DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yu Y et al. | DHA prevents altered 5-HT1A, 5-HT2A, CB1 and GABAA receptor binding densities in the brain of male rats fed a high-saturated-fat diet. | 2013 | J. Nutr. Biochem. | pmid:23337348 |
| Chen F et al. | Fish oil attenuates liver injury caused by LPS in weaned pigs associated with inhibition of TLR4 and nucleotide-binding oligomerization domain protein signaling pathways. | 2013 | Innate Immun | pmid:23339927 |
| Tikhonenko M et al. | N-3 polyunsaturated Fatty acids prevent diabetic retinopathy by inhibition of retinal vascular damage and enhanced endothelial progenitor cell reparative function. | 2013 | PLoS ONE | pmid:23383097 |
| Lee HJ et al. | Resolvin D1 inhibits TGF-β1-induced epithelial mesenchymal transition of A549 lung cancer cells via lipoxin A4 receptor/formyl peptide receptor 2 and GPR32. | 2013 | Int. J. Biochem. Cell Biol. | pmid:24120851 |
| Larson MK et al. | Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation. | 2013 | Am. J. Physiol., Cell Physiol. | pmid:23174566 |
| Mussi SV et al. | New approach to improve encapsulation and antitumor activity of doxorubicin loaded in solid lipid nanoparticles. | 2013 | Eur J Pharm Sci | pmid:23178339 |
| Braga SF and Almgren MM | Complementary therapies in cystic fibrosis: nutritional supplements and herbal products. | 2013 | J Pharm Pract | pmid:23178411 |
| Klingler M et al. | Comparison of the incorporation of orally administered DHA into plasma, erythrocyte and cheek cell glycerophospholipids. | 2013 | Br. J. Nutr. | pmid:22874641 |
| Robinson DT et al. | Docosahexaenoic and arachidonic acid levels in extremely low birth weight infants with prolonged exposure to intravenous lipids. | 2013 | J. Pediatr. | pmid:22878111 |
| Hu Y et al. | 15-Lipoxygenase-1-mediated metabolism of docosahexaenoic acid is required for syndecan-1 signaling and apoptosis in prostate cancer cells. | 2013 | Carcinogenesis | pmid:23066085 |
| Tang Y et al. | Proresolution therapy for the treatment of delayed healing of diabetic wounds. | 2013 | Diabetes | pmid:23043160 |
| Cedernaes J et al. | Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet. | 2013 | Lipids Health Dis | pmid:23298201 |
| Gillingham LG et al. | Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. | 2013 | Am. J. Clin. Nutr. | pmid:23221573 |
| Hong WK et al. | Production of lipids containing high levels of docosahexaenoic acid from empty palm fruit bunches by Aurantiochytrium sp. KRS101. | 2013 | Bioprocess Biosyst Eng | pmid:23053417 |
| Hjorth E et al. | Omega-3 fatty acids enhance phagocytosis of Alzheimer's disease-related amyloid-β42 by human microglia and decrease inflammatory markers. | 2013 | J. Alzheimers Dis. | pmid:23481688 |
| Lee MS et al. | Effects of eicosapentaenoic acid and docosahexaenoic acid on uncoupling protein 3 gene expression in C(2)C(12) muscle cells. | 2013 | Nutrients | pmid:23698161 |
| Kamolrat T and Gray SR | The effect of eicosapentaenoic and docosahexaenoic acid on protein synthesis and breakdown in murine C2C12 myotubes. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23438435 |
| Cieslik M et al. | Docosahexaenoic acid and tetracyclines as promising neuroprotective compounds with poly(ADP-ribose) polymerase inhibitory activities for oxidative/genotoxic stress treatment. | 2013 | Neurochem. Int. | pmid:23439385 |
| Oken E et al. | A pilot randomized controlled trial to promote healthful fish consumption during pregnancy: the Food for Thought Study. | 2013 | Nutr J | pmid:23496848 |
| Huang HL et al. | Docosahexaenoic acid in maternal and neonatal plasma phospholipids and milk lipids of Taiwanese women in Kinmen: fatty acid composition of maternal blood, neonatal blood and breast milk. | 2013 | Lipids Health Dis | pmid:23496882 |
| Kang JX and Gleason ED | Omega-3 Fatty acids and hippocampal neurogenesis in depression. | 2013 | CNS Neurol Disord Drug Targets | pmid:23574158 |
| Yamaguchi M et al. | Consumption of seafood, serum liver enzymes, and blood levels of PFOS and PFOA in the Japanese population. | 2013 | J Occup Health | pmid:23574777 |
| Correia M et al. | Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid. | 2013 | PLoS ONE | pmid:23577140 |
| Montes R et al. | Fatty-acid composition of maternal and umbilical cord plasma and early childhood atopic eczema in a Spanish cohort. | 2013 | Eur J Clin Nutr | pmid:23549201 |
| Emmett R et al. | Expanding awareness of docosahexaenoic acid during pregnancy. | 2013 | Nutrients | pmid:23549329 |
| Haller MJ et al. | Autologous umbilical cord blood infusion followed by oral docosahexaenoic acid and vitamin D supplementation for C-peptide preservation in children with Type 1 diabetes. | 2013 | Biol. Blood Marrow Transplant. | pmid:23611977 |
| Berman DR et al. | Docosahexaenoic acid augments hypothermic neuroprotection in a neonatal rat asphyxia model. | 2013 | Neonatology | pmid:23817197 |
| Singhal A et al. | Docosahexaenoic acid supplementation, vascular function and risk factors for cardiovascular disease: a randomized controlled trial in young adults. | 2013 | J Am Heart Assoc | pmid:23817470 |
| Kiernan M et al. | The effect of the in vitro supplementation of exogenous long-chain fatty acids on bovine sperm cell function. | 2013 | Reprod. Fertil. Dev. | pmid:23036717 |
| Hoss E et al. | Control of late cornified envelope genes relevant to psoriasis risk: upregulation by 1,25-dihydroxyvitamin D3 and plant-derived delphinidin. | 2013 | Arch. Dermatol. Res. | pmid:23839497 |
| Devaraj S et al. | Modulation of endothelial progenitor cell number and function with n-3 polyunsaturated fatty acids. | 2013 | Atherosclerosis | pmid:23528830 |
| Finlin BS et al. | Regulation of thrombospondin-1 expression in alternatively activated macrophages and adipocytes: role of cellular cross talk and omega-3 fatty acids. | 2013 | J. Nutr. Biochem. | pmid:23528972 |
| Rashid MA et al. | N-Docosahexaenoylethanolamine is a potent neurogenic factor for neural stem cell differentiation. | 2013 | J. Neurochem. | pmid:23570577 |
| Xie W et al. | Resolvin D1 reduces deterioration of tight junction proteins by upregulating HO-1 in LPS-induced mice. | 2013 | Lab. Invest. | pmid:23857007 |
| Li Q et al. | A comparative study: In vitro effects of EPA and DHA on immune functions of head-kidney macrophages isolated from large yellow croaker (Larmichthys crocea). | 2013 | Fish Shellfish Immunol. | pmid:23859878 |
| Chen S and Subbaiah PV | Regioisomers of phosphatidylcholine containing DHA and their potential to deliver DHA to the brain: role of phospholipase specificities. | 2013 | Lipids | pmid:23604781 |
| Klek S et al. | Four-week parenteral nutrition using a third generation lipid emulsion (SMOFlipid)--a double-blind, randomised, multicentre study in adults. | 2013 | Clin Nutr | pmid:22796064 |
| Kitson AP et al. | Treatment of ovariectomized rats with 17β-estradiol increases hepatic delta-6 desaturase enzyme expression and docosahexaenoic acid levels in hepatic and plasma phospholipids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23764042 |
| Taha AY et al. | A minimum of 3 months of dietary fish oil supplementation is required to raise amygdaloid afterdischarge seizure thresholds in rats--implications for treating complex partial seizures. | 2013 | Epilepsy Behav | pmid:23376336 |
| Chen J et al. | Docosahexaenoic acid (DHA) attenuated paraquat induced lung damage in mice. | 2013 | Inhal Toxicol | pmid:23293968 |
| Figueroa JD et al. | Dietary omega-3 polyunsaturated fatty acids improve the neurolipidome and restore the DHA status while promoting functional recovery after experimental spinal cord injury. | 2013 | J. Neurotrauma | pmid:23294084 |
| Opperman M and Benade S | Analysis of the omega-3 fatty acid content of South African fish oil supplements: a follow-up study. | 2013 | Cardiovasc J Afr | pmid:24240381 |
| Begum G et al. | ER stress and effects of DHA as an ER stress inhibitor. | 2013 | Transl Stroke Res | pmid:24323417 |
| Rosa A et al. | Potential anti-tumor effects of Mugil cephalus processed roe extracts on colon cancer cells. | 2013 | Food Chem. Toxicol. | pmid:23948356 |
| Bjorgvinsdottir L et al. | Do high levels of n-3 polyunsaturated fatty acids in cell membranes increase the risk of postoperative atrial fibrillation? | 2013 | Cardiology | pmid:23948862 |
| Lee AL and Park Y | The association between n-3 polyunsaturated fatty acid levels in erythrocytes and the risk of rheumatoid arthritis in Korean women. | 2013 | Ann. Nutr. Metab. | pmid:23949659 |
| Storck Lindholm E et al. | Different fatty acid pattern in breast milk of obese compared to normal-weight mothers. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23273824 |
| Atwell K et al. | Respiratory hospitalisation of infants supplemented with docosahexaenoic acid as preterm neonates. | 2013 | J Paediatr Child Health | pmid:23279074 |
| Marcon R et al. | Maresin 1, a proresolving lipid mediator derived from omega-3 polyunsaturated fatty acids, exerts protective actions in murine models of colitis. | 2013 | J. Immunol. | pmid:24038091 |
| Engel S et al. | Docosahexaenoic acid status at 9 months is inversely associated with communicative skills in 3-year-old girls. | 2013 | Matern Child Nutr | pmid:22642227 |