DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Martin CR et al. | The safety and efficacy of oral docosahexaenoic acid supplementation for the treatment of primary sclerosing cholangitis - a pilot study. | 2012 | Aliment. Pharmacol. Ther. | pmid:22129201 |
| Ooi SY and Andrews JM | Commentary: The association between high dietary intake of docosahexaenoic acid and reduced risk of Crohn's disease. | 2014 | Aliment. Pharmacol. Ther. | pmid:24803245 |
| Chan SS and Hart AR | Commentary: The association between high dietary intake of docosahexaenoic acid and reduced risk of Crohn's disease--authors' reply. | 2014 | Aliment. Pharmacol. Ther. | pmid:24803246 |
| Chan SS et al. | Association between high dietary intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn's disease. | 2014 | Aliment. Pharmacol. Ther. | pmid:24611981 |
| Greenfield SM et al. | A randomized controlled study of evening primrose oil and fish oil in ulcerative colitis. | 1993 | Aliment. Pharmacol. Ther. | pmid:8485269 |
| Kankaanpää P et al. | Polyunsaturated fatty acids in maternal diet, breast milk, and serum lipid fatty acids of infants in relation to atopy. | 2001 | Allergy | pmid:11421921 |
| Hernández E et al. | Prenatal determinants of cord blood total immunoglobulin E levels in Mexican newborns. | 2013 Sep-Oct | Allergy Asthma Proc | pmid:23998234 |
| Arm JP et al. | Leukotrienes, fish-oil, and asthma. | 1994 May-Jun | Allergy Proc | pmid:7926711 |
| Logan AC | Neurobehavioral aspects of omega-3 fatty acids: possible mechanisms and therapeutic value in major depression. | 2003 | Altern Med Rev | pmid:14653768 |
| Kidd PM | Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids. | 2007 | Altern Med Rev | pmid:18072818 |
| Docosahexaenoic acid (DHA). Monograph. | 2009 | Altern Med Rev | pmid:20030466 | |
| Yurko-Mauro K et al. | Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. | 2010 | Alzheimers Dement | pmid:20434961 |
| Wang X et al. | Resolution of inflammation is altered in Alzheimer's disease. | 2015 | Alzheimers Dement | pmid:24530025 |
| Cansev M et al. | Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses. | 2008 | Alzheimers Dement | pmid:18631994 |
| Buydens-Branchey L et al. | Low plasma levels of docosahexaenoic acid are associated with an increased relapse vulnerability in substance abusers. | 2009 Jan-Feb | Am J Addict | pmid:19219668 |
| New Alzheimer's clinical trials to be undertaken by NIA nationwide consortium. | 2006 Dec-2007 Jan | Am J Alzheimers Dis Other Demen | pmid:17288014 | |
| Fialkow J | Omega-3 Fatty Acid Formulations in Cardiovascular Disease: Dietary Supplements are Not Substitutes for Prescription Products. | 2016 | Am J Cardiovasc Drugs | pmid:27138439 |
| Fetterman JW and Zdanowicz MM | Therapeutic potential of n-3 polyunsaturated fatty acids in disease. | 2009 | Am J Health Syst Pharm | pmid:19535655 |
| Siahanidou T et al. | Oxidative stress in preterm infants fed a formula containing long-chain polyunsaturated fatty acids (LCPUFA). | 2007 | Am J Perinatol | pmid:17992715 |
| Cohen JT et al. | A quantitative analysis of prenatal intake of n-3 polyunsaturated fatty acids and cognitive development. | 2005 | Am J Prev Med | pmid:16242603 |
| Parker G et al. | Omega-3 fatty acids and mood disorders. | 2006 | Am J Psychiatry | pmid:16741195 |
| Nemets H et al. | Omega-3 treatment of childhood depression: a controlled, double-blind pilot study. | 2006 | Am J Psychiatry | pmid:16741212 |
| Sublette ME et al. | Omega-3 polyunsaturated essential fatty acid status as a predictor of future suicide risk. | 2006 | Am J Psychiatry | pmid:16741213 |
| Marangell LB et al. | A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression. | 2003 | Am J Psychiatry | pmid:12727707 |
| Chiu CC et al. | Omega-3 fatty acids for depression in pregnancy. | 2003 | Am J Psychiatry | pmid:12562593 |
| Kar S | Omacor and omega-3 fatty acids for treatment of coronary artery disease and the pleiotropic effects. | 2014 Jan-Feb | Am J Ther | pmid:21975796 |
| Ryan AS et al. | Clinical overview of algal-docosahexaenoic acid: effects on triglyceride levels and other cardiovascular risk factors. | 2009 Mar-Apr | Am J Ther | pmid:19145206 |
| Bucci KK | Fish oil supplements. | 1992 | Am Pharm | pmid:1535475 |
| Pratt CM et al. | Efficacy and safety of prescription omega-3-acid ethyl esters for the prevention of recurrent symptomatic atrial fibrillation: a prospective study. | 2009 | Am. Heart J. | pmid:19619690 |
| Mehta J et al. | Reduction in plasminogen activator inhibitor-1 (PAI-1) with omega-3 polyunsaturated fatty acid (PUFA) intake. | 1988 | Am. Heart J. | pmid:3142242 |
| Zhu BQ et al. | Is the reduction of myocardial infarct size by dietary fish oil the result of altered platelet function? | 1994 | Am. Heart J. | pmid:8154411 |
| Haglund O et al. | Effects of fish oil on some parameters of fibrinolysis and lipoprotein(a) in healthy subjects. | 1994 | Am. J. Cardiol. | pmid:8023790 |
| Engler MM et al. | Effect of docosahexaenoic acid on lipoprotein subclasses in hyperlipidemic children (the EARLY study). | 2005 | Am. J. Cardiol. | pmid:15781019 |
| Bays H | Fish oil composition of Omacor and the GISSI trial. | 2007 | Am. J. Cardiol. | pmid:17493490 |
| Barbir M et al. | Maxepa versus bezafibrate in hyperlipidemic cardiac transplant recipients. | 1992 | Am. J. Cardiol. | pmid:1466329 |
| Ito MK et al. | Omacor effects on serum lipids and clinical outcome. | 2007 | Am. J. Cardiol. | pmid:17196478 |
| Brouwer IA et al. | Association between n-3 fatty acid status in blood and electrocardiographic predictors of arrhythmia risk in healthy volunteers. | 2002 | Am. J. Cardiol. | pmid:11867059 |
| Bays H | Clinical overview of Omacor: a concentrated formulation of omega-3 polyunsaturated fatty acids. | 2006 | Am. J. Cardiol. | pmid:16919519 |
| Harris WS et al. | Effects of omega-3 fatty acids on heart rate in cardiac transplant recipients. | 2006 | Am. J. Cardiol. | pmid:17134636 |
| O'Keefe JH et al. | Effects of omega-3 fatty acids on resting heart rate, heart rate recovery after exercise, and heart rate variability in men with healed myocardial infarctions and depressed ejection fractions. | 2006 | Am. J. Cardiol. | pmid:16616012 |
| Silverman DI et al. | Usefulness of plasma phospholipid N-3 fatty acid levels in predicting dietary fish intake in patients with coronary artery disease. | 1990 | Am. J. Cardiol. | pmid:2145737 |
| Kim YT et al. | Neuroprotection and enhancement of spatial memory by herbal mixture HT008-1 in rat global brain ischemia model. | 2008 | Am. J. Chin. Med. | pmid:18457361 |
| Tolley EA and Carlson SE | Considerations of statistical power in infant studies of visual acuity development and docosahexaenoic acid status. | 2000 | Am. J. Clin. Nutr. | pmid:10617938 |
| Metcalf RG et al. | Effects of fish-oil supplementation on myocardial fatty acids in humans. | 2007 | Am. J. Clin. Nutr. | pmid:17490956 |
| Griffin MD et al. | Effects of altering the ratio of dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45-70 y: the OPTILIP Study. | 2006 | Am. J. Clin. Nutr. | pmid:17158408 |
| Krauss-Etschmann S et al. | Effects of fish-oil and folate supplementation of pregnant women on maternal and fetal plasma concentrations of docosahexaenoic acid and eicosapentaenoic acid: a European randomized multicenter trial. | 2007 | Am. J. Clin. Nutr. | pmid:17490978 |
| Connor WE and Connor SL | The importance of fish and docosahexaenoic acid in Alzheimer disease. | 2007 | Am. J. Clin. Nutr. | pmid:17413088 |
| van Gelder BM et al. | Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study. | 2007 | Am. J. Clin. Nutr. | pmid:17413117 |
| Katoku Y et al. | Effect of the cholesterol content of a formula on the lipid compositions of plasma lipoproteins and red blood cell membranes in early infancy. | 1996 | Am. J. Clin. Nutr. | pmid:8942411 |
| Woodman RJ et al. | Effects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension. | 2002 | Am. J. Clin. Nutr. | pmid:12399272 |
| Rosell MS et al. | Long-chain n-3 polyunsaturated fatty acids in plasma in British meat-eating, vegetarian, and vegan men. | 2005 | Am. J. Clin. Nutr. | pmid:16087975 |
| Innis SM and Elias SL | Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women. | 2003 | Am. J. Clin. Nutr. | pmid:12540410 |
| Gillingham LG et al. | Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. | 2013 | Am. J. Clin. Nutr. | pmid:23221573 |
| West AA et al. | Choline intake influences phosphatidylcholine DHA enrichment in nonpregnant women but not in pregnant women in the third trimester. | 2013 | Am. J. Clin. Nutr. | pmid:23446897 |
| Birch EE et al. | A randomized controlled trial of long-chain polyunsaturated fatty acid supplementation of formula in term infants after weaning at 6 wk of age. | 2002 | Am. J. Clin. Nutr. | pmid:11864865 |
| Farina EK et al. | Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study. | 2011 | Am. J. Clin. Nutr. | pmid:21367955 |
| de Groot RH et al. | Effect of alpha-linolenic acid supplementation during pregnancy on maternal and neonatal polyunsaturated fatty acid status and pregnancy outcome. | 2004 | Am. J. Clin. Nutr. | pmid:14749231 |
| Lemaitre RN et al. | n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study. | 2003 | Am. J. Clin. Nutr. | pmid:12540389 |
| Browning LM et al. | Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish. | 2012 | Am. J. Clin. Nutr. | pmid:22932281 |
| Harris WS et al. | Comparison of the effects of fish and fish-oil capsules on the n 3 fatty acid content of blood cells and plasma phospholipids. | 2007 | Am. J. Clin. Nutr. | pmid:18065578 |
| Muskiet FA et al. | The basis of recommendations for docosahexaenoic and arachidonic acids in infant formula: absolute or relative standards? | 2007 | Am. J. Clin. Nutr. | pmid:18065601 |
| Rump P et al. | Essential fatty acid composition of plasma phospholipids and birth weight: a study in term neonates. | 2001 | Am. J. Clin. Nutr. | pmid:11273856 |
| Fekete K et al. | Methods of assessment of n-3 long-chain polyunsaturated fatty acid status in humans: a systematic review. | 2009 | Am. J. Clin. Nutr. | pmid:19420097 |
| Carlson SE | Early determinants of development: a lipid perspective. | 2009 | Am. J. Clin. Nutr. | pmid:19321568 |
| Kestin M et al. | n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. | 1990 | Am. J. Clin. Nutr. | pmid:1971991 |
| Carlson SE et al. | Effect of long-chain n-3 fatty acid supplementation on visual acuity and growth of preterm infants with and without bronchopulmonary dysplasia. | 1996 | Am. J. Clin. Nutr. | pmid:8615350 |
| da Costa KA et al. | Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine N-methyltransferase activity in humans. | 2011 | Am. J. Clin. Nutr. | pmid:21411618 |
| Wander RC and Du SH | Oxidation of plasma proteins is not increased after supplementation with eicosapentaenoic and docosahexaenoic acids. | 2000 | Am. J. Clin. Nutr. | pmid:10966891 |
| Dewailly E E et al. | Relations between n-3 fatty acid status and cardiovascular disease risk factors among Quebecers. | 2001 | Am. J. Clin. Nutr. | pmid:11684528 |
| Lin YH et al. | Compartmental analyses of 2H5-alpha-linolenic acid and C-U-eicosapentaenoic acid toward synthesis of plasma labeled 22:6n-3 in newborn term infants. | 2010 | Am. J. Clin. Nutr. | pmid:20534748 |
| Decsi T and Boehm G | trans Isomeric fatty acids are inversely related to the availability of long-chain PUFAs in the perinatal period. | 2013 | Am. J. Clin. Nutr. | pmid:23824720 |
| Carlson SE et al. | Docosahexaenoic acid status of preterm infants at birth and following feeding with human milk or formula. | 1986 | Am. J. Clin. Nutr. | pmid:2947455 |
| Smithers LG et al. | Feeding preterm infants milk with a higher dose of docosahexaenoic acid than that used in current practice does not influence language or behavior in early childhood: a follow-up study of a randomized controlled trial. | 2010 | Am. J. Clin. Nutr. | pmid:20053878 |
| Popp-Snijders C and Blonk MC | Omega-3 fatty acids in adipose tissue of obese patients with non-insulin-dependent diabetes mellitus reflect long-term dietary intake of eicosapentaenoic and docosahexaenoic acid. | 1995 | Am. J. Clin. Nutr. | pmid:7840075 |
| Stirban A et al. | Effects of n-3 fatty acids on macro- and microvascular function in subjects with type 2 diabetes mellitus. | 2010 | Am. J. Clin. Nutr. | pmid:20071644 |
| Thies F et al. | Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y. | 2001 | Am. J. Clin. Nutr. | pmid:11237929 |
| Smithers LG et al. | Maternal supplementation with docosahexaenoic acid during pregnancy does not affect early visual development in the infant: a randomized controlled trial. | 2011 | Am. J. Clin. Nutr. | pmid:21490140 |
| Giltay EJ et al. | Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects. | 2004 | Am. J. Clin. Nutr. | pmid:15531662 |
| Otto SJ et al. | Comparison of the peripartum and postpartum phospholipid polyunsaturated fatty acid profiles of lactating and nonlactating women. | 2001 | Am. J. Clin. Nutr. | pmid:11382662 |
| van de Rest O et al. | Effect of fish-oil supplementation on mental well-being in older subjects: a randomized, double-blind, placebo-controlled trial. | 2008 | Am. J. Clin. Nutr. | pmid:18779287 |
| di Giuseppe R et al. | Alcohol consumption and n-3 polyunsaturated fatty acids in healthy men and women from 3 European populations. | 2009 | Am. J. Clin. Nutr. | pmid:19056552 |
| Agostoni C et al. | Docosahexaenoic acid supplementation and time at achievement of gross motor milestones in healthy infants: a randomized, prospective, double-blind, placebo-controlled trial. | 2009 | Am. J. Clin. Nutr. | pmid:19056592 |
| Heine-Bröring RC et al. | Intake of fish and marine n-3 fatty acids in relation to coronary calcification: the Rotterdam Study. | 2010 | Am. J. Clin. Nutr. | pmid:20219958 |
| Stene LC and Joner G | Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population-based, case-control study. | 2003 | Am. J. Clin. Nutr. | pmid:14668274 |
| Prisco D et al. | Effect of n-3 polyunsaturated fatty acid intake on phospholipid fatty acid composition in plasma and erythrocytes. | 1996 | Am. J. Clin. Nutr. | pmid:8644688 |
| Blasbalg TL et al. | Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. | 2011 | Am. J. Clin. Nutr. | pmid:21367944 |
| Yamazaki K et al. | Changes in fatty acid composition in rat blood and organs after infusion of docosahexaenoic acid ethyl ester. | 1991 | Am. J. Clin. Nutr. | pmid:1825741 |
| Marckmann P et al. | Biomarkers of habitual fish intake in adipose tissue. | 1995 | Am. J. Clin. Nutr. | pmid:7572741 |
| Francois CA et al. | Supplementing lactating women with flaxseed oil does not increase docosahexaenoic acid in their milk. | 2003 | Am. J. Clin. Nutr. | pmid:12499346 |
| van der Merwe LF et al. | Long-chain PUFA supplementation in rural African infants: a randomized controlled trial of effects on gut integrity, growth, and cognitive development. | 2013 | Am. J. Clin. Nutr. | pmid:23221579 |
| Lin DS and Conner WE | Are the n-3 fatty acids from dietary fish oil deposited in the triglyceride stores of adipose tissue? | 1990 | Am. J. Clin. Nutr. | pmid:2138861 |
| Christensen MS et al. | Intestinal absorption and lymphatic transport of eicosapentaenoic (EPA), docosahexaenoic (DHA), and decanoic acids: dependence on intramolecular triacylglycerol structure. | 1995 | Am. J. Clin. Nutr. | pmid:7825539 |
| Subbaiah PV et al. | Incorporation of dietary n-3 fatty acids into molecular species of phosphatidyl choline and cholesteryl ester in normal human plasma. | 1993 | Am. J. Clin. Nutr. | pmid:8237847 |
| Geelen A et al. | Effects of n-3 fatty acids from fish on premature ventricular complexes and heart rate in humans. | 2005 | Am. J. Clin. Nutr. | pmid:15699229 |
| Mantzioris E et al. | Biochemical effects of a diet containing foods enriched with n-3 fatty acids. | 2000 | Am. J. Clin. Nutr. | pmid:10871559 |
| Niu K et al. | Dietary long-chain n-3 fatty acids of marine origin and serum C-reactive protein concentrations are associated in a population with a diet rich in marine products. | 2006 | Am. J. Clin. Nutr. | pmid:16825699 |
| Elias SL and Innis SM | Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length. | 2001 | Am. J. Clin. Nutr. | pmid:11273857 |
| Zhou SJ et al. | Fish-oil supplementation in pregnancy does not reduce the risk of gestational diabetes or preeclampsia. | 2012 | Am. J. Clin. Nutr. | pmid:22552037 |
| Harris WS | n-3 fatty acids and serum lipoproteins: human studies. | 1997 | Am. J. Clin. Nutr. | pmid:9129504 |
| Innis SM et al. | n-6 Docosapentaenoic acid is not a predictor of low docosahexaenoic acid status in Canadian preschool children. | 2004 | Am. J. Clin. Nutr. | pmid:15321820 |