerosis | pmid:22727409 |
Hughes BH et al. | Oxidative stability and consumer acceptance of fish oil fortified nutrition bars. | 2012 | J. Food Sci. | pmid:22957916 |
Nakano M et al. | CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of ω-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant. | 2012 | Mol. Pharmacol. | pmid:22772592 |
Park Y et al. | Erythrocyte n-3 polyunsaturated fatty acid and seafood intake decrease the risk of depression: case-control study in Korea. | 2012 | Ann. Nutr. Metab. | pmid:22776859 |
Mraz J et al. | Culture of common carp (Cyprinus carpio) with defined flesh quality for prevention of cardiovascular diseases using finishing feeding strategy. | 2012 | Neuro Endocrinol. Lett. | pmid:23183512 |
Rogerio AP et al. | Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses. | 2012 | J. Immunol. | pmid:22802419 |
Jones CN et al. | Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23185003 |
Ewaschuk JB et al. | Docosahexanoic acid improves chemotherapy efficacy by inducing CD95 translocation to lipid rafts in ER(-) breast cancer cells. | 2012 | Lipids | pmid:23054549 |
Schott CK and Huang DT | ω-3 fatty acids, γ-linolenic acid, and antioxidants: immunomodulators or inert dietary supplements? | 2012 | Crit Care | pmid:23176247 |
Wang DC et al. | Serum fatty acid profiles using GC-MS and multivariate statistical analysis: potential biomarkers of Alzheimer's disease. | 2012 | Neurobiol. Aging | pmid:20980076 |
Kuipers RS et al. | Gestational age dependent changes of the fetal brain, liver and adipose tissue fatty acid compositions in a population with high fish intakes. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22425685 |
Cunningham E | Are krill oil supplements a better source of n-3 fatty acids than fish oil supplements? | 2012 | J Acad Nutr Diet | pmid:22459227 |
Jeckel KM et al. | Docosahexaenoic acid supplementation does not improve Western diet-induced cardiomyopathy in rats. | 2012 | PLoS ONE | pmid:23300587 |
Rognlien M et al. | Consumer perception and sensory effect of oxidation in savory-flavored yogurt enriched with n-3 lipids. | 2012 | J. Dairy Sci. | pmid:22459817 |
Pottala JV et al. | Red blood cell fatty acids are associated with depression in a case-control study of adolescents. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22464051 |
Chen YJ et al. | Docosahexaenoic acid suppresses the expression of FoxO and its target genes. | 2012 | J. Nutr. Biochem. | pmid:22444500 |
da Silva Acosta D et al. | Fullerene and omega-3 and omega-6 fatty acids on fish brain antioxidant status. | 2012 | Fish Physiol. Biochem. | pmid:22451341 |
Du Q et al. | Dairy fat blends high in α-linolenic acid are superior to n-3 fatty-acid-enriched palm oil blends for increasing DHA levels in the brains of young rats. | 2012 | J. Nutr. Biochem. | pmid:22445803 |
Krishnamoorthy S et al. | Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs. | 2012 | Am. J. Pathol. | pmid:22449948 |
Smink W et al. | Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. | 2012 | Animal | pmid:22436184 |
Sahin N et al. | A novel nutritional supplement containing chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron activates the antioxidant pathway Nrf2/HO-1 and protects the brain against oxidative stress in high-fat-fed rats. | 2012 | Nutr Neurosci | pmid:23232054 |
GarcÃa-RodrÃguez CE et al. | Plasma inflammatory and vascular homeostasis biomarkers increase during human pregnancy but are not affected by oily fish intake. | 2012 | J. Nutr. | pmid:22623389 |
Hughes BH et al. | Fish oil fortification of soft goat cheese. | 2012 | J. Food Sci. | pmid:22309698 |
Milte CM et al. | Eicosapentaenoic and docosahexaenoic acids, cognition, and behavior in children with attention-deficit/hyperactivity disorder: a randomized controlled trial. | 2012 | Nutrition | pmid:22541055 |
Dhobale M et al. | Association of brain-derived neurotrophic factor and tyrosine kinase B receptor in pregnancy. | 2012 | Neuroscience | pmid:22542551 |
Sharma S et al. | High-fat diet transition reduces brain DHA levels associated with altered brain plasticity and behaviour. | 2012 | Sci Rep | pmid:22666534 |
Sierra S et al. | Administration of docosahexaenoic acid before birth and until aging decreases kainate-induced seizures in adult zebrafish. | 2012 | Brain Res. Bull. | pmid:22542883 |
Tang X et al. | Short term effects of different omega-3 fatty acid formulation on lipid metabolism in mice fed high or low fat diet. | 2012 | Lipids Health Dis | pmid:22676394 |
Bazan NG et al. | Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke. | 2012 | Exp. Neurol. | pmid:22542947 |
Crawford MA and Broadhurst CL | The role of docosahexaenoic and the marine food web as determinants of evolution and hominid brain development: the challenge for human sustainability. | 2012 | Nutr Health | pmid:22544773 |
Imam MH and Lindor KD | Primary sclerosing cholangitis: providing a safe and effective treatment. | 2012 | Expert Rev Gastroenterol Hepatol | pmid:22646247 |
Vedin I et al. | Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study. | 2012 | PLoS ONE | pmid:22545106 |
Galicia-Connolly E et al. | Complementary, holistic, and integrative medicine: therapies for neurodevelopment in preterm infants. | 2012 | Pediatr Rev | pmid:22659260 |
Novak EM et al. | Low linoleic acid may facilitate Δ6 desaturase activity and docosahexaenoic acid accretion in human fetal development. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22365109 |
Labrousse VF et al. | Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice. | 2012 | PLoS ONE | pmid:22662127 |
Chiang N et al. | Infection regulates pro-resolving mediators that lower antibiotic requirements. | 2012 | Nature | pmid:22538616 |
Gil-Campos M and Sanjurjo Crespo P | Omega 3 fatty acids and inborn errors of metabolism. | 2012 | Br. J. Nutr. | pmid:22591887 |
Maki KC et al. | Prescription omega-3-acid ethyl esters reduce fasting and postprandial triglycerides and modestly reduce pancreatic β-cell response in subjects with primary hypertriglyceridemia. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21775113 |
Luxwolda MF et al. | The relation between the omega-3 index and arachidonic acid is bell shaped: synergistic at low EPA+DHA status and antagonistic at high EPA+DHA status. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21715149 |
Fabelo N et al. | Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson's disease and incidental Parkinson's disease. | 2011 Sep-Oct | Mol. Med. | pmid:21717034 |
Shilina NM et al. | [Changes in the fatty acid composition of blood cell membranes in children with inflammatory diseases]. | 2011 Sep-Oct | Biomed Khim | pmid:22629608 |
Dhobale MV et al. | Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21816593 |
Maki KC et al. | Effects of prescription omega-3-acid ethyl esters, coadministered with atorvastatin, on circulating levels of lipoprotein particles, apolipoprotein CIII, and lipoprotein-associated phospholipase A2 mass in men and women with mixed dyslipidemia. | 2011 Nov-Dec | J Clin Lipidol | pmid:22108152 |
Siddiqui RA et al. | Docosahexaenoic acid: a natural powerful adjuvant that improves efficacy for anticancer treatment with no adverse effects. | 2011 Nov-Dec | Biofactors | pmid:22038684 |
Opperman M et al. | Analysis of omega-3 fatty acid content of South African fish oil supplements. | 2011 Nov-Dec | Cardiovasc J Afr | pmid:22159321 |
Kim Y and Ilich JZ | Implications of dietary α-linolenic acid in bone health. | 2011 Nov-Dec | Nutrition | pmid:21726979 |
Jones JL et al. | A Mediterranean-style low-glycemic-load diet improves variables of metabolic syndrome in women, and addition of a phytochemical-rich medical food enhances benefits on lipoprotein metabolism. | 2011 May-Jun | J Clin Lipidol | pmid:21600524 |