DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Brenna T et al. | Docosahexaenoic acid in translational medicine: the Tenth Fatty Acids and Cell Signaling meeting (FACS-10). | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23103099 |
| Galvao TF et al. | Marine n3 polyunsaturated fatty acids enhance resistance to mitochondrial permeability transition in heart failure but do not improve survival. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:23103493 |
| Tai EK et al. | An update on adding docosahexaenoic acid (DHA) and arachidonic acid (AA) to baby formula. | 2013 | Food Funct | pmid:24150114 |
| Miller BJ et al. | Dietary supplements for preventing postnatal depression. | 2013 | Cochrane Database Syst Rev | pmid:24158923 |
| Stamey Lanier J et al. | Mammary uptake of fatty acids supplied by intravenous triacylglycerol infusion to lactating dairy cows. | 2013 | Lipids | pmid:23504269 |
| Yang YC et al. | Docosahexaenoic acid inhibition of inflammation is partially via cross-talk between Nrf2/heme oxygenase 1 and IKK/NF-κB pathways. | 2013 | J. Nutr. Biochem. | pmid:22901690 |
| Tsuboi H et al. | Associations of depressive symptoms with serum proportions of palmitic and arachidonic acids, and α-tocopherol effects among male population--a preliminary study. | 2013 | Clin Nutr | pmid:22901744 |
| Lindberg M et al. | Long-term tracking of plasma phospholipid fatty acid concentrations and their correlation with the dietary intake of marine foods in newly diagnosed diabetic patients: results from a follow-up of the HUNT Study, Norway. | 2013 | Br. J. Nutr. | pmid:22846205 |
| Lund I et al. | Importance of DHA for first feeding pikeperch larvae--influence on behavioural responses. | 2013 | Commun. Agric. Appl. Biol. Sci. | pmid:25141683 |
| Mesa-Rodriguez A et al. | Effect of increasing DHA content in new weaning diets for longfin yellowtail (Seriola rivoliana). | 2013 | Commun. Agric. Appl. Biol. Sci. | pmid:25141689 |
| Miyashima A et al. | DHA requirement of larval Japanese flounder Paralichthys olivaceus in the rotifer feeding period. | 2013 | Commun. Agric. Appl. Biol. Sci. | pmid:25141691 |
| Botelho PB et al. | Effect of Echium oil compared with marine oils on lipid profile and inhibition of hepatic steatosis in LDLr knockout mice. | 2013 | Lipids Health Dis | pmid:23510369 |
| Drover JR et al. | Addendum to "Cognitive function in 18-month-old term infants of the DIAMOND study: a randomized, controlled clinical trial with multiple dietary levels of docosahexaenoic acid" [Early Hum. Dev. 87 (2011) 223-230]. | 2013 | Early Hum. Dev. | pmid:23411369 |
| Sundrani D et al. | Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases-1, -2 in placentas from preterm pregnancies and their association with one-carbon metabolites. | 2013 | Reproduction | pmid:23412981 |
| Chien KL et al. | A Taiwanese food frequency questionnaire correlates with plasma docosahexaenoic acid but not with plasma eicosapentaenoic acid levels: questionnaires and plasma biomarkers. | 2013 | BMC Med Res Methodol | pmid:23414574 |
| Del Bó C et al. | Horse meat consumption affects iron status, lipid profile and fatty acid composition of red blood cells in healthy volunteers. | 2013 | Int J Food Sci Nutr | pmid:23025273 |
| Lim SN et al. | Improved outcome after spinal cord compression injury in mice treated with docosahexaenoic acid. | 2013 | Exp. Neurol. | pmid:23026410 |
| Lau BY et al. | Investigating the role of polyunsaturated fatty acids in bone development using animal models. | 2013 | Molecules | pmid:24248147 |
| Scholtz SA et al. | Clinical overview of effects of dietary long-chain polyunsaturated fatty acids during the perinatal period. | 2013 | Nestle Nutr Inst Workshop Ser | pmid:24107504 |
| McNamara RK et al. | Low docosahexaenoic acid status is associated with reduced indices in cortical integrity in the anterior cingulate of healthy male children: a 1H MRS Study. | 2013 | Nutr Neurosci | pmid:23582513 |
| Berberovic E et al. | Arachidonic and docosahexaenoic acid in the blood of a mother and umbilical vein in diabetic pregnant women. | 2013 | J. Matern. Fetal. Neonatal. Med. | pmid:23480524 |
| Lee HN et al. | Resolvin D1 stimulates efferocytosis through p50/p50-mediated suppression of tumor necrosis factor-α expression. | 2013 | J. Cell. Sci. | pmid:23788426 |
| Araújo JR et al. | Gestational diabetes mellitus decreases placental uptake of long-chain polyunsaturated fatty acids: involvement of long-chain acyl-CoA synthetase. | 2013 | J. Nutr. Biochem. | pmid:23790250 |
| Bruins MJ et al. | Plasma oxylipin profiling identifies polyunsaturated vicinal diols as responsive to arachidonic acid and docosahexaenoic acid intake in growing piglets. | 2013 | J. Lipid Res. | pmid:23543770 |
| Calder PC | Editorial: Fat chance to enhance B cell function. | 2013 | J. Leukoc. Biol. | pmid:23547174 |
| Bruno MJ et al. | Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonation. | 2013 | Faraday Discuss. | pmid:23805753 |
| Jung SB et al. | Docosahexaenoic acid improves vascular function via up-regulation of SIRT1 expression in endothelial cells. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23806688 |
| Sun YB et al. | Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney. | 2013 | PLoS ONE | pmid:24391884 |
| Zhang X et al. | Resolvin D1 reverts lipopolysaccharide-induced TJ proteins disruption and the increase of cellular permeability by regulating IκBα signaling in human vascular endothelial cells. | 2013 | Oxid Med Cell Longev | pmid:24381712 |
| German OL et al. | Retinoid X receptor activation is essential for docosahexaenoic acid protection of retina photoreceptors. | 2013 | J. Lipid Res. | pmid:23723389 |
| Hiratsuka S et al. | Effects of dietary sialic acid in n-3 fatty acid-deficient dams during pregnancy and lactation on the learning abilities of their pups after weaning. | 2013 | J. Nutr. Sci. Vitaminol. | pmid:23727644 |
| Giroud S et al. | Membrane phospholipid fatty acid composition regulates cardiac SERCA activity in a hibernator, the Syrian hamster (Mesocricetus auratus). | 2013 | PLoS ONE | pmid:23650545 |
| Ostapchenko VG et al. | Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease. | 2013 | J. Neurochem. | pmid:23651058 |
| Ramkumar HL et al. | Nutrient supplementation with n3 polyunsaturated fatty acids, lutein, and zeaxanthin decrease A2E accumulation and VEGF expression in the retinas of Ccl2/Cx3cr1-deficient mice on Crb1rd8 background. | 2013 | J. Nutr. | pmid:23677863 |
| Liu Y et al. | Fish oil alleviates activation of the hypothalamic-pituitary-adrenal axis associated with inhibition of TLR4 and NOD signaling pathways in weaned piglets after a lipopolysaccharide challenge. | 2013 | J. Nutr. | pmid:24005609 |
| Li X et al. | Cyclooxygenase-2 induction in macrophages is modulated by docosahexaenoic acid via interactions with free fatty acid receptor 4 (FFA4). | 2013 | FASEB J. | pmid:24005906 |
| Gordon WC and Bazan NG | Mediator lipidomics in ophthalmology: targets for modulation in inflammation, neuroprotection and nerve regeneration. | 2013 | Curr. Eye Res. | pmid:23981028 |
| Nobili V et al. | Docosahexaenoic acid for the treatment of fatty liver: randomised controlled trial in children. | 2013 | Nutr Metab Cardiovasc Dis | pmid:23220074 |
| Chung ML et al. | Profiling of oxidized lipid products of marine fish under acute oxidative stress. | 2013 | Food Chem. Toxicol. | pmid:23220612 |
| van der Merwe LF et al. | Long-chain PUFA supplementation in rural African infants: a randomized controlled trial of effects on gut integrity, growth, and cognitive development. | 2013 | Am. J. Clin. Nutr. | pmid:23221579 |
| Hoshi T et al. | A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid. | 2013 | J. Gen. Physiol. | pmid:24127525 |
| Latorre R and Contreras G | Keeping you healthy: BK channel activation by omega-3 fatty acids. | 2013 | J. Gen. Physiol. | pmid:24127527 |
| Nagai T et al. | Actual ratios of triacylglycerol positional isomers and enantiomers comprising saturated fatty acids and highly unsaturated fatty acids in fishes and marine mammals. | 2013 | J Oleo Sci | pmid:24292353 |
| Zeilmaker MJ et al. | Fish consumption during child bearing age: a quantitative risk-benefit analysis on neurodevelopment. | 2013 | Food Chem. Toxicol. | pmid:22079313 |
| Denis I et al. | Omega-3 fatty acids and brain resistance to ageing and stress: body of evidence and possible mechanisms. | 2013 | Ageing Res. Rev. | pmid:23395782 |
| Yan Y et al. | Enhanced catalysis of Yarrowia lipolytica lipase LIP2 immobilized on macroporous resin and its application in enrichment of polyunsaturated fatty acids. | 2013 | Bioresour. Technol. | pmid:23347925 |
| Jaudszus A et al. | Evaluation of suppressive and pro-resolving effects of EPA and DHA in human primary monocytes and T-helper cells. | 2013 | J. Lipid Res. | pmid:23349208 |
| Gruszfeld D and Socha P | Early nutrition and health: short- and long-term outcomes. | 2013 | World Rev Nutr Diet | pmid:24029784 |
| Przyrembel H and Agostoni C | Growing-up milk: a necessity or marketing? | 2013 | World Rev Nutr Diet | pmid:24029786 |
| Lyons MR et al. | Impact of sex on the heart's metabolic and functional responses to diabetic therapies. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:24043256 |