Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Mussi SV et al. | Novel nanostructured lipid carrier co-loaded with doxorubicin and docosahexaenoic acid demonstrates enhanced in vitro activity and overcomes drug resistance in MCF-7/Adr cells. | 2014 | Pharm. Res. | pmid:24522814 |
Arnold C et al. | Cytochrome P450-dependent metabolism of omega-6 and omega-3 long-chain polyunsaturated fatty acids. | 2010 May-Jun | Pharmacol Rep | pmid:20631419 |
Yetimler B et al. | Differential effect of age on the brain fatty acid levels and their correlation with animal cognitive status in mice. | 2012 | Pharmacol. Biochem. Behav. | pmid:22878041 |
Cao DH et al. | Protective effect of chronic ethyl docosahexaenoate administration on brain injury in ischemic gerbils. | 2004 | Pharmacol. Biochem. Behav. | pmid:15582673 |
Minami M et al. | Dietary docosahexaenoic acid increases cerebral acetylcholine levels and improves passive avoidance performance in stroke-prone spontaneously hypertensive rats. | 1997 | Pharmacol. Biochem. Behav. | pmid:9408223 |
Obajimi O et al. | Differential effects of eicosapentaenoic and docosahexaenoic acids upon oxidant-stimulated release and uptake of arachidonic acid in human lymphoma U937 cells. | 2005 | Pharmacol. Res. | pmid:15967385 |
Galli C | Health implications of DHA. | 1999 | Pharmacol. Res. | pmid:10479461 |
Lagarde M | Health benefits of docosahexaenoic acid (DHA) | 1999 | Pharmacol. Res. | pmid:10479462 |
Horrocks LA and Yeo YK | Health benefits of docosahexaenoic acid (DHA) | 1999 | Pharmacol. Res. | pmid:10479465 |
Lopez-Huertas E | Health effects of oleic acid and long chain omega-3 fatty acids (EPA and DHA) enriched milks. A review of intervention studies. | 2010 | Pharmacol. Res. | pmid:19897038 |
Rogers LK et al. | DHA supplementation: current implications in pregnancy and childhood. | 2013 | Pharmacol. Res. | pmid:23266567 |
Gorjão R et al. | Comparative effects of DHA and EPA on cell function. | 2009 | Pharmacol. Ther. | pmid:19318040 |
Schjøtt J et al. | Effects of eicosapentaenoic acid and docosahexaenoic acid diet supplement on tolerance to the cardiotoxicity of epirubicin and to ischaemia reperfusion in the isolated rat heart. | 1996 | Pharmacol. Toxicol. | pmid:8878248 |
Paulsen JE et al. | A fish oil-derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl esters inhibits the formation and growth of aberrant crypt foci in rat colon. | 1998 | Pharmacol. Toxicol. | pmid:9527643 |
Sametz W et al. | Influence of polyunsaturated fatty acids on vasoconstrictions induced by 8-iso-PGF(2alpha) and 8-iso-PGE(2). | 2000 | Pharmacology | pmid:10754452 |
Burns T et al. | Effect of omega-3 fatty acid supplementation on the arachidonic acid:eicosapentaenoic acid ratio. | 2007 | Pharmacotherapy | pmid:17461697 |
McKenney JM and Sica D | Role of prescription omega-3 fatty acids in the treatment of hypertriglyceridemia. | 2007 | Pharmacotherapy | pmid:17461707 |
Du J et al. | Palmitic acid and docosahexaenoic acid opposingly regulate the expression of insulin-degrading enzyme in neurons. | 2010 | Pharmazie | pmid:20383947 |
Gederaas OA et al. | Cell specific effects of polyunsaturated fatty acids on 5-aminolevulinic acid based photosensitization. | 2005 | Photochem. Photobiol. Sci. | pmid:15803209 |
Kello M et al. | PUFAs enhance oxidative stress and apoptosis in tumour cells exposed to hypericin-mediated PDT. | 2010 | Photochem. Photobiol. Sci. | pmid:20714672 |
Easley JT et al. | AT-RvD1 combined with DEX is highly effective in treating TNF-α-mediated disruption of the salivary gland epithelium. | 2016 | Physiol Rep | pmid:27694530 |
Kunesová M et al. | The influence of n-3 polyunsaturated fatty acids and very low calorie diet during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women. | 2006 | Physiol Res | pmid:15857162 |
Levant B et al. | Developmental effects of dietary n-3 fatty acids on activity and response to novelty. | 2010 | Physiol. Behav. | pmid:20457171 |
Correia Bacarin C et al. | Fish oil provides robust and sustained memory recovery after cerebral ischemia: influence of treatment regimen. | 2013 | Physiol. Behav. | pmid:23770426 |
Trofimiuk E and Braszko JJ | Concomitant docosahexaenoic acid administration ameliorates stress-induced cognitive impairment in rats. | 2013 | Physiol. Behav. | pmid:23672853 |
Bandaru SS et al. | Effects of PI3K inhibition and low docosahexaenoic acid on cognition and behavior. | 2010 | Physiol. Behav. | pmid:19914265 |
Turner N et al. | Scaling of Na+,K+-ATPase molecular activity and membrane fatty acid composition in mammalian and avian hearts. | 2006 May-Jun | Physiol. Biochem. Zool. | pmid:16691518 |
Georgiadi A et al. | Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. | 2012 | Physiol. Genomics | pmid:22274564 |
Guihéneuf F et al. | Use of radiolabeled substrates to determine the desaturase and elongase activities involved in eicosapentaenoic acid and docosahexaenoic acid biosynthesis in the marine microalga Pavlova lutheri. | 2013 | Phytochemistry | pmid:23528573 |
Mansour MP et al. | The effect of growth phase on the lipid class, fatty acid and sterol composition in the marine dinoflagellate, Gymnodinium sp. in batch culture. | 2003 | Phytochemistry | pmid:12711135 |
Zhou XR et al. | Isolation and characterization of genes from the marine microalga Pavlova salina encoding three front-end desaturases involved in docosahexaenoic acid biosynthesis. | 2007 | Phytochemistry | pmid:17291553 |
Innis SM | Essential fatty acid transfer and fetal development. | 2005 | Placenta | pmid:15837071 |
Johnsen GM et al. | Docosahexaenoic acid stimulates tube formation in first trimester trophoblast cells, HTR8/SVneo. | 2011 | Placenta | pmid:21741084 |
Xu Y et al. | Maternal di-(2-ethylhexyl)-phthalate exposure influences essential fatty acid homeostasis in rat placenta. | 2008 | Placenta | pmid:18829104 |
Johnsen GM et al. | Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (BeWo) cells. | 2009 | Placenta | pmid:19880178 |
Tobin KA et al. | Long-chain polyunsaturated fatty acid transport across human placental choriocarcinoma (BeWo) cells. | 2009 | Placenta | pmid:19010540 |
Serna-Saldivar SO et al. | Effect of DHA containing oils and powders on baking performance and quality of white pan bread. | 2006 | Plant Foods Hum Nutr | pmid:17031604 |
Jin F et al. | Supplementation of milled chia seeds increases plasma ALA and EPA in postmenopausal women. | 2012 | Plant Foods Hum Nutr | pmid:22538527 |
Metz JG et al. | Biochemical characterization of polyunsaturated fatty acid synthesis in Schizochytrium: release of the products as free fatty acids. | 2009 | Plant Physiol. Biochem. | pmid:19272783 |
Andersen MK et al. | Identification of Novel Genetic Determinants of Erythrocyte Membrane Fatty Acid Composition among Greenlanders. | 2016 | PLoS Genet. | pmid:27341449 |
Tikhonenko M et al. | N-3 polyunsaturated Fatty acids prevent diabetic retinopathy by inhibition of retinal vascular damage and enhanced endothelial progenitor cell reparative function. | 2013 | PLoS ONE | pmid:23383097 |
Rahman M et al. | Docosahexaenoic acid inhibits UVB-induced activation of NF-κB and expression of COX-2 and NOX-4 in HR-1 hairless mouse skin by blocking MSK1 signaling. | 2011 | PLoS ONE | pmid:22140508 |
Qin Y et al. | Fish Oil Supplements Lower Serum Lipids and Glucose in Correlation with a Reduction in Plasma Fibroblast Growth Factor 21 and Prostaglandin E2 in Nonalcoholic Fatty Liver Disease Associated with Hyperlipidemia: A Randomized Clinical Trial. | 2015 | PLoS ONE | pmid:26226139 |
Petrie JR et al. | Metabolic engineering plant seeds with fish oil-like levels of DHA. | 2012 | PLoS ONE | pmid:23145108 |
Polavarapu S et al. | Effect of polyunsaturated fatty acids and their metabolites on bleomycin-induced cytotoxic action on human neuroblastoma cells in vitro. | 2014 | PLoS ONE | pmid:25536345 |
Wales KM et al. | N-3 PUFAs protect against aortic inflammation and oxidative stress in angiotensin II-infused apolipoprotein E-/- mice. | 2014 | PLoS ONE | pmid:25398022 |
Jansen D et al. | Effects of specific multi-nutrient enriched diets on cerebral metabolism, cognition and neuropathology in AβPPswe-PS1dE9 mice. | 2013 | PLoS ONE | pmid:24086523 |
Abdelmoaty S et al. | Spinal actions of lipoxin A4 and 17(R)-resolvin D1 attenuate inflammation-induced mechanical hypersensitivity and spinal TNF release. | 2013 | PLoS ONE | pmid:24086560 |
Sugasini D and Subbaiah PV | Rate of acyl migration in lysophosphatidylcholine (LPC) is dependent upon the nature of the acyl group. Greater stability of sn-2 docosahexaenoyl LPC compared to the more saturated LPC species. | 2017 | PLoS ONE | pmid:29117232 |
Zhu G et al. | Enhanced production of docosahexaenoic acid in mammalian cells. | 2014 | PLoS ONE | pmid:24788769 |
Martin CR et al. | Resolvin D1 and lipoxin A4 improve alveolarization and normalize septal wall thickness in a neonatal murine model of hyperoxia-induced lung injury. | 2014 | PLoS ONE | pmid:24892762 |
Nakamoto K et al. | Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice. | 2017 | PLoS ONE | pmid:28723961 |
Musto AE et al. | Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin d1. | 2015 | PLoS ONE | pmid:25617763 |
Hsiao HM et al. | A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation. | 2013 | PLoS ONE | pmid:23484005 |
Chatterjee A et al. | The pro-resolving lipid mediator maresin 1 (MaR1) attenuates inflammatory signaling pathways in vascular smooth muscle and endothelial cells. | 2014 | PLoS ONE | pmid:25409514 |
Abe E et al. | Novel lysophospholipid acyltransferase PLAT1 of Aurantiochytrium limacinum F26-b responsible for generation of palmitate-docosahexaenoate-phosphatidylcholine and phosphatidylethanolamine. | 2014 | PLoS ONE | pmid:25090090 |
Mulder KA et al. | Omega-3 fatty acid deficiency in infants before birth identified using a randomized trial of maternal DHA supplementation in pregnancy. | 2014 | PLoS ONE | pmid:24427279 |
Shulse CN and Allen EE | Widespread occurrence of secondary lipid biosynthesis potential in microbial lineages. | 2011 | PLoS ONE | pmid:21629834 |
O'Flaherty JT et al. | 15-lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival. | 2012 | PLoS ONE | pmid:23029040 |
Xue B et al. | Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway. | 2012 | PLoS ONE | pmid:23071533 |
Kisos H et al. | Increased neuronal α-synuclein pathology associates with its accumulation in oligodendrocytes in mice modeling α-synucleinopathies. | 2012 | PLoS ONE | pmid:23077527 |
Joseph MS et al. | Effects of diet and/or exercise in enhancing spinal cord sensorimotor learning. | 2012 | PLoS ONE | pmid:22911773 |
Correia M et al. | Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid. | 2013 | PLoS ONE | pmid:23577140 |
Bonilla DL et al. | Incorporation of a dietary omega 3 fatty acid impairs murine macrophage responses to Mycobacterium tuberculosis. | 2010 | PLoS ONE | pmid:20526363 |
Kulkarni A et al. | Effects of altered maternal folic acid, vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats. | 2011 | PLoS ONE | pmid:21423696 |
Zhang X et al. | Resolvin D1 protects podocytes in adriamycin-induced nephropathy through modulation of 14-3-3β acetylation. | 2013 | PLoS ONE | pmid:23840712 |
Haas-Stapleton EJ et al. | Candida albicans modulates host defense by biosynthesizing the pro-resolving mediator resolvin E1. | 2007 | PLoS ONE | pmid:18091990 |
Markhus MW et al. | Low omega-3 index in pregnancy is a possible biological risk factor for postpartum depression. | 2013 | PLoS ONE | pmid:23844041 |
Bhatia HS et al. | Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood. | 2011 | PLoS ONE | pmid:22163304 |
Singh A et al. | Gene-metabolite expression in blood can discriminate allergen-induced isolated early from dual asthmatic responses. | 2013 | PLoS ONE | pmid:23844124 |
Arsenault D et al. | DHA improves cognition and prevents dysfunction of entorhinal cortex neurons in 3xTg-AD mice. | 2011 | PLoS ONE | pmid:21383850 |
Zúñiga J et al. | N-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: anti-inflammatory implications in liver ischemia-reperfusion injury. | 2011 | PLoS ONE | pmid:22174823 |
Sun YB et al. | Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney. | 2013 | PLoS ONE | pmid:24391884 |
Lee Y et al. | Analysis of endogenous lipids during intestinal wound healing. | 2017 | PLoS ONE | pmid:28800645 |
Nobili V et al. | Role of docosahexaenoic acid treatment in improving liver histology in pediatric nonalcoholic fatty liver disease. | 2014 | PLoS ONE | pmid:24505350 |
Katakura M et al. | Chronic Arachidonic Acid Administration Decreases Docosahexaenoic Acid- and Eicosapentaenoic Acid-Derived Metabolites in Kidneys of Aged Rats. | 2015 | PLoS ONE | pmid:26485038 |
Motter AL and Ahern GP | TRPA1 is a polyunsaturated fatty acid sensor in mammals. | 2012 | PLoS ONE | pmid:22723860 |
Astarita G et al. | Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. | 2010 | PLoS ONE | pmid:20838618 |
Giroud S et al. | Membrane phospholipid fatty acid composition regulates cardiac SERCA activity in a hibernator, the Syrian hamster (Mesocricetus auratus). | 2013 | PLoS ONE | pmid:23650545 |
Turk HF et al. | Alteration of EGFR spatiotemporal dynamics suppresses signal transduction. | 2012 | PLoS ONE | pmid:22761867 |
Baselga-Escudero L et al. | Chronic administration of proanthocyanidins or docosahexaenoic acid reverses the increase of miR-33a and miR-122 in dyslipidemic obese rats. | 2013 | PLoS ONE | pmid:23922812 |
Khairallah RJ et al. | Improved mitochondrial function with diet-induced increase in either docosahexaenoic acid or arachidonic acid in membrane phospholipids. | 2012 | PLoS ONE | pmid:22479624 |
Fecchio C et al. | α-Synuclein oligomers induced by docosahexaenoic acid affect membrane integrity. | 2013 | PLoS ONE | pmid:24312431 |
Jeckel KM et al. | Docosahexaenoic acid supplementation does not improve Western diet-induced cardiomyopathy in rats. | 2012 | PLoS ONE | pmid:23300587 |
Candelario J et al. | PTH1 receptor is involved in mediating cellular response to long-chain polyunsaturated fatty acids. | 2012 | PLoS ONE | pmid:23300710 |
Kjær MA et al. | Regulation of the Omega-3 Fatty Acid Biosynthetic Pathway in Atlantic Salmon Hepatocytes. | 2016 | PLoS ONE | pmid:27973547 |
Nuez-OrtÃn WG et al. | Preliminary Validation of a High Docosahexaenoic Acid (DHA) and -Linolenic Acid (ALA) Dietary Oil Blend: Tissue Fatty Acid Composition and Liver Proteome Response in Atlantic Salmon (Salmo salar) Smolts. | 2016 | PLoS ONE | pmid:27556399 |
Derogis PB et al. | The development of a specific and sensitive LC-MS-based method for the detection and quantification of hydroperoxy- and hydroxydocosahexaenoic acids as a tool for lipidomic analysis. | 2013 | PLoS ONE | pmid:24204871 |
Zhao Y et al. | Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease models. | 2011 | PLoS ONE | pmid:21246057 |
Khaddaj-Mallat R et al. | Pro-Resolving Effects of Resolvin D2 in LTD4 and TNF-α Pre-Treated Human Bronchi. | 2016 | PLoS ONE | pmid:27935998 |
Zhao Z et al. | The Association of Fatty Acid Levels and Gleason Grade among Men Undergoing Radical Prostatectomy. | 2016 | PLoS ONE | pmid:27880795 |
Gladine C et al. | Lipid profiling following intake of the omega 3 fatty acid DHA identifies the peroxidized metabolites F4-neuroprostanes as the best predictors of atherosclerosis prevention. | 2014 | PLoS ONE | pmid:24558496 |
Vedin I et al. | Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study. | 2012 | PLoS ONE | pmid:22545106 |
Gronroos NN et al. | Fish, fish-derived n-3 fatty acids, and risk of incident atrial fibrillation in the Atherosclerosis Risk in Communities (ARIC) study. | 2012 | PLoS ONE | pmid:22570739 |
Labrousse VF et al. | Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice. | 2012 | PLoS ONE | pmid:22662127 |
Mottola G et al. | Aspirin-triggered resolvin D1 attenuates PDGF-induced vascular smooth muscle cell migration via the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway. | 2017 | PLoS ONE | pmid:28362840 |
de Waal H et al. | The effect of souvenaid on functional brain network organisation in patients with mild Alzheimer's disease: a randomised controlled study. | 2014 | PLoS ONE | pmid:24475144 |
Eickmeier O et al. | Pro-resolving lipid mediator Resolvin D1 serves as a marker of lung disease in cystic fibrosis. | 2017 | PLoS ONE | pmid:28158236 |
Desai A et al. | Depletion of brain docosahexaenoic acid impairs recovery from traumatic brain injury. | 2014 | PLoS ONE | pmid:24475126 |
Correia M et al. | Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization. | 2012 | PLoS ONE | pmid:22529974 |