Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Noguchi M et al. | Effects of eicosapentaenoic and docosahexaenoic acid on cell growth and prostaglandin E and leukotriene B production by a human breast cancer cell line (MDA-MB-231). | 1995 Nov-Dec | Oncology | pmid:7478431 |
Noguchi M et al. | The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. | 1995 Jul-Aug | Oncology | pmid:7777237 |
Li S et al. | The targeting mechanism of DHA ligand and its conjugate with Gemcitabine for the enhanced tumor therapy. | 2014 | Oncotarget | pmid:25004114 |
Lam SM et al. | Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of rhesus macaques during normative aging. | 2016 | Oncotarget | pmid:27517158 |
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Simonelli F et al. | Evaluation of fatty acids in membrane phospholipids of erythrocytes in retinitis pigmentosa patients. | 1996 | Ophthalmic Res. | pmid:8792359 |
Moriguchi K et al. | Suppression of N-methyl-N-nitrosourea-induced photoreceptor apoptosis in rats by docosahexaenoic acid. | 2004 Mar-Apr | Ophthalmic Res. | pmid:15017106 |
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Weise C et al. | Dietary polyunsaturated fatty acids and non-digestible oligosaccharides reduce dermatitis in mice. | 2013 | Pediatr Allergy Immunol | pmid:23577592 |
Weise C et al. | Dietary docosahexaenoic acid in combination with arachidonic acid ameliorates allergen-induced dermatitis in mice. | 2011 | Pediatr Allergy Immunol | pmid:21294775 |
Furuhjelm C et al. | Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. | 2011 | Pediatr Allergy Immunol | pmid:21332799 |
Wang L et al. | Comparison of the fatty acid composition of total lipids and phospholipids in breast milk from Japanese women. | 2000 | Pediatr Int | pmid:10703228 |
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Ahmad A et al. | Decrease in neuron size in docosahexaenoic acid-deficient brain. | 2002 | Pediatr. Neurol. | pmid:11955929 |
Kurlandsky LE et al. | The absorption and effect of dietary supplementation with omega-3 fatty acids on serum leukotriene B4 in patients with cystic fibrosis. | 1994 | Pediatr. Pulmonol. | pmid:7838619 |
Llanos A et al. | Infants with intrauterine growth restriction have impaired formation of docosahexaenoic acid in early neonatal life: a stable isotope study. | 2005 | Pediatr. Res. | pmid:16189202 |
Agostoni C and Verduci E | DHA in pregnancy benefits child development. | 2003 | Pediatr. Res. | pmid:12904586 |
Liu CC et al. | Increase in plasma phospholipid docosahexaenoic and eicosapentaenoic acids as a reflection of their intake and mode of administration. | 1987 | Pediatr. Res. | pmid:2821474 |
Woods J et al. | Is docosahexaenoic acid necessary in infant formula? Evaluation of high linolenate diets in the neonatal rat. | 1996 | Pediatr. Res. | pmid:8910933 |
Lauritzen L et al. | Maternal fish oil supplementation in lactation and growth during the first 2.5 years of life. | 2005 | Pediatr. Res. | pmid:16006428 |
Ponder DL et al. | Docosahexaenoic acid status of term infants fed breast milk or infant formula containing soy oil or corn oil. | 1992 | Pediatr. Res. | pmid:1287559 |
Curatolo N et al. | Oral administration of docosahexaenoic acid/eicosapentaeinoic acids is not anticonvulsant in rats: implications for translational research. | 2011 | Pediatr. Res. | pmid:21857379 |
Greiner RC et al. | Brain docosahexaenoate accretion in fetal baboons: bioequivalence of dietary alpha-linolenic and docosahexaenoic acids. | 1997 | Pediatr. Res. | pmid:9396565 |
Salem N | What is the right level of DHA in the infant diet? Commentary on article by Hsieh et al. on page 537. | 2007 | Pediatr. Res. | pmid:17413853 |
Hsieh AT et al. | The influence of moderate and high dietary long chain polyunsaturated fatty acids (LCPUFA) on baboon neonate tissue fatty acids. | 2007 | Pediatr. Res. | pmid:17413857 |
Lim SY et al. | N-3 fatty acid deficiency induced by a modified artificial rearing method leads to poorer performance in spatial learning tasks. | 2005 | Pediatr. Res. | pmid:16189203 |
Colombo J et al. | Long-chain polyunsaturated fatty acid supplementation in infancy reduces heart rate and positively affects distribution of attention. | 2011 | Pediatr. Res. | pmid:21705959 |
Farquharson J et al. | Age- and dietary-related distributions of hepatic arachidonic and docosahexaenoic acid in early infancy. | 1995 | Pediatr. Res. | pmid:7494660 |
Sauerwald TU et al. | Intermediates in endogenous synthesis of C22:6 omega 3 and C20:4 omega 6 by term and preterm infants. | 1997 | Pediatr. Res. | pmid:9029636 |
GarcÃa-Calatayud S et al. | Brain docosahexaenoic acid status and learning in young rats submitted to dietary long-chain polyunsaturated fatty acid deficiency and supplementation limited to lactation. | 2005 | Pediatr. Res. | pmid:15718358 |
Lefkowitz W et al. | Where does the developing brain obtain its docosahexaenoic acid? Relative contributions of dietary alpha-linolenic acid, docosahexaenoic acid, and body stores in the developing rat. | 2005 | Pediatr. Res. | pmid:15531740 |
Mollard RC and Weiler HA | Dietary arachidonic acid and docosahexaenoic acid elevate femur calcium and reduce zinc content in piglets. | 2006 | Pediatr. Res. | pmid:16940244 |
Su HM et al. | Bioequivalence of dietary alpha-linolenic and docosahexaenoic acids as sources of docosahexaenoate accretion in brain and associated organs of neonatal baboons. | 1999 | Pediatr. Res. | pmid:9890614 |
Bouwstra H et al. | Neurologic condition of healthy term infants at 18 months: positive association with venous umbilical DHA status and negative association with umbilical trans-fatty acids. | 2006 | Pediatr. Res. | pmid:16857765 |
Damsgaard CT et al. | The effects of n-3 long-chain polyunsaturated fatty acids on bone formation and growth factors in adolescent boys. | 2012 | Pediatr. Res. | pmid:22337227 |
Anderson GJ et al. | Docosahexaenoic acid is the preferred dietary n-3 fatty acid for the development of the brain and retina. | 1990 | Pediatr. Res. | pmid:2136947 |
Champoux M et al. | Fatty acid formula supplementation and neuromotor development in rhesus monkey neonates. | 2002 | Pediatr. Res. | pmid:11861930 |
Lapillonne A et al. | The use of low-EPA fish oil for long-chain polyunsaturated fatty acid supplementation of preterm infants. | 2000 | Pediatr. Res. | pmid:11102555 |
Larqué E et al. | Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats. | 2000 | Pediatr. Res. | pmid:10674359 |
Bowen RA et al. | Does increasing dietary linolenic acid content increase the docosahexaenoic acid content of phospholipids in neuronal cells of neonatal rats? | 1999 | Pediatr. Res. | pmid:10367771 |
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Makrides M et al. | Erythrocyte docosahexaenoic acid correlates with the visual response of healthy, term infants. | 1993 | Pediatr. Res. | pmid:8479826 |
Birch EE et al. | Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants. | 1998 | Pediatr. Res. | pmid:9702915 |
Carlson SE et al. | Effect of fish oil supplementation on the n-3 fatty acid content of red blood cell membranes in preterm infants. | 1987 | Pediatr. Res. | pmid:2954026 |
Dunstan JA et al. | The effects of fish oil supplementation in pregnancy on breast milk fatty acid composition over the course of lactation: a randomized controlled trial. | 2007 | Pediatr. Res. | pmid:17957152 |
Carlson SE et al. | Long-term feeding of formulas high in linolenic acid and marine oil to very low birth weight infants: phospholipid fatty acids. | 1991 | Pediatr. Res. | pmid:1684416 |
Carlson SE et al. | Visual acuity and fatty acid status of term infants fed human milk and formulas with and without docosahexaenoate and arachidonate from egg yolk lecithin. | 1996 | Pediatr. Res. | pmid:8726246 |
Morris SA et al. | Developmental sensitivity of the piglet brain to docosahexanoic acid. | 1999 | Pediatr. Res. | pmid:10509359 |
Cetin I et al. | Intrauterine growth restriction is associated with changes in polyunsaturated fatty acid fetal-maternal relationships. | 2002 | Pediatr. Res. | pmid:12409524 |
Clandinin MT et al. | Assessment of the efficacious dose of arachidonic and docosahexaenoic acids in preterm infant formulas: fatty acid composition of erythrocyte membrane lipids. | 1997 | Pediatr. Res. | pmid:9396564 |
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Carnielli VP et al. | The very low birth weight premature infant is capable of synthesizing arachidonic and docosahexaenoic acids from linoleic and linolenic acids. | 1996 | Pediatr. Res. | pmid:8798265 |
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