DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Vyncke KE et al. | Intake and serum profile of fatty acids are weakly correlated with global dietary quality in European adolescents. | 2013 | Nutrition | pmid:23312763 |
| Lotrich FE et al. | Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids. | 2013 | J Psychosom Res | pmid:24182638 |
| Murphy EJ | A lipid neurochemist's siren: docosahexaenoic acid and its elusive function in the central nervous system. | 2013 | J. Neurochem. | pmid:24117623 |
| Flock MR et al. | Long-chain omega-3 fatty acids: time to establish a dietary reference intake. | 2013 | Nutr. Rev. | pmid:24117792 |
| Nozue T et al. | Effects of statins on serum n-3 to n-6 polyunsaturated fatty acid ratios in patients with coronary artery disease. | 2013 | J. Cardiovasc. Pharmacol. Ther. | pmid:23324995 |
| Méndez L et al. | Reduced protein oxidation in Wistar rats supplemented with marine ω3 PUFAs. | 2013 | Free Radic. Biol. Med. | pmid:23159545 |
| Cooke M et al. | Expression and function of OXE receptor, an eicosanoid receptor, in steroidogenic cells. | 2013 | Mol. Cell. Endocrinol. | pmid:23159987 |
| Al-Hilal M et al. | Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement. | 2013 | J. Lipid Res. | pmid:23160180 |
| Cao AH et al. | Composition of long chain polyunsaturated fatty acids (LC-PUFAs) in different encephalic regions and its association with behavior in spontaneous hypertensive rat (SHR). | 2013 | Brain Res. | pmid:23811335 |
| Tu WC et al. | Dietary alpha-linolenic acid does not enhance accumulation of omega-3 long-chain polyunsaturated fatty acids in barramundi (Lates calcarifer). | 2013 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:23085323 |
| Lagarde M et al. | Dose-effect and metabolism of docosahexaenoic acid: pathophysiological relevance in blood platelets. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22520055 |
| Lohner S et al. | Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. | 2013 | Ann. Nutr. Metab. | pmid:23327902 |
| Kondo T et al. | Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. | 2013 | Cell Stem Cell | pmid:23434393 |
| MacIntosh BA et al. | Low-n-6 and low-n-6 plus high-n-3 diets for use in clinical research. | 2013 | Br. J. Nutr. | pmid:23328113 |
| GarcÃa-Layana A et al. | Effects of lutein and docosahexaenoic Acid supplementation on macular pigment optical density in a randomized controlled trial. | 2013 | Nutrients | pmid:23434908 |
| Williams JJ et al. | N-3 fatty acid rich triglyceride emulsions are neuroprotective after cerebral hypoxic-ischemic injury in neonatal mice. | 2013 | PLoS ONE | pmid:23437099 |
| Carey AN et al. | The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. | 2013 | Nutr Neurosci | pmid:23321679 |
| Kimura AK and Kim HY | Phosphatidylserine synthase 2: high efficiency for synthesizing phosphatidylserine containing docosahexaenoic acid. | 2013 | J. Lipid Res. | pmid:23071296 |
| Pettit LK et al. | Modulating the inflammatory properties of activated microglia with Docosahexaenoic acid and Aspirin. | 2013 | Lipids Health Dis | pmid:23398903 |
| Sugasini D and Lokesh BR | Enhanced incorporation of docosahexaenoic acid in serum, heart, and brain of rats given microemulsions of fish oil. | 2013 | Mol. Cell. Biochem. | pmid:23812902 |
| Fukui M et al. | EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: role of ROS accumulation, caspase-8 activation, and autophagy induction. | 2013 | J. Cell. Biochem. | pmid:22903547 |
| Stark MJ et al. | Differential effects of docosahexaenoic acid on preterm and term placental pro-oxidant/antioxidant balance. | 2013 | Reproduction | pmid:23813449 |
| Rupp TP et al. | Replacement of reduced highly unsaturated fatty acids (HUFA deficiency) in dilative heart failure: dosage of EPA/DHA and variability of adverse peroxides and aldehydes in dietary supplement fish oils. | 2013 | Cardiology | pmid:23816637 |
| Wu Z et al. | Reduction of histamine H1 receptor binding induced by high-fat diet can be prevented by DHA and dietary fiber in specific brain areas of male rats. | 2013 | Brain Res. Bull. | pmid:23817050 |
| Friedman AN et al. | Fatty acids and other risk factors for sudden cardiac death in patients starting hemodialysis. | 2013 | Am. J. Nephrol. | pmid:23816975 |
| Gódor-Kacsándi A et al. | Developmental docosahexaenoic and arachidonic acid supplementation improves adult learning and increases resistance against excitotoxicity in the brain. | 2013 | Acta Physiol Hung | pmid:23524180 |
| Meijerink J et al. | N-Acyl amines of docosahexaenoic acid and other n-3 polyunsatured fatty acids - from fishy endocannabinoids to potential leads. | 2013 | Br. J. Pharmacol. | pmid:23088259 |
| Simões T et al. | Seasonal variation in proximate composition and fatty acid profile of grey triggerfish (Balistes capriscus) captured along the coast of Portugal. | 2013 | J. Food Sci. | pmid:23551246 |
| Guihéneuf F et al. | Use of radiolabeled substrates to determine the desaturase and elongase activities involved in eicosapentaenoic acid and docosahexaenoic acid biosynthesis in the marine microalga Pavlova lutheri. | 2013 | Phytochemistry | pmid:23528573 |
| Davidson MH | Omega-3 fatty acids: new insights into the pharmacology and biology of docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid. | 2013 | Curr. Opin. Lipidol. | pmid:24184945 |
| Kagan ML et al. | Acute appearance of fatty acids in human plasma--a comparative study between polar-lipid rich oil from the microalgae Nannochloropsis oculata and krill oil in healthy young males. | 2013 | Lipids Health Dis | pmid:23855409 |
| Lee HN and Surh YJ | Resolvin D1-mediated NOX2 inactivation rescues macrophages undertaking efferocytosis from oxidative stress-induced apoptosis. | 2013 | Biochem. Pharmacol. | pmid:23856291 |
| Mizia-Stec K et al. | N-3 polyunsaturated fatty acids do not influence the efficacy of dual antiplatelet therapy in stable angina pectoris patients after percutaneous coronary intervention. | 2013 | Cardiol J | pmid:24469870 |
| Eickmeier O et al. | Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury. | 2013 | Mucosal Immunol | pmid:22785226 |
| Hunina LM et al. | [Effectiveness of use of omega-3 polyunsaturated fatty acids at physical loads]. | 2013 | Fiziol Zh | pmid:23713352 |
| Dangour AD et al. | N-3 fatty acids and retinal function. | 2013 | Ophthalmology | pmid:23714605 |
| Qu L et al. | Batch, fed-batch and repeated fed-batch fermentation processes of the marine thraustochytrid Schizochytrium sp. for producing docosahexaenoic acid. | 2013 | Bioprocess Biosyst Eng | pmid:23673897 |
| Harris WS et al. | Docosahexaenoic acid ethyl esters ineffective? | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23671065 |
| Fecchio C et al. | α-Synuclein oligomers induced by docosahexaenoic acid affect membrane integrity. | 2013 | PLoS ONE | pmid:24312431 |
| Trofimiuk E and Braszko JJ | Concomitant docosahexaenoic acid administration ameliorates stress-induced cognitive impairment in rats. | 2013 | Physiol. Behav. | pmid:23672853 |
| Dabkowski ER et al. | Docosahexaenoic acid supplementation alters key properties of cardiac mitochondria and modestly attenuates development of left ventricular dysfunction in pressure overload-induced heart failure. | 2013 | Cardiovasc Drugs Ther | pmid:24013804 |
| Porta A et al. | Biology and chemistry of neuroprostanes. First total synthesis of 17-A4-NeuroP: validation of a convergent strategy to a number of cyclopentenone neuroprostanes. | 2013 | Chem. Phys. Lipids | pmid:23895793 |
| Costa S et al. | The emerging farmed fish species meagre (Argyrosomus regius): how culinary treatment affects nutrients and contaminants concentration and associated benefit-risk balance. | 2013 | Food Chem. Toxicol. | pmid:23900006 |
| Gibson RA et al. | Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22515943 |
| Yee LD et al. | The inhibition of early stages of HER-2/neu-mediated mammary carcinogenesis by dietary n-3 PUFAs. | 2013 | Mol Nutr Food Res | pmid:23213007 |
| Qu L et al. | Biomass composition, lipid characterization, and metabolic profile analysis of the fed-batch fermentation process of two different docosahexanoic acid producing Schizochytrium sp. strains. | 2013 | Appl. Biochem. Biotechnol. | pmid:24061873 |
| Becerir C et al. | The protective effect of docosahexaenoic acid on the bilirubin neurotoxicity. | 2013 | J Enzyme Inhib Med Chem | pmid:22591320 |
| Siddiqui RA et al. | Characterization of synergistic anti-cancer effects of docosahexaenoic acid and curcumin on DMBA-induced mammary tumorigenesis in mice. | 2013 | BMC Cancer | pmid:24034496 |
| Borghetti G et al. | Tumor growth reduction is regulated at the gene level in Walker 256 tumor-bearing rats supplemented with fish oil rich in EPA and DHA. | 2013 | Braz. J. Med. Biol. Res. | pmid:24036940 |
| Innis SM et al. | Long chain omega-3 fatty acids: micronutrients in disguise. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22709913 |