Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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van Goor SA et al. | The influence of supplemental docosahexaenoic and arachidonic acids during pregnancy and lactation on neurodevelopment at eighteen months. | 2011 May-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21316208 |
Kilari A et al. | Associations of long-chain polyunsaturated fatty acid concentrations with birth outcome in term Indian mothers and their neonates. | 2011 May-Jun | Am. J. Hum. Biol. | pmid:21484911 |
Jones JL et al. | A Mediterranean-style low-glycemic-load diet improves variables of metabolic syndrome in women, and addition of a phytochemical-rich medical food enhances benefits on lipoprotein metabolism. | 2011 May-Jun | J Clin Lipidol | pmid:21600524 |
Gladyshev MI et al. | Effect of water temperature on the content of essential polyunsaturated fatty acids in freshwater zooplankton. | 2011 Mar-Apr | Dokl. Biochem. Biophys. | pmid:21590375 |
Larson MK et al. | Omega-3 fatty acids modulate collagen signaling in human platelets. | 2011 Mar-Apr | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21177087 |
McDaniel JC et al. | Fish oil supplementation alters levels of lipid mediators of inflammation in microenvironment of acute human wounds. | 2011 Mar-Apr | Wound Repair Regen | pmid:21362086 |
Lam YY et al. | Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: the effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids. | 2011 Jul-Aug | Biochim. Biophys. Acta | pmid:21570480 |
Mason CM et al. | Prescription omega-3s: an overview for nurse practitioners. | 2011 Jul-Aug | J Cardiovasc Nurs | pmid:21666421 |
Gao F et al. | Liver conversion of docosahexaenoic and arachidonic acids from their 18-carbon precursors in rats on a DHA-free but α-LNA-containing n-3 PUFA adequate diet. | 2011 Jul-Aug | Biochim. Biophys. Acta | pmid:21651989 |
Trimarco B et al. | [The Alpha Omega study]. | 2011 Jul-Aug | G Ital Cardiol (Rome) | pmid:21779112 |
Lamaziere A et al. | Differential distribution of DHA-phospholipids in rat brain after feeding: A lipidomic approach. | 2011 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21109411 |
Vilaseca MA et al. | Long-chain polyunsaturated fatty acid concentration in patients with inborn errors of metabolism. | 2011 Jan-Feb | Nutr Hosp | pmid:21519739 |
Sato SB et al. | Differential roles of internal and terminal double bonds in docosahexaenoic acid: Comparative study of cytotoxicity of polyunsaturated fatty acids to HT-29 human colorectal tumor cell line. | 2011 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20952172 |
Kulkarni AV et al. | Reduced placental docosahexaenoic acid levels associated with increased levels of sFlt-1 in preeclampsia. | 2011 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20956072 |
Leon MM et al. | [Resolution of inflammation--pharmacological aspects]. | 2011 Apr-Jun | Rev Med Chir Soc Med Nat Iasi | pmid:21870743 |
Yang R et al. | Metabolomics-lipidomics of eicosanoids and docosanoids generated by phagocytes. | 2011 | Curr Protoc Immunol | pmid:22048801 |
Solakivi T et al. | Serum fatty acid profile in subjects with irritable bowel syndrome. | 2011 | Scand. J. Gastroenterol. | pmid:21073373 |
Vasickova L et al. | Possible effect of DHA intake on body weight reduction and lipid metabolism in obese children. | 2011 | Neuro Endocrinol. Lett. | pmid:22101886 |
Amano T et al. | Impact of omega-3 polyunsaturated fatty acids on coronary plaque instability: an integrated backscatter intravascular ultrasound study. | 2011 | Atherosclerosis | pmid:21684546 |
Morin C et al. | Docosahexaenoic acid derivative prevents inflammation and hyperreactivity in lung: implication of PKC-Potentiated inhibitory protein for heterotrimeric myosin light chain phosphatase of 17 kD in asthma. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:21057106 |
Yui K et al. | [Therapeutic effects of larger doses of arachidonic acid added to DHA on social impairment and its relation to alterations of polyunsaturated fatty acids in individuals with autism spectrum disorders]. | 2011 | Nihon Shinkei Seishin Yakurigaku Zasshi | pmid:21800702 |
Stoeckel K et al. | Fatty acid patterns of dog erythrocyte membranes after feeding of a fish-oil based DHA-rich supplement with a base diet low in n-3 fatty acids versus a diet containing added n-3 fatty acids. | 2011 | Acta Vet. Scand. | pmid:22024384 |
Curatolo N et al. | Oral administration of docosahexaenoic acid/eicosapentaeinoic acids is not anticonvulsant in rats: implications for translational research. | 2011 | Pediatr. Res. | pmid:21857379 |
Bazan NG et al. | Endogenous signaling by omega-3 docosahexaenoic acid-derived mediators sustains homeostatic synaptic and circuitry integrity. | 2011 | Mol. Neurobiol. | pmid:21918832 |
Schuchardt JP et al. | Moderate doses of EPA and DHA from re-esterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: Results from a six month randomized controlled trial. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21862301 |
Sanders TA et al. | Effect of low doses of long-chain n-3 PUFAs on endothelial function and arterial stiffness: a randomized controlled trial. | 2011 | Am. J. Clin. Nutr. | pmid:21865334 |
Altenburg JD et al. | A novel 2,6-diisopropylphenyl-docosahexaenoamide conjugate induces apoptosis in T cell acute lymphoblastic leukemia cell lines. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21749860 |
Westerberg AC et al. | Attention among very low birth weight infants following early supplementation with docosahexaenoic and arachidonic acid. | 2011 | Acta Paediatr. | pmid:20624152 |
Frisardi V et al. | Glycerophospholipids and glycerophospholipid-derived lipid mediators: a complex meshwork in Alzheimer's disease pathology. | 2011 | Prog. Lipid Res. | pmid:21703303 |
Brignardello J et al. | Increase of plasma fatty acids without changes in n-6/n-3-PUFA ratio in asymptomatic obese subjects. | 2011 | Arch Latinoam Nutr | pmid:22308941 |
Walczewska A et al. | [The role of docosahexaenoic acid in neuronal function]. | 2011 | Postepy Hig Med Dosw (Online) | pmid:21677356 |
Davis-Bruno K and Tassinari MS | Essential fatty acid supplementation of DHA and ARA and effects on neurodevelopment across animal species: a review of the literature. | 2011 | Birth Defects Res. B Dev. Reprod. Toxicol. | pmid:21678548 |
Klingler M et al. | Fatty acid status determination by cheek cell sampling combined with methanol-based ultrasound extraction of glycerophospholipids. | 2011 | Lipids | pmid:21681560 |
Kim HY et al. | A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21810478 |
Friedrichs W et al. | Omega-3 fatty acid inhibition of prostate cancer progression to hormone independence is associated with suppression of mTOR signaling and androgen receptor expression. | 2011 | Nutr Cancer | pmid:21667400 |
Sakayori N et al. | Distinctive effects of arachidonic acid and docosahexaenoic acid on neural stem /progenitor cells. | 2011 | Genes Cells | pmid:21668588 |
Jing K et al. | Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53. | 2011 | Autophagy | pmid:21811093 |
Zargar A and Ito MK | Long chain omega-3 dietary supplements: a review of the National Library of Medicine Herbal Supplement Database. | 2011 | Metab Syndr Relat Disord | pmid:21787228 |
Garcia C et al. | French mothers' milk deficient in DHA contains phospholipid species of potential interest for infant development. | 2011 | J. Pediatr. Gastroenterol. Nutr. | pmid:21788764 |
Hu H et al. | Isolation and characterization of a mesophilic Arthrospira maxima strain capable of producing docosahexaenoic acid. | 2011 | J. Microbiol. Biotechnol. | pmid:21791955 |
Abu-Saad K et al. | Rapid assessment tools for ranking pregnant minority women into multi-nutrient exposure groups. | 2011 | Public Health Nutr | pmid:20519048 |
McGee SL et al. | DHA protects against zinc mediated alterations in neuronal cellular bioenergetics. | 2011 | Cell. Physiol. Biochem. | pmid:21865858 |
Ethier S et al. | Continuous culture of the microalgae Schizochytrium limacinum on biodiesel-derived crude glycerol for producing docosahexaenoic acid. | 2011 | Bioresour. Technol. | pmid:20570140 |
Serhan CN et al. | Novel proresolving aspirin-triggered DHA pathway. | 2011 | Chem. Biol. | pmid:21867913 |
O'Sullivan TA et al. | Dietary intake and food sources of fatty acids in Australian adolescents. | 2011 | Nutrition | pmid:20338727 |
Boucher O et al. | Neurophysiologic and neurobehavioral evidence of beneficial effects of prenatal omega-3 fatty acid intake on memory function at school age. | 2011 | Am. J. Clin. Nutr. | pmid:21389181 |
Grant GE et al. | Enhanced formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by cancer cells in response to oxidative stress, docosahexaenoic acid and neutrophil-derived 5-hydroxy-6,8,11,14-eicosatetraenoic acid. | 2011 | Carcinogenesis | pmid:21393477 |
Trofimiuk E and Braszko JJ | Long-term administration of cod liver oil ameliorates cognitive impairment induced by chronic stress in rats. | 2011 | Lipids | pmid:21442272 |
Chauveau F et al. | Brain-targeting form of docosahexaenoic acid for experimental stroke treatment: MRI evaluation and anti-oxidant impact. | 2011 | Curr Neurovasc Res | pmid:21443458 |
Collins CT et al. | Pre- and post-term growth in pre-term infants supplemented with higher-dose DHA: a randomised controlled trial. | 2011 | Br. J. Nutr. | pmid:21443815 |
Sala-Vila A et al. | Determinants of the omega-3 index in a Mediterranean population at increased risk for CHD. | 2011 | Br. J. Nutr. | pmid:21450116 |
Vincentini O et al. | Docosahexaenoic acid modulates in vitro the inflammation of celiac disease in intestinal epithelial cells via the inhibition of cPLA2. | 2011 | Clin Nutr | pmid:21421277 |
Fedorova-Dahms I et al. | Safety evaluation of DHA-rich Algal Oil from Schizochytrium sp. | 2011 | Food Chem. Toxicol. | pmid:21914458 |
Lebbadi M et al. | Endogenous conversion of omega-6 into omega-3 fatty acids improves neuropathology in an animal model of Alzheimer's disease. | 2011 | J. Alzheimers Dis. | pmid:21914946 |
Kuan CY et al. | Long-chain polyunsaturated fatty acids promote paclitaxel cytotoxicity via inhibition of the MDR1 gene in the human colon cancer Caco-2 cell line. | 2011 | J Am Coll Nutr | pmid:21917707 |
Hashimoto M et al. | Protective effects of prescription n-3 fatty acids against impairment of spatial cognitive learning ability in amyloid β-infused rats. | 2011 | Food Funct | pmid:21894325 |
Ladesich JB et al. | Membrane level of omega-3 docosahexaenoic acid is associated with severity of obstructive sleep apnea. | 2011 | J Clin Sleep Med | pmid:21897776 |
Raatz SK et al. | Baking reduces prostaglandin, resolvin, and hydroxy-fatty acid content of farm-raised Atlantic salmon (Salmo salar). | 2011 | J. Agric. Food Chem. | pmid:21919483 |
Wiedemann HP | Fish oil is not the fix for acute lung injury. | 2011 | Crit. Care Med. | pmid:21685749 |
Berry KA et al. | MALDI imaging MS of phospholipids in the mouse lung. | 2011 | J. Lipid Res. | pmid:21508254 |
Nochera CL et al. | Consumption of DHA + EPA by low-income women during pregnancy and lactation. | 2011 | Nutr Clin Pract | pmid:21724916 |
Klebanoff MA et al. | Fish consumption, erythrocyte fatty acids, and preterm birth. | 2011 | Obstet Gynecol | pmid:21508745 |
Bento AF et al. | Omega-3 fatty acid-derived mediators 17(R)-hydroxy docosahexaenoic acid, aspirin-triggered resolvin D1 and resolvin D2 prevent experimental colitis in mice. | 2011 | J. Immunol. | pmid:21724996 |
Altenburg JD et al. | A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone. | 2011 | BMC Cancer | pmid:21510869 |
Mancini I et al. | Fatty acid composition of common barbel (Barbus barbus) roe and evaluation of its haemolytic and cytotoxic activities. | 2011 | Toxicon | pmid:21510968 |
Hadders-Algra M | Prenatal and early postnatal supplementation with long-chain polyunsaturated fatty acids: neurodevelopmental considerations. | 2011 | Am. J. Clin. Nutr. | pmid:21525202 |
Rapoport SI et al. | Docosahexaenoic acid (DHA) incorporation into the brain from plasma, as an in vivo biomarker of brain DHA metabolism and neurotransmission. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21704722 |
Escolano-Margarit MV et al. | Prenatal DHA status and neurological outcome in children at age 5.5 years are positively associated. | 2011 | J. Nutr. | pmid:21525247 |
Rockett BD et al. | Membrane raft organization is more sensitive to disruption by (n-3) PUFA than nonraft organization in EL4 and B cells. | 2011 | J. Nutr. | pmid:21525263 |
Siddiqui NF et al. | Enhanced generation of megakaryocytes from umbilical cord blood-derived CD34(+) cells expanded in the presence of two nutraceuticals, docosahexanoic acid and arachidonic acid, as supplements to the cytokine-containing medium. | 2011 | Cytotherapy | pmid:20230224 |
Decsi T and Kennedy K | Sex-specific differences in essential fatty acid metabolism. | 2011 | Am. J. Clin. Nutr. | pmid:22089435 |
Sengupta A and Ghosh M | Integrity of erythrocytes of hypercholesterolemic and normocholesterolemic rats during ingestion of different structured lipids. | 2011 | Eur J Nutr | pmid:21127890 |
Lin YH et al. | Altered essential fatty acid metabolism and composition in rat liver, plasma, heart and brain after microalgal DHA addition to the diet. | 2011 | J. Nutr. Biochem. | pmid:21111595 |
Pomponi MF et al. | Why docosahexaenoic acid and aspirin supplementation could be useful in women as a primary prevention therapy against Alzheimer's disease? | 2011 | Ageing Res. Rev. | pmid:20920611 |
Wojcicki JM and Heyman MB | Maternal omega-3 fatty acid supplementation and risk for perinatal maternal depression. | 2011 | J. Matern. Fetal. Neonatal. Med. | pmid:20925595 |
Kim SH et al. | Prospective randomized comparison between omega-3 fatty acid supplements plus simvastatin versus simvastatin alone in Korean patients with mixed dyslipidemia: lipoprotein profiles and heart rate variability. | 2011 | Eur J Clin Nutr | pmid:20877395 |
Myhrstad MC et al. | Effect of the fat composition of a single high-fat meal on inflammatory markers in healthy young women. | 2011 | Br. J. Nutr. | pmid:21736782 |
Zhao J et al. | Deposition of docosahexaenoic acid (DHA) is limited in forebrain of young obese fa/fa Zucker rats fed a diet high in α-linolenic acid but devoid of DHA. | 2011 | J. Nutr. Biochem. | pmid:21129946 |
Teichert SA and Akoh CC | Modifications of stearidonic acid soybean oil by enzymatic acidolysis for the production of human milk fat analogues. | 2011 | J. Agric. Food Chem. | pmid:22097918 |
Huang L et al. | Enduring prevention and transient reduction of postoperative pain by intrathecal resolvin D1. | 2011 | Pain | pmid:21255928 |
van der Pols JC et al. | Serum omega-3 and omega-6 fatty acids and cutaneous p53 expression in an Australian population. | 2011 | Cancer Epidemiol. Biomarkers Prev. | pmid:21217086 |
Poudel-Tandukar K et al. | Long chain n-3 fatty acids intake, fish consumption and suicide in a cohort of Japanese men and women--the Japan Public Health Center-based (JPHC) prospective study. | 2011 | J Affect Disord | pmid:20692041 |
Mariee AD and Abd-Ellah MF | Protective effect of docosahexaenoic acid against cyclosporine A-induced nephrotoxicity in rats: a possible mechanism of action. | 2011 | Ren Fail | pmid:21219208 |
Safarinejad MR | Effect of omega-3 polyunsaturated fatty acid supplementation on semen profile and enzymatic anti-oxidant capacity of seminal plasma in infertile men with idiopathic oligoasthenoteratospermia: a double-blind, placebo-controlled, randomised study. | 2011 | Andrologia | pmid:21219381 |
Cotogni P et al. | Impact of the omega-3 to omega-6 polyunsaturated fatty acid ratio on cytokine release in human alveolar cells. | 2011 | JPEN J Parenter Enteral Nutr | pmid:21224438 |
Burrows T et al. | Omega-3 index, obesity and insulin resistance in children. | 2011 | Int J Pediatr Obes | pmid:21226540 |
Zhao Y et al. | Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease models. | 2011 | PLoS ONE | pmid:21246057 |
Gomez-Pinilla F | The combined effects of exercise and foods in preventing neurological and cognitive disorders. | 2011 | Prev Med | pmid:21281667 |
The brainy omega-3 fails an Alzheimer's test. | 2011 | Harv Health Lett | pmid:21344681 | |
Itoh T et al. | Efficient synthesis of the very-long-chain n-3 fatty acids, tetracosahexaenoic acid (C24:6n-3) and tricosahexaenoic acid (C23:6n-3). | 2011 | Lipids | pmid:21347745 |
Shimshoni JA et al. | Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorder. | 2011 | Biochim. Biophys. Acta | pmid:21184843 |
Serini S et al. | Docosahexaenoic acid reverts resistance to UV-induced apoptosis in human keratinocytes: involvement of COX-2 and HuR. | 2011 | J. Nutr. Biochem. | pmid:21185708 |
Wang RX et al. | Activation of vascular BK channels by docosahexaenoic acid is dependent on cytochrome P450 epoxygenase activity. | 2011 | Cardiovasc. Res. | pmid:21187320 |
Riedel M et al. | Membrane lipid modification by docosahexaenoic acid (DHA) promotes the formation of α-synuclein inclusion bodies immunopositive for SUMO-1 in oligodendroglial cells after oxidative stress. | 2011 | J. Mol. Neurosci. | pmid:20725866 |
Hamazaki K et al. | Docosahexaenoic acid is an independent predictor of all-cause mortality in hemodialysis patients. | 2011 | Am. J. Nephrol. | pmid:21196723 |
Cho JY et al. | Oral administration of docosahexaenoic acid attenuates colitis induced by dextran sulfate sodium in mice. | 2011 | Mol Nutr Food Res | pmid:20824662 |
Pawlik D et al. | Fish-oil fat emulsion supplementation may reduce the risk of severe retinopathy in VLBW infants. | 2011 | Pediatrics | pmid:21199856 |
Turk HF et al. | Linoleic acid and butyrate synergize to increase Bcl-2 levels in colonocytes. | 2011 | Int. J. Cancer | pmid:20232381 |
Ji RR et al. | Emerging roles of resolvins in the resolution of inflammation and pain. | 2011 | Trends Neurosci. | pmid:21963090 |
Toufektsian MC et al. | Dietary flavonoids increase plasma very long-chain (n-3) fatty acids in rats. | 2011 | J. Nutr. | pmid:21068183 |